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2012-010 – A cognitive assessment test that uses a video game to gage performance with real time feedback in a variety of environments: The test will engage the user and give insight to several cognitive metrics that are integrated with physiological metrics under varying conditions of stress, both mental and physical. The ultimate goal is to create a versatile game that assesses the totality of human... Read More
Nuclear Reprogramming Through Oxygen-Independent Metabotype Purges Dysfunctional Mitochondrial Heteroplasmy
2012-007 – Mitochondrial disease is inherited through maternal transmission of mutated mitochondrial DNA (mtDNA) with disease phenotypes determined by the unpredictable mixture of mutant and wild-type mtDNA. Mitochondrial heteroplasmy is dependent upon stochastic segregation of mtDNA into discrete units during early embryogenesis as mtDNA replication is shut off during blastomere expansion. Since... Read More
2012-004 – What is envisioned is a system of electrochemical and electrical monitoring coupled with directed stimulation to bypass damaged nerve tissue. The combination of information detection, conversion algorithm and programmed stimulation will provide regeneration of the neural commands. Further it is envisioned that a pump can be added to provide neural modular/growth factors to maintain the nerve... Read More
2011-274 – The invention uses ultrasound to measure the nonlinear mechanical properties of an object including those of biological tissues. This information can be used to detect abnormalities in tissues.
2011-273 – Urinary incontinence or loss of bladder control affects millions of people worldwide. An artificial urinary sphincter is one treatment option to restore continence. The basic design of the current artificial urinary sphincter was introduced in the 1980’s and has 3 separate components implanted at 3 separate surgical locations. Mechanical failure or complications often lead to revision or... Read More
2011-271 – We identified a novel translocation of TP63 gene which encodes p63 protein. The translocation leads to overexpression of a dominant negative TP63 isoform. Dominant negative TP63 isoforms lead to inactivation of p53, the most important tumor suppressor known. The translocation can be useful for diagnosis and subclassification of certain peripheral T cell lymphomas, B-cell lymphomas... Read More
2011-267 – Ink filled disk placed on patient at time of simulation (CT). Used to help mark and guide needle to give permanent tattoo.
2011-261 – A mouse monoclonal anti-human TRAIL-s antibody has been made against the novel c-terminus of the TRAIL isoform detailed in: Isolation of a TRAIL antagonist from the serum of HIV-infected patients. Schnepple DJ, Shepard B, Bren GD, Cummins NW, Natesampillai S, Trushin S, Algeciras-Schimich A, Meng XW, Sainski AM, Rizza SA, Kaufmann SH, Badley AD. J Biol Chem. 2011 Oct 14;286(41):35742-54.
2011-250 – The immune function plays an important role in many diseases including cancer. However, it is often difficult to interpret the role and responsibility of immune cells during treatment because it has been difficult to visualize all components of the immune response. We have taken global approach to understanding the immune system by measuring common multi-factorial immune profiles in patients... Read More
2011-249 – TB-ELISPOT is an optimized Interferon-gamma release assay (IGRA) that accurately detects latent tuberculosis infection (LTBI). This novel TB-ELISPOT method incorporate research-grade technology to enhance antigen-specific activation of T-cells by utilizing co-stimulatory antibodies and best antigen stimulation conditions (48 hrs) in a multiparametric platform that compare specific M.... Read More
2011-245 – Immune responses directed toward many cancers are characterized by targeted cell-killing activities mediated by cytotoxic T cells (a.k.a. Thl responses). However, certain tumors such as bladder cancer, instead appear to elicit immune responses that are traditionally linked with allergies (a.k.a. Th2 responses). These immune responses also include the tissue recruitment of rare white blood... Read More
Photo-Degradable Polycaprolactone Fumarate Block Copolymers: The First Example of Approaches to Nanoporous Biomaterials
2011-242 – Nanoporous materials have numerous applications in nonmedical industries for uses such as membranes, surface patterning, and templates for inorganic materials. These applications have typically used block copolymer (one example is A-B block copolymer) self-assembly, the block copolymers assembly by phase separation of A and B blocks to form nanostructures. Although these types of... Read More
Individualized CT Scan Protocols for Scanning with Either Lower Radiation Dose or Lower IV Contrast Dose
2011-229 – We developed a technique for creating individualized CT protocols that allow patients to be scanned with either lower radiation dose or lower intravenous contrast dose whilst maintaining iodine contrast-to-noise ratio and diagnostic image quality.
2011-226 – The segmental loss of peripheral nerve may result from open or closed extremity trauma, resection of benign or malignant primary nerve tumors, or limb-sparing tumor surgery. Currently available reconstructive options include vascularized and conventional (nonvascularised) nerve autografts, nerve conduits from a variety of materials, nerve allografts and nerve transfer. Of these, autografting... Read More
2011-224 – A method to quantify tissue mechanical properties in a model-independent way by estimating complex elastic modulus from time-dependant creep response induced by acoustic radiation force. This method uses a formula that converts time-domain creep compliance to frequency domain complex modulus. Then Shearwave Dispersion Ultrasound Vibrometry (SDUV) is used to calibrate the complex modulus so... Read More
2011-210 – Multiple short-duration ultrasound push pulses are used to deform tissue. The duration and PRF (Pulse Repetition Frequency) of these push pulses are compatible with current ultrasound scanners because these pulses are comparable to Doppler pulses. The collective effect from many push pulses generates shear waves of high amplitude for elasticity imaging. Two shear waves are produced: one at... Read More
2011-197 – Many attempts have been made to replace circumferential segments of the esophagus with tubular prostheses of various materials, but experimental and clinical trials have not been successful due to frequent complications. An artificial esophageal replacement device which aims to overcome the problems of the previous attempts. Development of viable esophageal replacement would dramatically... Read More
2011-188 – Ileostomy or colostomy are common permanent bowel procedures performed for inflammatory disease, trauma, or cancer. The development of an internal reservoir, obviating the need for an external appliance, has been hampered by the need for an interface between living tissue and the device. The invention disclosed herein is an adaptation of a floating ball valve. Within the bowel lumen lies a... Read More
2011-184 – Methods and Materials for Assessing Responsiveness PARP Inhibitors and Platinating Agents Methods and materials have been developed for assessing responsiveness to PARP inhibitors and platinating agents by using levels of non-homogous end-joining (NHEI) pathway members to determine if cancer cells that are homologous recombination (hr) - deficient are likely to be susceptible or resistant... Read More
2011-178 – Radiation dose from CT scanning is an increasing health concern, but lowering radiation dose alone generally produces a noisier image and may degrade diagnostic performance. Non-local means (NLM) denoising has become widely accepted as a very effective denoising tool in the image processing community, and has yielded very promising results in lung and abdominal CT. However, NLM requires an... Read More
2011-176 – Calcitonin gene related peptide (CGRP) and Substance P (SP) were elevated in the nasal secretions of patients with postnasal drip who also have chronic cough compared to levels from nasal secretions from patients without cough. A point-of-care test which can assay the level of CGRP and SP may be helpful in predicting whether or not chronic cough is due to postnasal drip.
2011-154 – The purpose of SAMR is to help clinicians find answers to clinical questions. The medical literature needed to correctly treat a patient grows exponentially. Data shows that both health care institutions and individual physicians are overwhelmed trying to incorporate this new knowledge. SAMR is a tool that could bridge this gap to improve patient care. SAMR uses semantic elements, the meaning... Read More
A Novel Simple Scoring System to Predict the Risk of Prosthetic Joint Infection, the Mayo PJI Risk Score
2011-141 – A list of risk factors have been identified for patients undergoing prosthetic joint infections that has been statistically weighted to develop a novel scoring system that has a strong prognostic ability for determining the risk of patients developing postsurgical prosthetic joint infection. The scores could be used potentially as guides for prophylactic infection control and patient... Read More
2011-130 – The calibration data for an accelerated contrast-enhanced MRA acquisition are acquired in the short time after contrast injection and before contrast arrival. This eliminates the separate acquisition for calibration data.
Mutations in the KCND3-Encoded Kv4.3 Potassium Ion Channel and Use in Diagnostic Methodologies for the Detection of Sudden Death-Predisposing Cardiac Channelopathies
2011-122 – The present invention details mutations in the KCND3-encoded Kv4.3 potassium ion channel that are associated with sudden death predisposing genetic conditions such as Brugada syndrome (BrS) and long QT syndrome (LQTS) and the mechanism by which at risk individuals can be screend for potentially life threatening mutation isn this gene. This invention is based on the that mutations within the... Read More
2011-114 – In dynamic time series imaging, noise varies from image to image, but the underlying structure (although it can vary somewhat) is generally preserved. Techniques that take advantage of this are capable of efficiently denoising such data sets. In this invention, time series images are decomposed into overlapping subblocks of size NxN, with each subblock sampled T times in the time dimension.... Read More
2011-113 – The IgA lambda expressing JMW cell line was derived from the blood of a 67-year old female presenting with aggressive multiple myeloma and many circulating plasma cells. The cell line harbors a t(4;14) chromosomal translocation. This cell line provides a useful tool to study the cellular and molecular biology of myeloma cells.
2011-111 – Modulating the Autonomic Nervous System to Treat Hypertension and Heart Failure Mayo Clinic physicians have demonstrated that modulation of the autonomic nervous system can reduce blood pressure and improve symptoms in congestive heart failure (CHF) patients. Afferent nerves originating from skeletal muscle or from the kidneys are blocked to achieve the reduction in blood pressure and the... Read More
2011-108 – Parallel Imaging is a widely used strategy for accelerating MRI acquisitions. Auto-calibrated coil-by-coil methods such as GRAPPA and ARC have become increasingly popular since they do not require a separate calibration scan (as do SENSE and ASSET) nor explicit estimation of coil sensitivity profiles, making them attractive for time-limited and dynamic applications like cardiac imaging.... Read More
Method for Reconstructing Dynamic Resonance Imaging Series From Limited Measurements Using Matrix Rank Constraints
2011-106 – This disclosure allows for image series to be reconstructed from only a subset of the data normally required to form the image series, and correspondingly for image acquisition time to be reduced. As demonstrated, the proposed reconstruction mechanism can provide improved temporal fidelity compared to other rank-based MRI series reconstruction methods.
2011-104 – Ileostomy patients with highly liquid effluent can experience high frequency emptying requirements that can be inconvenient to patients. This invention is a dual chamber ostomy pouch with the chambers separated by a filter. The filter allows water to pass into the second chamber while containing solid waste in the first chamber. The chambers can have separate drain valves allowing them to be... Read More
2011-097 – Polypropylene fumarate (PPF) is a biodegradable polyester that can be fabricated into any 3-dimensional structure via stereolithography, and implanted to stabilize bone defects while regenerating bone infiltrates, degrades, and ulitimately replaces the PPF scaffold. In order to increase the PPF scaffolds ability to promote bone regeneration the scaffolds were coated with three calcium... Read More
2011-092 – T cells drive adaptive immune responses that can turn out pathogenic when directed against your own body tissues and organs causing autoimmune diseases. On the other hand, T cells are the main cellular component driving acute organ rejection after transplantation. Therefore different strategies to deplete/inactivate T cells have been pursued to treat patients either suffering from autoimmime... Read More
2011-086 – A data reporting system for competency metrics has been developed that takes trainee endoscopic performance data collected by a validated assessment tool and presents the data in such a manner that allows fellowship directors to identify which trainees have achieved competence and which ones may be in need of remediation and all points between. With this system we have also identified unique... Read More
2011-080 – The quantitative accuracy of CT numbers in myocardial perfusion computed tomography (MPCT) is degraded by artifacts arising from the use of partial scan reconstruction (PSR), which is used in cardiac CT to improve temporal resolution. Full scans do not suffer from this artifact. PSR artifacts appear because of inconsistencies in the angular range of projection data used for partial scans due... Read More
2011-076 – pEct2 antibody
2011-075 – This invention includes the development of Inducible transgenic mice expressing human TDP-cDNA encoding the TAR-binding protein 43kD utilizing the MoPrpTta promoter.
2011-074 – This invention includes the development of inducible M17 neuroblastoma cell lines expressing human TDP-43 cDNA encoding the wild type, disease associated mutants, nuclear localization mutant and RNA binding mutant TAR-binding protein 43kD.
2011-073 – Technology Description Hospitals and surgery centers face significant cost pressure when it comes to maintaining materials and supplies. With supply costs representing a significant expense in surgical services, close and careful monitoring is needed to reduce costs and improve efficiencies. Developed at Mayo Clinic, the Supply Inventory Management System (SIMS) is a comprehensive program... Read More
2011-065 – Three decades after the eradication of smallpox, the threat of bioterrorism and outbreaks of emerging diseases such as monkeypox have renewed interest in the development of safe and effective next-generation poxvirus vaccines and biodefense research. Current smallpox vaccines contain live virus and are contraindicated for a large percentage of the population. Safer, yet still effective... Read More
2011-060 – A significant hindrance to wound healing in both previously healthy individuals or those with penetrating Crohn’s disease is the presence of “dead space” as a result of pockets of inflammatory or infectious material. Keeping this dead space adequately drained and free from infection/inflammation throughout the healing process is a significant challenge resulting in significant cost and... Read More
2011-059 – This web or CD-ROM based electromyography (EMG) training tool consists of an interactive, case-based program that assists trainees in learning the application of electrodiagnostic studies and interpretation of findings.
2011-042 – DNA Aptamers Promoting Remyelination in Neurodegenerative Disease Single-stranded DNA aptamers 40 nucleotides in length were selected for binding to mouse myelin and were evaluated for their ability to promote remyelination. This approach was based upon previous reports indicating that IgM antibodies are capable of promoting remyelination in animal models of multiple sclerosis. After... Read More
2011-030 – Studies from our laboraties have shown that deleted in breast cancer 1 (DBC1) is an important negative regulator of SIRT1 in vivo. Deletion of DBC1 in mice results in higher SIRT1 activity in various moust tissues, and these mice are protected from metabolic diseases, such as high fat diet-induced liver disease. Therefore, DBC1 knockout mice will be a valuble tool to study SIRT1 function and... Read More
2011-027 – RU486 for Decreasing Suppressive Monocytes in Cancer and Sepsis Suppressive monocytes have been found in a number of different conditions including sepsis, cancer, and trauma victims. Presence of large numbers of these cells (typically CD14+/DR-) is predictive of poor prognosis. Suppressive monocytes contribute to systemic immune suppression, prevent the differentiation of monocytes into... Read More
2011-026 – Propagation of shear wave (e.g., frequency dependent propagation speed and attenuation) in tissues is determined by mechanical properties of tissues. In ultrasound elasticity imaging, focused ultrasound beams are used to generate and detect shear waves in tissues. The 3D shape of the ultrasound beam can artificially increase measured shear wave speed in the transducer near field and... Read More
2011-021 – A method is developed for eliminating the calibration scan in SENSE-accelerated time-resolved MRA.
2011-020 – Progress of an intravenously administered contrast bolus along the peripheral vasculature is tracked in real time by generating diagnostic quality images and then using the information to cause the patient table to move so as to allow generation a high quality angiogram along the entire extent of the vasculature.
2011-018 – Technology Description Several recent studies suggest that the microbiome bacterial community of an individual’s gut may play a role in obesity by increasing or decreasing that individual’s energy harvesting efficiency of its caloric intake. Obese individuals contain bacterial species that are known to ferment carbohydrates to acetate and other short-chain fatty acids. These fatty acids are... Read More
2011-002 – Nonfocused ultrasound waves are produced by merely transmitting long tonebursts on each of several elements in a linear or curved or phased array. This produces an unfocused beam. Shearwave can be imaged by beams from a two-dimensional array if a shearwave is produced in a rectangular section, then the shearwaves can propagate away from the rectangular section and can be imaged. The effect... Read More