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2008-144 – Antibiotics fail when pathogens acquire genes that confer resistance to these drugs. This invention proposes generating vaccines specifically against the gene products of antibiotic resistance genes. These vaccines have the potential to counterselect against drug-resistant pathogens or may be used as an adjuvent to enhance drug therapy with the antibiotic by depleting the resistance gene. The... Read More
2008-088 – A novel surface wave method is developed for non-invasively estimating viscoelasticity of tissues. In this method, a very small force is generated on the surface of tissue either by a mechanical shaker or the radiation force of ultrasound. The surface vibration of tissue is measured non-contact by laser or ultrasound. We have developed theory and techniques for measuring the surface wave for... Read More
2008-084 – Validated bowel disease questionaire
2008-079 – The antibiotic impregnated cement spacer replaces a shoulder arthroplasty that has been removed due to infection. There are several advantages: provides antibiotic release locally, facilitates revision surgery by maintaining joint space, allows for immediate motion, and provides faster recovery. There is only one shoulder spacer in the market, and it does not have a variety of sizes and does... Read More
2008-059 – Clear plastic container used to transport up to 4 (1" square pathology tissue blocks) via suggested method of external transportation from Client site to a pathology lab. This container is designed to ensure that all Surgical Blocks are transported in an easily identifiable and safe manner. A Provisional patent application was filed on July 15, 2008.
Quantitative Imaging of Chemical Compositions Using Dual-Energy, Dual-Source CT: Two Material Decomposition Using Reconstructed Images
2008-022 – Quantitative imaging of chemical composition in patients may be a very useful diagnostic technique for a variety of condidtions, such as iron overload in the liver - a serious and potentially life-threatening chronic disease. We have developed a method to noninvasively measure the quantity of a specific element in vivo. This method is based upon the fact that very different atomic numbers and... Read More
Quantitative Imaging of Chemical Composition Using Dual-Energy, Dual-Source CT: Three Material Decompostion Using Reconstructed Images
2008-021 – Quantitative imaging of chemical composition may be accomplished using dual energy CT. However, dual energy CT can only quantify at most two materials because dual energy CT provides two independent measures with the dual (two) energy x-ray spectra. However, it is very common to need to quantify more than two materials. We have developed a technique to quantify three materials that is an... Read More
2008-039 – This optical edge connector is designed to meet future board-to-board optical interconnect requirements of orthogonally connected optical printed circuit boards that contain embedded optical communication channels, typically utilized for High Performance Compute Systems. The orthogonal implementation of this design is not found in any commercially available optical connectors. The design... Read More
2008-016 – Four mouse anti-SINA/SIAH monoclonal antibodies are available for licensing. Details are as follows. Two monoclonal antibodies against the SINA-C-terminal peptide (C-GC-FDTSIAQLFADNGNLGINVTISLV) (a 27-mer): (1) 8G7H12, (2) 4B4B6. Two monoclonal antibodies against the SINA-N-terminal peptide (SNKINPKRREPTAA-GGC) (a 17-mer): (1) 24E6H3, (2) 22B9B5. References Rebecca L. Schmidt,... Read More
2008-014 – A fracture fixation system particularly useful for bones of the hand and foot is disclosed. The system uses curved shape-memory alloy (e.g., Nitinol) wires that have a predetermined radius of curvature to accommodate different sized bones. These shape-memory alloy wire forms can be inserted into phalanx, metacarpal or metatarsal bones via a percutaneous technique. The technique uses small... Read More
2008-035 – Mice lacking 53BPI were developed at Mayo to study DNA damage responses and tumor suppression. See Ward et al. (2003) Mol Cell Biol 23(7):2556-2563
2008-027 – An algorithm has been developed to computationally define significance (in the sense of objects in noisy images which differ significantly from the background noise) in two and three dimensional image volumes. The algorithm uses this definition of significance in the course of reviewing image volumes containing zero mean noise and optional object regions, to automatically and reproducibly... Read More
2008-026 – An algorithm has been developed to automatically define intensity properties for key tissues in magnetic resonance brain images. The algorithm is completely automated in that it does not require that the user provide samples of any tissues, and it does not require that the user provide a brain parenchyma mask. The algorithm is additionally robust in that it is applicable to images acquired... Read More
2008-001 – Adenoviruses are used for gene therapy, vaccines, and cancer killing. For gene therapy and vaccine they are generally used as non- “live” viruses and cannot make more of themselves. For cancer killing they are “live” and kill cells. This invention utilizes “single-cycle” adenoviruses for vaccine and other applications where the virus is engineered to only undergo one round of its life cycle... Read More
2007-334 – In accordance with the present invention, there is provided a device (e-pill) and technology for delivery, sensing and monitoring an exercise program that is prescribed by a health worker (or any person interested in health) to a patient (some-one with a disease or propensity for a disease that can be helped by exercise) or any person interested in completing a prescribed program for... Read More
2007-330 – We created mice that contain human LRRK2 cDNA encoding either the wild-type or G2019S mutant form of the gene (hereafter termed “responder line(s).” The cDNA in these animals has been placed behind a minimal CMV promoter containing TetO and will only produce human LRRK2 protein when combined (in bigenic mice) with tTA. We have demonstrated in COS7 cells that the human LRRK2 expression from... Read More
2007-328 – Cardiovascular disease is the leading cause of death in the United States. Our research focuses on the discovery and development of novel therapies for protecting the heart and the kidneys against harmful effects of ischemia (inadequate blood supply), heart failure, and high blood pressure. We have designed a novel peptide by combining amino acid (AA) sequences from the human natriuretic... Read More
2007-326 – JJ12 is a mouse monoclonal IgG antibody that was prepared against the human protein p23, a co-chaperone for the molecular chaperone protein Hsp90. p23 was isolated into balb/c mice, and hybridoma cells were made by fusion with the cell line P3NS-11-AG4-1(NS-1). JJ12 has a high affinity for p23 from humans and several other vertebrates. It is useful for the measurement of p23 by western... Read More
2007-325 – JJ6 is a mouse monoclonal IgG antibody that was prepared against the human protein p23, a co-chaperone for the molecular chaperone protein Hsp90. p23 was isolated and injected into balb/c mice, and hybridoma cells were made by fusion with the cell line P3NS-11-AG4-1 (NS-1). JJ6 has a high affinity for p23 from humans and several other vertebrates. It is useful for the measurement of p23 by... Read More
2007-324 – This is a monoclonal antibody, produced in mice, to the human protein tsp23 which has sequence similarity to the molecular co-chaperone p23.
2007-323 – This is a monoclonal antibody against GCUNC45 (General Cell UNC45) also called SMAP-1 which has sequence similarity with the SMUNC45 (Striated muscle UNC45). These are homologues of the C. elegans UNC45. This antibody is useful western blotting and imunohistochemistry.
2007-295 – To address difficulties in the identification of microsporidia from stool specimens in the clinical diagnostic laboratory, we developed two rapid, real-time PCR assays designed for the LightCycler instrument (Roche Applied Sciences). The LightCycler PCR (LC PCR) assay sensitivities were compared to that of the reference method, a routine smear with trichrome blue stain. Microsporidia DNA is... Read More
2007-293 – Cardiovascular disease is the leading cause of death in the United States. Our research focuses on the development of novel therapies for protecting the heart and the kidneys during vulnerable periods of inadequate blood supply (ischemia) and upon restoration of blood flow (reperfusion). We designed a series of peptides by combining amino acid (AA) sequences from human natriuretic peptides... Read More
2007-288 – Mice in which the endogenous leucine-rich repeat kinase 2 gene (LRRK2) has been ablated. Exon 41 has been flanked with loxP sites to alow Cre-mediated deletion. The region deleted contains the serion/threonine protein kinase catalytic domain. Splicing of exon 40 to 42 causes a frameshift mutation with the introduction of an early stop codon (TGA).
2007-279 – Description - Bilateral Denoising Optimal noise control is critical for dose reduction and image quality improvement in CT. Noise in CT images results from data noise in the projections, which have two principal sources: quantum noise and electronic noise. To overcome the effects of excessive noise, it is necessary to increase either the x-ray tube energy or the current, both which... Read More
2007-300 – Friedreich ataxia (FRDA) is an autosomal recessive degenerative disease caused by a deficiency of frataxin, a conserved mitochondrial protein of unknown function. Mitochondrial iron accumulation, loss of iron-sulfur cluster-containing enzymes and increased oxidative damage occur in yeast and mouse frataxin-depleted mutants as well as tissues and cell lines from FRDA patients, suggesting that... Read More
2007-216 – An adaptive circuit that compensates for phase skew between the true and complement sides of a differential signal.
2007-184 – In MR and CT imaging, any reduction in scan time offers potential benefits ranging from high temporal rate observation of physiologic processes to reduction of motion artifacts to lower radiation dose (for CT) to improved patient comfort and throughout. Following recent developments in compressive sensing theory, it has been shown that certain classes of MR imaging can be accurately... Read More
2007-230 – We have replace the mouse islet amyloid polypeptide (IAPP, amylin) gene with the human IAPP gene. Human IAPP is readily converted to amyloid fibrils. Amyloids have been associated with a large number of human diseases that are associated with cell death. Mouse IAPP is non-amyloidogenic. By replacing the mouse IAPP with the human IAPP gene we have created a physiologic model of hman IAPP... Read More
A Novel Series of Designer Natriuretic Peptides Combining the Natriuretic Peptides and Angiotensin-(1-7)
2007-196 – Heart Failure (HF) is an important public health problem and is the leading cause of hospitalization in adults over 65 years of age. Our research focuses on the development of novel therapies for the treatment of heart failure and other cardiorenal disease states. The first of this series of designer peptides is CLJB1c which consists of human C-type natriuretic peptide and angiotensin-(1-7),... Read More
2007-193 – The invention combines information from two different energies to create a greatly improved visualization over commonly available dual energy imaging blending techniques. Dual-energy CT may provide additional diagnostic information to the physician, but the question arises on how to best illustrate it. In conventional single energy CT, patient data is presented to the physicians using very... Read More
2007-192 – During mapping and ablation of tachyarrhythmias, the ablation catheter is moved around one or more of the cardiac chambers and electrograms are obtained from the tip electrode (usually with respect to a ring electrode situated a few millimeters proximal to the tip electrode) and used to create a map of the cardiac chamber (the map could be a real electro-anatomic map or an abstract one based... Read More
2007-154 – This invention is a technique that enables two or four port vector network analyzers (VNAs) to be probe-tip calibrated and used in applications such as automated test equipment . “Calibration” is understood to include a range of things described in more detail below. The technique complements (but is independent of) many industry¬wide standard probe-tip calibration methods such as... Read More
Rapid Electrical Link Analysis Technique for Simulating Electrical Signals Through Transmission Media Characterized by Scattering Parameters
2007-135 – This technique is a software program which permits very rapid simulation of electrical signals through passive transmission or any other interconnect characterized by scattering parameters (S-parameters). An unlimited number of 2-port and 4-port passive interconnect models are combined into a single interconnect using proper S-parameter cascading. External transient voltage waveforms... Read More
2007-132 – The test system will automate multi-port VNA S-parameters measurements of printed wiring boards (PWB). The information gathered is automatically evaluated against complex pass/fail criteria and used to grade the signal integrity quality of PWBs.
Adaptive Determination of Optimal Weighting Coefficient for Linear Combination of Low- and High-Energy Images
2007-117 – In dual-energy imaging, individually reconstructed images from the low- and high-energy acquisitions can be linearly combined to produce a weighted average of the respective images. This disclosure describes an optimization scheme and software tool to select the optimal weighting value. Optimization can be performed using a variety of criteria, including minimizing image noise, maximizing the... Read More
2007-129 – Material-specific removal of image signal using dual-energy CT subtraction paradigms has the undesirable effect of altering signal throughout the image while increasing image noise. This novel algorithm preselects the material of interest and performs the dual-energy subtraction process only on those voxels meeting certain criteria. In this manner, material-specific subtraction is... Read More
2007-111 – An olecranon fracture fixation system includes an intramedullary core that is dimensioned for insertion in an intramedullary canal of the bone, and a hollow shell that is dimensioned for insertion in the intramedullary canal. The shell includes fixation elements that extend outwardly away from a proximal end of the shell. A fastener is provided for attaching the shell to the core in the... Read More
2007-103 – The abnormal accumulation of TDP-43 protein has been recently identified as the major protein constituent for several neurodegenerative diseases. The protein undergoes several post-translational modifications including phosphorylation, ubiquitination and proteolytic cleavage. The pathologic accumulation of these truncated species is believed to be pathologic. Using cell culture models, we... Read More
2007-100 – A mathematical method is described that is used to estimate the inherent phase offsets and timing differences between data acquisitions of raw data acquisitions from the Magnetic Resonance scanner during MR Spectroscopy. Knowledge of the phase offset and time delay of each data set allows the correction of the data so that each set reflects data collected at the same time points with the... Read More
2007-123 – Metal implants are common in patients receiving CT examinations, which can produce artifacts that can significantly degrade the diagnostic value of the image. We have developed a method to reduce the metal artifacts in multi-slice helical CT. This method is based upon the virtual radiographs (VR) created from the helical projection data for each view angle. Automatic segmentation and removal... Read More
2007-067 – This disclosure is based on the continuing development of our technique Shearwave Dispersion Ultrasound Vibrometry or SDUV (2004-237 & 2006-088) which non-invasively quantifies tissue stiffness and viscosity with ultrasound. Herein we propose methods to generate and detect larger SDUV motions for in vivo applications. (vibrometry) (SDUV)
2007-091 – Technology Description There is no available test that predicts the onset of preeclampsia, and current diagnostic methodologies of blood pressure and proteinuria measurement need improvement. Mayo Clinic researchers have discovered an epithelial cell type (podocyte) present in the urine of patients with preeclampsia, and these cells are present in the urine of patients several weeks before... Read More
Establishment and Characterization of an Immunoglobulin Lambda Secreting Cell Line from a Patient with AL Amyloidosis
2007-050 – The ALMC-1 and ALMC-2 cell lines were established from samples before and after peripheral blood stem cell transplant. Both cell lines secrete lambda light chains and these light chains have been shown to contain a beta structure, which is necessary for the configuration of amyloid. Therefore, this cell line provides a useful tool to study the underlying biology of amloidogenic light chains... Read More
2007-027 – Mice that over-express the human wild-type and mutant leucine-rich repeat kinase 2 gene (LRRK2).
2007-012 – Technology Description The past 20 years have witnessed an unprecedented increase in eosinophil-associated diseases such as allergy, asthma, and inflammatory gastrointestinal syndromes. Despite this rise in the need for an eosinophil-specific assay few reagents are available. Mayo Clinic researchers have developed a unique monoclonal antibody reactive to the eosinophil specific protein... Read More
2007-009 – Currently, radiologists interpreting CT colonography exams find it most efficient to view colons primarily in a 2D axial mode, scrolling these slices up and down the abdomen. Typically, the entire colon is scanned twice on the computer screen, first with a “lung” window/level setting (analogous to contrast/brightness) that clearly shows protrusions into the lumen and identifies most typical... Read More
2007-008 – CT colonography (CTC) is being extensively studied for its potential value in colon examinations. Like traditional colonoscopy, CTC requires extensive preparation to cleanse the colon of fecal material. The inconvenience and discomfort associated with this preparation is an important obstacle to compliance with currently recommended colorectal screening guidelines. An alternative is to tag... Read More
2007-007 – This invention consists of a novel display technique for CT colonography data. It is based on automatic generation of a midline trace (centerline) of the colon, followed by display of a sequence of images of the colon that follow this centerline, and display a small field of view centered on it and perpendicular to it. This allows the radiologist the benefit of always seeing the colon in... Read More
2007-006 – This invention consists of a novel display technique for CT colonography data. It is based on automatic generation of a midline trace (centerline) of the colon, followed by display of a sequence of axial images that display a small field of view centered on the trace, and follow along it. This allows the radiologist the benefit of a small field of view to examine the image, but frees him from... Read More