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2008-292 – Guiding catheters must be of sufficient stiffness to offer support during endovascular procedures, but must not be too stiff to track to their intended target. We describe a system with a relatively supple catheter that has a separate lumens or lumens within its walls, which do not communicate with the main, working lumen. The extra lumens can be used to place stiffening wires after the... Read More
Aquaporin-4-Binding Autoantibodies in Patients with Neuromyelitis Optica Impair Glutamate Transport by Down-Regulating EAAT2
2008-303 – Materials and Methods for Treating Neuromyelitis Optics (NMO) Methods for treating NMO are claimed including the use of glulamate receptor antagonists and/or compounds that inhibit complement.
2008-268 – Methods and devices are disclosed for the attachment of a soft tissue structure (e.g., tendon or ligament) to bone or a prosthetic implant. In one form, the device includes a clamp comprising a porous metallic material. The clamp includes a convex tissue engaging surface. The device also includes a fastener for compressing the soft tissue between the tissue engaging surface and the bone or... Read More
2008-266 – In multiple animal models of cardiovascular disease, including hypertrophic cardiomyopathy (enlargement of the heart), dilated cardiomyopathy (dilation and weakening of the heart), and heart failure (ineffective heart function), a protein which plays a key role in the heart is lost - junctophilin type-2 encoded by the gene JPH2. Our invention, a “recombinant junctophilin - 2”, provides a... Read More
2008-279 – When a coronary artery is blocked options include angioplasty (ballooning or stenting across the blockage) or bypass surgery. The most effective means of bypass surgery in terms of long-term results is to use the left internal mammary artery as the bypass vessel. Angioplasty in stenting is frequently not possible when a complete obstruction to a coronary artery is present. Placing the left... Read More
2008-249 – Tendon injuries are very common, but functional restoration of the injured tendon still presents a challenge. Tissue engineering approaches provide the possibility of enhancing tendon healing or tendon tissue regeneration. Mayo Clinic researches have developed an engineered tendon substitute using acellular tendon slices seeded with cultured bone marrow stem cells as a regeneration scaffold... Read More
2008-277 – Anaplastic thyroid carcinoma (ATC) is one of the deadliest cancers with lethality of >99% and survival average of 4 months. Recent publications have demonstrated over 40% of thyroid cell lines are of questionable origin especially ATC cell lines (Schweppe et al., J Clin Endocrinol Metab 2008). We have developed four cell lines from human ATC tumor tissues. These cell lines represent the... Read More
2008-202 – Balloons are used to create cavities in bones for several applications, including cement injection. Current design features include initial placement of a cannula into the bone, through which the balloon is inserted. An alternative design would be to mount the balloon on the outside of the cannula itself, such that the balloon could simply be inflated once the cannula reaches its intended... Read More
Mathematical Model of Insulin Secretion in Response to Changing Glucose Concentrations to Allow Creation of an Artificial Pancreas
2008-201 – The relationship between insulin secretion and changes in glucose concentrations is not linear and is affected by parameters such as body weight, rate of change, time of day, concomitant activities such as exercise or eating and insulin sensitivity. This model attempts to relate the relationship of insulin to glucose in terms that would be used to program an insulin pump that could respond to... Read More
2008-214 – The present invention is a circuit block used to condition and sample a variety of electrical signals in characterization and system applications. The internal passive circuitry eases characterization of high-speed differential and single-ended applications by providing impedance-matched environment and integrating unique capabilities such as true differential termination, pass-through... Read More
2008-195 – Retroviral or lentiviral vector-mediated stable introduction of some stem cell-associated genes can reprogram adult somatic cells into embryonic stem cell-like “induced pluripotent stem (iPS) cells.” Our inventions are i) cross-species reprogramming (e.g. use of human factors to generate iPS cells from non-human origin, such as a mouse, rat, hampster, cat, dog, pig, cow, sheep, horse or... Read More
2008-163 – These mice conditionally express the human tau cDNA (4RON isoform) containing the FTDP-17 mutation (P301L) in exon 10. These mice utilize the TET-ON/TET-OFF® system to express approximately 7X human tau in comparison to murine tau. Both the tTA transgene (Memory Pharmaceuticals) and the tau transgene (Mayo) must be present to yield expression of the human tau. Doxycycline in the diet of the... Read More
2008-141 – Dual energy CT performed using dual source scanner geometry is limited to dual energy algorithms that operate using reconstructed images. This limits the ability to remove beam hardening artifacts, which are introduced during the image reconstruction process. The novel algorithm disclosed here allows for realignmnet of the high- and low-energy datasets, which are 90degrees out of phase, such... Read More
2008-139 – Mouse monoclonal Ab9-A, isotype A of the original Ab9 mouse monoclonal made to human amyloid beta 1-16, was created by class-switching the original Ab9 IgG isotype. This was done with serial dilutions to find the very few clones of isotype A, identifying these clones, and growing them up. Fourteen clones were identified. All are likely to be useful. Only one, 15E7.17.10 (see table), was grown... Read More
2008-184 – This invention relates to the production in large quantity and high purity of a novel peptide expression plasmid. Peptides are short polymers formed from amino acids, working as signaling molecules. In biomedicine, peptides are used as probes to resolve protein interactions, a key biological process governing multiple vital functions, as well as drugs to target disease-causing proteins.... Read More
2008-136 – A method is described which provides reduction of acquisition time for 3DFT MRI. It is based on a specific way to sample k-space which is robust to undersampling. It can be used in conjunction with other methods for reduction of acquisition time.
A Novel Series of Designer Peptides Combining Angiotensin - (1-7) With Selected Amino Acid Sequences from the Natriuretic Peptides and a Novel Strategy of Co-Administration of Angiotensin - (1-7) With a Native or Designer Natriuretic Peptide
2008-179 – Our research focuses on the discovery and development of new drugs for the prevention and treatment of diseases affecting the heart, the blood vessels, and the kidneys. We have designed a novel series of ten peptides by combining angiotensin-(1-7) with selected amino sequences from the natriuretic peptides, as both angiotensin-(1-7) and the natriuretic peptides have been demonstrated to exert... Read More
2008-178 – A technique is described for MR imaging of an extended field of which uses a combination of multiple-fixed-station and continuously moving table acquisitions. This preserves the ability to perform acceleration techniques and also provides high time efficiency.
2008-177 – A coil array is designed for 2D acceleration in MRI for imaging an object with markedly different fields of view in the two phase encoding directions in which the coil elements in one direction have markedly different size than elements in the other direction.
2008-126 – Monoclonal antibodies were raised to human Abeta1-42. The peptide used to immunize was Abeta 35-42. This antibody is also known as MM40-21.3.1
2008-125 – Monoclonal antibodies were raised to human Abeta 1-42. The peptide used to immunize was Abeta 35-42. This antibody is also known as MM26-2.1.3 and also as clone MM26-18.104.22.168.86 and also as Ab42.2
2008-124 – Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was fibrillar Abeta 1-42. This antibody is also known as AB42-5.
2008-123 – Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was Abeta 1-16. This antibody is also known as Ab-9
2008-121 – Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was Abeta 1-16. This antibody is also known as MM27-33.1.1
2008-120 – Monoclonal antibodies were raised to human Abeta 1-40. The peptide used to immunize was Abeta 35-40. This antibody is also known as MM32-13.1.1 and also as Ab40.1
2008-115 – Technology Description Purified antibodies from rabbit serum that specifically recognize the Eps15 protein at two different and distinct regions. These antibodies have a wide variety of applications in research as well as diagnostic uses where recognition of Eps15 protein is necessary. Reference “Eps15 Mediates Vesicle Trafficking from the trans-Golgi Network via an Interaction with the... Read More
2008-114 – Purified antibodies from rabbit serum that recognize, specifically, the caveolin-1 protein. This specific set of antibodies has a wide variety of uses in research and diagnostic applications where recognition of caveolin protein is necessary.
2008-144 – Antibiotics fail when pathogens acquire genes that confer resistance to these drugs. This invention proposes generating vaccines specifically against the gene products of antibiotic resistance genes. These vaccines have the potential to counterselect against drug-resistant pathogens or may be used as an adjuvent to enhance drug therapy with the antibiotic by depleting the resistance gene. The... Read More
2008-088 – A novel surface wave method is developed for non-invasively estimating viscoelasticity of tissues. In this method, a very small force is generated on the surface of tissue either by a mechanical shaker or the radiation force of ultrasound. The surface vibration of tissue is measured non-contact by laser or ultrasound. We have developed theory and techniques for measuring the surface wave for... Read More
2008-084 – Validated bowel disease questionaire
2008-104 – Monoclonal antibodies were raised to rodent Abeta 1-16. The peptide used to immuize was rodent Abeta 1-16. This antibody is also known as MM44-32.4.1
2008-103 – Monoclonal antibodies were raised to human Abeta 1-38. The peptide used to immunize was Abeta 35-40. This antibody is also known as MM43-14.1.1
2008-079 – The antibiotic impregnated cement spacer replaces a shoulder arthroplasty that has been removed due to infection. There are several advantages: provides antibiotic release locally, facilitates revision surgery by maintaining joint space, allows for immediate motion, and provides faster recovery. There is only one shoulder spacer in the market, and it does not have a variety of sizes and does... Read More
2008-059 – Clear plastic container used to transport up to 4 (1" square pathology tissue blocks) via suggested method of external transportation from Client site to a pathology lab. This container is designed to ensure that all Surgical Blocks are transported in an easily identifiable and safe manner. A Provisional patent application was filed on July 15, 2008.
2008-100 – The device involves use of high frequency radiation to image simultaneously the mechanical contraction and electro-magnetic field dispersions with higher spatial and temporal resolution than yet realized. This refers to any part of the human body, in particular that cardiovascular system, in order to create a map non-invasively of the local electrophysiology and to determine abnormal areas of... Read More
Quantitative Imaging of Chemical Compositions Using Dual-Energy, Dual-Source CT: Two Material Decomposition Using Reconstructed Images
2008-022 – Quantitative imaging of chemical composition in patients may be a very useful diagnostic technique for a variety of condidtions, such as iron overload in the liver - a serious and potentially life-threatening chronic disease. We have developed a method to noninvasively measure the quantity of a specific element in vivo. This method is based upon the fact that very different atomic numbers and... Read More
Quantitative Imaging of Chemical Composition Using Dual-Energy, Dual-Source CT: Three Material Decompostion Using Reconstructed Images
2008-021 – Quantitative imaging of chemical composition may be accomplished using dual energy CT. However, dual energy CT can only quantify at most two materials because dual energy CT provides two independent measures with the dual (two) energy x-ray spectra. However, it is very common to need to quantify more than two materials. We have developed a technique to quantify three materials that is an... Read More
2008-039 – This optical edge connector is designed to meet future board-to-board optical interconnect requirements of orthogonally connected optical printed circuit boards that contain embedded optical communication channels, typically utilized for High Performance Compute Systems. The orthogonal implementation of this design is not found in any commercially available optical connectors. The design... Read More
2008-016 – Four mouse anti-SINA/SIAH monoclonal antibodies are available for licensing. Details are as follows. Two monoclonal antibodies against the SINA-C-terminal peptide (C-GC-FDTSIAQLFADNGNLGINVTISLV) (a 27-mer): (1) 8G7H12, (2) 4B4B6. Two monoclonal antibodies against the SINA-N-terminal peptide (SNKINPKRREPTAA-GGC) (a 17-mer): (1) 24E6H3, (2) 22B9B5. References Rebecca L. Schmidt,... Read More
2008-014 – A fracture fixation system particularly useful for bones of the hand and foot is disclosed. The system uses curved shape-memory alloy (e.g., Nitinol) wires that have a predetermined radius of curvature to accommodate different sized bones. These shape-memory alloy wire forms can be inserted into phalanx, metacarpal or metatarsal bones via a percutaneous technique. The technique uses small... Read More
2008-035 – Mice lacking 53BPI were developed at Mayo to study DNA damage responses and tumor suppression. See Ward et al. (2003) Mol Cell Biol 23(7):2556-2563
2008-027 – An algorithm has been developed to computationally define significance (in the sense of objects in noisy images which differ significantly from the background noise) in two and three dimensional image volumes. The algorithm uses this definition of significance in the course of reviewing image volumes containing zero mean noise and optional object regions, to automatically and reproducibly... Read More
2008-026 – An algorithm has been developed to automatically define intensity properties for key tissues in magnetic resonance brain images. The algorithm is completely automated in that it does not require that the user provide samples of any tissues, and it does not require that the user provide a brain parenchyma mask. The algorithm is additionally robust in that it is applicable to images acquired... Read More
2008-001 – Adenoviruses are used for gene therapy, vaccines, and cancer killing. For gene therapy and vaccine they are generally used as non- “live” viruses and cannot make more of themselves. For cancer killing they are “live” and kill cells. This invention utilizes “single-cycle” adenoviruses for vaccine and other applications where the virus is engineered to only undergo one round of its life cycle... Read More
2007-334 – In accordance with the present invention, there is provided a device (e-pill) and technology for delivery, sensing and monitoring an exercise program that is prescribed by a health worker (or any person interested in health) to a patient (some-one with a disease or propensity for a disease that can be helped by exercise) or any person interested in completing a prescribed program for... Read More
2007-330 – We created mice that contain human LRRK2 cDNA encoding either the wild-type or G2019S mutant form of the gene (hereafter termed “responder line(s).” The cDNA in these animals has been placed behind a minimal CMV promoter containing TetO and will only produce human LRRK2 protein when combined (in bigenic mice) with tTA. We have demonstrated in COS7 cells that the human LRRK2 expression from... Read More
2007-328 – Cardiovascular disease is the leading cause of death in the United States. Our research focuses on the discovery and development of novel therapies for protecting the heart and the kidneys against harmful effects of ischemia (inadequate blood supply), heart failure, and high blood pressure. We have designed a novel peptide by combining amino acid (AA) sequences from the human natriuretic... Read More
2007-326 – JJ12 is a mouse monoclonal IgG antibody that was prepared against the human protein p23, a co-chaperone for the molecular chaperone protein Hsp90. p23 was isolated into balb/c mice, and hybridoma cells were made by fusion with the cell line P3NS-11-AG4-1(NS-1). JJ12 has a high affinity for p23 from humans and several other vertebrates. It is useful for the measurement of p23 by western... Read More
2007-325 – JJ6 is a mouse monoclonal IgG antibody that was prepared against the human protein p23, a co-chaperone for the molecular chaperone protein Hsp90. p23 was isolated and injected into balb/c mice, and hybridoma cells were made by fusion with the cell line P3NS-11-AG4-1 (NS-1). JJ6 has a high affinity for p23 from humans and several other vertebrates. It is useful for the measurement of p23 by... Read More
2007-324 – This is a monoclonal antibody, produced in mice, to the human protein tsp23 which has sequence similarity to the molecular co-chaperone p23.