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2007-193 – The invention combines information from two different energies to create a greatly improved visualization over commonly available dual energy imaging blending techniques. Dual-energy CT may provide additional diagnostic information to the physician, but the question arises on how to best illustrate it. In conventional single energy CT, patient data is presented to the physicians using very... Read More
2007-192 – During mapping and ablation of tachyarrhythmias, the ablation catheter is moved around one or more of the cardiac chambers and electrograms are obtained from the tip electrode (usually with respect to a ring electrode situated a few millimeters proximal to the tip electrode) and used to create a map of the cardiac chamber (the map could be a real electro-anatomic map or an abstract one based... Read More
2007-154 – This invention is a technique that enables two or four port vector network analyzers (VNAs) to be probe-tip calibrated and used in applications such as automated test equipment . “Calibration” is understood to include a range of things described in more detail below. The technique complements (but is independent of) many industry¬wide standard probe-tip calibration methods such as... Read More
Rapid Electrical Link Analysis Technique for Simulating Electrical Signals Through Transmission Media Characterized by Scattering Parameters
2007-135 – This technique is a software program which permits very rapid simulation of electrical signals through passive transmission or any other interconnect characterized by scattering parameters (S-parameters). An unlimited number of 2-port and 4-port passive interconnect models are combined into a single interconnect using proper S-parameter cascading. External transient voltage waveforms... Read More
2007-132 – The test system will automate multi-port VNA S-parameters measurements of printed wiring boards (PWB). The information gathered is automatically evaluated against complex pass/fail criteria and used to grade the signal integrity quality of PWBs.
Adaptive Determination of Optimal Weighting Coefficient for Linear Combination of Low- and High-Energy Images
2007-117 – In dual-energy imaging, individually reconstructed images from the low- and high-energy acquisitions can be linearly combined to produce a weighted average of the respective images. This disclosure describes an optimization scheme and software tool to select the optimal weighting value. Optimization can be performed using a variety of criteria, including minimizing image noise, maximizing the... Read More
2007-129 – Material-specific removal of image signal using dual-energy CT subtraction paradigms has the undesirable effect of altering signal throughout the image while increasing image noise. This novel algorithm preselects the material of interest and performs the dual-energy subtraction process only on those voxels meeting certain criteria. In this manner, material-specific subtraction is... Read More
2007-111 – An olecranon fracture fixation system includes an intramedullary core that is dimensioned for insertion in an intramedullary canal of the bone, and a hollow shell that is dimensioned for insertion in the intramedullary canal. The shell includes fixation elements that extend outwardly away from a proximal end of the shell. A fastener is provided for attaching the shell to the core in the... Read More
2007-103 – The abnormal accumulation of TDP-43 protein has been recently identified as the major protein constituent for several neurodegenerative diseases. The protein undergoes several post-translational modifications including phosphorylation, ubiquitination and proteolytic cleavage. The pathologic accumulation of these truncated species is believed to be pathologic. Using cell culture models, we... Read More
2007-100 – A mathematical method is described that is used to estimate the inherent phase offsets and timing differences between data acquisitions of raw data acquisitions from the Magnetic Resonance scanner during MR Spectroscopy. Knowledge of the phase offset and time delay of each data set allows the correction of the data so that each set reflects data collected at the same time points with the... Read More
2007-123 – Metal implants are common in patients receiving CT examinations, which can produce artifacts that can significantly degrade the diagnostic value of the image. We have developed a method to reduce the metal artifacts in multi-slice helical CT. This method is based upon the virtual radiographs (VR) created from the helical projection data for each view angle. Automatic segmentation and removal... Read More
2007-067 – This disclosure is based on the continuing development of our technique Shearwave Dispersion Ultrasound Vibrometry or SDUV (2004-237 & 2006-088) which non-invasively quantifies tissue stiffness and viscosity with ultrasound. Herein we propose methods to generate and detect larger SDUV motions for in vivo applications. (vibrometry) (SDUV)
2007-091 – Technology Description There is no available test that predicts the onset of preeclampsia, and current diagnostic methodologies of blood pressure and proteinuria measurement need improvement. Mayo Clinic researchers have discovered an epithelial cell type (podocyte) present in the urine of patients with preeclampsia, and these cells are present in the urine of patients several weeks before... Read More
Establishment and Characterization of an Immunoglobulin Lambda Secreting Cell Line from a Patient with AL Amyloidosis
2007-050 – The ALMC-1 and ALMC-2 cell lines were established from samples before and after peripheral blood stem cell transplant. Both cell lines secrete lambda light chains and these light chains have been shown to contain a beta structure, which is necessary for the configuration of amyloid. Therefore, this cell line provides a useful tool to study the underlying biology of amloidogenic light chains... Read More
2007-027 – Mice that over-express the human wild-type and mutant leucine-rich repeat kinase 2 gene (LRRK2).
2007-012 – Technology Description The past 20 years have witnessed an unprecedented increase in eosinophil-associated diseases such as allergy, asthma, and inflammatory gastrointestinal syndromes. Despite this rise in the need for an eosinophil-specific assay few reagents are available. Mayo Clinic researchers have developed a unique monoclonal antibody reactive to the eosinophil specific protein... Read More
2007-009 – Currently, radiologists interpreting CT colonography exams find it most efficient to view colons primarily in a 2D axial mode, scrolling these slices up and down the abdomen. Typically, the entire colon is scanned twice on the computer screen, first with a “lung” window/level setting (analogous to contrast/brightness) that clearly shows protrusions into the lumen and identifies most typical... Read More
2007-008 – CT colonography (CTC) is being extensively studied for its potential value in colon examinations. Like traditional colonoscopy, CTC requires extensive preparation to cleanse the colon of fecal material. The inconvenience and discomfort associated with this preparation is an important obstacle to compliance with currently recommended colorectal screening guidelines. An alternative is to tag... Read More
2007-007 – This invention consists of a novel display technique for CT colonography data. It is based on automatic generation of a midline trace (centerline) of the colon, followed by display of a sequence of images of the colon that follow this centerline, and display a small field of view centered on it and perpendicular to it. This allows the radiologist the benefit of always seeing the colon in... Read More
2007-006 – This invention consists of a novel display technique for CT colonography data. It is based on automatic generation of a midline trace (centerline) of the colon, followed by display of a sequence of axial images that display a small field of view centered on the trace, and follow along it. This allows the radiologist the benefit of a small field of view to examine the image, but frees him from... Read More
2006-295 – Tandem Biomarkers Identifies a Unique Population of Cardiopoietic Stem Cells Biomarkers used to purify a cardiac-specific stem cell population have not previously been reported. This invention reports the discovery of 1) the first cell surface tag that identifies cardiac progenitors from stem cell population and 2) an efficient approach to enrich large quantities of cardiac progenitors for... Read More
Algorithm for Identification of Regions of Change in Three Dimensional Magnetic Resonance Brain Images
2006-260 – The algorithm examines serial three dimensional magnetic resonance brain image data and identifies regions which have changed from one acquisition to the next.
2006-259 – The algorithm automatically generates samples of key tissues from magnetic resonance brain images.
2006-258 – The algorithm identifies regions of real signal, and eliminates regions where signal is due only to noise.
2006-257 – Technology Description The comparison of serial MR examinations of the brain is a procedure performed frequently by neuroradiologists for diseases such as tumors, multiple sclerosis, Alzheimer’s disease, and others. The primary objective of such imaging is to detect and characterize any changes. Comparison of serial MR studies of brain-tumor patients is a task whose difficulty is widely... Read More
2006-245 – This differential test probe was designed to meet the requirements of an automated test system. It has features not found in commercially available test probes. The ruggedness, compliance of all test pins, and the versatility to test more than one signal/ground pattern makes it useful for the automated test system. The mounting of micro probing pins directly in the center of the signal... Read More
2006-231 – Rabbit polyclonal antibodies were generated to two components of the calcium-release activated calcium (CRAC) channel, Orai1 and STIM1. These antibodies can be used for immunofluorescence, immunoprecipitation and immunoblotting of Orai1 and STIM1.
2006-224 – This is to provide knowledge about the use of neurotensin receptor agonists for treatment of various medical problems, including acute and chronic pain due to various causes and abuse of various types of psychostimulants (such as nicotine, cocaine, and amphetamines).
2006-196 – The MR shell k-space trajectory is a way to acquire MRI data. It has several intrinsic advantages over standard methods, including improved acquisition efficiency per unit time, compatibility with motion correction methods, and a high degree of venous suppression when used to acquire contrast-enhanced MR angiograms of arteries with intravenous injection of gadolinium-chelate contrast agents.... Read More
2006-159 – The natriuretic peptide family consists of natural hormones involved in the maintenance of fluid and sodium levels through their interactions with the heart and kidneys. Mayo Clinic researchers have developed a novel natriuretic peptide (ABC) which is made up of a unique amino acid sequence designed to preferentially target the kidney to preserve its function and protect it from... Read More
2006-154 – To increase progranulin in animals, progranulin levels and biologically active fragments of progranulin can be elevated in animals by direct administration of the protein or its fragments, either in the presence or absence of agents that stabilize the biological activity. Routes of delivery include, but are not limited to, intranasal, oral, inhalation, intracerebro-ventricular injection,... Read More
2006-145 – Heart diseases are detected by producing a series of ultrasound images that depict the blood flow pattern in the left ventricle at successive phases of the cardiac cycle. The blood flow pattern images are produced by injecting a diluted contrast agent and tracking the contrast agent particles as they flow through the left ventricle by acquiring ultrasound images at a high frame rate.
2006-111 – A harvested bovine colon is layed out on a specially designed tray that allows for the colon to be arranged in a human configuration. This can then be used as a model that allows the performance of a simulated coloscopy for the purposes of training and competency assessment.
2006-104 – Soluble and Extracellular Markers for Early Detection of Prostate Cancer A discriminating panel of genes has been identified that may be used for early detection of prostate cancer. Many of these genes demonstrate prostate-specific expression. Genes encoding extracellular and membrane proteins were selected to facilitate a minimally invasive (e.g. blood sample) form of detection. ... Read More
2006-059 – Peptide or GST-fusion proteins containing antigenic epitopes of WAVE2, Evl, VASP, HS1, STIM, CIN85 and TUBA were used to create polyclonal rabbit antisera. The antibodies are useful for IP, Western blotting and IF.
2006-018 – Technology Description B7-H4 is a cell surface protein whose expression on tumor cells and tumor-associated vasculature is greatly increased in renal cancers. B7-H4 expression levels on renal tumors have been shown to be a predictor of tumor aggressiveness and to increase mortality rates. B7-H4 is highly expressed on tumors and tumor-associated vasculature but not on normal tissues and... Read More
Quantitative Imaging of Iron as a Marker of Vulnerable Atherosclerotic Lesions Using Computed Tomography
2006-017 – Intraplaque hemorrhage represents an event in the induction and/or as a consequence of instability of advanced atherosclerotic lesions. Iron should accumulate in a lesion after hemorrhage, as part of each erythrocyte, whether isolated or within macrophage-derived cells that have phagocytosed the red blood cells. Moreover, ectopic neovascularization is also a major feature of... Read More
2005-316 – These mice do not express the gene for CD229.
2005-273 – Methods and materials related to identifying, assessing, and predicting hypertrophic cardiomyopathy (HCM) in mammals.
2005-237 – A protein from the fungus alternaria which induces recruitment and activation of eosinophils.
2005-231 – Under the Minnesota Partnership, researchers at the University of Minnesota and at Mayo have developed a database for use in the evaluation of potential prostate cancer biomarkers. Researchers have profiled gene expression of benign and malignant cells that were laser capture microdissected (LCM) from prostate tissues and metastatic adenocarcinomas. In addition, researchers have conducted... Read More
2005-180 – The subsynovial connective tissue (SSCT) is a thin (~1 mm), loose tissue layer around the tendons and median nerve in the carpal tunnel, which has been implicated in the etiology of carpal tunnel syndrome (CTS). A test which could detect abnormalities in the SSCT before the nerve becomes involved could allow interventions before surgery becomes necessary. We have combined a diverse set of... Read More
2005-172 – Serotype selective and nonpeptidic inhibitors of botulinum neurotoxin serotype A (BoNTA) have been developed. These inhibitors are effective in detoxifying botulinum neurotoxin serotype A; they can be used as therapeutics for treating food poisoning by BoNTA, overdose of BoNTA-based cosmetics such as Botox, and they can also be used as countermeausres to BoNTA-based biological weapons.
2005-165 – The use of HIV protease inhibitors in HIV negative patients increases naive T cell production, which may be useful in helping to boost immune responses. Potential uses include enhancing responses to immunizations, boosting immune function in patients with cancer, and/or immune deficiency disorders.
Genetic Polymorphisms in the Human Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) gene in Caucasian, African American, Han Chinese and Mexican American Populations
2005-156 – Some of the known substrates of CYP19A1 (aromatase) include testosterone and androstenedione. It is expressed in the ovaries, testes, placenta, fetal liver, adipose tissue, chondrocytes, osteoblasts, vasculature smooth muscle, and brain. Increased or decreased enzyme activity is associated with several diseases including breast and endometrial cancer. Several novel polymorphisms have been... Read More
2005-136 – This device is used to treat a painful thumb base joint (1st CMC joint) from arthritis. It is composed of three parts: 1) a screw that threads across the wrist bones; 2) a screw that threads into the thumb metacarpal; and, 3) a plastic liner for the ball-and-socket joint formed by the two screws.
2005-127 – Antibodies to various isoforms of HP-1 and SP-1
2005-124 – Common, functionally relevant mutations in the SULT1A1 have been recently discovered. These mutations have a significant effect on SULT1A1 enzyme activity.
A Device to Sense and Modify Daily Standing and Ambulating Time in Humans. STAM (Standing/Ambulating Meter)
2005-091 – Mayo Clinic researchers have developed a device to promote standing & ambulating time as a treatment for obesity and deconditioning. The device is worn on the belt and has two operational modes: i) it measures the time the user spends standing/ambulating per day; and ii) it displays a goal for the user in standing/ambulating minutes per day.
Hydrophilic/hydrophobic Hybrid Polymer Networks Based on Poly(caprolactone fumarate) (PCLF), Poly(Ethylene Glycol Fumarate) (PEGF), and PEGF-co-PCLF
2005-077 – We have developed a new route to synthesize the biodegradeable and injectable polymer poly(ethylene glycol fumarate) (PEGF) and its copolymer with Poly (caprolactone fumarate) (PCLF), PEGF-co-PCLF. These materials can be crosslinked with other unsaturated polymers via redox- or photo-initiation to form hybrid polymer networks. Characteristics of these hybrid networks, such as... Read More