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2006-059 – Peptide or GST-fusion proteins containing antigenic epitopes of WAVE2, Evl, VASP, HS1, STIM, CIN85 and TUBA were used to create polyclonal rabbit antisera. The antibodies are useful for IP, Western blotting and IF.
2006-019 – The invention relates to porous three dimensional structures that may be used to deliver one or more bioactive agents into a location within the body.
2006-018 – Technology Description B7-H4 is a cell surface protein whose expression on tumor cells and tumor-associated vasculature is greatly increased in renal cancers. B7-H4 expression levels on renal tumors have been shown to be a predictor of tumor aggressiveness and to increase mortality rates. B7-H4 is highly expressed on tumors and tumor-associated vasculature but not on normal tissues and... Read More
Quantitative Imaging of Iron as a Marker of Vulnerable Atherosclerotic Lesions Using Computed Tomography
2006-017 – Intraplaque hemorrhage represents an event in the induction and/or as a consequence of instability of advanced atherosclerotic lesions. Iron should accumulate in a lesion after hemorrhage, as part of each erythrocyte, whether isolated or within macrophage-derived cells that have phagocytosed the red blood cells. Moreover, ectopic neovascularization is also a major feature of... Read More
2005-327 – There is a need for a technique to minimize or eliminate the flow of current or heat to unintended tissue during radio-frequency ablation (RFA). By forcing the current/heat to flow only through target tissue, higher ablation energies may be used without the risk of perforation or fistulization.
2005-318 – Mayo Clinic Researchers have created a positively charged hydrogel for controlled DNA delivery for cell transplantation. Oligo- (polyethylene glycol) fumarate (OPF) hydrogel was copolymerized with 2-(methacryloyloxy) ethyl-trimethylammonium chloride (MAETAC) to produce a positively charged hydrogel. This hydrogel can be crosslinked with multiple systems and fabricated into sheets, sponges,... Read More
2005-316 – These mice do not express the gene for CD229.
2005-293 – This antibody selectively recognizes the 38 amino acid from the amyloid beta peptide.
2005-274 – This invention describes a device that slides into the coronary sinus and applies uniform pressure in a stable manner against the limbus.
2005-273 – Methods and materials related to identifying, assessing, and predicting hypertrophic cardiomyopathy (HCM) in mammals.
2005-247 – MAPT (tau) is a protein involved in regulating the structure and function of nerve cells. The clones contain DNA that encodes the tau protein and allow it to be made in cell lines.
2005-239 – A new method to acquire the data for reconstructing 3D magnetization prepared fast gradient echo MR images has been developed. Comparing with existing methods, the MR signals for only a fraction of data points with the combined phase encoding in two directions satisfying a certain criteria are acquired. The acquisitions of these data points are arranged into multiple groups proceed by... Read More
2005-237 – A protein from the fungus alternaria which induces recruitment and activation of eosinophils.
2005-231 – Under the Minnesota Partnership, researchers at the University of Minnesota and at Mayo have developed a database for use in the evaluation of potential prostate cancer biomarkers. Researchers have profiled gene expression of benign and malignant cells that were laser capture microdissected (LCM) from prostate tissues and metastatic adenocarcinomas. In addition, researchers have conducted... Read More
2005-180 – The subsynovial connective tissue (SSCT) is a thin (~1 mm), loose tissue layer around the tendons and median nerve in the carpal tunnel, which has been implicated in the etiology of carpal tunnel syndrome (CTS). A test which could detect abnormalities in the SSCT before the nerve becomes involved could allow interventions before surgery becomes necessary. We have combined a diverse set of... Read More
2005-172 – Serotype selective and nonpeptidic inhibitors of botulinum neurotoxin serotype A (BoNTA) have been developed. These inhibitors are effective in detoxifying botulinum neurotoxin serotype A; they can be used as therapeutics for treating food poisoning by BoNTA, overdose of BoNTA-based cosmetics such as Botox, and they can also be used as countermeausres to BoNTA-based biological weapons.
2005-167 – Chronic obstructive pulmonary disease is a common disorder in which regions of the lung are non-functional or function poorly. One treatment has been surgical resection of non-functioning lung. This invention describes a percutaneous and endoscopic technique that permits the use of ablation between an tranvenous or transarterial catheter and a bronchoscope positioned within the diseased... Read More
2005-165 – The use of HIV protease inhibitors in HIV negative patients increases naive T cell production, which may be useful in helping to boost immune responses. Potential uses include enhancing responses to immunizations, boosting immune function in patients with cancer, and/or immune deficiency disorders.
Genetic Polymorphisms in the Human Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) gene in Caucasian, African American, Han Chinese and Mexican American Populations
2005-156 – Some of the known substrates of CYP19A1 (aromatase) include testosterone and androstenedione. It is expressed in the ovaries, testes, placenta, fetal liver, adipose tissue, chondrocytes, osteoblasts, vasculature smooth muscle, and brain. Increased or decreased enzyme activity is associated with several diseases including breast and endometrial cancer. Several novel polymorphisms have been... Read More
2005-136 – This device is used to treat a painful thumb base joint (1st CMC joint) from arthritis. It is composed of three parts: 1) a screw that threads across the wrist bones; 2) a screw that threads into the thumb metacarpal; and, 3) a plastic liner for the ball-and-socket joint formed by the two screws.
2005-131 – A guide for the use of the patient intervention manual: “My Path to a Smoke Free Future”. It contains rationale for each section of the manual, highlights of key points to be covered during the consultation and examples of phrases to use to explain the key concepts to patients. It is designed for the health care professional to maximize the use of the intervention manual. The accompanying DVD... Read More
2005-127 – Antibodies to various isoforms of HP-1 and SP-1
2005-124 – Common, functionally relevant mutations in the SULT1A1 have been recently discovered. These mutations have a significant effect on SULT1A1 enzyme activity.
2005-115 – Frequently in medical practice there is a need for devices to access tissues that may be difficult to reach. Examples may include: delivery of therapy in the pericardial space outside of the heart (for pacing, defibrillation, placement of medications, or other therapies or energy forms); delivery of treatment for neoplastic or epileptogenic lesions within the brain; or delivery of therapy to... Read More
My Path to a Smoke-Free Future - An Interactive Patient Manual (Suite of Products Including Certification)
2005-112 – An interactive patient manual to assist the health care provider in delivering an effective intervention to patients who use tobacco. The structure of the manual with graphs and illustrations is supported by a motivational approach and is designed to facilitate behavior change when used by a trained health care provider as part of the intervention. It is not another self-help material, but... Read More
A Device to Sense and Modify Daily Standing and Ambulating Time in Humans. STAM (Standing/Ambulating Meter)
2005-091 – Mayo Clinic researchers have developed a device to promote standing & ambulating time as a treatment for obesity and deconditioning. The device is worn on the belt and has two operational modes: i) it measures the time the user spends standing/ambulating per day; and ii) it displays a goal for the user in standing/ambulating minutes per day.
2005-084 – This invention describes a technique and set of tools used to ablate tissue. In this particular embodiment, the specially-designed electrodes have coiled screw mechanisms. These are inserted into the heart and positioned such that intervening tissue can be subjected to radiofrequency ablation. In this particular embodiment, it can be used to cause tissue necrosis of the basal ventricular... Read More
Hydrophilic/hydrophobic Hybrid Polymer Networks Based on Poly(caprolactone fumarate) (PCLF), Poly(Ethylene Glycol Fumarate) (PEGF), and PEGF-co-PCLF
2005-077 – We have developed a new route to synthesize the biodegradeable and injectable polymer poly(ethylene glycol fumarate) (PEGF) and its copolymer with Poly (caprolactone fumarate) (PCLF), PEGF-co-PCLF. These materials can be crosslinked with other unsaturated polymers via redox- or photo-initiation to form hybrid polymer networks. Characteristics of these hybrid networks, such as... Read More
Fluorescent In Situ Hybridization (FISH) Probe Development to Detect Immunoglobulin Light Chains Kapa (IGK) and Lambda (IGL) Translocations
2005-072 – Lymphoma, the cancer to the lymph glands and lymphocytes develop as a consequence of acquired genetic/chromosomal changes. In clinical practice identification of these genetic changes are critical in diagnosis and treatment of lymphoma patient. We have developed fluorescent in situ hybridization (FISH) for two targets frequently involved in lymphoma development. We believe that these probes... Read More
2005-063 – Imaging systems, such as computed tomography, magnetic resonance, or echocardiography are complex devices that not only acquire imaging data but also provide various measurements and displays based on the data. Clinical diagnostic decisions, based on the imaging data, are subjective, experience-based, and affected by stress. This invention describes algorithmical implementation of a trainable... Read More
2005-055 – This implant is a fixation device, shaped in the form of a plate for use in the fixation and stabilization of the thoracolumbar spine. Its design and configuration allow for an anatoic fit of the plate to the spine. Its improved fixation allows it an anatomical and biomechanical advantage in stabilizing thoracolumbar spine trauma both in a primary fashion and/or in conjunction with vertebral... Read More
2005-053 – The shell trajectory is an existing method that is used to acquire MR data. Although to date it has not been as widely used as other methods (e.g., Cartesian acquisition, radial acquisition, or spirals) it has advantages for motion correction and for MR angiography with contrast agents. The current invention is a method to accelerate the shell acquisition by selectively omitting some of the... Read More
2005-031 – Technology Description HIV infected cells express an HIV protease that cleaves caspase 8 to form a polypeptide (Casp8p41) that is not expressed in uninfected cells. Mayo Clinic researchers have demonstrated that this fragment alone promotes mitochondrial depolarization, cytochrome C release, and cell death, while HIV protease resistant procaspase 8 does not. A Casp8p41-specific antibody has... Read More
Self-Contained Semi-Active Cooling Mechanism for Very High Power Density Integrated Circuits and Electronic Modules Using a Reversible Endothermic Chemical Reaction
2005-026 – This invention is a completely self-contained and encapsulated “package” into which a high power integrated circuit (“chip”) such as an amplifier, or an entire subsystem (such as a radar “transmit-receive” module), can be installed to provide the necessary thermal and electrical environment to assure that the chip or multi-chip subsystem works correctly. The packaging approach not only... Read More
2005-022 – CT colonography (CTC) offers advantages for colon examinations such as lower risk and less patient discomfort. However, CTC requires complete bowel preparation (cleansing). The inconvenience and discomfort of this process greatly reduces patient compliance and is a major obstacle to widespread colorectal screening. An alternative is to tag the stool with an opacifying agent so that it is... Read More
2005-021 – Injectable, biodegradable oligo(poly(ethylene glycol) fumarate) (OPF) hydrogels were made from photopolymerization of OPF macromer with UV light and photoinitiator. Hydrogels with varying mechanical property and water content can be made with the change in macromer and crosslinking agent concentration in precursor solution. The biodegradable OPF hydrogels can be injected as fluid into the... Read More
Tandem Mass Spectrometry (MS/MS) of Thiopurine Methyltransferase (TPMT) Reaction Products in order to Quantitate TPMT Enzyme Activity
2005-017 – This invention provides methods and materials related to the measurement of TPMT enzymatic activity in biological samples. The assay involves the incubation of a cell lysate with a TPMT substrate and S-adenosyl-L-methionine (SAM), which acts as a methyl donor, and an isotopically labeled internal standard corresponding to the enzymatically produced methylation product of the TPMT substrate.... Read More
2005-016 – These transgenic mice have regulatable tau expression and profound neurofibrillary pathology, neurodegeneration and memory impairment. The key features are (1) Protein expressed is human tau P301L; (2) Expression of transgenic tau is restricted to the forebrain; (3) Mice develop memory impairment by 2.5 months; (4) Mice develop argyrophilic neurofibrillary tangles by 4 months; (5) Mice... Read More
2005-015 – Software that is able to recognize internal fat within the valve and eliminate it as a diagnostic possibility.
2005-014 – Proteins of the Rho family of GTP-binding proteins regulate multiple cellular phenomenon. There are 17 separate genes that encode 18 proteins (one results from an alternatively spliced gene product). We have used a molecular genetic approach to purify all 18 proteins to homogeneity. These proteins can be used in biochemical assays to test their association and activity with upstream... Read More
Wild-type Constructs for human sulfotransferase genes: namely SULT 1A1, 1A2, 1A3, 1B1, 1C1, 1C2, 2A1, 4A1, 6B1
2005-012 – Wild-type Constructs for human sulfotransferase genes: namely SULT 1A1, 1A2, 1A3, 1B1, 1C1, 1C2, 2A1, 4A1, 6B1. Encoded by these genes are critical for enzymes, metabolism, activation and also detoxification of numerous drugs and compounds.
Hardware Prescription: System and Method for Providing Hospital Quality Medical Care for Home-Based and Mobile Patients. (1) Prescription-Customized Medical Hardware, and (2) the Intelligent Medical Cabinet
2005-002 – A “hardware prescription” comprises (a) re-configurable pieces(s) of hardware (including the PCMH, or prescription-customized medical hardware, that is attached in some way to the patient; and the IMC, or intelligent medical cabinet, that doles out the correct amount and types of medicines based on the patient’s progression) that afford(s) the medical care provider flexibility in managing... Read More
2004-291 – Technology Description Pathogenic mutations of the Leucine-Rich Repeat Kinase 2 (LRRK2) enzyme are recognized as the most frequent genetic cause of both familial and sporadic parkinsonism. Mayo Clinic researchers were the first to identify this association and have gone on to develop an in-depth understanding of LRRK2 function as well as numerous tools to help identify therapeutic agents to... Read More
2004-286 – This invention is a completely self-contained and encapsulated “package” into which a high power integrated circuit (“chip”) such as an amplifier, or an entire subsystem (such as a radar “transmit-receive” module), can be installed to provide the necessary thermal and electrical environment to assure that the chip or multi-chip subsystem works correctly. The packaging approach not only... Read More
Genetic Polymorphisms in the Human Hydroxy-delta-5-steroid Dehydrogenase, 3 Beta-and steroid delta-isomerase 1 (HSD3B1) gene in Caucasian, African American, Han Chinese and Mexican American populations
2004-274 – Substrates include pregnenolone, 17-hydroxypregnenolone (17-OH-Preg), dehydroepiandrosterone (DHEA) and androst-5-ene-3-B,17B-diol. Tissue specificity includes the placenta and skin but it is predominantly expressed in mammary gland tissue. Subcellularly, it is located in the endoplasmic reticulum and the mitochondrial membrane. Congenital deficiency of 3 beta HSD activity causes severe... Read More
Genetic Polymorphisms in the Human Glutathione S-transferase Omega 2 (GSTO2) Gene in Caucasian, African American, Han Chinese and Mexican American Populations
2004-273 – GST02 is a phase II enzyme that utilize glutathione in reactions contributing to the transformation of a wide range of exogenous and endogenous compounds, including carcinogens, therapeutic drugs, and products of oxidative stress. Known substrates are glutathione (GSH) and dehydroascorbate (DHA. It is expressed in liver, kidney and skeletal muscle and at high levels in the testes and low... Read More
2004-268 – Technology Description Mayo Clinic researchers have demonstrated that cAMP inhibitors, such as somatostatin analogs, are effective in treating polycystic liver disease in both animal models and in clinical studies. Current therapeutic options for polycystic liver disease primarily involve surgery, including liver cyst fenestration, and liver resection or liver transplantation. The... Read More
2004-267 – Acoustic energy at, for instance 1kHz stimulated healing of fractures and wounds. In Vitro cells are activated with 1kHz sound and are induced to, for instance, produce extra cellular matrix which accelerates fracture healing. We are exploiting this acoustic activation response of cells in this application for inducing cell responses that advance healing.
2004-263 – A semi-automated computer program to measure joint space width from radiographic images.
2004-258 – Mayo Clinic Researchers have developed a new synthetic, biodegradable, injectable polymer, poly (epsilon-caprolactone fumarate) that is also photocrosslinkable. This new material is colorless or light-colored, and is shown to be self-crosslinkable by both redox initiation and photoinitiation. The molecular weight, chain flexibility, crystallinity, degradation rate, and mechanical properties... Read More