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2003-090 – Hydrogel microparticles with entrapped liquid are used as the porogen to reproducibly form interconnected pore networks in a porous scaffold. In one embodiment, a biodegradable unsaturated polymer (for example, PPF or PCF), a crosslinking agent (like a free radical initiator), and a porogen comprising biodegradable hydrogel microparticles (such as OPEF) are mixed together and allowed to form... Read More
2003-048 – Method to Optimize Antigen Expression When Culturing Cells for Cancer Vaccines The culture of cells for use in cancer vaccines or for use in the discovery of tumor antigens occurs in a standard oxygen pressure environment of about 20 kilopascals (kPa). Mayo Clinic researchers have discovered that culturing cancer cells in a low (2 kPa) or high (90kPa) oxygen pressure increases expression... Read More
Synthesis of Poly (caprolactone-fumarate) Polymer as a Novel Biocompatible, Bioresorbable, Injectable, and In-situ Hardening Scaffold for Tissue Engineering Applications
2003-044 – Mayo Clinic researchers have created a biocompatible and bioresorbable PCF material for injectable and in-situ scaffolds by polymerizing a PCF macromer with a salt of fumaric acid that self-crosslinks.
2003-034 – Mayo Clinic clinicians have created a clear, air - inflatable compression dressing that controls swelling and promotes wound healing.
2002-244 – Mayo has discovered a gene, PKHDL1, that shows significant homology to PKHD1 (the gene mutated in autosomal recessive polycystic kidney disease that was discovered at Mayo and for which a patent application is pending). The protein predicted to be encoded by PKHDL1, fibrocystin-L, is a large receptor-like protein that is highly expressed on T lymphocytes. The protein is postulated to be an... Read More
2002-227 – The enzyme utilizes S-adenosylmethionine to methylate aresenite to monomethylarsonate, and can further methylate this product to form dimethylarsinic acid. Known substrates are Aresenite, Methylarsonous acid, Methylarsonous acid. It is known to be expressed in liver, kidney and brain. Arsenic exposure outcomes (death, cancer, neurotoxicity, liver damage, and cardiovascular disease et. al.)... Read More
2002-226 – Our invention is the use biological, pharmacological or saccharide intervention, genetic modification or selection, for antagonist or modulation of Toll-like receptor 4 (TLR4) or other TLRs for the increase and/or maintenance of bone density, osteoporosis, Paget’s disease, or any disease or condition in which bone loss is a factor.
Modulation of Toll-like Receptor 4 Signaling, or Other TLRs for Treatment or Prevention of Obesity and Excess Fat
2002-225 – Our invention is the use biological, pharmacological or saccharide intervention, genetic modification or selection, for antagonist or modulation of Toll-like receptor 4 (TLR4) or other TLRs for the maintenance, or reduction of fat body mass, obesity or any related conditions or diseases where body fat is a contributing factor.
2002-179 – Mayo researchers have developed a method to allow clinical x-ray imaging to reach its full potential. This is achieved by reducing the x-ray dose absorbed by the patient by orders of magnitude and by enhancing the contrast discrimination of the x-ray interaction with different soft-tissue components so that little, if any, contrast agent need be administered. The Time-Of-Flight X-ray... Read More
2002-167 – An RF coil with added coils which transmit only to reduce artifactual signals due to flow or poor magnet shim.
2002-152 – PNMT is the terminal enzyme in catecholamine biosynthesis and catalyses the synthesis of epinephrine from norepinephrine. Norepinephrine and Phenylethanolamine are substrates. The activation is methylation. It is expressed in Chromaffin cells of the Adrenal Medulla, medulla oblongata, hypothalamus, and sensory nuclei of the vagus nerve. Diseases and conditions that may be associated with... Read More
2002-151 – SULT1A3 is involved in the sulfation of Dopamine,other catechol monoamines, serotonin, and Troglitazone. It is expressed in liver, brain, jejunum, kidney and platelets. It may be associated with schizophrenia, affective disorders, renal disease and chemical carcinogenesis. One particular polymorphism, resulting in an amino acid change, was found to be present in 4% of the African American... Read More
2002-136 – Rabbit polyclonal antisera were produced against human and murine Vav-3 proteins using KLH-conjuaged peptides. These antisera recognize an approximately 98 kilodalton protein corresponding to Vav3.
2002-126 – The activity of the gene product is Sulfate conjugation. Several non-synonymous CSNPs have been discovered that affect the enzyme activity.
2002-121 – A monoclonal antibody that interacts with the liver and bone isoenzymes of human alkaline phosphatase.
Transmission Matrix De-embedding/Two-Tier Calibration Methods for Vector Network Analyzer (VNA) Measurement
2002-103 – We present a method for performing de-embedding (or equivalently, second-tier calibration) of vector network analyzer (VNA) measurements allowing for very accurate measurement to reference planes beyond those of a first tier calibration. The method has been proven to be useful up to very high frequencies (at least 110 GHz) and eliminates many of the complexities and limitations associated... Read More
Antibiotic Impregnated Peripherally Inserted Central Catheters (PICC's) with Continuous Central Venous Oximetry
2002-074 – A peripherally inserted central catheter includes three lumens that communicate with its proximal end. A large lumen terminates short of the distal end of the catheter and is used for the infusion of fluids into the venous system. A second lumen terminates at the distal end and is suitable for measuring blood pressure in the central venous system and infusion of fluids into the central venous... Read More
2002-072 – Mayo Clinic researchers have developed a biodegradable polymer device for bridging a gap in a severed nerve. This implant functions both as a scaffold to support axon growth across a gap and as a conduit for the controlled local delivery of agents which may promote axon regeneration.
2002-068 – Mayo Clinic researchers have created microspheres between 1-300 micrometers comprising a blend of cross-linkable PPF for the immobilized controlled release of any bioactive agent.
2002-047 – This is a portable (hand carried), adjustable height, suitcase-style device which stores, in insultated storage compartments, and permits correct anatomic mounting of, harvested porcine upper and lower gastrointestinal tracts on each half of the opened device. This device is intended to demonstrate endoscopic procedures, both diagnostic and therapeutic, using ex vivo animal gastrointestinal... Read More
2002-039 – Technology Description T cell-mediated immune responses are often harmful in transplant patients and patients with autoimmune disease. Currents treatments to suppress T cell-mediated immune responses include a number of immunosuppressive and anti-inflammatory therapies. A novel means of suppressing this immune response has been developed that utilizes mutant forms of a protein normally... Read More
2002-038 – A synthetic valve/leaflet for manufacturing cardiac valve prostheses - mechanical characteristics include anysotopic elasticity - contains stress-bering fibers and is fitted with a thicker area resembling the Nodule of Arantzius of the mature aortic valves.
2002-025 – Computer software which locates polyps and cancers of the colon on CT colonography data sets.
2001-160 – A common problem in clinical magnetic resonance imaging is misalignment of the individual imaging slices on sequential patient examinations. This inter-image misregistration frequently confounds accurate assignment of change or lack thereof in pathologic lesions across serial studies. We describe a rapid and accurate method to register the individual slices of MR images obtained at... Read More
2001-158 – The Avian Leukosis Virus (AVL) group of retroviruses offers a novel platform for the display of polypeptides and offers novel applications for polypeptide display technology. The ability to display polypeptides on the ALV envelope glycoproteins in a replicating retrovirus with an additional expression cassette presents several unique approaches to use this display platform to probe the... Read More
2001-153 – Circulating smooth muscle progenitor cells (SPC) in humans.
2001-152 – Technology portfolio related to Pharmaceutical Dosage Form for Colonic Delivery, Pharmaceutical Dosage Form With Multiple Enteric Polymer Coatings for Colonic Delivery, and Bisacodyl Dosage Form with Multiple Enteric Polymer Coatings for Colonic Delivery
2001-139 – There are two separate 3'-phosphoadenosine 5'-phosphosulfate synthetase (PAPSS) isoforms in humans (PAPSS1 and PAPSS2). Both isoforms catalyze the formation of PAPS, the universal high-energy sulfate donor for all sulfotransferases. Functionally relevant PAPSS1 polymorphisms have been discovered that decrease PAPSS1 activity and result in undersulfation of drugs, procarcinogens, glycoproteins... Read More
2001-138 – SULT1E1 catalyzes reactions with steroid hormones e.g. ß-Estradiol, by transferring a sulfonate group from PAPS to the hydroxy group at position 3 of the estrogen to form Estradiol 3-O-sulfate. Known substrates are estrone and estradiol, catecholestrogens and 2-Methoxyestradiol. SULT1E1 is expressed in the liver, small intestine, adrenal cortex, adrenal medulla, lung, kidney, mammary gland,... Read More
2001-127 – Technology Description Compositions and methods have been developed for detecting plaques and treating CNS disorders. Polyamine modification of amyloid beta peptides or antibodies binding to amyloid beta increases blood-brain barrier (BBB) permeability and incorporation of a contrast agent permits MRI detection of plaque deposits. A novel peptide-based imaging agent has also been developed... Read More
2001-087 – Pedicle oblique support pillar system; shares loads applied to pedicle implant in spine fracture fixation; reduces large bending moments, re-deformity, screw loosening, bending, or breakage; also may be utilized in spinal segmental unit fixation and fusion.
2001-069 – Rigid body translations of an object in MRI will create image artifacts along the phase enclode (PE) direction in standard 2DFT imaging. If two images are acquired with swapped PE direction, it is theoretically possible to determine and correct for arbitrary translational motions in both images directly from the phase differences in the k-space acquisitions by solving a large system of... Read More
2001-050 – Device reproducibly positions subject’s upper extremities while allowing measurement of actively generated forearm torque against resisted rotation in variable forearm positions; used with MMV-01-049.
2001-049 – Device reproducibly positions subject’s upper extremities in field of CT imaging system; allows variable positioning of forearm rotation; allows present forearm positions to be maintained and for active force generation by patient to optimize displacement of bones to demonstrate joint instability.
2001-042 – MR based technique for accurately detecting seed locations following prostate brachytherapy seed therapy. This method optimizes phase perturbations introduced into prostate and surrounding tissue resulting from implantation of brachytherapy seeds with differing susceptibility values and can accurately determine seed location and orientation in the prosstate and surrounding tissue.
2001-040 – Using monoclonal antibodies (mAb) to 4-1BB (CD137) T cell molecule, we will be able to show that this treatment can regress established tumors in mouse models in combination with antigenic peptides and cytokine-modified tumor vaccines. Furthermore, treatment by anti-4-1BB mAb also ameliorates experimental autoimmune encephalomyelitis (EAE) in mice, a model of multiple sclerosis in human. ... Read More
2001-023 – A novel expression system has been developed that selectively expresses ABeta40 or ABeta42 in the secretory pathway. This system enables expression of high levels of specific ABeta peptides. Such a system may be invaluable in developing animal models that critically determine the pathogenicity of individual ABeta peptides. In addition, the system may have general utility as a means of... Read More
2001-021 – Monoclonal antibodies developed against specific portion of the huma sodium iodide symporter (hNIS). Antibody 2-2 and 14f were developed against synthetic peptides representing the 2nd and 14th extramembranous loops of hNIS and antibody FP5a was developed against an MBP-hNIS fusion protein including a carboxyl terminal sequence of hNIS. The antibodies have been characterized and were found... Read More
2001-013 – A non-iterative motion correction that does not use any navigators is described. It can be used with any 3D application and spirals.
2001-009 – SULT2A1 catalyzes the transfer of inorganic sulfate to hydroxysteroids and uses PAPS as the sulfate donor. Genetically based variations in SULT2A1 may affect the metabolism of steroid compounds (DHEA, ethinyl estradiol, minoxidil, androsterone, androstenediol, epiandrosterone, androgens, estrogens, testosterone, and pregnenolone) that are used for drugs, as well as structurally related... Read More
2001-001 – Nearly all elderly persons develop pathologic areas of cell loss and demyelination (called leukoaraiosis), in the central areas of the brain. We have developed an accurate and highly reproducible method for quantitatively measuring the volume of leukoaraiosis from a magnetic resonance image of the brain.
2000-176 – Polyclonal antibodies, NR1, NR2 and NR3 against human and rat PMCa isoforms 1, 2 and 3.
2000-155 – Prosthesis with varying stem stiffness from proximal to distal ends; minimizes stress shielding; decreases bone re-sorption adjacent to proximal end of stem.
2000-131 – An interactive software interface to a detailed brain atlas developed by Kent Ridge Digital Laboratories in Singapore which permits access, display and manipulation of the atlas within the analyze software system. The interface permits rapid and accurate registration of the brain atlas to MRI scans of the brain for the purpose of labeling, segmentation or other functions where defined and... Read More
2000-100 – PAPSS2 is an enzyme that synthesizes PAPS; the high-energy sulfate donor molecule involved in the sulfate conjugation (metabolism) of thousands of drugs, hormones (estrogen), neurotransmitters (dopamine) and many other macromolecules. Rare inactivating mutations in orthologous PAPSS2 genes have been identified as the genetic causes for human spondyloepimetaphyseal dysplasia and murine... Read More
2000-089 – Analytical/software method to quantitate beat-to-beat non-alternating, chaotic variability in electrical repolarization of the heart. This index (TWLI) indicates the presence of a highly malignant arrhythogenic substrate and may be useful for the identification and primary prevention of sudden cardiac death.
2000-080 – The treatment of neutrophil-associated pulmonary inflammation including chronic obstructive pulmonary disease (smoker’s bronchitis), chronic bronchitis, cystic fibrosis, alphal-antitrypsin deficiency, adult respiratory distress syndrome and idiopathic pulmonary fibrosis by lidocaine inhalation.
2000-066 – We have created two lines of transgenic mice expressing human tau with the P301L mutation. Mice expressing the 2-3-10+ human isoform with the P301L mutation develop tau neurofibrillary tangles, motor deficits, and behavioral abnormalities. Mice expressing the longest human tau isofrom (2+3+10+) with the P301L mutation develop balloned neurons as well as neurofibrillary tangles. Motor and... Read More
2000-065 – Mouse class II-deficient HLA-DQB10302, DQA10301 (DQ8) transgenic mice are susceptible to severe collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. To examine whether polymorphism at the DRB1 locus can modulate DQ-restricted arthritis, we generated double- transgenic (DR/DQ) mice. DRB1*0301 (DR3) was introduced into CIA susceptible DQ8.Abeta transgenic mice to generate... Read More
2000-064 – We developed an HLA-DR3.Abo mouse by introducing the DR3 transgene into a H2Abo mouse, class II negative strain, by mating with BIO.M-DRB1*0301 mice. Experimental autoimmune thyroiditis (EAT) is induced in these mice when immunized with either MTg or HTg.