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2005-231 – Under the Minnesota Partnership, researchers at the University of Minnesota and at Mayo have developed a database for use in the evaluation of potential prostate cancer biomarkers. Researchers have profiled gene expression of benign and malignant cells that were laser capture microdissected (LCM) from prostate tissues and metastatic adenocarcinomas. In addition, researchers have conducted... Read More
2005-180 – The subsynovial connective tissue (SSCT) is a thin (~1 mm), loose tissue layer around the tendons and median nerve in the carpal tunnel, which has been implicated in the etiology of carpal tunnel syndrome (CTS). A test which could detect abnormalities in the SSCT before the nerve becomes involved could allow interventions before surgery becomes necessary. We have combined a diverse set of... Read More
2005-172 – Serotype selective and nonpeptidic inhibitors of botulinum neurotoxin serotype A (BoNTA) have been developed. These inhibitors are effective in detoxifying botulinum neurotoxin serotype A; they can be used as therapeutics for treating food poisoning by BoNTA, overdose of BoNTA-based cosmetics such as Botox, and they can also be used as countermeausres to BoNTA-based biological weapons.
2005-167 – Chronic obstructive pulmonary disease is a common disorder in which regions of the lung are non-functional or function poorly. One treatment has been surgical resection of non-functioning lung. This invention describes a percutaneous and endoscopic technique that permits the use of ablation between an tranvenous or transarterial catheter and a bronchoscope positioned within the diseased... Read More
2005-165 – The use of HIV protease inhibitors in HIV negative patients increases naive T cell production, which may be useful in helping to boost immune responses. Potential uses include enhancing responses to immunizations, boosting immune function in patients with cancer, and/or immune deficiency disorders.
Genetic Polymorphisms in the Human Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) gene in Caucasian, African American, Han Chinese and Mexican American Populations
2005-156 – Some of the known substrates of CYP19A1 (aromatase) include testosterone and androstenedione. It is expressed in the ovaries, testes, placenta, fetal liver, adipose tissue, chondrocytes, osteoblasts, vasculature smooth muscle, and brain. Increased or decreased enzyme activity is associated with several diseases including breast and endometrial cancer. Several novel polymorphisms have been... Read More
2005-136 – This device is used to treat a painful thumb base joint (1st CMC joint) from arthritis. It is composed of three parts: 1) a screw that threads across the wrist bones; 2) a screw that threads into the thumb metacarpal; and, 3) a plastic liner for the ball-and-socket joint formed by the two screws.
2005-131 – A guide for the use of the patient intervention manual: “My Path to a Smoke Free Future”. It contains rationale for each section of the manual, highlights of key points to be covered during the consultation and examples of phrases to use to explain the key concepts to patients. It is designed for the health care professional to maximize the use of the intervention manual. The accompanying DVD... Read More
2005-127 – Antibodies to various isoforms of HP-1 and SP-1
2005-124 – Common, functionally relevant mutations in the SULT1A1 have been recently discovered. These mutations have a significant effect on SULT1A1 enzyme activity.
2005-115 – Frequently in medical practice there is a need for devices to access tissues that may be difficult to reach. Examples may include: delivery of therapy in the pericardial space outside of the heart (for pacing, defibrillation, placement of medications, or other therapies or energy forms); delivery of treatment for neoplastic or epileptogenic lesions within the brain; or delivery of therapy to... Read More
My Path to a Smoke-Free Future - An Interactive Patient Manual (Suite of Products Including Certification)
2005-112 – An interactive patient manual to assist the health care provider in delivering an effective intervention to patients who use tobacco. The structure of the manual with graphs and illustrations is supported by a motivational approach and is designed to facilitate behavior change when used by a trained health care provider as part of the intervention. It is not another self-help material, but... Read More
A Device to Sense and Modify Daily Standing and Ambulating Time in Humans. STAM (Standing/Ambulating Meter)
2005-091 – Mayo Clinic researchers have developed a device to promote standing & ambulating time as a treatment for obesity and deconditioning. The device is worn on the belt and has two operational modes: i) it measures the time the user spends standing/ambulating per day; and ii) it displays a goal for the user in standing/ambulating minutes per day.
2005-084 – This invention describes a technique and set of tools used to ablate tissue. In this particular embodiment, the specially-designed electrodes have coiled screw mechanisms. These are inserted into the heart and positioned such that intervening tissue can be subjected to radiofrequency ablation. In this particular embodiment, it can be used to cause tissue necrosis of the basal ventricular... Read More
Hydrophilic/hydrophobic Hybrid Polymer Networks Based on Poly(caprolactone fumarate) (PCLF), Poly(Ethylene Glycol Fumarate) (PEGF), and PEGF-co-PCLF
2005-077 – We have developed a new route to synthesize the biodegradeable and injectable polymer poly(ethylene glycol fumarate) (PEGF) and its copolymer with Poly (caprolactone fumarate) (PCLF), PEGF-co-PCLF. These materials can be crosslinked with other unsaturated polymers via redox- or photo-initiation to form hybrid polymer networks. Characteristics of these hybrid networks, such as... Read More
Fluorescent In Situ Hybridization (FISH) Probe Development to Detect Immunoglobulin Light Chains Kapa (IGK) and Lambda (IGL) Translocations
2005-072 – Lymphoma, the cancer to the lymph glands and lymphocytes develop as a consequence of acquired genetic/chromosomal changes. In clinical practice identification of these genetic changes are critical in diagnosis and treatment of lymphoma patient. We have developed fluorescent in situ hybridization (FISH) for two targets frequently involved in lymphoma development. We believe that these probes... Read More
2005-063 – Imaging systems, such as computed tomography, magnetic resonance, or echocardiography are complex devices that not only acquire imaging data but also provide various measurements and displays based on the data. Clinical diagnostic decisions, based on the imaging data, are subjective, experience-based, and affected by stress. This invention describes algorithmical implementation of a trainable... Read More
2005-055 – This implant is a fixation device, shaped in the form of a plate for use in the fixation and stabilization of the thoracolumbar spine. Its design and configuration allow for an anatoic fit of the plate to the spine. Its improved fixation allows it an anatomical and biomechanical advantage in stabilizing thoracolumbar spine trauma both in a primary fashion and/or in conjunction with vertebral... Read More
2005-053 – The shell trajectory is an existing method that is used to acquire MR data. Although to date it has not been as widely used as other methods (e.g., Cartesian acquisition, radial acquisition, or spirals) it has advantages for motion correction and for MR angiography with contrast agents. The current invention is a method to accelerate the shell acquisition by selectively omitting some of the... Read More
Self-Contained Semi-Active Cooling Mechanism for Very High Power Density Integrated Circuits and Electronic Modules Using a Reversible Endothermic Chemical Reaction
2005-026 – This invention is a completely self-contained and encapsulated “package” into which a high power integrated circuit (“chip”) such as an amplifier, or an entire subsystem (such as a radar “transmit-receive” module), can be installed to provide the necessary thermal and electrical environment to assure that the chip or multi-chip subsystem works correctly. The packaging approach not only... Read More
2005-022 – CT colonography (CTC) offers advantages for colon examinations such as lower risk and less patient discomfort. However, CTC requires complete bowel preparation (cleansing). The inconvenience and discomfort of this process greatly reduces patient compliance and is a major obstacle to widespread colorectal screening. An alternative is to tag the stool with an opacifying agent so that it is... Read More
2005-021 – Injectable, biodegradable oligo(poly(ethylene glycol) fumarate) (OPF) hydrogels were made from photopolymerization of OPF macromer with UV light and photoinitiator. Hydrogels with varying mechanical property and water content can be made with the change in macromer and crosslinking agent concentration in precursor solution. The biodegradable OPF hydrogels can be injected as fluid into the... Read More
Tandem Mass Spectrometry (MS/MS) of Thiopurine Methyltransferase (TPMT) Reaction Products in order to Quantitate TPMT Enzyme Activity
2005-017 – This invention provides methods and materials related to the measurement of TPMT enzymatic activity in biological samples. The assay involves the incubation of a cell lysate with a TPMT substrate and S-adenosyl-L-methionine (SAM), which acts as a methyl donor, and an isotopically labeled internal standard corresponding to the enzymatically produced methylation product of the TPMT substrate.... Read More
2005-016 – These transgenic mice have regulatable tau expression and profound neurofibrillary pathology, neurodegeneration and memory impairment. The key features are (1) Protein expressed is human tau P301L; (2) Expression of transgenic tau is restricted to the forebrain; (3) Mice develop memory impairment by 2.5 months; (4) Mice develop argyrophilic neurofibrillary tangles by 4 months; (5) Mice... Read More
2005-015 – Software that is able to recognize internal fat within the valve and eliminate it as a diagnostic possibility.
Wild-type Constructs for human sulfotransferase genes: namely SULT 1A1, 1A2, 1A3, 1B1, 1C1, 1C2, 2A1, 4A1, 6B1
2005-012 – Wild-type Constructs for human sulfotransferase genes: namely SULT 1A1, 1A2, 1A3, 1B1, 1C1, 1C2, 2A1, 4A1, 6B1. Encoded by these genes are critical for enzymes, metabolism, activation and also detoxification of numerous drugs and compounds.
Hardware Prescription: System and Method for Providing Hospital Quality Medical Care for Home-Based and Mobile Patients. (1) Prescription-Customized Medical Hardware, and (2) the Intelligent Medical Cabinet
2005-002 – A “hardware prescription” comprises (a) re-configurable pieces(s) of hardware (including the PCMH, or prescription-customized medical hardware, that is attached in some way to the patient; and the IMC, or intelligent medical cabinet, that doles out the correct amount and types of medicines based on the patient’s progression) that afford(s) the medical care provider flexibility in managing... Read More
2004-291 – Technology Description Pathogenic mutations of the Leucine-Rich Repeat Kinase 2 (LRRK2) enzyme are recognized as the most frequent genetic cause of both familial and sporadic parkinsonism. Mayo Clinic researchers were the first to identify this association and have gone on to develop an in-depth understanding of LRRK2 function as well as numerous tools to help identify therapeutic agents to... Read More
2004-286 – This invention is a completely self-contained and encapsulated “package” into which a high power integrated circuit (“chip”) such as an amplifier, or an entire subsystem (such as a radar “transmit-receive” module), can be installed to provide the necessary thermal and electrical environment to assure that the chip or multi-chip subsystem works correctly. The packaging approach not only... Read More
Genetic Polymorphisms in the Human Hydroxy-delta-5-steroid Dehydrogenase, 3 Beta-and steroid delta-isomerase 1 (HSD3B1) gene in Caucasian, African American, Han Chinese and Mexican American populations
2004-274 – Substrates include pregnenolone, 17-hydroxypregnenolone (17-OH-Preg), dehydroepiandrosterone (DHEA) and androst-5-ene-3-B,17B-diol. Tissue specificity includes the placenta and skin but it is predominantly expressed in mammary gland tissue. Subcellularly, it is located in the endoplasmic reticulum and the mitochondrial membrane. Congenital deficiency of 3 beta HSD activity causes severe... Read More
Genetic Polymorphisms in the Human Glutathione S-transferase Omega 2 (GSTO2) Gene in Caucasian, African American, Han Chinese and Mexican American Populations
2004-273 – GST02 is a phase II enzyme that utilize glutathione in reactions contributing to the transformation of a wide range of exogenous and endogenous compounds, including carcinogens, therapeutic drugs, and products of oxidative stress. Known substrates are glutathione (GSH) and dehydroascorbate (DHA. It is expressed in liver, kidney and skeletal muscle and at high levels in the testes and low... Read More
2004-268 – Technology Description Mayo Clinic researchers have demonstrated that cAMP inhibitors, such as somatostatin analogs, are effective in treating polycystic liver disease in both animal models and in clinical studies. Current therapeutic options for polycystic liver disease primarily involve surgery, including liver cyst fenestration, and liver resection or liver transplantation. The... Read More
2004-263 – A semi-automated computer program to measure joint space width from radiographic images.
2004-258 – Mayo Clinic Researchers have developed a new synthetic, biodegradable, injectable polymer, poly (epsilon-caprolactone fumarate) that is also photocrosslinkable. This new material is colorless or light-colored, and is shown to be self-crosslinkable by both redox initiation and photoinitiation. The molecular weight, chain flexibility, crystallinity, degradation rate, and mechanical properties... Read More
2004-244 – Technology Description Measurement of patient vitamin D levels in clinical laboratories is one of the most rapidly growing clinical tests in the United States. This is due in part to recent studies demonstrating the beneficial effects of vitamin D and the surprising percentage of the population that is vitamin D deficient. Assays measuring vitamin D are used to diagnose vitamin D deficiency... Read More
2004-237 – The present invention detects the harmonic motion of vibro-acoustography using pulse echo ultrasound and several signal processing methods. The invention estimates the amplitude and phase of the motion at a desired location within a tissue region with a high sensitivity. The tissue harmonic motion generated by the ultrasound radiation force of vibro-acoustography is presented as oscillatory... Read More
2004-231 – The present invention details a substantial implementation improvement for a broad class of Direct Digital Synthesizers (DDSs). A DDS synthesizes a predetermined waveform via digital (i.e., sampled) methods. Typically, the output waveforms are based on sinusoidal functions. For example, a DDS may generate sine waves of various frequency (under digital control). Chirp waveforms (which are... Read More
Decrease of Mitral Regurgitation Severity by Cardiac Resynchronization Therapy as a Novel Method for Treatment of Central Sleep Apnea and/or Left Ventricular Dysfunction
2004-205 – Use of cardiac resynchronization therapy (CRT) as a novel method for treatment of central sleep apnea.
2004-200 – Mayo Clinic Researchers have developed a new synthetic, biodegradable, injectable polymer, poly (propylene fumarate-co-caprolactone) [P(PF-co-CL)]. This new material is a block copolymer of poly (propylene fumarate) (PPF) and poly (epsilon caprolactone) (PCL). The molecular weight, mechanical strength, chain flexibility, degradation rate, and crystallinity can be controlled by varying the... Read More
2004-194 – Invention represents ARMA model describing dynamic behavior between QT and RR intervals in ECG signal. Model predicts QT behavior from detected RR changes. Parameters of model seem to be identical for healthy subjects in all age groups and for both genders. Model may be applied for better understanding of QT interval regulation physiology and pathophysiology, individual sudden arrhythmic... Read More
2004-185 – Discovery of the genetic cause of clinical, late-onset (typical) Parkinson’s disease in multiple families with an autosomal pattern of disease inheritance. Six coding mutations have now been identified within eight families, in a novel gene that is comprised of 61 exons (alternately spliced) that encodes a protein of ~280kD. The gene is located on chromosome 12p11.2-q13.1 and is responsible... Read More
2004-163 – Composite of porous scaffold with cartilage growth from autologous periosteum chondrogenesis induced by tissue engineering techniques. Biological resurfacing of large osteochondral defects, or a complete joint may be feasible using a porous metal scaffold/autologous periosteal construct. The use of this construct eliminates the necessity of using normal cartilage surface as a donor site and... Read More
2004-154 – Expression of GALV-fuse gene in tumor cells causes them to fuse with their nontransfected neighbors forming a multicellular syncytia which eventually dies.
In vivo Visualization of Alzheimer's Amyloid Plaques by MRI in Transgenic Mice without a Contrast Agent
2004-139 – One of the cardinal pathologic features of Alzheimer’s disease (AD) is formation of senile or amyloid, plaques. Transgenic mice have been developed that express one or more of the genes responsible for familial AD in humans. Doubly transgenic mice develop “human-like” plaques, providing a mechanism to study amyloid plaque biology in a controlled manner. Imaging of labeled plaques has been... Read More
2004-109 – This invention is a mouse line in which we disrupted the gene for FKBP52, a protein component of steroid receptor complexes. The animals are reproductively compromised. These animals can be helpful in screening for environmental compounds and drugs that might bind FKBP52 and alter FKBP52-dependent processes. Of particular interest will be compounds that may promote defects in sexual... Read More
2004-108 – The invention is a mouse line in which we disrupted the gene for FKBP51, a protein component of steroid receptor complexes. These animals can be helpful in screening for compounds and drugs that bind FKBP51 and alter FKBP51-dependent processes.
2004-085 – Tissue engineering scaffolds are biomimetic “trellis-like” structures which, on implantation and integration, act as tissue/organ surrogates. This disclosure enables the construction of multi-resolution, variably-refineable, globally interconnected, monolithic and maximally porous scaffolds.
2004-084 – Tissue engineering attempts to address the widening gap between the demand and supply of organ and tissue transplants using natural and biomimetic scaffolds. This invention provides a method to enable the repeatable and rapid fabrication of structurally and functionally enhanced and maximally characterized traditional scaffolds.
2004-061 – We have developed a series of polyclonal antibodies specific for SRC-2 and REA steroid receptor coregulators. The affinity purified antibodies have demonstrated a marked specificity of each polyclonal antibody to its specific co-regulator and this has shown to be functional with western blot analysis, co-precipitations, competition with the specific peptide used as an immunogen, and even the... Read More
2004-056 – This disclosure provides a way to improve the Talairach Labeling scheme that allows labelings to be reported at 0.2 mm resolution - providing 2500% increase over the current standard.