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2009-131 – CD2 Binding Agents for Decreasing Suppressive Monocytes in Cancer and Sepsis CD2 binding molecules, such as alefacept, have been shown to deplete immunosuppressive monocytes (e.g., CD14+/DR- or CD14+/DRlow) in patients with lymphoma. Increased levels of immunosuppressive monocytes have been found to be associated with poor prognosis. Continued depletion of immunosuppressive monocytes appeared... Read More
2009-126 – This invention includes the developement of inducible transgenic mice expressing human TDP-43 cDNA encoding the TAR-binding protein 43kD.
2009-125 – This invention includes the development of a homozygous transgenic mouse model expressing wild-type human TDP-43 cDNA encoding the TAR-binding protein 43kD endogenous levels.
2009-107 – A device which allows for rapid cleaning of the colon in preparation for colon examination by an endoscope or other imaging methods such as CT or MR colonography. The device is aimed at facilitating colonic lavage to allow either minimal prep, or no prep prior to colonoscopy.
WINCSWare: Two-way Wireless Communication Between Sensor and Control Unit for Data Aquisition and Selection of Sensing Parameters (Neurochemicals, Time, etc.) and Software for Processing of Incoming Data and Visual Display in Real-Time
2009-106 – Two-way Wireless Communication Between Sensor and Control Unit for Data Acquisition and Selection of Sensing Parameters (Neurochemicals, Time, etc.) and Software for Processing of Incoming Data and Visual Display in Real-Time.
2009-104 – Proximal migration of biliary stents can lead to difficult and time consuming endoscopic removal procedures. Separately, while the use of prophylactic pancreatic stents may be increasing due to potentially decreased risk of pancreatitis, endoscopic procedures are often required to facilitate stent removal. Design features to improve spontaneous stent removal and ease retrieval have been... Read More
Visual Syntactic Text Formatting to Improve Human Reading in Patient-Data Secure Electronic Health Systems
2009-089 – The invention combines computer-executed syntactic parsing algorithms with spatial layout parameters to reformat electronic text in cascading-phrase patterns that are designed to guide eye-movements, reduce visual regressions, and provide visual cues to sentence structure. Empirical studies, in both laboratory and real-world educational settings, have shown that this parser-generated format... Read More
2009-083 – MR Spectroscopy data is analyzed to yield high quality spectral images. Multiple acquisitions of MRS data are combines. The images are combined by time a phase shifting the data in the time domain (equivalent to interpolation) so that the data points all coincide on the same set of frequency points after fourier transforming. This avoids cancelation of the desired signal that would occur... Read More
WINCS Hardware & Combination of Amperometry and Voltametry in One System for Measuring Neurochemicals in Real-Time
2009-065 – Emerging evidence supports the hypothesis that modulation of specific central neuronal systems contributes to the clinical efficacy of deep brain and motor cortex stimulation. Real-time monitoring of the neurochemical output of targeted regions may therefore advance functional neurosurgery by, among other goals, providing a strategy for investigation of mechanism, identification of new... Read More
2009-064 – Previous studies had demonstrated the importance of adenosine in the mechanism of Thalamic DBS for Essential Tremor. Real-time monitoring of the neurochemical output of targeted regions may therefore advance functional neurosurgery by, among other goals, providing a strategy for investigation of mechanism, identification of new candidate neurotransmitters, and chemically guided placement of... Read More
2009-055 – Hydogels have wide applications in the biomedical field due to their ability to absorb incredible amounts of aqueous solutions and support cell viability. One particular application hydrogels are being investigated for is nerveguidance conduits to direct and stimulate nerve regeneration by supporting cell growth while simulatanously delivering biologically active molecules. Incorporation of... Read More
2009-049 – Technology Description Due to the rapid increase in use of CT imaging and the recently-heightened awareness of radiation-induced cancer, improving the diagnostic quality of low dose CT has become increasingly important. The signal-to-noise level of low dose CT scans is significantly lower than for normal dose scans, and thus may cause a decrease in diagnostic accuracy. Mayo Clinic... Read More
2009-048 – Technology Description Intracranial aneurysms represent a difficult to detect cause of morbidity and mortality. Digital subtraction angiography is considered the gold standard for intracranial aneurysm detection, but this technique is associated with risk of neurologic complications. 3D time-of-flight magnetic resonance angiograpy (MRA) has recently emerged as a non- invasive screening... Read More
2009-047 – A complex set of gestures which, when performed using a screen pointer, facilitate fast and accurate selection of radial menu items from a radial menu.
2009-046 – A complex set of gestures which when performed using a screen pointer, facilitates fast and accurate selection of radial menu items from a radial menu.
2009-043 – To reduce radiation dose and/or improve image quality in CT, it is very important to select the optimal tube potential (kV), which is highly dependent on patient size and specific diagnostic task. In this invention, we developed a general strategy that allows for individualized automatic kV selection for each patient size and each diagnostic task. We proposed a novel concept, kV dose index... Read More
2009-017 – Very long chain polyunsaturated fatty acids (VLPUFAs) are present in the human retina and play an important role in maintaining the structure and function of the retina. A disease with a defect in the gene that synthesizes VLPUFAs in the retina leads to an early onset degeneration of the macula and severe loss of vision. Currently, these VLPUFAs and other very long chain fatty acids are not... Read More
2008-380 – A novel electrically conductive polymer composite composed of polycaprolactone fumarate- polypyrrole (PCLF-PPy) for applications in nerve regeneration is disclosed. The synthesis and characterization of PCLF-PPy and in vitro studies showing PCLF-PPy supports both PC12 cell and dorsal root ganglia neurite extension. PCLF-PPy composite materials were synthesized by polymerizing pyrrole in... Read More
2008-368 – We have generated a human neuronal culture to model formation of alpha-synuclein aggregates in Parkinson’s disease (PD) and dementia with Lewy bodies (DLBD). By engineering conditional expression of alpha-synuclein, we established a novel cell-based model 3D5, in which production of wild-synuclein was regulated by the tetracycline off inducible mechanism. Two to four weeks following... Read More
2008-348 – Radiation therapy treatment is used in nearly two-thirds of all cancer patients. Accurate targeting of the tumor over the treatment period is critical to effective therapy. Placement of permanent tattoos is the current standard practice to aid in the alignment and targeting of radiation therapy over multiple treatments. Existing tattoo methods involve the use of freehand needle sticks,... Read More
2008-325 – The invention described herein is a method by which to visually verify and quantify the amount of radiation dose delivered to a patient during the administration of radiation therapy. A Compton camera imaging system is used to detect and reconstruct the original interaction position and energy of photons that are scattered out of the patient during treatment. The result is a three... Read More
2008-332 – Both natural and chimeric natriuretic peptides have anti-proliferative properties i.e. they prevent abnormal growth, in muscle cells, endothelial cells and fibroblast cells. Blocked arteries and veins are a common cause of cardiovascular problems and blockage of muscular tubes, such as the ureter or esophagus can result serious complications. Stents are currently used to unblock blood vessel... Read More
2008-322 – Synthetic atrial natriuretic peptide (ANP) (carperitide) and B-type natriuretic peptide (BNP) (nesiritide) are used to treat congestive heart failure. However, despite beneficial cardiac unloading properties, reductions in renal perfusion pressures limit their clinical effectiveness. Recently, CD-NP, a chimeric peptide composed of CNP fused to the carboxyl terminal tail of Dendroaspis... Read More
2008-317 – A novel electrically conductive polymer composite composed of polycaprolactone fumarate- polypyrrole (PCLF-PPy) for applications in nerve regeneration is disclosed. The synthesis and characterization of PCLF-PPy and in vitro studies showing PCLF-PPy supports both PC12 cell and dorsal root ganglia neurite extension. PCLF-PPy composite materials were synthesized by polymerizing pyrrole in... Read More
2008-299 – A technique is described for taking images generated from an MRI acquisition done with contrast administration and converting the image data into a single image which portrays the time of arrival (TOA) of the advancing contrast bolus. The TOA image allows distinction of arterial from venous structures based on their different arrival times. The quality of the results depends on... Read More
2008-315 – Parallel imaging can be applied to further reduce acquisition times. To do so, coil sensativities have to be determined. One option is to use self-or-auto calibrated methods which in general use unaccelerated sampling in some central region of the otherwise undersampled k-space. However, the fraction of acquisition time devoted to calibration can be substantial, particularly in high... Read More
Further Development of System and Method for Overlaying Ultrasound Imagery on a Laparoscopic Camera Display
2008-313 – Software algorithm to fuse images and correct for distortion for overlaying ultrasound imagery on a laparoscopic camera.
2008-294 – We have developed a method to assess the relative motion of various structures in the human carpal tunnel (tendon, nerve, and synovium) simultaneously using ultrasound We have also developed a method of comparing these motions by means of ratios and have shown that the ratios differ in normal individuals and those with carpal tunnel syndrome. The methods include both specific testing... Read More
Aquaporin-4-Binding Autoantibodies in Patients with Neuromyelitis Optica Impair Glutamate Transport by Down-Regulating EAAT2
2008-303 – Materials and Methods for Treating Neuromyelitis Optics (NMO) Methods for treating NMO are claimed including the use of glulamate receptor antagonists and/or compounds that inhibit complement.
2008-268 – Methods and devices are disclosed for the attachment of a soft tissue structure (e.g., tendon or ligament) to bone or a prosthetic implant. In one form, the device includes a clamp comprising a porous metallic material. The clamp includes a convex tissue engaging surface. The device also includes a fastener for compressing the soft tissue between the tissue engaging surface and the bone or... Read More
2008-266 – In multiple animal models of cardiovascular disease, including hypertrophic cardiomyopathy (enlargement of the heart), dilated cardiomyopathy (dilation and weakening of the heart), and heart failure (ineffective heart function), a protein which plays a key role in the heart is lost - junctophilin type-2 encoded by the gene JPH2. Our invention, a “recombinant junctophilin - 2”, provides a... Read More
2008-249 – Tendon injuries are very common, but functional restoration of the injured tendon still presents a challenge. Tissue engineering approaches provide the possibility of enhancing tendon healing or tendon tissue regeneration. Mayo Clinic researches have developed an engineered tendon substitute using acellular tendon slices seeded with cultured bone marrow stem cells as a regeneration scaffold... Read More
2008-277 – Anaplastic thyroid carcinoma (ATC) is one of the deadliest cancers with lethality of >99% and survival average of 4 months. Recent publications have demonstrated over 40% of thyroid cell lines are of questionable origin especially ATC cell lines (Schweppe et al., J Clin Endocrinol Metab 2008). We have developed four cell lines from human ATC tumor tissues. These cell lines represent the... Read More
2008-202 – Balloons are used to create cavities in bones for several applications, including cement injection. Current design features include initial placement of a cannula into the bone, through which the balloon is inserted. An alternative design would be to mount the balloon on the outside of the cannula itself, such that the balloon could simply be inflated once the cannula reaches its intended... Read More
Mathematical Model of Insulin Secretion in Response to Changing Glucose Concentrations to Allow Creation of an Artificial Pancreas
2008-201 – The relationship between insulin secretion and changes in glucose concentrations is not linear and is affected by parameters such as body weight, rate of change, time of day, concomitant activities such as exercise or eating and insulin sensitivity. This model attempts to relate the relationship of insulin to glucose in terms that would be used to program an insulin pump that could respond to... Read More
2008-214 – The present invention is a circuit block used to condition and sample a variety of electrical signals in characterization and system applications. The internal passive circuitry eases characterization of high-speed differential and single-ended applications by providing impedance-matched environment and integrating unique capabilities such as true differential termination, pass-through... Read More
2008-195 – Retroviral or lentiviral vector-mediated stable introduction of some stem cell-associated genes can reprogram adult somatic cells into embryonic stem cell-like “induced pluripotent stem (iPS) cells.” Our inventions are i) cross-species reprogramming (e.g. use of human factors to generate iPS cells from non-human origin, such as a mouse, rat, hampster, cat, dog, pig, cow, sheep, horse or... Read More
2008-163 – These mice conditionally express the human tau cDNA (4RON isoform) containing the FTDP-17 mutation (P301L) in exon 10. These mice utilize the TET-ON/TET-OFF® system to express approximately 7X human tau in comparison to murine tau. Both the tTA transgene (Memory Pharmaceuticals) and the tau transgene (Mayo) must be present to yield expression of the human tau. Doxycycline in the diet of the... Read More
2008-141 – Dual energy CT performed using dual source scanner geometry is limited to dual energy algorithms that operate using reconstructed images. This limits the ability to remove beam hardening artifacts, which are introduced during the image reconstruction process. The novel algorithm disclosed here allows for realignmnet of the high- and low-energy datasets, which are 90degrees out of phase, such... Read More
2008-184 – This invention relates to the production in large quantity and high purity of a novel peptide expression plasmid. Peptides are short polymers formed from amino acids, working as signaling molecules. In biomedicine, peptides are used as probes to resolve protein interactions, a key biological process governing multiple vital functions, as well as drugs to target disease-causing proteins.... Read More
2008-136 – A method is described which provides reduction of acquisition time for 3DFT MRI. It is based on a specific way to sample k-space which is robust to undersampling. It can be used in conjunction with other methods for reduction of acquisition time.
A Novel Series of Designer Peptides Combining Angiotensin - (1-7) With Selected Amino Acid Sequences from the Natriuretic Peptides and a Novel Strategy of Co-Administration of Angiotensin - (1-7) With a Native or Designer Natriuretic Peptide
2008-179 – Our research focuses on the discovery and development of new drugs for the prevention and treatment of diseases affecting the heart, the blood vessels, and the kidneys. We have designed a novel series of ten peptides by combining angiotensin-(1-7) with selected amino sequences from the natriuretic peptides, as both angiotensin-(1-7) and the natriuretic peptides have been demonstrated to exert... Read More
2008-178 – A technique is described for MR imaging of an extended field of which uses a combination of multiple-fixed-station and continuously moving table acquisitions. This preserves the ability to perform acceleration techniques and also provides high time efficiency.
2008-177 – A coil array is designed for 2D acceleration in MRI for imaging an object with markedly different fields of view in the two phase encoding directions in which the coil elements in one direction have markedly different size than elements in the other direction.
2008-125 – Monoclonal antibodies were raised to human Abeta 1-42. The peptide used to immunize was Abeta 35-42. This antibody is also known as MM26-2.1.3 and also as clone MM26-126.96.36.199.86 and also as Ab42.2
2008-124 – Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was fibrillar Abeta 1-42. This antibody is also known as AB42-5.
2008-123 – Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was Abeta 1-16. This antibody is also known as Ab-9
2008-121 – Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was Abeta 1-16. This antibody is also known as MM27-33.1.1
2008-120 – Monoclonal antibodies were raised to human Abeta 1-40. The peptide used to immunize was Abeta 35-40. This antibody is also known as MM32-13.1.1 and also as Ab40.1
2008-115 – Technology Description Purified antibodies from rabbit serum that specifically recognize the Eps15 protein at two different and distinct regions. These antibodies have a wide variety of applications in research as well as diagnostic uses where recognition of Eps15 protein is necessary. Reference “Eps15 Mediates Vesicle Trafficking from the trans-Golgi Network via an Interaction with the... Read More