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2009-234 – High Speed serializer/de-serializer (SerDes) paths are rapidly replacing slower local communication paths in digital systems. Engineers must accurately model the SerDes electrical interconnect paths (channels). An important structure used in many channels is loosely described as a “pin-field”. We have developed software which automatically creates these pin-field models for input into... Read More
2009-219 – Suppressive Monocytes as Markers of Response to Renal Cell Carcinoma Therapy The incidence of and deaths caused by renal cell carcinoma (RCC) are increasing in the United States. Over 80 percent of renal cell carcinomas are due to the subtype clear cell renal cell carcinoma (ccRCC). The majority of patients with renal cell carcinoma confined to the kidney can be cured by surgery; however,... Read More
2009-211 – Technology Description Mayo Clinic researchers have discovered that USP10 is the missing link between autophagy and cancer formation. USP10 is a regulator of p53 degradation and activity. USP10 is stabilized upon DNA damage and deubiquitinates p53, reversing Mdm-2 induced nuclear export and degradation. USP10 suppresses tumor cell proliferation in cells expressing wild-type p53. USP10... Read More
2009-202 – Bacterial infection continues to negatively affect outcomes for orthopedic patients despite heightened awareness and increased technologies. Infections at the shoulder may be three times more prevalent than at the knee or hip and is recognized as a considerable clinical problem. The shoulder represents a significant challenge for infection prevention: bacteria contamination of the skin... Read More
2009-196 – Technology Description There is no available test that predicts the onset of preeclampsia, and current diagnostic methodologies of blood pressure and proteinuria measurement need improvement. Mayo Clinic researchers have discovered an epithelial cell type (podocyte) present in the urine of patients with preeclampsia, and these cells are present in the urine of patients several weeks before... Read More
2009-191 – In MR and CT imaging, any reduction in scan time offers potential benefits ranging from high temporal rate observation of physiologic processes to reduction of motion artifacts to lower radiation dose (for CT) to improve patient comfort and throughput. With compressing sensing (CS) techniques, certain classes of MR and CT images can be accurately reconstructed from highly undersampled (and... Read More
2009-189 – We have invented a technique for rapidly removing biofilms from the surface of explanted orthopaedic implants (e.g. prosthetic joints). The dislodged and disaggregated bacteria are suspended in solution and amenable to detection using culture or rapid detection strategies. This disclosure lists the bacteria that would need to be targeted to detect most cases of orthopaedic implant... Read More
2009-179 – For certain types of time series CT studies, Prior Image Constrained Compressed Sensing (PICCS) has been shown to significantly reduce the number of required data samples that must be acquired, thereby reducing the radiation dose to patients. PICCS is based on standard compressed sensing L1-norm minimization techniques. An alternative homotopic L0-based minimization technique developed... Read More
Peritrode Minimally Invasive Cirmcumferential Peripheral Nerve Stimulation Electrode, Anchoring System and Placement Assist Device
2009-175 – An eight contact electrode placed “through the needle"via ultrasound visual guidance. The electrode is able to pass under a target nerve and curve over and reside circumferentially around the nerve in a "cuff” configuration thus facilitating efficient pain management.
2009-173 – Insulin-Stimulating Peptides for Diabetes and Metabolic Disorders Mayo Clinic Researchers have developed a series of peptides that have been shown to modulate glucose levels and reduce fibrotic damage to the heart and kidneys in diabetic animal models. These peptides are structural analogs of glucagon-like peptide (GLP) and natriuretic peptides. Application Control of glucose levels in... Read More
2009-172 – Glucagon-like peptide-1 (GLP-1) is derived from the transcription product of the proglucagon gene and is currently used for the management of DM. We have created a peptide with GLP-1 Properties.
2009-144 – Using audiovisual support we have created educational videos in all facets of General Surgery Education: Knot tying, Syringe, Specimen handling, Operative procedures, reading Chest X-rays/CT Scans/ MRI, etc. Basically we are creating a library of AV clips (30 seconds - 5 minutes) that educate Students/Residents/Fellows/Staff on everything in surgery.
2009-140 – This technology relates to materials and methods for inhibiting botulinum neurotoxins (BoNTs), and more particularly to materials and methods for inhibiting the zinc endopeptidase of BoNT serotypes A, D, and/or E (BoNTA, BoNTD and /or BoNTE to (1) treat botulism, (2) Protect against botulism, or (3) use as an adjunct therapy during administration of medical toxins that are based upon... Read More
2009-139 – Technology Description Mayo Clinic researchers have exploited normal blood-brain barrier (BBB) transport mechanisms utilized by apolipoproteins to deliver agents across the BBB and have designed peptides incorporating apolipoprotein LDL receptor binding sequences. These peptides contain additional amino acid sequences to facilitate the binding and delivery of various biological and chemical... Read More
2009-132 – A monoclonal antibody to MDC1, a key mediator of DNA damage response.
2009-131 – CD2 Binding Agents for Decreasing Suppressive Monocytes in Cancer and Sepsis CD2 binding molecules, such as alefacept, have been shown to deplete immunosuppressive monocytes (e.g., CD14+/DR- or CD14+/DRlow) in patients with lymphoma. Increased levels of immunosuppressive monocytes have been found to be associated with poor prognosis. Continued depletion of immunosuppressive monocytes appeared... Read More
2009-126 – This invention includes the developement of inducible transgenic mice expressing human TDP-43 cDNA encoding the TAR-binding protein 43kD.
2009-125 – This invention includes the development of a homozygous transgenic mouse model expressing wild-type human TDP-43 cDNA encoding the TAR-binding protein 43kD endogenous levels.
2009-107 – A device which allows for rapid cleaning of the colon in preparation for colon examination by an endoscope or other imaging methods such as CT or MR colonography. The device is aimed at facilitating colonic lavage to allow either minimal prep, or no prep prior to colonoscopy.
WINCSWare: Two-way Wireless Communication Between Sensor and Control Unit for Data Aquisition and Selection of Sensing Parameters (Neurochemicals, Time, etc.) and Software for Processing of Incoming Data and Visual Display in Real-Time
2009-106 – Two-way Wireless Communication Between Sensor and Control Unit for Data Acquisition and Selection of Sensing Parameters (Neurochemicals, Time, etc.) and Software for Processing of Incoming Data and Visual Display in Real-Time.
2009-104 – Proximal migration of biliary stents can lead to difficult and time consuming endoscopic removal procedures. Separately, while the use of prophylactic pancreatic stents may be increasing due to potentially decreased risk of pancreatitis, endoscopic procedures are often required to facilitate stent removal. Design features to improve spontaneous stent removal and ease retrieval have been... Read More
2009-095 – Embolization to the head/brain may occur during cardiac catheterization percutaneous intervention of the coronary arteries a treatment of structural heart disease such as percutaneous aortic valve replacement a treatment of paravalvular leak. This has been the result of embolization of atherosclerosis debris. This current device has several iterations. 1) as expandable filter that can be... Read More
Visual Syntactic Text Formatting to Improve Human Reading in Patient-Data Secure Electronic Health Systems
2009-089 – The invention combines computer-executed syntactic parsing algorithms with spatial layout parameters to reformat electronic text in cascading-phrase patterns that are designed to guide eye-movements, reduce visual regressions, and provide visual cues to sentence structure. Empirical studies, in both laboratory and real-world educational settings, have shown that this parser-generated format... Read More
2009-083 – MR Spectroscopy data is analyzed to yield high quality spectral images. Multiple acquisitions of MRS data are combines. The images are combined by time a phase shifting the data in the time domain (equivalent to interpolation) so that the data points all coincide on the same set of frequency points after fourier transforming. This avoids cancelation of the desired signal that would occur... Read More
2009-078 – This write-up describes a wearable electronic device, referred to as a “Biomedical Platform”, with the capability of collecting and storing within its own structure and data collected from biomedical sensors attached to a human volunteer or patient (or, in appropriate circumstances, on an experimental animal). The unit is “sensor-agnostic”, in that it can collect data from analog sensors... Read More
WINCS Hardware & Combination of Amperometry and Voltametry in One System for Measuring Neurochemicals in Real-Time
2009-065 – Emerging evidence supports the hypothesis that modulation of specific central neuronal systems contributes to the clinical efficacy of deep brain and motor cortex stimulation. Real-time monitoring of the neurochemical output of targeted regions may therefore advance functional neurosurgery by, among other goals, providing a strategy for investigation of mechanism, identification of new... Read More
2009-064 – Previous studies had demonstrated the importance of adenosine in the mechanism of Thalamic DBS for Essential Tremor. Real-time monitoring of the neurochemical output of targeted regions may therefore advance functional neurosurgery by, among other goals, providing a strategy for investigation of mechanism, identification of new candidate neurotransmitters, and chemically guided placement of... Read More
2009-055 – Hydogels have wide applications in the biomedical field due to their ability to absorb incredible amounts of aqueous solutions and support cell viability. One particular application hydrogels are being investigated for is nerveguidance conduits to direct and stimulate nerve regeneration by supporting cell growth while simulatanously delivering biologically active molecules. Incorporation of... Read More
2009-049 – Technology Description Due to the rapid increase in use of CT imaging and the recently-heightened awareness of radiation-induced cancer, improving the diagnostic quality of low dose CT has become increasingly important. The signal-to-noise level of low dose CT scans is significantly lower than for normal dose scans, and thus may cause a decrease in diagnostic accuracy. Mayo Clinic... Read More
2009-048 – Technology Description Intracranial aneurysms represent a difficult to detect cause of morbidity and mortality. Digital subtraction angiography is considered the gold standard for intracranial aneurysm detection, but this technique is associated with risk of neurologic complications. 3D time-of-flight magnetic resonance angiograpy (MRA) has recently emerged as a non- invasive screening... Read More
2009-047 – A complex set of gestures which, when performed using a screen pointer, facilitate fast and accurate selection of radial menu items from a radial menu.
2009-046 – A complex set of gestures which when performed using a screen pointer, facilitates fast and accurate selection of radial menu items from a radial menu.
2009-043 – To reduce radiation dose and/or improve image quality in CT, it is very important to select the optimal tube potential (kV), which is highly dependent on patient size and specific diagnostic task. In this invention, we developed a general strategy that allows for individualized automatic kV selection for each patient size and each diagnostic task. We proposed a novel concept, kV dose index... Read More
2009-017 – Very long chain polyunsaturated fatty acids (VLPUFAs) are present in the human retina and play an important role in maintaining the structure and function of the retina. A disease with a defect in the gene that synthesizes VLPUFAs in the retina leads to an early onset degeneration of the macula and severe loss of vision. Currently, these VLPUFAs and other very long chain fatty acids are not... Read More
2009-006 – The new Mayo SRBAL is a novel, second generation liver support device that combines liver cell therapy with albumin dialysis to create a hybrid system that addresses past limitations of both forms of extracorporeal artificial liver therapy. In short, we have shown that albumin dialysis and primary hepatocytes are synergistic for treatment of acute liver failure (ALF).
2008-386 – The use of ionizing radiation for diagnostic and interventional procedures has been growing at an exponential rate. The technical differences which exist among the sources of ionizing radiation are large - and necessitate computationally intensive and patient specific information in order to form a reasonable summary of an individual patient’s radiation dose. The invention specifies a... Read More
2008-380 – A novel electrically conductive polymer composite composed of polycaprolactone fumarate- polypyrrole (PCLF-PPy) for applications in nerve regeneration is disclosed. The synthesis and characterization of PCLF-PPy and in vitro studies showing PCLF-PPy supports both PC12 cell and dorsal root ganglia neurite extension. PCLF-PPy composite materials were synthesized by polymerizing pyrrole in... Read More
2008-368 – We have generated a human neuronal culture to model formation of alpha-synuclein aggregates in Parkinson’s disease (PD) and dementia with Lewy bodies (DLBD). By engineering conditional expression of alpha-synuclein, we established a novel cell-based model 3D5, in which production of wild-synuclein was regulated by the tetracycline off inducible mechanism. Two to four weeks following... Read More
2008-348 – Radiation therapy treatment is used in nearly two-thirds of all cancer patients. Accurate targeting of the tumor over the treatment period is critical to effective therapy. Placement of permanent tattoos is the current standard practice to aid in the alignment and targeting of radiation therapy over multiple treatments. Existing tattoo methods involve the use of freehand needle sticks,... Read More
2008-346 – Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was Fibrillar Abeta 1-42. The antibody is also known as AB42-2.
2008-325 – The invention described herein is a method by which to visually verify and quantify the amount of radiation dose delivered to a patient during the administration of radiation therapy. A Compton camera imaging system is used to detect and reconstruct the original interaction position and energy of photons that are scattered out of the patient during treatment. The result is a three... Read More
2008-332 – Both natural and chimeric natriuretic peptides have anti-proliferative properties i.e. they prevent abnormal growth, in muscle cells, endothelial cells and fibroblast cells. Blocked arteries and veins are a common cause of cardiovascular problems and blockage of muscular tubes, such as the ureter or esophagus can result serious complications. Stents are currently used to unblock blood vessel... Read More
2008-322 – Synthetic atrial natriuretic peptide (ANP) (carperitide) and B-type natriuretic peptide (BNP) (nesiritide) are used to treat congestive heart failure. However, despite beneficial cardiac unloading properties, reductions in renal perfusion pressures limit their clinical effectiveness. Recently, CD-NP, a chimeric peptide composed of CNP fused to the carboxyl terminal tail of Dendroaspis... Read More
2008-317 – A novel electrically conductive polymer composite composed of polycaprolactone fumarate- polypyrrole (PCLF-PPy) for applications in nerve regeneration is disclosed. The synthesis and characterization of PCLF-PPy and in vitro studies showing PCLF-PPy supports both PC12 cell and dorsal root ganglia neurite extension. PCLF-PPy composite materials were synthesized by polymerizing pyrrole in... Read More
2008-299 – A technique is described for taking images generated from an MRI acquisition done with contrast administration and converting the image data into a single image which portrays the time of arrival (TOA) of the advancing contrast bolus. The TOA image allows distinction of arterial from venous structures based on their different arrival times. The quality of the results depends on... Read More
2008-315 – Parallel imaging can be applied to further reduce acquisition times. To do so, coil sensativities have to be determined. One option is to use self-or-auto calibrated methods which in general use unaccelerated sampling in some central region of the otherwise undersampled k-space. However, the fraction of acquisition time devoted to calibration can be substantial, particularly in high... Read More
Further Development of System and Method for Overlaying Ultrasound Imagery on a Laparoscopic Camera Display
2008-313 – Software algorithm to fuse images and correct for distortion for overlaying ultrasound imagery on a laparoscopic camera.
2008-294 – We have developed a method to assess the relative motion of various structures in the human carpal tunnel (tendon, nerve, and synovium) simultaneously using ultrasound We have also developed a method of comparing these motions by means of ratios and have shown that the ratios differ in normal individuals and those with carpal tunnel syndrome. The methods include both specific testing... Read More
2008-292 – Guiding catheters must be of sufficient stiffness to offer support during endovascular procedures, but must not be too stiff to track to their intended target. We describe a system with a relatively supple catheter that has a separate lumens or lumens within its walls, which do not communicate with the main, working lumen. The extra lumens can be used to place stiffening wires after the... Read More
Aquaporin-4-Binding Autoantibodies in Patients with Neuromyelitis Optica Impair Glutamate Transport by Down-Regulating EAAT2
2008-303 – Materials and Methods for Treating Neuromyelitis Optics (NMO) Methods for treating NMO are claimed including the use of glulamate receptor antagonists and/or compounds that inhibit complement.