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2007-100 – A mathematical method is described that is used to estimate the inherent phase offsets and timing differences between data acquisitions of raw data acquisitions from the Magnetic Resonance scanner during MR Spectroscopy. Knowledge of the phase offset and time delay of each data set allows the correction of the data so that each set reflects data collected at the same time points with the... Read More
2007-123 – Metal implants are common in patients receiving CT examinations, which can produce artifacts that can significantly degrade the diagnostic value of the image. We have developed a method to reduce the metal artifacts in multi-slice helical CT. This method is based upon the virtual radiographs (VR) created from the helical projection data for each view angle. Automatic segmentation and removal... Read More
2007-067 – This disclosure is based on the continuing development of our technique Shearwave Dispersion Ultrasound Vibrometry or SDUV (2004-237 & 2006-088) which non-invasively quantifies tissue stiffness and viscosity with ultrasound. Herein we propose methods to generate and detect larger SDUV motions for in vivo applications. (vibrometry) (SDUV)
2007-091 – Technology Description There is no available test that predicts the onset of preeclampsia, and current diagnostic methodologies of blood pressure and proteinuria measurement need improvement. Mayo Clinic researchers have discovered an epithelial cell type (podocyte) present in the urine of patients with preeclampsia, and these cells are present in the urine of patients several weeks before... Read More
Establishment and Characterization of an Immunoglobulin Lambda Secreting Cell Line from a Patient with AL Amyloidosis
2007-050 – The ALMC-1 and ALMC-2 cell lines were established from samples before and after peripheral blood stem cell transplant. Both cell lines secrete lambda light chains and these light chains have been shown to contain a beta structure, which is necessary for the configuration of amyloid. Therefore, this cell line provides a useful tool to study the underlying biology of amloidogenic light chains... Read More
2007-027 – Mice that over-express the human wild-type and mutant leucine-rich repeat kinase 2 gene (LRRK2).
2007-012 – Technology Description The past 20 years have witnessed an unprecedented increase in eosinophil-associated diseases such as allergy, asthma, and inflammatory gastrointestinal syndromes. Despite this rise in the need for an eosinophil-specific assay few reagents are available. Mayo Clinic researchers have developed a unique monoclonal antibody reactive to the eosinophil specific protein... Read More
2007-009 – Currently, radiologists interpreting CT colonography exams find it most efficient to view colons primarily in a 2D axial mode, scrolling these slices up and down the abdomen. Typically, the entire colon is scanned twice on the computer screen, first with a “lung” window/level setting (analogous to contrast/brightness) that clearly shows protrusions into the lumen and identifies most typical... Read More
2007-008 – CT colonography (CTC) is being extensively studied for its potential value in colon examinations. Like traditional colonoscopy, CTC requires extensive preparation to cleanse the colon of fecal material. The inconvenience and discomfort associated with this preparation is an important obstacle to compliance with currently recommended colorectal screening guidelines. An alternative is to tag... Read More
2007-007 – This invention consists of a novel display technique for CT colonography data. It is based on automatic generation of a midline trace (centerline) of the colon, followed by display of a sequence of images of the colon that follow this centerline, and display a small field of view centered on it and perpendicular to it. This allows the radiologist the benefit of always seeing the colon in... Read More
2007-006 – This invention consists of a novel display technique for CT colonography data. It is based on automatic generation of a midline trace (centerline) of the colon, followed by display of a sequence of axial images that display a small field of view centered on the trace, and follow along it. This allows the radiologist the benefit of a small field of view to examine the image, but frees him from... Read More
2006-295 – Tandem Biomarkers Identifies a Unique Population of Cardiopoietic Stem Cells Biomarkers used to purify a cardiac-specific stem cell population have not previously been reported. This invention reports the discovery of 1) the first cell surface tag that identifies cardiac progenitors from stem cell population and 2) an efficient approach to enrich large quantities of cardiac progenitors for... Read More
Algorithm for Identification of Regions of Change in Three Dimensional Magnetic Resonance Brain Images
2006-260 – The algorithm examines serial three dimensional magnetic resonance brain image data and identifies regions which have changed from one acquisition to the next.
2006-259 – The algorithm automatically generates samples of key tissues from magnetic resonance brain images.
2006-258 – The algorithm identifies regions of real signal, and eliminates regions where signal is due only to noise.
2006-257 – Technology Description The comparison of serial MR examinations of the brain is a procedure performed frequently by neuroradiologists for diseases such as tumors, multiple sclerosis, Alzheimer’s disease, and others. The primary objective of such imaging is to detect and characterize any changes. Comparison of serial MR studies of brain-tumor patients is a task whose difficulty is widely... Read More
2006-245 – This differential test probe was designed to meet the requirements of an automated test system. It has features not found in commercially available test probes. The ruggedness, compliance of all test pins, and the versatility to test more than one signal/ground pattern makes it useful for the automated test system. The mounting of micro probing pins directly in the center of the signal... Read More
2006-244 – Your Path to Smokeless Tobacco Freedom (Your Path) MC6013-01, is a new intervention booklet for patients who use smokeless tobacco that has been designed by the Nicotine Dependence Center (NDC) counselors and physicians with an emphasis on a patient-centered therapeutic approach to tobacco treatment. Your Path uses the spirit and tools of motivational interviewing to facilitate behavior... Read More
Mayo Clinic Nicotine Dependence Education Program: Customized Workshops for Health-Care Professionals
2006-243 – A training program to teach health-care professionals how to effectively treat patients who use tobacco. The staff of the Mayo Clinic Nicotine Dependence Center (NDC) works with the workshop organizer to develop a curriculum that fits the needs of the participants. Workshops can range in duration from ½ day to 5 days, depending on the depth of knowledge and skills requested. Faculty is... Read More
2006-231 – Rabbit polyclonal antibodies were generated to two components of the calcium-release activated calcium (CRAC) channel, Orai1 and STIM1. These antibodies can be used for immunofluorescence, immunoprecipitation and immunoblotting of Orai1 and STIM1.
2006-224 – This is to provide knowledge about the use of neurotensin receptor agonists for treatment of various medical problems, including acute and chronic pain due to various causes and abuse of various types of psychostimulants (such as nicotine, cocaine, and amphetamines).
2006-196 – The MR shell k-space trajectory is a way to acquire MRI data. It has several intrinsic advantages over standard methods, including improved acquisition efficiency per unit time, compatibility with motion correction methods, and a high degree of venous suppression when used to acquire contrast-enhanced MR angiograms of arteries with intravenous injection of gadolinium-chelate contrast agents.... Read More
2006-159 – The natriuretic peptide family consists of natural hormones involved in the maintenance of fluid and sodium levels through their interactions with the heart and kidneys. Mayo Clinic researchers have developed a novel natriuretic peptide (ABC) which is made up of a unique amino acid sequence designed to preferentially target the kidney to preserve its function and protect it from... Read More
2006-154 – To increase progranulin in animals, progranulin levels and biologically active fragments of progranulin can be elevated in animals by direct administration of the protein or its fragments, either in the presence or absence of agents that stabilize the biological activity. Routes of delivery include, but are not limited to, intranasal, oral, inhalation, intracerebro-ventricular injection,... Read More
2006-145 – Heart diseases are detected by producing a series of ultrasound images that depict the blood flow pattern in the left ventricle at successive phases of the cardiac cycle. The blood flow pattern images are produced by injecting a diluted contrast agent and tracking the contrast agent particles as they flow through the left ventricle by acquiring ultrasound images at a high frame rate.
2006-111 – A harvested bovine colon is layed out on a specially designed tray that allows for the colon to be arranged in a human configuration. This can then be used as a model that allows the performance of a simulated coloscopy for the purposes of training and competency assessment.
2006-104 – Soluble and Extracellular Markers for Early Detection of Prostate Cancer A discriminating panel of genes has been identified that may be used for early detection of prostate cancer. Many of these genes demonstrate prostate-specific expression. Genes encoding extracellular and membrane proteins were selected to facilitate a minimally invasive (e.g. blood sample) form of detection. ... Read More
2006-059 – Peptide or GST-fusion proteins containing antigenic epitopes of WAVE2, Evl, VASP, HS1, STIM, CIN85 and TUBA were used to create polyclonal rabbit antisera. The antibodies are useful for IP, Western blotting and IF.
2006-019 – The invention relates to porous three dimensional structures that may be used to deliver one or more bioactive agents into a location within the body.
2006-018 – Technology Description B7-H4 is a cell surface protein whose expression on tumor cells and tumor-associated vasculature is greatly increased in renal cancers. B7-H4 expression levels on renal tumors have been shown to be a predictor of tumor aggressiveness and to increase mortality rates. B7-H4 is highly expressed on tumors and tumor-associated vasculature but not on normal tissues and... Read More
Quantitative Imaging of Iron as a Marker of Vulnerable Atherosclerotic Lesions Using Computed Tomography
2006-017 – Intraplaque hemorrhage represents an event in the induction and/or as a consequence of instability of advanced atherosclerotic lesions. Iron should accumulate in a lesion after hemorrhage, as part of each erythrocyte, whether isolated or within macrophage-derived cells that have phagocytosed the red blood cells. Moreover, ectopic neovascularization is also a major feature of... Read More
2005-327 – There is a need for a technique to minimize or eliminate the flow of current or heat to unintended tissue during radio-frequency ablation (RFA). By forcing the current/heat to flow only through target tissue, higher ablation energies may be used without the risk of perforation or fistulization.
2005-318 – Mayo Clinic Researchers have created a positively charged hydrogel for controlled DNA delivery for cell transplantation. Oligo- (polyethylene glycol) fumarate (OPF) hydrogel was copolymerized with 2-(methacryloyloxy) ethyl-trimethylammonium chloride (MAETAC) to produce a positively charged hydrogel. This hydrogel can be crosslinked with multiple systems and fabricated into sheets, sponges,... Read More
2005-316 – These mice do not express the gene for CD229.
2005-274 – This invention describes a device that slides into the coronary sinus and applies uniform pressure in a stable manner against the limbus.
2005-273 – Methods and materials related to identifying, assessing, and predicting hypertrophic cardiomyopathy (HCM) in mammals.
2005-237 – A protein from the fungus alternaria which induces recruitment and activation of eosinophils.
2005-231 – Under the Minnesota Partnership, researchers at the University of Minnesota and at Mayo have developed a database for use in the evaluation of potential prostate cancer biomarkers. Researchers have profiled gene expression of benign and malignant cells that were laser capture microdissected (LCM) from prostate tissues and metastatic adenocarcinomas. In addition, researchers have conducted... Read More
2005-180 – The subsynovial connective tissue (SSCT) is a thin (~1 mm), loose tissue layer around the tendons and median nerve in the carpal tunnel, which has been implicated in the etiology of carpal tunnel syndrome (CTS). A test which could detect abnormalities in the SSCT before the nerve becomes involved could allow interventions before surgery becomes necessary. We have combined a diverse set of... Read More
2005-172 – Serotype selective and nonpeptidic inhibitors of botulinum neurotoxin serotype A (BoNTA) have been developed. These inhibitors are effective in detoxifying botulinum neurotoxin serotype A; they can be used as therapeutics for treating food poisoning by BoNTA, overdose of BoNTA-based cosmetics such as Botox, and they can also be used as countermeausres to BoNTA-based biological weapons.
2005-167 – Chronic obstructive pulmonary disease is a common disorder in which regions of the lung are non-functional or function poorly. One treatment has been surgical resection of non-functioning lung. This invention describes a percutaneous and endoscopic technique that permits the use of ablation between an tranvenous or transarterial catheter and a bronchoscope positioned within the diseased... Read More
2005-165 – The use of HIV protease inhibitors in HIV negative patients increases naive T cell production, which may be useful in helping to boost immune responses. Potential uses include enhancing responses to immunizations, boosting immune function in patients with cancer, and/or immune deficiency disorders.
Genetic Polymorphisms in the Human Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) gene in Caucasian, African American, Han Chinese and Mexican American Populations
2005-156 – Some of the known substrates of CYP19A1 (aromatase) include testosterone and androstenedione. It is expressed in the ovaries, testes, placenta, fetal liver, adipose tissue, chondrocytes, osteoblasts, vasculature smooth muscle, and brain. Increased or decreased enzyme activity is associated with several diseases including breast and endometrial cancer. Several novel polymorphisms have been... Read More
2005-136 – This device is used to treat a painful thumb base joint (1st CMC joint) from arthritis. It is composed of three parts: 1) a screw that threads across the wrist bones; 2) a screw that threads into the thumb metacarpal; and, 3) a plastic liner for the ball-and-socket joint formed by the two screws.
2005-131 – A guide for the use of the patient intervention manual: “My Path to a Smoke Free Future”. It contains rationale for each section of the manual, highlights of key points to be covered during the consultation and examples of phrases to use to explain the key concepts to patients. It is designed for the health care professional to maximize the use of the intervention manual. The accompanying DVD... Read More
2005-127 – Antibodies to various isoforms of HP-1 and SP-1
2005-124 – Common, functionally relevant mutations in the SULT1A1 have been recently discovered. These mutations have a significant effect on SULT1A1 enzyme activity.
2005-115 – Frequently in medical practice there is a need for devices to access tissues that may be difficult to reach. Examples may include: delivery of therapy in the pericardial space outside of the heart (for pacing, defibrillation, placement of medications, or other therapies or energy forms); delivery of treatment for neoplastic or epileptogenic lesions within the brain; or delivery of therapy to... Read More
My Path to a Smoke-Free Future - An Interactive Patient Manual (Suite of Products Including Certification)
2005-112 – An interactive patient manual to assist the health care provider in delivering an effective intervention to patients who use tobacco. The structure of the manual with graphs and illustrations is supported by a motivational approach and is designed to facilitate behavior change when used by a trained health care provider as part of the intervention. It is not another self-help material, but... Read More
A Device to Sense and Modify Daily Standing and Ambulating Time in Humans. STAM (Standing/Ambulating Meter)
2005-091 – Mayo Clinic researchers have developed a device to promote standing & ambulating time as a treatment for obesity and deconditioning. The device is worn on the belt and has two operational modes: i) it measures the time the user spends standing/ambulating per day; and ii) it displays a goal for the user in standing/ambulating minutes per day.