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2014-321 – TGR5 antagonist for the treatment of cholangiopathies including polycystic liver disease.
2014-330 – An adult hypomorphic model of Propionic acidemia (PA) in Pcca− mice using a transgene bearing an A138T mutant of the human PCCA protein. Pcca−/−(A138T) mice have 2% of wild-type PCC activity, survive to adulthood, and have elevations in propionylcarnitine, methylcitrate, glycine, alanine, lysine, ammonia, and markers associated with cardiomyopathy similar to those in patients with PA. Data... Read More
2014-229 – Computer modeling followed by synthesis of novel compounds and testing for stearoyl CoA desaturase 1 (SCD1) specific growth inhibition of cancer cells has led to the identification of four novel lead SCD1 inhibitors.
2014-148 – The SR4G transgenic zebrafish stress response reporter line utilizes a tandem array of glucocorticoid response element sequences to drive expression of a short half-life green fluorescent protein when bound by active glucocorticoid receptors. High-resolution imaging and qRT-PCR have been used to characterized the spatiotemporal responses of this reporter line following exposure to exogenous... Read More
2014-102 – The device harvests a small strip of rectus fascia (1 x 5 cm) by simultaneously dilating the rectus fascial, stapling and then cutting the fascia. The device is small enough to fit through a 3-5 cm lower abdominal incision and articulates to an adjustable angle to account for possible patient obesity.
2014-055 – Exon 41 of LRRK2 is floxed, thus LRRK2 can be removed by cre-mediated deletion. Genotype/Phenotype: homozygous LRRK2loxp/ LRRK2loxp, phenotype would be dependent on which cells express Cre after crossing. Utility: Parkinson’s Disease Research PMID: 22647713
2013-206 – This invention has benefit over other methods since it directly quantitates the mAb without the need for interaction with the antigen. By monitoring tryptic peptides from the unique variable regions of the therapeutic mAb and comparing them to the constant regions of a non-human antibody added as an internal standard, the mAb can be measured. This method is superior to other methods using... Read More
2012-285 – A method to identify if an M-spike contains either a kappa or lambda light chain has been discovered through the use of liquid chromatography tandem mass spectrometry (LC-MS/MS).
2012-139 – In normal healty individuals, the plasma cells produce numerous immunoglobulins each with its own unique protein sequence and hence a unique mass. When examined together, the distribution of the masses forms a Gaussian distribution. Patients whom have plasma cells that overproduce immunoglobulins (M-proteins) are at risk for developing serious diseases such as multiple myeloma. Currently,... Read More
2012-062 – Broad patent claims have issued claiming methods for treating renal cell carcinoma by using SCD1 inhibitors and are available for licensing.
2010-196 – iPhil mouse line permitting inducible loss of eosinophils to study eosinophil-related diseases. Genotype/Phenotype: Inducible ablation of eosinophils is accomplished through expression of the human diptheria toxin receptor exclusively in cells of the eosinophil lineage. Diptheria toxin exposure completely eliminates circulating osinophils without affecting other cell types. Depletion is... Read More
2010-142 – Conditional NKAP knockout mouse. Genotype/Phenotype: NKAP is a transcriptional repressor of the Notch signaling pathway. The cre-lox system was used to remove exon 3 of NKAP and disrupt repressor function of NKAP. Loss of NKAP function early in T cell development resulted in a severe block in T cell development. Utility: Mouse model for examining NKAP function and the role of NKAP in T... Read More
2010-040 – Mouse overexpressing PAPP-A in arterial smooth muscle for the study of atherosclerotic lesion development. Genotype/Phenotype: A modified SM22alpha promoter with a deleted repressor element drives smooth muscle overexpression. Upon crossbreeding with ApoE knockout mice, PAPP-A transgenic mice develop larger atherosclerotic lesions than ApoE knockout mice. Utility: Model for examining the... Read More
2009-333 – ERB (estrogen receptor beta) mouse monoclonal antibody. Epitope: amino acids 1-140 Known Applications: Enzyme-linked immunosorbent assay (ELISA), Immunohistochemistry (IHC), Western blot (WB) Known Reactivity: Human
2009-216 – Mouse expressing human rab9 GTPase. Genotype/Phenotype: Mice demonstrate a dramatic reduction in storage of gangliosides and an approximately 22% increase in lifespan relative to controls. Utility: Useful for studies of secretion in the intestine and/or liver. Possible application to other lysosomal storage diseases. Model for in vivo studies of rab9 regulation and activity. PMID:... Read More
2008-229 – Computer input devices are claimed for use in manipulating digital images on a display apparatus in, for example, medical diagnostics. A computer input device as claimed may be particularly useful for manipulation of one or more digital images such as, for example, digital histological images, including but not limited to images of a microscopic tissue section. Manipulation of digital... Read More
2007-110 – Genotype/Phenotype: Mice expressing human MUC1 (mucin) were mated with mice expressing elastase-driven SV40 T antigen. The resulting mice spontaneously develop pancreatic tumors that express high levels of the MUC1. Utility: Useful for investigating immune responses during tumor progression. PMID link: 10975866
2007-064 – Panel is comprised of immortalized lymphopblastoid cell lines from nearly 300 healthy individuals of varying ethnicities. For each line, genome-wide SNP characterization, gene expression, genome wide copy number, and substantial genomic sequencing data are available. This panel is valuable for pharmacogenomic evaluation of drug efficacy and safety in addition to identification of... Read More
2007-016 – Mouse expressing the human alpha-synuclein gene for the study of Parkinson’s disease. Genotype/Phenotype: These mice express the human alpha-synuclein gene, under the control of its endogenous human promoter and regulatory elements. Genomic multiplication of this locus in humans results in Parkinson’s disease with subsequent dementia, with post-mortem transitional or diffuse Lewy body... Read More
2006-220 – Hi52C is a mouse monoclonal antibody (IgG) generated against recombinant human FKBP52. The antibody is highly specific for FKBP52 and recognizes antigen on Western blots and will immunoprecipitate native protein complexes containing FKBP52. Hi52C is known to crossreact with FKBP52 from human, mouse, and rabbit sources. PMID Publication:15831525
2006-219 – Hi51B is a mouse monoclonal antibody (IgG) generated against recombinant human FKBP51. The antibody is highly specific for FKBP51 and recognizes antigen on Western blots and will immunoprecipitate native protein complexes containing FKBP51. Hi51B is known to crossreact with FKBP51 from human, mouse, and rabbit sources.
2006-116 – Mice expressing multiple human HLA class II molecules for the study of immune response to bacterial superantigens. Genotype/Phenotype: Mice express multiple varieties of human HLA class II molecules. Utility: Model systems for studying bacterial superantigens. PMID: 16428778 PMID: 18501769 PMID: 18086265
2004-287 – Rabbit polyclonal antibodies were generated to a specific phosphorylated peptide in the Smad3 protein. Epitope: COOH-GSPSIRCSpSVpS Known Applications: Western blot (WB) Known Reactivity: Human PMID 15520863
2003-128 – Human brain tumors that show invasive behavior in the brains of immunocompromised mice. Numerous, well-characterized tissue grafts are available.
2000-124 – Rat IgG Monoclonal Antibody Reactive Against Murine MBP Major basic protein, Clone 14.7.4 Known Applications: Immunohistochemistry (IHC), Western blot (WB) Known Reactivity: Mouse NIH publication 11067904
2000-020 – Mouse strain allowing inducible gene expression in the heart. Genotype/Phenotype: Utilizes a tetracycline- inducible cardiac-specific promoter (a-MHC) to drive a transactivator activating expression of any target gene. Utility: System for modulating gene expression in cardiac tissue. This technology uses the TET-ON/TET-OFF System®. PMID publication: 11437283
2014-268 – Spinal instrumentation surgeries can often include the use of one or more pedicle screws. The pedicle screws are typically cancellous bone screws and can sustain high loads, which may render them susceptible to failure by loosening or pullout. Various devices and methods have been developed for locking or fixating pedicle screws; however, most of these devices and methods include complicated... Read More
2013-312 – A series of novel prodrugs of K channel openers demonstrated significant intraocular pressure (IOP) lowering in normal mice and in a mouse model of glaucoma. The IOP lowering response obtained from using a K channel openers prodrug combined with other glaucoma drugs on the market seems to be somewhat synergistic
2011-044 – Technology Description Triple reuptake inhibitors (TRIs) are a relatively new class of antidepressants that impact dopamine, serotonin and norepinephrine neurotransmission. Mayo Clinic researchers, in collaboration with researchers from Virginia Tech, developed a novel TRI (PRC200-SS) with potent transporter binding and efficacy in mouse behavioral models. A large pharmaceutical company... Read More
2007-163 – The invention is a series of compounds that block the human transporters for serotonin (hSERT), norepinephrine (hNET), and dopamine (hDAT). Compounds of this series are “triple re-uptake inhibitors” that can be grouped as follows based on their rank-order of potency and affinity at the 3 transporters: 1) potent antagonist of hSERT, hNET, and hDAT with affinity rankings of hSERT (greater than... Read More
2000-090 – Novel small molecule compounds that selectively inhibit norepinephrine, serotonin and dopamine reuptake have been developed. Specifically, the invention provides amine compounds, methods for synthesizing amine compounds, and methods for inhibiting neurotransmitter reuptake. The amine compounds provided herein can be used as potent, wide-spectrum antidepressant medications for inhibiting... Read More
2013-287 – Researchers at Mayo Clinic have generated immortalized osteocytes derived from sclerostin (Sost-/-) knock out and wild-type (Sost+/+) mice. Clonal populations of cells were immortalized with SV40 T-antigen-containing viral constructs and maintained on collagen coated plates. Clone 8 (derived from Sost knock out mice) and clone 12 (derived from Sost wild-type mice) expressed mRNAs for... Read More
2013-288 – The balance between bone loss and deposition is important for normal bone growth and remodeling, and depends on a complex interplay between the resident bone cells: osteoclasts, osteoblasts, and osteocytes. Here we show enhanced cellular production of prostacyclin and increased intra-cellular concentrations of prostacyclin synthase in osteocytes derived from sclerostin knockout mice.... Read More
2013-280 – Background: Mayo Clinic Supply Chain Management is recognized as one of the top supply chain organizations in the country and was recently designated as the number two supply chain organization by Gartner in the healthcare category. One large driver in this recognition is our ability to link financial, operational, and clinical data systems to provide patient outcome and procedure cost... Read More
2013-285 – Mayo Case No.: 2013-285 Title: Application-based VAD Interrogation System to Prevent Adverse Events Background: According to The Advisory Board Company, the incidence of heart failure in the United States continues to increase with the number of new cases reported growing from 500,000 to 676,000 per year. They estimate that 10% of these cases represent class IV heart failure which is... Read More
2013-273 – Background: Aerobic fitness is one of the best predictors of all-cause mortality but not easily assessed on a large scale accurately. Technology Description: A web based health fitness assessment tool which may be carried out at any location and requires nothing more than a device camera, web portal, a step, and a chair. Using technology based light reflection and color spectrum, heart... Read More
2013-225 – MC Health Connection Patient Decision Support Tool is a software program which can aid patients in important medical decision making. The tool works by organizing medical decision making into decision trees. For each potential limb of decision, the program provides education, risks and benefits and the predicted course of care for each choice. It also delivers, for each choice, an... Read More
2013-180 – Snail is a protein that, when it is active induces an invasive phenotype in cancer cells. Inactivation of Snail can occur by phosphorylation of its amino acid residue serine 11 (see attached publication). We have generated a phosphosite specific antibody that targets the protein Snail, when it is phosphorylated at serine 11. This antibody can be utilized as a research tool, but also allows to... Read More
Two Stable H4 Neuroglioma Cell Lines Expressing Alpha-synuclein Bioluminescent- and Fluorescent- Protein Complemention Pairs
2013-134 – A plasmid was constructed to contain an FRT cassette, hygromycin resistance, and a tetracycline-driven bidirectional promoter. Then the cDNA encoding alpha-synuclein protein was fused with either the N- or C-terminal half of gaussia luciferase, or with the N- or C-terminal half of Yellow Fluorescent Protein sequences. These fusion constructs were then inserted in the bidirectional plasmid... Read More
Improvements to a Novel System for Assessing and Documenting a Trainees Competence in Endoscopic Procedures
2013-112 – This represents improvements to the Mayo Colonoscopy Skills Assessment Tool (MCSAT). The Original MCSAT is a tool designed to be used for assessing endoscopy skills at the bedside In GI fellows throughout the training process. This improvement streamlines the previous tool to make it shorter but also adds the ability to track polyp detection rates lacking in the previous form.
"FACS-TB" a Novel Laboratory Method and Biomarker for Detection and Stratification of Latent Tuberculosis Infection
2013-109 – Accurate detection of the latent form of tuberculosis (TB) infection remains a major clinical and public health problem worldwide, which in the United States, disproportionally affects minorities, foreign-born individuals and patients with weak immune defenses (e.g. patients with HIV infection andlor on immunosuppressive medications). We designed and validated a new method that detects... Read More
2013-107 – The generation of a mouse strain with knockout of B7-H1 gene.
2013-105 – The ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD) compared to the more common ε3 allele. Studies in animal models and humans suggest that apoE4 exhibits both loss-of-function and gain-of-toxic-function compared to apoE3. In regulating amyloid pathology, apoE4 is less efficient than apoE3 in mediating the clearance of... Read More
2013-102 – The Hdac3 conditional knockout mouse model made with Osx-Cre is a useful tool to study the molecular and physiological mechanisms by which factors (e.g., OPG and others) produced in the skeleton, particularly by immature osteoblasts and osteoblast progenitor cells, influence energy metabolism and prevent diseases like type 2 diabetes.
2013-100 – Background: This invention creates a digital dash board which is integrated into a monitor within any invasive laboratory. The digital dash board displays real-time information on the patient during the procedure. The dash board also can be used to assess the risk of the patient and safety assessment prior to the procedure.
2013-099 – Immobilization board that would be positioned under patient’s pelvis. This would allow radiation therapist to tilt pelvis when aligning patient for treatment.
2013-082 – Antigen specific recognition is involved in adaptive immune responses. Most T lymphocytes express an antigen specific αβ T Cell Receptor (TCR) responsible for recognizing its ligand (peptide/MHC) and responding through various effector functions. In an attempt to better understand TCR function, extensive efforts have been placed in discerning the structural and biochemical makeup of the TCR.... Read More
2013-081 – Magnetic resonance imaging (MRI) is widely used to diagnostically investigate the human body. However, unlike other medical imaging modalities (e.g., X-ray CT), MRI data is not explicitly quantitative - pixel values do not directly represent physiological information. There is strong clinical interest in transforming MRI into a quantitative modality, and to measure quantities such as flow,... Read More
2013-061 – We have developed an ongoing procedure at Mayo Clinic for obtaining and xenografting fresh pancreatic adenocarcinoma tumors into SCID mice. The tissues are obtained through an institutionally review board approved process, and informed consent is obtained from the patients. We have full annotation of clinical characteristics and disease course of the patients. Pretreatment blood samples... Read More
Genetically Engineered Mouse Model of Multiple Myeloma Without IoxP Sites (Vk*MYCwoLoxP) and Transplantable Cell Lines
2013-058 – A transgenic mouse model of multiple myeloma. Vk*MYCwoLoxP mice have conditional MYC activation in germinal center B cells. Mice progress to indolent myeloma with features highly characteristic of human disease. These mice can be used to study the biology and drug treatment of multiple myeloma, and can be crossed with conditional mice strains expressing Cre recombinase. Transplantable... Read More