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2003-128 – Human brain tumors that show invasive behavior in the brains of immunocompromised mice. Numerous, well-characterized tissue grafts are available.
2000-124 – Rat IgG Monoclonal Antibody Reactive Against Murine MBP Major basic protein, Clone 14.7.4 Known Applications: Immunohistochemistry (IHC), Western blot (WB) Known Reactivity: Mouse NIH publication 11067904
2000-020 – Mouse strain allowing inducible gene expression in the heart. Genotype/Phenotype: Utilizes a tetracycline- inducible cardiac-specific promoter (a-MHC) to drive a transactivator activating expression of any target gene. Utility: System for modulating gene expression in cardiac tissue. This technology uses the TET-ON/TET-OFF System®. PMID publication: 11437283
2014-268 – Spinal instrumentation surgeries can often include the use of one or more pedicle screws. The pedicle screws are typically cancellous bone screws and can sustain high loads, which may render them susceptible to failure by loosening or pullout. Various devices and methods have been developed for locking or fixating pedicle screws; however, most of these devices and methods include complicated... Read More
2013-312 – A series of novel prodrugs of K channel openers demonstrated significant intraocular pressure (IOP) lowering in normal mice and in a mouse model of glaucoma. The IOP lowering response obtained from using a K channel openers prodrug combined with other glaucoma drugs on the market seems to be somewhat synergistic
2011-044 – Technology Description Triple reuptake inhibitors (TRIs) are a relatively new class of antidepressants that impact dopamine, serotonin and norepinephrine neurotransmission. Mayo Clinic researchers, in collaboration with researchers from Virginia Tech, developed a novel TRI (PRC200-SS) with potent transporter binding and efficacy in mouse behavioral models. A large pharmaceutical company... Read More
2007-163 – The invention is a series of compounds that block the human transporters for serotonin (hSERT), norepinephrine (hNET), and dopamine (hDAT). Compounds of this series are “triple re-uptake inhibitors” that can be grouped as follows based on their rank-order of potency and affinity at the 3 transporters: 1) potent antagonist of hSERT, hNET, and hDAT with affinity rankings of hSERT (greater than... Read More
2000-090 – Novel small molecule compounds that selectively inhibit norepinephrine, serotonin and dopamine reuptake have been developed. Specifically, the invention provides amine compounds, methods for synthesizing amine compounds, and methods for inhibiting neurotransmitter reuptake. The amine compounds provided herein can be used as potent, wide-spectrum antidepressant medications for inhibiting... Read More
2013-287 – Researchers at Mayo Clinic have generated immortalized osteocytes derived from sclerostin (Sost-/-) knock out and wild-type (Sost+/+) mice. Clonal populations of cells were immortalized with SV40 T-antigen-containing viral constructs and maintained on collagen coated plates. Clone 8 (derived from Sost knock out mice) and clone 12 (derived from Sost wild-type mice) expressed mRNAs for... Read More
2013-288 – The balance between bone loss and deposition is important for normal bone growth and remodeling, and depends on a complex interplay between the resident bone cells: osteoclasts, osteoblasts, and osteocytes. Here we show enhanced cellular production of prostacyclin and increased intra-cellular concentrations of prostacyclin synthase in osteocytes derived from sclerostin knockout mice.... Read More
2013-280 – Background: Mayo Clinic Supply Chain Management is recognized as one of the top supply chain organizations in the country and was recently designated as the number two supply chain organization by Gartner in the healthcare category. One large driver in this recognition is our ability to link financial, operational, and clinical data systems to provide patient outcome and procedure cost... Read More
2013-293 – Background: In 2011, Mayo Clinic Florida piloted a skeleton or framework for the scheduling of appointments. After much success, the framework was categorized as best practice and was expanded to include Mayo Clinic Rochester, Mayo Clinic Arizona, and Mayo Clinic Health Systems. Technology Description: The Decision Tree Software - Appointment Scheduling houses the appointment scheduling... Read More
2013-258 – Technology Description: As a patient-driven design, Shared Care Plan creates a compelling, interactive experience for patients to collaborate with their care team. Patients and caregivers have a single place to communicate their priority concerns, to have meaningful conversations around the plan of care and to understand all aspects of their health. This tool is connected to the patient’s... Read More
2013-285 – Mayo Case No.: 2013-285 Title: Application-based VAD Interrogation System to Prevent Adverse Events Background: According to The Advisory Board Company, the incidence of heart failure in the United States continues to increase with the number of new cases reported growing from 500,000 to 676,000 per year. They estimate that 10% of these cases represent class IV heart failure which is... Read More
2013-273 – Background: Aerobic fitness is one of the best predictors of all-cause mortality but not easily assessed on a large scale accurately. Technology Description: A web based health fitness assessment tool which may be carried out at any location and requires nothing more than a device camera, web portal, a step, and a chair. Using technology based light reflection and color spectrum, heart... Read More
2013-225 – MC Health Connection Patient Decision Support Tool is a software program which can aid patients in important medical decision making. The tool works by organizing medical decision making into decision trees. For each potential limb of decision, the program provides education, risks and benefits and the predicted course of care for each choice. It also delivers, for each choice, an... Read More
2013-180 – Snail is a protein that, when it is active induces an invasive phenotype in cancer cells. Inactivation of Snail can occur by phosphorylation of its amino acid residue serine 11 (see attached publication). We have generated a phosphosite specific antibody that targets the protein Snail, when it is phosphorylated at serine 11. This antibody can be utilized as a research tool, but also allows to... Read More
2013-154 – Synthesis is a platform that provides integration and aggregation across disparate data systems across a common EMR ontology. Synthesis inculdes a rich set of web services as well as viewers for both the Windows and IOS operating systems. Synthesis allows organization to connect an indefinate number of systems and integrate and aggregate them into a consolodated set of data.
2013-152 – This invention record covers following three topics regarding the software development for eye tracking data processing and analysis: 1) Classifying fixations and saccades from raw eye movements and extracting eye tracking features - The analysis of the eye movements is typically performed in terms of “fixations” (maintaing visual gaze within a specific area of the screen or region of... Read More
Two Stable H4 Neuroglioma Cell Lines Expressing Alpha-synuclein Bioluminescent- and Fluorescent- Protein Complemention Pairs
2013-134 – A plasmid was constructed to contain an FRT cassette, hygromycin resistance, and a tetracycline-driven bidirectional promoter. Then the cDNA encoding alpha-synuclein protein was fused with either the N- or C-terminal half of gaussia luciferase, or with the N- or C-terminal half of Yellow Fluorescent Protein sequences. These fusion constructs were then inserted in the bidirectional plasmid... Read More
Improvements to a Novel System for Assessing and Documenting a Trainees Competence in Endoscopic Procedures
2013-112 – This represents improvements to the Mayo Colonoscopy Skills Assessment Tool (MCSAT). The Original MCSAT is a tool designed to be used for assessing endoscopy skills at the bedside In GI fellows throughout the training process. This improvement streamlines the previous tool to make it shorter but also adds the ability to track polyp detection rates lacking in the previous form.
"FACS-TB" a Novel Laboratory Method and Biomarker for Detection and Stratification of Latent Tuberculosis Infection
2013-109 – Accurate detection of the latent form of tuberculosis (TB) infection remains a major clinical and public health problem worldwide, which in the United States, disproportionally affects minorities, foreign-born individuals and patients with weak immune defenses (e.g. patients with HIV infection andlor on immunosuppressive medications). We designed and validated a new method that detects... Read More
2013-107 – The generation of a mouse strain with knockout of B7-H1 gene.
2013-105 – The ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD) compared to the more common ε3 allele. Studies in animal models and humans suggest that apoE4 exhibits both loss-of-function and gain-of-toxic-function compared to apoE3. In regulating amyloid pathology, apoE4 is less efficient than apoE3 in mediating the clearance of... Read More
2013-102 – The Hdac3 conditional knockout mouse model made with Osx-Cre is a useful tool to study the molecular and physiological mechanisms by which factors (e.g., OPG and others) produced in the skeleton, particularly by immature osteoblasts and osteoblast progenitor cells, influence energy metabolism and prevent diseases like type 2 diabetes.
2013-100 – Background: This invention creates a digital dash board which is integrated into a monitor within any invasive laboratory. The digital dash board displays real-time information on the patient during the procedure. The dash board also can be used to assess the risk of the patient and safety assessment prior to the procedure.
2013-099 – Immobilization board that would be positioned under patient’s pelvis. This would allow radiation therapist to tilt pelvis when aligning patient for treatment.
2013-082 – Antigen specific recognition is involved in adaptive immune responses. Most T lymphocytes express an antigen specific αβ T Cell Receptor (TCR) responsible for recognizing its ligand (peptide/MHC) and responding through various effector functions. In an attempt to better understand TCR function, extensive efforts have been placed in discerning the structural and biochemical makeup of the TCR.... Read More
2013-081 – Magnetic resonance imaging (MRI) is widely used to diagnostically investigate the human body. However, unlike other medical imaging modalities (e.g., X-ray CT), MRI data is not explicitly quantitative - pixel values do not directly represent physiological information. There is strong clinical interest in transforming MRI into a quantitative modality, and to measure quantities such as flow,... Read More
2013-061 – We have developed an ongoing procedure at Mayo Clinic for obtaining and xenografting fresh pancreatic adenocarcinoma tumors into SCID mice. The tissues are obtained through an institutionally review board approved process, and informed consent is obtained from the patients. We have full annotation of clinical characteristics and disease course of the patients. Pretreatment blood samples... Read More
Genetically Engineered Mouse Model of Multiple Myeloma Without IoxP Sites (Vk*MYCwoLoxP) and Transplantable Cell Lines
2013-058 – A transgenic mouse model of multiple myeloma. Vk*MYCwoLoxP mice have conditional MYC activation in germinal center B cells. Mice progress to indolent myeloma with features highly characteristic of human disease. These mice can be used to study the biology and drug treatment of multiple myeloma, and can be crossed with conditional mice strains expressing Cre recombinase. Transplantable... Read More
2013-056 – The invention is a method to prepare hydroxamate resin for use in metal ion separations.
Automating Colonoscopy Follow-up to Facilitate Appropriate Colonoscopy Screening and Survellance Intervals
2013-055 – This is an innovative software application that will process clinical variables pertinent to determining colonoscopy follow up intervals for each patient undergoing colonoscopy. This patient management algorithms improves the ability of health care providers to provide high-quality care for patients and to identify appropriate intervals between and timing for the first colon cancer... Read More
2013-044 – Computer-aided detection of polyps in a colonoscopy video may enhance overall polyp detection. We investigated the feasibility of a boundary classification approach for automatic polyp detection. Given a colonoscopy image, the main idea is to identify the edge pixels that lie on the boundary of polyps. To do so, we first use the Canny edge detector to form a crude set of edge pixels, and... Read More
2013-032 – We are developing vesicular stomatitis virus (VSV) for the treatment of MM. We show that when pseudotyped with Maraba virus G glycoprotein, VSV retains its parental cell tropism and replication kinetics. More importantly, in contrast to the parental VSV, the pseudotyped VSV demonstrated considerable resistance to neutralization by both non-immune and VSV-immune serum.
2013-015 – This is an automated tool that assigns a risk score to patients as they are admitted and move through their hospital course. It makes the patient risk factors as well as potential interventions to reduce the risk of readmission transparent to the patient’s care team, closing the loop on the process. We are utilizing AMALGA from Microsoft but the value is in the scoring methodology as a... Read More
2013-014 – Laparoscopic Bowel Retractor for Intra-Abdominal Surgical Exposure. Development of a device that has an ease of operation and keeps the bowel away from the surgical area.
2013-005 – Mechanical, Time-based, Probiotic Delivery Device.
2012-302 – A 12 gene-panel is described capable of predicting whether an induced pluripotent stem (iPS) cell line will have high or low cardiogenic potential upon in vitro differentiation. By comparing microarray data from high-cardiogenic versus low-cardiogenic lines, a discrete panel of genes was extracted and validated in 18 undifferentiated mouse iPS lines. Using PCR for these 12 genes from... Read More
2012-272 – Technology Description The Mayo Clinic Post-Bariatric Surgery App is designed by the bariatric surgery team at Mayo Clinic to help you stay healthy and to achieve your goals following bariatric surgery. This App has a number of exciting features which support your efforts to continue a healthy lifestyle. A pre-bariatric surgery education and engagement app is also available. See... Read More
2012-271 – Technology Description The Mayo Clinic Pre-Bariatric Surgery App is designed by the bariatric surgery team at Mayo Clinic to help you get ready for bariatric surgery. This App has a number of exciting features that are designed to guide you along the path to a healthier lifestyle. These changes are essential to getting the most benefit from your surgery. A post-bariatric surgery... Read More
2012-258 – We have invented an apparatus that automates the standard Drosophila climbing behavioral assay. Traditionally, the climbing assay is performed manually, one vial at a time using the human eye and a stopwatch. 10 flies are place in a vial with a mark placed 2cm from the bottom of the vail. The flies are tapped down to the bottom of the vial by hand and a stopwatch started. The number of flies... Read More
2012-253 – Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are devastating neurodegenerative diseases. FTLD results from the degeneration of the frontal and temporal lobes of the brain, and encompasses a group of disorders distinguished by abnormalities in behavior, language and personalityl. ALS is characterized by the degeneration of motor neurons, resulting in muscle... Read More
2012-252 – Patient derived tumor tissue samples that have been demonstrated to grow in mice.
2012-246 – Mayo has available licensing its patient education materials and videos within the areas of: Allergic Diseases Anesthesiology Cardiac Surgery Cardiovascular Colorectal Surgery Dental Specialties Dermatology Endocrine ENT Gastroenterology General Internal Medicine General Thoracic Surgery Gland General Surgery Hematology Hospital Internal Medicine Infectious Diseases Laboratory Medicine... Read More
2012-224 – Increase in bladder stiffness could be associated with various pathophysiologic conditions. We introduce Ultrasound Bladder Vibrometry (UBV), a novel method for rapid and noninvasive measurement of bladder wall viscoelasticity. UBV uses acoustic radiation force to excite mechanical waves in the bladder wall and track the motion using ultrasound pulse-echo techniques. Fourier domain analysis... Read More
2012-221 – Ultrasound radiation force is used to create propagating waves in soft tissue or other soft materials. The wave propagation is measured using pulse-echo ultrasound methods. We use a two-dimensional Fourier transform method to obtain the Fourier-space (k-space) with the coordinates of frequency (f) and wave number (k). The wave velocity © at each frequency is calculated by finding the... Read More
Application to Automatically Upload Photographs of Skin Lesions to a Patient's Electronic Medical Record
2012-208 – This application would be available for use on portable electronic devices for the purpose of photographing skin lesions or “mole mapping” with the subsequent ability to easily upload/transfer images wirelessly to the patient’s electronic medical record.
2012-206 – This novel digital exam camera (DEC) will allow for visualization in multiple orifices or cavities such as rectum, vagina, wounds, oropharynx, ears, nasal cavity, etc.
2012-196 – A catheter based solution to drain tube obstruction. Surgical drainage tubes often obstruct with blood clots and other debris despite adequate drain care such as stripping the drain and increasing suction. Removal of these clots is often difficult. We provide an instrument and method that may be used to remove these clots without replacing the drain under the radiological guidance or... Read More