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2011-001 – PCLF is currently about to enter clinical trials as a nerve conduit for guiding nerve regeneration across segmental defects. Unlike previous PCLF formulations that lead to the toxic small molecule diethylene glycol in concentrations exceeding the FDA limit, this invention utilizes 1,2 propanediol or glycerol as the initiators for the polymerization of PCL multi-alcohols as necessary for the... Read More
2010-333 – A major problem in the area of electrochemistry and fast scan cyclic voltammetry is the occurrence of multiple complex analytes being measured by the fast scan cyclic voltammetry. In this invention, we developed the technique of Double Pulse Voltammetry (DPV) in which very fast scan cyclic voltammetry can be done at various voltages in this case from -0.4 volt to +1.5 volt and back down... Read More
2010-320 – The MDQ-30 is a 28-item instrument in which the items query symptoms over the previous 30 days. Seventeen items use a dichotomous format, two items use a Likert scale, one item uses multiple non-hierarchical options, six items use multiple hierarchical options, and two items are multi-item dichotomous scales. MDQ-30 items follow a stem-and-leaf format and are divided into three symptom... Read More
2010-318 – An innovative freight management solution has been developed which represents a new business model developed on transparency and risk-sharing within a reseller market. Working with supply partners, key individuals within supply chain management have developed this program which involves practice, process and designs generally not used or common within healthcare. The solution results in... Read More
2010-316 – Technology Description C-type natriuretic peptide (CNP) is a 22 amino acid peptide which is primarily produced by endothelial cells and possesses potent antifibrotic and antiproliferative properties. Mayo Clinic researchers have shown that elevated levels of CNP in the urine correlate with renal fibrosis and decline in renal function. In congestive heart failure patients, urinary CNP... Read More
2010-306 – Thyroid cancer cell lines were created from patient tumor tissues directly from the resected tumor tissue, tissue minced and cultured in cell culture media. These cells lines will be characterized at the molecular level [genetic defects, short tandem DNA repeat analysis (STR)] and phenotypically with regards to growth in cell culture and animals. These well characterized cell lines should... Read More
2010-305 – Cell lines were created from patient tumor tissues directly from the resected tumor tissue, tissue minced and cultured in cell culture media. These cells lines will be characterized at the molecular level (genetic defects, short tandem DNA repeat analysis (STR)) and phenotypically with regards to growth in cell culture and animals. These well characterized cell lines should prove to be useful... Read More
2010-299 – Molecular breast imaging (MBI) is a molecular imaging technique that can be used for the detection of breast cancer. MBI can detect breast tumors not visible on mammography or ultrasound. MBI images usually take 5-10 minutes to acquire 1 view. A slant-hole collimator can be used to estimate tumor depth and enable tumor biopsy using a radiolabeled guide. However, the long imaging time of 5-10... Read More
2010-297 – A single transmission line with a well-defined characteristic impedance may be terminated with a single resistor of the same value as the impedance, thereby eliminating reflections and providing an accurate replica of the input signal at the output. It is much less widely known (but is known as prior art) that, in principle, it is possible to do the same thing with a set of uniform coupled... Read More
2010-296 – Communications between electronic components employ one of a number of signaling schemes. Generally, digital communications use one of two classes of signaling schemes: single-ended or differential signaling. A single-ended signaling channel employs transmission of n-level (typically 2-level) signals through a single signal conductor, using a ground or power conductor as the reference for... Read More
2010-294 – In laparoscopic radical prostatectomy (RP), the pedicle is transected, but care must be taken to preserve the adjacent neurovascular bundle. Electrocautery or other hemostatic energy sources are not used due to concerns over collateral thermal damage, adhesives or sutures alone have not been shown to provide reliable hemostatis, and existing clips can be difficult to place and adjust. A... Read More
Transpulmonary Induction of Therapeutic Hypothermia (In Collaboration with Minnesota High-Tech Resources LLC)
2010-284 – Therapeutic hypothermia is a widely accepted methodology for mitigating injury to vital organs following ischemic insults. Cellular metabolism decreases with lower temperatures and this reduction in metabolism protects metabolically active organs including the heart and brain during episodes of ischemia and hypoxia. Therapeutic hypothermia is currently practiced in association with a number... Read More
2010-278 – Nuclear reprogramming technology has provided the fundamental basis to convert ordinary cells in the adult body into pluripotent stem cells that can function as embryonic stem cells. This bioengineering platform enables a revolutionary breakthrough for stem cell biology and regenerative medicine applications despite current technology being challenged by low efficiencies and ill-defined... Read More
2010-271 – The normal immune system contains T cells bearing antigen receptors which are not readily reactive to self. This invention describes a new method for activating self-reactive T cells in a peptide specific manner, a strategy designed to focus autoimmune cellular responses against cancers and persisting virus infections.
2010-238 – There is a need for an inexpensive, small laparoscopic scope holder that would allow for maximum flexibility and rapid position changes. We have designed a small manually adjustable holder that can be disposable or reusable (on a limited basis). This device sits at the abdominal opening and remains stable by means of adhesive tape at the lower rim. There are no robotic mounts or arms holding... Read More
2010-233 – The inner ear vestibular system reflexively controls eye position in the orbits. For example, when the head is tilted to the side (ear moved toward the shoulder) the eyes roll in the opposite direction so that they stay oriented to the horizon. This eye movement is called head tilt induced ocular counter roll and is mediated in part by the otolith organs of the vascular system. Damage to... Read More
2010-222 – This invention covers the design, genetic engineering and construction of the inducible TDP-43 wild-type and D89/219E double mutant constructs utilized to create the iTDP Tg mice.
2010-220 – Radiation therapy treatment is used in nearly two-thirds of all cancer patients. Accurate targeting of the tumor over the treatment period is critical to effective therapy. Placement of permanent tattoos is the current standard practice to aid in the alignment and targeting of radiation therapy over multiple treatments. Existing tattoo methods involve the use of freehand needle sticks,... Read More
2010-206 – Patient derived tumor tissue samples that have been demonstrated to grow in mice.
2010-203 – Reagents to study the biology of the rare human bronchopulmonary carcinoid tumor are very limited. We have created cell lines derived from tumors resected from patients treated at Mayo Clinic. These cell lines will aid investigators to test existing and future medications for efficacy in killing these tumors on the cell lines prior to human studies. These cell lines will aid investigations... Read More
2010-184 – Although anterior cervical fusion is one of the most commonly performed spine procedures in the world, adequate retraction and plate placement remains difficult. A Mayo inventor has created an anterior cervical retractor that minimizes its displacement, prevents tissue creep into the surgical field, does not need to be repositioned in multilevel cases, and eases the application of an... Read More
2010-178 – Technology Description We have developed human lung cancer cell lines in which the expression of the PKClota oncogene has been genetically manipulated. Specifically, the cell lines are transduced with rec ombinant lentiviruses that express either a shRNA targeting the PKCiota mRNA or a non-target control shRNA that does not target any known RNA. These cell lines allow one to investigate the... Read More
2010-177 – Background: The incidence of Barrett’s esophagus and esophageal adenocarcinoma (EAC) is rising in Western nations, and, according to the National Cancer Institute, EAC is the fastest growing form of cancer in the United States. Esophagectomy is standard treatment for Barrett’s esophagus with high grade dysplasia and malignancy. However, due to high morbidity rates associated with... Read More
2010-170 – The Enterprise Data Model is a schematic entity-relationship diagram depicting how data relates to each other within the context of Mayo’s practice, education and research activities. It collectively forms the basis around which all information at Mayo is organized, and from which the system pulls data for purposes of developing the logical and physical representation of data within its... Read More
2010-168 – The caloric test is commonly used as an assessment of vestibular function. The test entails delivering air or water into the external ear canal at varying temperatures, thereby stimulating vestibular labyrinthine responses. Historically, water has been the preferred stimulus for the caloric test. However, pumping air into the external canal is more convenient and is increasingly popular in... Read More
2010-167 – This invention is a software product (Virtual Audi (gram) that automates the standard audiological report writing process. The application creates a graphic of all audiological tests in the basic comprehensive hearing evaluation and uses a pull down menu interface to create custom, grammatically correct reports. Reports and graphics are formatted for easy import into an electronic medical... Read More
2010-162 – The application works on the iPod Touch and iPhone platform and will improve access to exposure-based therapy for individuals with anxiety disorders. The application can be used independently as a self-help program or in conjunction with a health professional. To Access the App through the iTunes Store, click on the link below. AnxietyCoach App
2010-157 – Transoral robotic surgery (TORS) offers potential advantages and benefits over other current treatment modalities in surgical procedures of the head and neck, but in some patients, inadequate exposure to target tissues reduces the number of cases that can be performed by this method. Transoral retractors are used to provide access to a patient’s oral cavity and larynx during these procedures,... Read More
2010-155 – Suppressive Monocytes as Markers of Immune & Therapeutic Responses Mayo Clinic researchers have identified immune phenotypes that can be used to measure the level of systemic immune suppression in patients with cancer and sepsis. Subsets of peripheral blood leukocytes can be measured using standard flow cytometry methods and used as prognostic markers in cancer and sepsis patients. ... Read More
2010-152 – A device and method for MRI in-scanner imaging of chronic exertional compartment syndrome (CECS) of the lower legs has been developed and validated.
2010-138 – This invention describes a mathematical method for reliably describing audiometric configuration and classifying the severity of hearing impairment. It has been shown to accurately correlate with the patient self reports of hearing difficulty better than any other classification method currently used in clinical audiology.
2010-137 – This invention describes a novel calculation called the Speech Transmission Index based Social Hearing Index (STI-SHI or social hearing index for short). The social hearing index can be calculated using standard pure tone hearing threshold data and supra-threshold measures of speech intelligibility. The STI-SHI can be useful in refining the legal definition of hearing disability and will also... Read More
2010-115 – Photon counting detector technology is being actively adopted for commercial CT. One compelling reason is the advantages that it brings for spectral imaging (multi-energy CT) which allows material characterization using energy information from the detected x-rays. The ability to identify material composition regardless of material density (e.g. distinguishing iodine from bone even though they... Read More
2010-108 – SDUV is a non-invasive ultrasound technology that can qualify tissue stiffness and viscosity, which are sensitive indexes of pathology such as liver fibrosis. SDUV uses one long push toneburst of ultrasound followed by multiple detect pulses to generate and detect shear waves in tissue. Shear wave propagation information is used to estimate tissue stiffness and viscosity. The push-detect... Read More
2010-061 – Calcific aortic valve stenosis is a growing problem in developed countries, and valve replacement surgery is the second most common thoracic surgery performed worldwide (>100,000 procedures performed in the US in 2008). Bioprosthetic valves are the most commonly used devices to replace the stenotic valve, but only have a projected lifespan of 10-12 years. Cells infiltrating the... Read More
Matrix Metalloproteinase Inhibition to Slow Calcification and Failure of Bioprosthetic Aortic Valves
2010-060 – Calcific aortic valve stenosis is a growing problem in developed countries, and valve replacement surgery is the second most common thoracic surgery performed worldwide (>100,000 procedures performed in the US in 2008). Bioprosthetic valves are the most commonly used devices to replace the stenotic valve, but only have a projected lifespan of 10-12 years. During this time, endothelial... Read More
2010-054 – Transapical access is being performed increasingly for treatment for a variety of structural heart diseases. In the past, that has been done through a small mini thoracotomy. However, a percutaneous approach is being studied and will be an important means of optimizing and enhancing care of patients. Such a percutaneous transapical approach will need to have a means to percutaneously close... Read More
2010-038 – The individual cross-sectional images along the arteries were analyzed individually by creating a Region-of-Interest (ROI) that encompassed the vessel wall. To ensure that the entire arterial wall was included into the ROI, the radius of the lumen ® was measured, which was used as the width of the annular ROI surrounding the arterial lumen (12). By creating a binary image of the punctate... Read More
2010-032 – A method for producing tissue motion with customized frequency content is described in which push pulses are designed using orthogonal basis functions which then produce desired tissue motion. The push pulses can be a sequence of long duration, in which case motion detection A-lines can be interleaved among the pulses. The result is a more efficient method of making tissue move with optimal... Read More
2010-026 – Accelerated MRI: A method is described for improving parallel acquisition along the longitudinal direction.
Use of Pittsburgh Compound B (PiB) Molecules and PiB-Positron Emission Tomography/Computed Tomography (PiB-PET/CT) Imaging for the Identification and Diagnosis of Meningiomas
2010-007 – Meningiomas are a common tumor often found in the thin layers of tissue that surround the brain. However, many other types of tumors can arise in the same locations. Variation in the appearance of meningiomas can make the accurate diagnosis of meningioma difficult based on current methods, such as Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). Pathologists can accurately... Read More
2009-379 – Technology Description Patients with extensive, longstanding inflammatory bowel diseases (ulcerative colitis or Crohn’s disease), which are diseases of chronic colonic inflammation, are at risk for colorectal cancer (CRC). Surveillance of this at-risk population remains challenging. Mayo Clinic researchers have identified biomarkers for colorectal cancer in inflammatory bowel disease... Read More
2009-375 – Existing systems for positioning a patient for radiation therapy treatment include use of moldable masks (aquaplast) that aid in alignment of bony anatomy and fiducial markers and the tumor target. The current process of aligning the multiple markers can be time consuming and tedious. Gloves are required and the reflective surface coating on the markers is prone to wear out. This invention... Read More
2009-374 – Technology Description An immunotherapy approach that delivers multiple antigens within a vesicular stomatitis virus (VSV) vector. The delivery of multiple antigens allows for a multipronged immune response against a tumor while the VSV vector serves as an activator of the innate and adaptive immune response. A three antigen combination delivered via a VSV vector has been demonstrated to be... Read More
2009-366 – A method and system for producing 3-dimensional ultrasound images of a patient’s breast and also producing planar emission images from a radiopharmaceutical is described. The system allows perfect co-registration of both the ultrasound image and the emission image, thereby allowing comparison of anatomical and functional features of the breast tissue. The system comprises 3 primary components... Read More
2009-362 – Background Topoisomerase I has been used as a drug target for cancer treatment. By inhibiting the religation step of the enzyme, the formation of topo I-DNA complexes block the advancing replication complexes, which will ultimately cause cell death. Thus, measurement of the covalent topo I-DNA complexes can potentially be used to assess therapeutic efficacy of topoisomerase I poisons. ... Read More
Improved Quality for Magnetic Resonance Spectroscopy Spectra Using Eigenvalve Deconvolution and Special Lower Triangular Matrix of Time Activity Data
2009-323 – Eigenvector decomposition allows consistent eigenvalues to be produced from different data set acquisition of the same sample material.
2009-315 – Devices and methods for in situ graft fenestration. These concepts are meant to modify aortic stent grafts to allow for placement of branch stent grafts off of the main graft body to cannulate vessels such at the renal arteries. The core concept is to utilize devices placed both within the lumen of the aortic graft and on the outside surface of the aortic graft to create a fenestration... Read More
2009-314 – This disclosure is for a continuation-in-part to US Patent Application No: US 2006/0056310 A1. The original patent application uses only a symmetrical THRU structure for de-embedding. In this disclosure both OPEN and SHORT structures are presented as additional structures that, once measured with a VNA, can yield additional equations.
2009-309 – The general method has been discussed in “System and Method for Phone Offset and Time Delay Correction in Magnetic Resonance Spectroscopy Data”. (2007-100). Here it is added that the magnitude of the real imaging parts of the data are used for the spectrum.