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Fluorescent In Situ Hybridization (FISH) Probe Development to Detect Immunoglobulin Light Chains Kapa (IGK) and Lambda (IGL) Translocations
2005-072 – Lymphoma, the cancer to the lymph glands and lymphocytes develop as a consequence of acquired genetic/chromosomal changes. In clinical practice identification of these genetic changes are critical in diagnosis and treatment of lymphoma patient. We have developed fluorescent in situ hybridization (FISH) for two targets frequently involved in lymphoma development. We believe that these probes... Read More
2005-063 – Imaging systems, such as computed tomography, magnetic resonance, or echocardiography are complex devices that not only acquire imaging data but also provide various measurements and displays based on the data. Clinical diagnostic decisions, based on the imaging data, are subjective, experience-based, and affected by stress. This invention describes algorithmical implementation of a trainable... Read More
2005-055 – This implant is a fixation device, shaped in the form of a plate for use in the fixation and stabilization of the thoracolumbar spine. Its design and configuration allow for an anatoic fit of the plate to the spine. Its improved fixation allows it an anatomical and biomechanical advantage in stabilizing thoracolumbar spine trauma both in a primary fashion and/or in conjunction with vertebral... Read More
2005-053 – The shell trajectory is an existing method that is used to acquire MR data. Although to date it has not been as widely used as other methods (e.g., Cartesian acquisition, radial acquisition, or spirals) it has advantages for motion correction and for MR angiography with contrast agents. The current invention is a method to accelerate the shell acquisition by selectively omitting some of the... Read More
Self-Contained Semi-Active Cooling Mechanism for Very High Power Density Integrated Circuits and Electronic Modules Using a Reversible Endothermic Chemical Reaction
2005-026 – This invention is a completely self-contained and encapsulated “package” into which a high power integrated circuit (“chip”) such as an amplifier, or an entire subsystem (such as a radar “transmit-receive” module), can be installed to provide the necessary thermal and electrical environment to assure that the chip or multi-chip subsystem works correctly. The packaging approach not only... Read More
2005-022 – CT colonography (CTC) offers advantages for colon examinations such as lower risk and less patient discomfort. However, CTC requires complete bowel preparation (cleansing). The inconvenience and discomfort of this process greatly reduces patient compliance and is a major obstacle to widespread colorectal screening. An alternative is to tag the stool with an opacifying agent so that it is... Read More
2005-021 – Injectable, biodegradable oligo(poly(ethylene glycol) fumarate) (OPF) hydrogels were made from photopolymerization of OPF macromer with UV light and photoinitiator. Hydrogels with varying mechanical property and water content can be made with the change in macromer and crosslinking agent concentration in precursor solution. The biodegradable OPF hydrogels can be injected as fluid into the... Read More
Tandem Mass Spectrometry (MS/MS) of Thiopurine Methyltransferase (TPMT) Reaction Products in order to Quantitate TPMT Enzyme Activity
2005-017 – This invention provides methods and materials related to the measurement of TPMT enzymatic activity in biological samples. The assay involves the incubation of a cell lysate with a TPMT substrate and S-adenosyl-L-methionine (SAM), which acts as a methyl donor, and an isotopically labeled internal standard corresponding to the enzymatically produced methylation product of the TPMT substrate.... Read More
2005-016 – These transgenic mice have regulatable tau expression and profound neurofibrillary pathology, neurodegeneration and memory impairment. The key features are (1) Protein expressed is human tau P301L; (2) Expression of transgenic tau is restricted to the forebrain; (3) Mice develop memory impairment by 2.5 months; (4) Mice develop argyrophilic neurofibrillary tangles by 4 months; (5) Mice... Read More
2005-015 – Software that is able to recognize internal fat within the valve and eliminate it as a diagnostic possibility.
Wild-type Constructs for human sulfotransferase genes: namely SULT 1A1, 1A2, 1A3, 1B1, 1C1, 1C2, 2A1, 4A1, 6B1
2005-012 – Wild-type Constructs for human sulfotransferase genes: namely SULT 1A1, 1A2, 1A3, 1B1, 1C1, 1C2, 2A1, 4A1, 6B1. Encoded by these genes are critical for enzymes, metabolism, activation and also detoxification of numerous drugs and compounds.
2004-291 – Technology Description Pathogenic mutations of the Leucine-Rich Repeat Kinase 2 (LRRK2) enzyme are recognized as the most frequent genetic cause of both familial and sporadic parkinsonism. Mayo Clinic researchers were the first to identify this association and have gone on to develop an in-depth understanding of LRRK2 function as well as numerous tools to help identify therapeutic agents to... Read More
2004-286 – This invention is a completely self-contained and encapsulated “package” into which a high power integrated circuit (“chip”) such as an amplifier, or an entire subsystem (such as a radar “transmit-receive” module), can be installed to provide the necessary thermal and electrical environment to assure that the chip or multi-chip subsystem works correctly. The packaging approach not only... Read More
Genetic Polymorphisms in the Human Hydroxy-delta-5-steroid Dehydrogenase, 3 Beta-and steroid delta-isomerase 1 (HSD3B1) gene in Caucasian, African American, Han Chinese and Mexican American populations
2004-274 – Substrates include pregnenolone, 17-hydroxypregnenolone (17-OH-Preg), dehydroepiandrosterone (DHEA) and androst-5-ene-3-B,17B-diol. Tissue specificity includes the placenta and skin but it is predominantly expressed in mammary gland tissue. Subcellularly, it is located in the endoplasmic reticulum and the mitochondrial membrane. Congenital deficiency of 3 beta HSD activity causes severe... Read More
Genetic Polymorphisms in the Human Glutathione S-transferase Omega 2 (GSTO2) Gene in Caucasian, African American, Han Chinese and Mexican American Populations
2004-273 – GST02 is a phase II enzyme that utilize glutathione in reactions contributing to the transformation of a wide range of exogenous and endogenous compounds, including carcinogens, therapeutic drugs, and products of oxidative stress. Known substrates are glutathione (GSH) and dehydroascorbate (DHA. It is expressed in liver, kidney and skeletal muscle and at high levels in the testes and low... Read More
2004-268 – Technology Description Mayo Clinic researchers have demonstrated that cAMP inhibitors, such as somatostatin analogs, are effective in treating polycystic liver disease in both animal models and in clinical studies. Current therapeutic options for polycystic liver disease primarily involve surgery, including liver cyst fenestration, and liver resection or liver transplantation. The... Read More
2004-263 – A semi-automated computer program to measure joint space width from radiographic images.
2004-258 – Mayo Clinic Researchers have developed a new synthetic, biodegradable, injectable polymer, poly (epsilon-caprolactone fumarate) that is also photocrosslinkable. This new material is colorless or light-colored, and is shown to be self-crosslinkable by both redox initiation and photoinitiation. The molecular weight, chain flexibility, crystallinity, degradation rate, and mechanical properties... Read More
2004-244 – Technology Description Measurement of patient vitamin D levels in clinical laboratories is one of the most rapidly growing clinical tests in the United States. This is due in part to recent studies demonstrating the beneficial effects of vitamin D and the surprising percentage of the population that is vitamin D deficient. Assays measuring vitamin D are used to diagnose vitamin D deficiency... Read More
2004-237 – The present invention detects the harmonic motion of vibro-acoustography using pulse echo ultrasound and several signal processing methods. The invention estimates the amplitude and phase of the motion at a desired location within a tissue region with a high sensitivity. The tissue harmonic motion generated by the ultrasound radiation force of vibro-acoustography is presented as oscillatory... Read More
2004-231 – The present invention details a substantial implementation improvement for a broad class of Direct Digital Synthesizers (DDSs). A DDS synthesizes a predetermined waveform via digital (i.e., sampled) methods. Typically, the output waveforms are based on sinusoidal functions. For example, a DDS may generate sine waves of various frequency (under digital control). Chirp waveforms (which are... Read More
2004-200 – Mayo Clinic Researchers have developed a new synthetic, biodegradable, injectable polymer, poly (propylene fumarate-co-caprolactone) [P(PF-co-CL)]. This new material is a block copolymer of poly (propylene fumarate) (PPF) and poly (epsilon caprolactone) (PCL). The molecular weight, mechanical strength, chain flexibility, degradation rate, and crystallinity can be controlled by varying the... Read More
2004-185 – Discovery of the genetic cause of clinical, late-onset (typical) Parkinson’s disease in multiple families with an autosomal pattern of disease inheritance. Six coding mutations have now been identified within eight families, in a novel gene that is comprised of 61 exons (alternately spliced) that encodes a protein of ~280kD. The gene is located on chromosome 12p11.2-q13.1 and is responsible... Read More
2004-163 – Composite of porous scaffold with cartilage growth from autologous periosteum chondrogenesis induced by tissue engineering techniques. Biological resurfacing of large osteochondral defects, or a complete joint may be feasible using a porous metal scaffold/autologous periosteal construct. The use of this construct eliminates the necessity of using normal cartilage surface as a donor site and... Read More
2004-154 – Expression of GALV-fuse gene in tumor cells causes them to fuse with their nontransfected neighbors forming a multicellular syncytia which eventually dies.
In vivo Visualization of Alzheimer's Amyloid Plaques by MRI in Transgenic Mice without a Contrast Agent
2004-139 – One of the cardinal pathologic features of Alzheimer’s disease (AD) is formation of senile or amyloid, plaques. Transgenic mice have been developed that express one or more of the genes responsible for familial AD in humans. Doubly transgenic mice develop “human-like” plaques, providing a mechanism to study amyloid plaque biology in a controlled manner. Imaging of labeled plaques has been... Read More
2004-109 – This invention is a mouse line in which we disrupted the gene for FKBP52, a protein component of steroid receptor complexes. The animals are reproductively compromised. These animals can be helpful in screening for environmental compounds and drugs that might bind FKBP52 and alter FKBP52-dependent processes. Of particular interest will be compounds that may promote defects in sexual... Read More
2004-108 – The invention is a mouse line in which we disrupted the gene for FKBP51, a protein component of steroid receptor complexes. These animals can be helpful in screening for compounds and drugs that bind FKBP51 and alter FKBP51-dependent processes.
2004-061 – We have developed a series of polyclonal antibodies specific for SRC-2 and REA steroid receptor coregulators. The affinity purified antibodies have demonstrated a marked specificity of each polyclonal antibody to its specific co-regulator and this has shown to be functional with western blot analysis, co-precipitations, competition with the specific peptide used as an immunogen, and even the... Read More
2004-056 – This disclosure provides a way to improve the Talairach Labeling scheme that allows labelings to be reported at 0.2 mm resolution - providing 2500% increase over the current standard.
2004-055 – This invention performs a robust, fast and fully automatic parameterization of T2 images into an intensity space that all existing approaches optimized to handle T1 images can benefit from.
2004-027 – To accomplish a given computational task, a number of algorithmic and heuristic approaches can be implemented to act upon the given instance of the input data. Depending upon the intrinsic and extrinsic assumptions made regarding the data, algorithm and the task, the end result from each of these approaches could be different. Currently, there does not exist an automatic fast, robust, precise... Read More
Prior Knowledge-Based Rapid Predicted Preview of Multiple Contrast Magnetic Resonance Images Derived from a Single Time Budgeted Acquisition
2004-023 – This invention presents a method for producing multiple MR images with different contrast from a single image acquisition. (MR T2) The methodology is used to enhance the T2 related contrast in an MRI image acquired at, but no restricted to, just-enough-to-highlight-T2, repetition time so as to produce a computed mosaic of the same image at different repetition (TR) and echo (TE) times. This... Read More
2004-020 – The CCAP program accurately and efficiently counts and analyzes cells in microscope images. A user interactively completes the followings steps: 1) Inhomogeneity correction: A digital filter is applied to correct for uneven illumination. 2) Calibration: A line is placed over an object of known size, usually a ruler, to determine the size of the image pixels. 3) Segmentation: The cells... Read More
2004-012 – There are a variety of devices being developed to significantly improve the testing, characterization, and development of differential protocols, equipment, and devices. In essence, these devices provide a way of dealing with differential signals within a laboratory environment.
Discovery and Identification of Naturally Processed and Presented HLA Class II Measles Vaccine Virus Peptides
2004-011 – Two measles vaccine virus-derived peptides, from the nucleoprotein (N peptide) and Phosphoprotein P peptide). Specifically, 1) N-1 peptide: SAGKVSSTLASELG (14 amino acid peptide); 2) P-1 peptide: ASDVETAEGGEIHELLRLQ (19 amino acid peptide)
Projection Angle Order and Correction Algorithm to Compensate In-Plane Rotation and Translation in Radial MRI Scans
2004-008 – The motion correction strategy compensates for rigid-body in-plane rotation and translation of the imaged object by collecting radial MRI data with a novel projection view angle acquisition order followed by a data correction algorithm. A custom MR pulse sequence was created to collect radial projections with a consistent spacing of approximately 45 degrees, which is crucial for the novel... Read More
2003-199 – The invention is an ultra-miniature transceiver technology that allows positioning, data relaying and identification in a very tiny form factor (e.g., “pinhead” size). The transceiver is based on a system-on-a-chip (SOC) design of a radio frequency (RF) transceiver that is combined with a micro-miniature battery and an antenna (or in some cases two antennas). The invention enables... Read More
2003-196 – Transgenic mice were created through DNA microinjection of a construct utilizing mouse EPO derived regulatory sequences in conjunction with the Diptheria Toxin A chain (DT-A) open reading frame and a series of exons/introns derived from the human growth hormone gene to provide the necessary splicing events required for high-level expression. Assessments of circulating leukocytes and other... Read More
2003-185 – The invention describes a new algorithm and hardware architecture to compute the fast Fourier transform (FFT). The new algorithm uses a divide and conquer approach to reduce an N point FFT to a plurality of sqrt(N) point FFTs arranged in a pipeline configuration. A new specialized center element joins identical, conventional pipeline FFT units together and provides the necessary control logic... Read More
2003-150 – A mouse lacking both copies of the IEX-1 gene was generated. These mice have a mean arterial blood pressure that is approximately 30mm of Hg higher than that seen in wild type mice. These mice are useful for assessing compounds for the ability to reduce high blood pressure.
2003-149 – Technology Description Compositions and methods have been developed for detecting plaques and treating CNS disorders. Polyamine modification of amyloid beta peptides or antibodies binding to amyloid beta increases blood-brain barrier (BBB) permeability and incorporation of a contrast agent permits MRI detection of plaque deposits. A novel peptide-based imaging agent has also been developed... Read More
2003-119 – A device to facilitate epicardial placement of permanent pacing leads, ablation catheters, and other therapeutic leads/catheters.
2003-048 – Method to Optimize Antigen Expression When Culturing Cells for Cancer Vaccines The culture of cells for use in cancer vaccines or for use in the discovery of tumor antigens occurs in a standard oxygen pressure environment of about 20 kilopascals (kPa). Mayo Clinic researchers have discovered that culturing cancer cells in a low (2 kPa) or high (90kPa) oxygen pressure increases expression... Read More
Synthesis of Poly (caprolactone-fumarate) Polymer as a Novel Biocompatible, Bioresorbable, Injectable, and In-situ Hardening Scaffold for Tissue Engineering Applications
2003-044 – Mayo Clinic researchers have created a biocompatible and bioresorbable PCF material for injectable and in-situ scaffolds by polymerizing a PCF macromer with a salt of fumaric acid that self-crosslinks.
2003-034 – Mayo Clinic clinicians have created a clear, air - inflatable compression dressing that controls swelling and promotes wound healing.
2002-244 – Mayo has discovered a gene, PKHDL1, that shows significant homology to PKHD1 (the gene mutated in autosomal recessive polycystic kidney disease that was discovered at Mayo and for which a patent application is pending). The protein predicted to be encoded by PKHDL1, fibrocystin-L, is a large receptor-like protein that is highly expressed on T lymphocytes. The protein is postulated to be an... Read More
2002-227 – The enzyme utilizes S-adenosylmethionine to methylate aresenite to monomethylarsonate, and can further methylate this product to form dimethylarsinic acid. Known substrates are Aresenite, Methylarsonous acid, Methylarsonous acid. It is known to be expressed in liver, kidney and brain. Arsenic exposure outcomes (death, cancer, neurotoxicity, liver damage, and cardiovascular disease et. al.)... Read More
2002-226 – Our invention is the use biological, pharmacological or saccharide intervention, genetic modification or selection, for antagonist or modulation of Toll-like receptor 4 (TLR4) or other TLRs for the increase and/or maintenance of bone density, osteoporosis, Paget’s disease, or any disease or condition in which bone loss is a factor.
Modulation of Toll-like Receptor 4 Signaling, or Other TLRs for Treatment or Prevention of Obesity and Excess Fat
2002-225 – Our invention is the use biological, pharmacological or saccharide intervention, genetic modification or selection, for antagonist or modulation of Toll-like receptor 4 (TLR4) or other TLRs for the maintenance, or reduction of fat body mass, obesity or any related conditions or diseases where body fat is a contributing factor.