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2010-233 – The inner ear vestibular system reflexively controls eye position in the orbits. For example, when the head is tilted to the side (ear moved toward the shoulder) the eyes roll in the opposite direction so that they stay oriented to the horizon. This eye movement is called head tilt induced ocular counter roll and is mediated in part by the otolith organs of the vascular system. Damage to... Read More
2010-222 – This invention covers the design, genetic engineering and construction of the inducible TDP-43 wild-type and D89/219E double mutant constructs utilized to create the iTDP Tg mice.
2010-220 – Radiation therapy treatment is used in nearly two-thirds of all cancer patients. Accurate targeting of the tumor over the treatment period is critical to effective therapy. Placement of permanent tattoos is the current standard practice to aid in the alignment and targeting of radiation therapy over multiple treatments. Existing tattoo methods involve the use of freehand needle sticks,... Read More
2010-206 – Patient derived tumor tissue samples that have been demonstrated to grow in mice.
2010-203 – Reagents to study the biology of the rare human bronchopulmonary carcinoid tumor are very limited. We have created cell lines derived from tumors resected from patients treated at Mayo Clinic. These cell lines will aid investigators to test existing and future medications for efficacy in killing these tumors on the cell lines prior to human studies. These cell lines will aid investigations... Read More
2010-184 – Although anterior cervical fusion is one of the most commonly performed spine procedures in the world, adequate retraction and plate placement remains difficult. A Mayo inventor has created an anterior cervical retractor that minimizes its displacement, prevents tissue creep into the surgical field, does not need to be repositioned in multilevel cases, and eases the application of an... Read More
2010-178 – Technology Description We have developed human lung cancer cell lines in which the expression of the PKClota oncogene has been genetically manipulated. Specifically, the cell lines are transduced with rec ombinant lentiviruses that express either a shRNA targeting the PKCiota mRNA or a non-target control shRNA that does not target any known RNA. These cell lines allow one to investigate the... Read More
2010-177 – Background: The incidence of Barrett’s esophagus and esophageal adenocarcinoma (EAC) is rising in Western nations, and, according to the National Cancer Institute, EAC is the fastest growing form of cancer in the United States. Esophagectomy is standard treatment for Barrett’s esophagus with high grade dysplasia and malignancy. However, due to high morbidity rates associated with... Read More
2010-170 – The Enterprise Data Model is a schematic entity-relationship diagram depicting how data relates to each other within the context of Mayo’s practice, education and research activities. It collectively forms the basis around which all information at Mayo is organized, and from which the system pulls data for purposes of developing the logical and physical representation of data within its... Read More
2010-168 – The caloric test is commonly used as an assessment of vestibular function. The test entails delivering air or water into the external ear canal at varying temperatures, thereby stimulating vestibular labyrinthine responses. Historically, water has been the preferred stimulus for the caloric test. However, pumping air into the external canal is more convenient and is increasingly popular in... Read More
2010-167 – This invention is a software product (Virtual Audi (gram) that automates the standard audiological report writing process. The application creates a graphic of all audiological tests in the basic comprehensive hearing evaluation and uses a pull down menu interface to create custom, grammatically correct reports. Reports and graphics are formatted for easy import into an electronic medical... Read More
2010-162 – The application works on the iPod Touch and iPhone platform and will improve access to exposure-based therapy for individuals with anxiety disorders. The application can be used independently as a self-help program or in conjunction with a health professional. To Access the App through the iTunes Store, click on the link below. AnxietyCoach App
2010-157 – Transoral robotic surgery (TORS) offers potential advantages and benefits over other current treatment modalities in surgical procedures of the head and neck, but in some patients, inadequate exposure to target tissues reduces the number of cases that can be performed by this method. Transoral retractors are used to provide access to a patient’s oral cavity and larynx during these procedures,... Read More
2010-155 – Suppressive Monocytes as Markers of Immune & Therapeutic Responses Mayo Clinic researchers have identified immune phenotypes that can be used to measure the level of systemic immune suppression in patients with cancer and sepsis. Subsets of peripheral blood leukocytes can be measured using standard flow cytometry methods and used as prognostic markers in cancer and sepsis patients. ... Read More
2010-152 – A device and method for MRI in-scanner imaging of chronic exertional compartment syndrome (CECS) of the lower legs has been developed and validated.
2010-138 – This invention describes a mathematical method for reliably describing audiometric configuration and classifying the severity of hearing impairment. It has been shown to accurately correlate with the patient self reports of hearing difficulty better than any other classification method currently used in clinical audiology.
2010-137 – This invention describes a novel calculation called the Speech Transmission Index based Social Hearing Index (STI-SHI or social hearing index for short). The social hearing index can be calculated using standard pure tone hearing threshold data and supra-threshold measures of speech intelligibility. The STI-SHI can be useful in refining the legal definition of hearing disability and will also... Read More
2010-115 – Photon counting detector technology is being actively adopted for commercial CT. One compelling reason is the advantages that it brings for spectral imaging (multi-energy CT) which allows material characterization using energy information from the detected x-rays. The ability to identify material composition regardless of material density (e.g. distinguishing iodine from bone even though they... Read More
2010-108 – SDUV is a non-invasive ultrasound technology that can qualify tissue stiffness and viscosity, which are sensitive indexes of pathology such as liver fibrosis. SDUV uses one long push toneburst of ultrasound followed by multiple detect pulses to generate and detect shear waves in tissue. Shear wave propagation information is used to estimate tissue stiffness and viscosity. The push-detect... Read More
2010-061 – Calcific aortic valve stenosis is a growing problem in developed countries, and valve replacement surgery is the second most common thoracic surgery performed worldwide (>100,000 procedures performed in the US in 2008). Bioprosthetic valves are the most commonly used devices to replace the stenotic valve, but only have a projected lifespan of 10-12 years. Cells infiltrating the... Read More
Matrix Metalloproteinase Inhibition to Slow Calcification and Failure of Bioprosthetic Aortic Valves
2010-060 – Calcific aortic valve stenosis is a growing problem in developed countries, and valve replacement surgery is the second most common thoracic surgery performed worldwide (>100,000 procedures performed in the US in 2008). Bioprosthetic valves are the most commonly used devices to replace the stenotic valve, but only have a projected lifespan of 10-12 years. During this time, endothelial... Read More
2010-054 – Transapical access is being performed increasingly for treatment for a variety of structural heart diseases. In the past, that has been done through a small mini thoracotomy. However, a percutaneous approach is being studied and will be an important means of optimizing and enhancing care of patients. Such a percutaneous transapical approach will need to have a means to percutaneously close... Read More
2010-038 – The individual cross-sectional images along the arteries were analyzed individually by creating a Region-of-Interest (ROI) that encompassed the vessel wall. To ensure that the entire arterial wall was included into the ROI, the radius of the lumen ® was measured, which was used as the width of the annular ROI surrounding the arterial lumen (12). By creating a binary image of the punctate... Read More
2010-032 – A method for producing tissue motion with customized frequency content is described in which push pulses are designed using orthogonal basis functions which then produce desired tissue motion. The push pulses can be a sequence of long duration, in which case motion detection A-lines can be interleaved among the pulses. The result is a more efficient method of making tissue move with optimal... Read More
2010-026 – Accelerated MRI: A method is described for improving parallel acquisition along the longitudinal direction.
Use of Pittsburgh Compound B (PiB) Molecules and PiB-Positron Emission Tomography/Computed Tomography (PiB-PET/CT) Imaging for the Identification and Diagnosis of Meningiomas
2010-007 – Meningiomas are a common tumor often found in the thin layers of tissue that surround the brain. However, many other types of tumors can arise in the same locations. Variation in the appearance of meningiomas can make the accurate diagnosis of meningioma difficult based on current methods, such as Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). Pathologists can accurately... Read More
2009-379 – Technology Description Patients with extensive, longstanding inflammatory bowel diseases (ulcerative colitis or Crohn’s disease), which are diseases of chronic colonic inflammation, are at risk for colorectal cancer (CRC). Surveillance of this at-risk population remains challenging. Mayo Clinic researchers have identified biomarkers for colorectal cancer in inflammatory bowel disease... Read More
2009-375 – Existing systems for positioning a patient for radiation therapy treatment include use of moldable masks (aquaplast) that aid in alignment of bony anatomy and fiducial markers and the tumor target. The current process of aligning the multiple markers can be time consuming and tedious. Gloves are required and the reflective surface coating on the markers is prone to wear out. This invention... Read More
2009-374 – Technology Description An immunotherapy approach that delivers multiple antigens within a vesicular stomatitis virus (VSV) vector. The delivery of multiple antigens allows for a multipronged immune response against a tumor while the VSV vector serves as an activator of the innate and adaptive immune response. A three antigen combination delivered via a VSV vector has been demonstrated to be... Read More
2009-366 – A method and system for producing 3-dimensional ultrasound images of a patient’s breast and also producing planar emission images from a radiopharmaceutical is described. The system allows perfect co-registration of both the ultrasound image and the emission image, thereby allowing comparison of anatomical and functional features of the breast tissue. The system comprises 3 primary components... Read More
2009-362 – Background Topoisomerase I has been used as a drug target for cancer treatment. By inhibiting the religation step of the enzyme, the formation of topo I-DNA complexes block the advancing replication complexes, which will ultimately cause cell death. Thus, measurement of the covalent topo I-DNA complexes can potentially be used to assess therapeutic efficacy of topoisomerase I poisons. ... Read More
Improved Quality for Magnetic Resonance Spectroscopy Spectra Using Eigenvalve Deconvolution and Special Lower Triangular Matrix of Time Activity Data
2009-323 – Eigenvector decomposition allows consistent eigenvalues to be produced from different data set acquisition of the same sample material.
2009-315 – Devices and methods for in situ graft fenestration. These concepts are meant to modify aortic stent grafts to allow for placement of branch stent grafts off of the main graft body to cannulate vessels such at the renal arteries. The core concept is to utilize devices placed both within the lumen of the aortic graft and on the outside surface of the aortic graft to create a fenestration... Read More
2009-314 – This disclosure is for a continuation-in-part to US Patent Application No: US 2006/0056310 A1. The original patent application uses only a symmetrical THRU structure for de-embedding. In this disclosure both OPEN and SHORT structures are presented as additional structures that, once measured with a VNA, can yield additional equations.
2009-309 – The general method has been discussed in “System and Method for Phone Offset and Time Delay Correction in Magnetic Resonance Spectroscopy Data”. (2007-100). Here it is added that the magnitude of the real imaging parts of the data are used for the spectrum.
2009-300 – An endoscopic vessel harvesting device/modification will allow for independent fixation of vessel branches during the harvesting process, and thereby minimizing vessel shrinkage during vessel cauterization. This device/modification will also redirect vessel tension away from the origin of the primary vessel during the harvesting process. This redirection of stress forces along the vessel... Read More
2009-296 – Mouse model of recessive polycystic Kidney Disease (ARPKD)
2009-281 – An ultrasound imaging system transmits a train of pulses along each scan line. The pulses are reflected at various depths and interfaces (objects). In color Doppler mode, the reflected signals from the corresponding scan line and depth correlated frame by frame. A loss of correlation is interpreted as object displacement and indicated by a color overlay. Even if an object does not move... Read More
2009-280 – Sonometry is real-time distance measurement between two piezoelectric crystals by the time of flight of an acoustic signal, transmitted by one and received by the other crystal. Three “locator” crystals define a plane. Another “navigator: crystal can be instantaneously spatially located by the distances from the "locator” crystals.
2009-278 – Specific and highly sensitive ultrasound localization of catheter placement can be accomplished by use of a catheter navigation crystal with an active (vibrating) element whose ultrasonic signal interferes with the ultrasound imaging signal as the latter propagates with each transmitted bearn though issue. The interference signal (caused by the crystal) occurs directly within the Doppler... Read More
2009-275 – Technology Description Neuroradiologists’ ability to successfully interpret MR angiography images is enhanced when projection images called Maximum Intensity Projection (MIP) renderings are independently generated for the three main vascular structures in the head. Currently, this process is performed manually by the MR technician immediately following the acquisition of an MR angiography... Read More
2009-274 – System for Minimally Invasive Local Drug Delivery Local drug delivery is a useful approach to deliver much higher concentrations of a drug to a target site while minimizing systemic side effects. Drug-eluting polymers can be delivered via local injection to deliver drug over an extended period of time. Current systems for local drug delivery have two long-standing challenges: local injections... Read More
2009-264 – Conventionally, nuclear medicine gamma cameras employ an energy window centered in the primary gamma ray energy emitted by the radioisotope being detected. For example, with Tc-99m, a 20% energy window (from 126-154 keV) is centered on the 140 keV gamma rays. At lower energies, scatter within the patient and the gamma camera degrade image quality and these events are not considered useful. ... Read More
2009-259 – The spectra are improved by correcting for the distortion caused by 1. The distance for sample to detect 2. Time delay between excitation of the sample and initial recording of the spectra 3. The physical size of the volume of the sample emitting the signal. Details in separate write up.
Portable Photodynamic Therapy Dosimetry Device - Hand-Held Optical Device for Rapid Determination of Local Tissue Photosensitizer Content and Oxygenation
2009-258 – This invention is a convenient, portable optical instrument for use in photodynamic therapy (PDT) dosimetry. It will provide real-time values of photosensitizer content in tissue as well as values of local tissue as well as values of local tissue oxygenation. The instrument contains a laser light source and a broad band (white) light as well as an optical detector. A fiber optic cable is... Read More
2009-246 – In a communication system consisting of multiple nodes, optical interconnects and wave-division multiplexing (WDM), this can be used to broadcast the data stream from any one node-receivers using a broadcast element such as a star coupler. “All-in-all” or “many-to-all” nodes can thus be connected for high speed data transfer. At any receiver node, the optical signal contains all of the... Read More
2009-235 – Using accelerated time-resolved 3-D imaging methods such as the Mayo-developed Cartesian Acquisition with Projection Reconstruction like sampling (CAPR) it is possible to generate data for both a time series of MR angiograms as well as an image of perfusion.
2009-234 – High Speed serializer/de-serializer (SerDes) paths are rapidly replacing slower local communication paths in digital systems. Engineers must accurately model the SerDes electrical interconnect paths (channels). An important structure used in many channels is loosely described as a “pin-field”. We have developed software which automatically creates these pin-field models for input into... Read More
2009-219 – Suppressive Monocytes as Markers of Response to Renal Cell Carcinoma Therapy The incidence of and deaths caused by renal cell carcinoma (RCC) are increasing in the United States. Over 80 percent of renal cell carcinomas are due to the subtype clear cell renal cell carcinoma (ccRCC). The majority of patients with renal cell carcinoma confined to the kidney can be cured by surgery; however,... Read More
2009-211 – Technology Description Mayo Clinic researchers have discovered that USP10 is the missing link between autophagy and cancer formation. USP10 is a regulator of p53 degradation and activity. USP10 is stabilized upon DNA damage and deubiquitinates p53, reversing Mdm-2 induced nuclear export and degradation. USP10 suppresses tumor cell proliferation in cells expressing wild-type p53. USP10... Read More