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2009-278 – Specific and highly sensitive ultrasound localization of catheter placement can be accomplished by use of a catheter navigation crystal with an active (vibrating) element whose ultrasonic signal interferes with the ultrasound imaging signal as the latter propagates with each transmitted bearn though issue. The interference signal (caused by the crystal) occurs directly within the Doppler... Read More
2009-275 – Technology Description Neuroradiologists’ ability to successfully interpret MR angiography images is enhanced when projection images called Maximum Intensity Projection (MIP) renderings are independently generated for the three main vascular structures in the head. Currently, this process is performed manually by the MR technician immediately following the acquisition of an MR angiography... Read More
2009-274 – System for Minimally Invasive Local Drug Delivery Local drug delivery is a useful approach to deliver much higher concentrations of a drug to a target site while minimizing systemic side effects. Drug-eluting polymers can be delivered via local injection to deliver drug over an extended period of time. Current systems for local drug delivery have two long-standing challenges: local injections... Read More
2009-264 – Conventionally, nuclear medicine gamma cameras employ an energy window centered in the primary gamma ray energy emitted by the radioisotope being detected. For example, with Tc-99m, a 20% energy window (from 126-154 keV) is centered on the 140 keV gamma rays. At lower energies, scatter within the patient and the gamma camera degrade image quality and these events are not considered useful. ... Read More
2009-259 – The spectra are improved by correcting for the distortion caused by 1. The distance for sample to detect 2. Time delay between excitation of the sample and initial recording of the spectra 3. The physical size of the volume of the sample emitting the signal. Details in separate write up.
Portable Photodynamic Therapy Dosimetry Device - Hand-Held Optical Device for Rapid Determination of Local Tissue Photosensitizer Content and Oxygenation
2009-258 – This invention is a convenient, portable optical instrument for use in photodynamic therapy (PDT) dosimetry. It will provide real-time values of photosensitizer content in tissue as well as values of local tissue as well as values of local tissue oxygenation. The instrument contains a laser light source and a broad band (white) light as well as an optical detector. A fiber optic cable is... Read More
2009-246 – In a communication system consisting of multiple nodes, optical interconnects and wave-division multiplexing (WDM), this can be used to broadcast the data stream from any one node-receivers using a broadcast element such as a star coupler. “All-in-all” or “many-to-all” nodes can thus be connected for high speed data transfer. At any receiver node, the optical signal contains all of the... Read More
2009-235 – Using accelerated time-resolved 3-D imaging methods such as the Mayo-developed Cartesian Acquisition with Projection Reconstruction like sampling (CAPR) it is possible to generate data for both a time series of MR angiograms as well as an image of perfusion.
2009-234 – High Speed serializer/de-serializer (SerDes) paths are rapidly replacing slower local communication paths in digital systems. Engineers must accurately model the SerDes electrical interconnect paths (channels). An important structure used in many channels is loosely described as a “pin-field”. We have developed software which automatically creates these pin-field models for input into... Read More
2009-219 – Suppressive Monocytes as Markers of Response to Renal Cell Carcinoma Therapy The incidence of and deaths caused by renal cell carcinoma (RCC) are increasing in the United States. Over 80 percent of renal cell carcinomas are due to the subtype clear cell renal cell carcinoma (ccRCC). The majority of patients with renal cell carcinoma confined to the kidney can be cured by surgery; however,... Read More
2009-211 – Technology Description Mayo Clinic researchers have discovered that USP10 is the missing link between autophagy and cancer formation. USP10 is a regulator of p53 degradation and activity. USP10 is stabilized upon DNA damage and deubiquitinates p53, reversing Mdm-2 induced nuclear export and degradation. USP10 suppresses tumor cell proliferation in cells expressing wild-type p53. USP10... Read More
2009-202 – Bacterial infection continues to negatively affect outcomes for orthopedic patients despite heightened awareness and increased technologies. Infections at the shoulder may be three times more prevalent than at the knee or hip and is recognized as a considerable clinical problem. The shoulder represents a significant challenge for infection prevention: bacteria contamination of the skin... Read More
2009-196 – Technology Description There is no available test that predicts the onset of preeclampsia, and current diagnostic methodologies of blood pressure and proteinuria measurement need improvement. Mayo Clinic researchers have discovered an epithelial cell type (podocyte) present in the urine of patients with preeclampsia, and these cells are present in the urine of patients several weeks before... Read More
2009-191 – In MR and CT imaging, any reduction in scan time offers potential benefits ranging from high temporal rate observation of physiologic processes to reduction of motion artifacts to lower radiation dose (for CT) to improve patient comfort and throughput. With compressing sensing (CS) techniques, certain classes of MR and CT images can be accurately reconstructed from highly undersampled (and... Read More
2009-189 – We have invented a technique for rapidly removing biofilms from the surface of explanted orthopaedic implants (e.g. prosthetic joints). The dislodged and disaggregated bacteria are suspended in solution and amenable to detection using culture or rapid detection strategies. This disclosure lists the bacteria that would need to be targeted to detect most cases of orthopaedic implant... Read More
2009-179 – For certain types of time series CT studies, Prior Image Constrained Compressed Sensing (PICCS) has been shown to significantly reduce the number of required data samples that must be acquired, thereby reducing the radiation dose to patients. PICCS is based on standard compressed sensing L1-norm minimization techniques. An alternative homotopic L0-based minimization technique developed... Read More
Peritrode Minimally Invasive Cirmcumferential Peripheral Nerve Stimulation Electrode, Anchoring System and Placement Assist Device
2009-175 – An eight contact electrode placed “through the needle"via ultrasound visual guidance. The electrode is able to pass under a target nerve and curve over and reside circumferentially around the nerve in a "cuff” configuration thus facilitating efficient pain management.
2009-173 – Insulin-Stimulating Peptides for Diabetes and Metabolic Disorders Mayo Clinic Researchers have developed a series of peptides that have been shown to modulate glucose levels and reduce fibrotic damage to the heart and kidneys in diabetic animal models. These peptides are structural analogs of glucagon-like peptide (GLP) and natriuretic peptides. Application Control of glucose levels in... Read More
2009-172 – Glucagon-like peptide-1 (GLP-1) is derived from the transcription product of the proglucagon gene and is currently used for the management of DM. We have created a peptide with GLP-1 Properties.
2009-144 – Using audiovisual support we have created educational videos in all facets of General Surgery Education: Knot tying, Syringe, Specimen handling, Operative procedures, reading Chest X-rays/CT Scans/ MRI, etc. Basically we are creating a library of AV clips (30 seconds - 5 minutes) that educate Students/Residents/Fellows/Staff on everything in surgery.
2009-140 – This technology relates to materials and methods for inhibiting botulinum neurotoxins (BoNTs), and more particularly to materials and methods for inhibiting the zinc endopeptidase of BoNT serotypes A, D, and/or E (BoNTA, BoNTD and /or BoNTE to (1) treat botulism, (2) Protect against botulism, or (3) use as an adjunct therapy during administration of medical toxins that are based upon... Read More
2009-139 – Technology Description Mayo Clinic researchers have exploited normal blood-brain barrier (BBB) transport mechanisms utilized by apolipoproteins to deliver agents across the BBB and have designed peptides incorporating apolipoprotein LDL receptor binding sequences. These peptides contain additional amino acid sequences to facilitate the binding and delivery of various biological and chemical... Read More
2009-132 – A monoclonal antibody to MDC1, a key mediator of DNA damage response.
2009-131 – CD2 Binding Agents for Decreasing Suppressive Monocytes in Cancer and Sepsis CD2 binding molecules, such as alefacept, have been shown to deplete immunosuppressive monocytes (e.g., CD14+/DR- or CD14+/DRlow) in patients with lymphoma. Increased levels of immunosuppressive monocytes have been found to be associated with poor prognosis. Continued depletion of immunosuppressive monocytes appeared... Read More
2009-126 – This invention includes the developement of inducible transgenic mice expressing human TDP-43 cDNA encoding the TAR-binding protein 43kD.
2009-125 – This invention includes the development of a homozygous transgenic mouse model expressing wild-type human TDP-43 cDNA encoding the TAR-binding protein 43kD endogenous levels.
2009-107 – A device which allows for rapid cleaning of the colon in preparation for colon examination by an endoscope or other imaging methods such as CT or MR colonography. The device is aimed at facilitating colonic lavage to allow either minimal prep, or no prep prior to colonoscopy.
WINCSWare: Two-way Wireless Communication Between Sensor and Control Unit for Data Aquisition and Selection of Sensing Parameters (Neurochemicals, Time, etc.) and Software for Processing of Incoming Data and Visual Display in Real-Time
2009-106 – Two-way Wireless Communication Between Sensor and Control Unit for Data Acquisition and Selection of Sensing Parameters (Neurochemicals, Time, etc.) and Software for Processing of Incoming Data and Visual Display in Real-Time.
2009-104 – Proximal migration of biliary stents can lead to difficult and time consuming endoscopic removal procedures. Separately, while the use of prophylactic pancreatic stents may be increasing due to potentially decreased risk of pancreatitis, endoscopic procedures are often required to facilitate stent removal. Design features to improve spontaneous stent removal and ease retrieval have been... Read More
Visual Syntactic Text Formatting to Improve Human Reading in Patient-Data Secure Electronic Health Systems
2009-089 – The invention combines computer-executed syntactic parsing algorithms with spatial layout parameters to reformat electronic text in cascading-phrase patterns that are designed to guide eye-movements, reduce visual regressions, and provide visual cues to sentence structure. Empirical studies, in both laboratory and real-world educational settings, have shown that this parser-generated format... Read More
2009-083 – MR Spectroscopy data is analyzed to yield high quality spectral images. Multiple acquisitions of MRS data are combines. The images are combined by time a phase shifting the data in the time domain (equivalent to interpolation) so that the data points all coincide on the same set of frequency points after fourier transforming. This avoids cancelation of the desired signal that would occur... Read More
WINCS Hardware & Combination of Amperometry and Voltametry in One System for Measuring Neurochemicals in Real-Time
2009-065 – Emerging evidence supports the hypothesis that modulation of specific central neuronal systems contributes to the clinical efficacy of deep brain and motor cortex stimulation. Real-time monitoring of the neurochemical output of targeted regions may therefore advance functional neurosurgery by, among other goals, providing a strategy for investigation of mechanism, identification of new... Read More
2009-064 – Previous studies had demonstrated the importance of adenosine in the mechanism of Thalamic DBS for Essential Tremor. Real-time monitoring of the neurochemical output of targeted regions may therefore advance functional neurosurgery by, among other goals, providing a strategy for investigation of mechanism, identification of new candidate neurotransmitters, and chemically guided placement of... Read More
2009-049 – Technology Description Due to the rapid increase in use of CT imaging and the recently-heightened awareness of radiation-induced cancer, improving the diagnostic quality of low dose CT has become increasingly important. The signal-to-noise level of low dose CT scans is significantly lower than for normal dose scans, and thus may cause a decrease in diagnostic accuracy. Mayo Clinic... Read More
2009-048 – Technology Description Intracranial aneurysms represent a difficult to detect cause of morbidity and mortality. Digital subtraction angiography is considered the gold standard for intracranial aneurysm detection, but this technique is associated with risk of neurologic complications. 3D time-of-flight magnetic resonance angiograpy (MRA) has recently emerged as a non- invasive screening... Read More
2009-047 – A complex set of gestures which, when performed using a screen pointer, facilitate fast and accurate selection of radial menu items from a radial menu.
2009-046 – A complex set of gestures which when performed using a screen pointer, facilitates fast and accurate selection of radial menu items from a radial menu.
2009-043 – To reduce radiation dose and/or improve image quality in CT, it is very important to select the optimal tube potential (kV), which is highly dependent on patient size and specific diagnostic task. In this invention, we developed a general strategy that allows for individualized automatic kV selection for each patient size and each diagnostic task. We proposed a novel concept, kV dose index... Read More
2009-017 – Very long chain polyunsaturated fatty acids (VLPUFAs) are present in the human retina and play an important role in maintaining the structure and function of the retina. A disease with a defect in the gene that synthesizes VLPUFAs in the retina leads to an early onset degeneration of the macula and severe loss of vision. Currently, these VLPUFAs and other very long chain fatty acids are not... Read More
2008-380 – A novel electrically conductive polymer composite composed of polycaprolactone fumarate- polypyrrole (PCLF-PPy) for applications in nerve regeneration is disclosed. The synthesis and characterization of PCLF-PPy and in vitro studies showing PCLF-PPy supports both PC12 cell and dorsal root ganglia neurite extension. PCLF-PPy composite materials were synthesized by polymerizing pyrrole in... Read More
2008-368 – We have generated a human neuronal culture to model formation of alpha-synuclein aggregates in Parkinson’s disease (PD) and dementia with Lewy bodies (DLBD). By engineering conditional expression of alpha-synuclein, we established a novel cell-based model 3D5, in which production of wild-synuclein was regulated by the tetracycline off inducible mechanism. Two to four weeks following... Read More
2008-348 – Radiation therapy treatment is used in nearly two-thirds of all cancer patients. Accurate targeting of the tumor over the treatment period is critical to effective therapy. Placement of permanent tattoos is the current standard practice to aid in the alignment and targeting of radiation therapy over multiple treatments. Existing tattoo methods involve the use of freehand needle sticks,... Read More
2008-325 – The invention described herein is a method by which to visually verify and quantify the amount of radiation dose delivered to a patient during the administration of radiation therapy. A Compton camera imaging system is used to detect and reconstruct the original interaction position and energy of photons that are scattered out of the patient during treatment. The result is a three... Read More
2008-332 – Both natural and chimeric natriuretic peptides have anti-proliferative properties i.e. they prevent abnormal growth, in muscle cells, endothelial cells and fibroblast cells. Blocked arteries and veins are a common cause of cardiovascular problems and blockage of muscular tubes, such as the ureter or esophagus can result serious complications. Stents are currently used to unblock blood vessel... Read More
2008-322 – Synthetic atrial natriuretic peptide (ANP) (carperitide) and B-type natriuretic peptide (BNP) (nesiritide) are used to treat congestive heart failure. However, despite beneficial cardiac unloading properties, reductions in renal perfusion pressures limit their clinical effectiveness. Recently, CD-NP, a chimeric peptide composed of CNP fused to the carboxyl terminal tail of Dendroaspis... Read More
2008-299 – A technique is described for taking images generated from an MRI acquisition done with contrast administration and converting the image data into a single image which portrays the time of arrival (TOA) of the advancing contrast bolus. The TOA image allows distinction of arterial from venous structures based on their different arrival times. The quality of the results depends on... Read More
2008-315 – Parallel imaging can be applied to further reduce acquisition times. To do so, coil sensativities have to be determined. One option is to use self-or-auto calibrated methods which in general use unaccelerated sampling in some central region of the otherwise undersampled k-space. However, the fraction of acquisition time devoted to calibration can be substantial, particularly in high... Read More
2008-294 – We have developed a method to assess the relative motion of various structures in the human carpal tunnel (tendon, nerve, and synovium) simultaneously using ultrasound We have also developed a method of comparing these motions by means of ratios and have shown that the ratios differ in normal individuals and those with carpal tunnel syndrome. The methods include both specific testing... Read More
Aquaporin-4-Binding Autoantibodies in Patients with Neuromyelitis Optica Impair Glutamate Transport by Down-Regulating EAAT2
2008-303 – Materials and Methods for Treating Neuromyelitis Optics (NMO) Methods for treating NMO are claimed including the use of glulamate receptor antagonists and/or compounds that inhibit complement.
2008-268 – Methods and devices are disclosed for the attachment of a soft tissue structure (e.g., tendon or ligament) to bone or a prosthetic implant. In one form, the device includes a clamp comprising a porous metallic material. The clamp includes a convex tissue engaging surface. The device also includes a fastener for compressing the soft tissue between the tissue engaging surface and the bone or... Read More