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2012-253 – Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are devastating neurodegenerative diseases. FTLD results from the degeneration of the frontal and temporal lobes of the brain, and encompasses a group of disorders distinguished by abnormalities in behavior, language and personalityl. ALS is characterized by the degeneration of motor neurons, resulting in muscle... Read More
2012-252 – Patient derived tumor tissue samples that have been demonstrated to grow in mice.
2012-246 – Mayo has available licensing its patient education materials and videos within the areas of: Allergic Diseases Anesthesiology Cardiac Surgery Cardiovascular Colorectal Surgery Dental Specialties Dermatology Endocrine ENT Gastroenterology General Internal Medicine General Thoracic Surgery Gland General Surgery Hematology Hospital Internal Medicine Infectious Diseases Laboratory Medicine... Read More
2012-224 – Increase in bladder stiffness could be associated with various pathophysiologic conditions. We introduce Ultrasound Bladder Vibrometry (UBV), a novel method for rapid and noninvasive measurement of bladder wall viscoelasticity. UBV uses acoustic radiation force to excite mechanical waves in the bladder wall and track the motion using ultrasound pulse-echo techniques. Fourier domain analysis... Read More
2012-221 – Ultrasound radiation force is used to create propagating waves in soft tissue or other soft materials. The wave propagation is measured using pulse-echo ultrasound methods. We use a two-dimensional Fourier transform method to obtain the Fourier-space (k-space) with the coordinates of frequency (f) and wave number (k). The wave velocity © at each frequency is calculated by finding the... Read More
2012-182 – Lung cancer is the leading couse of cancer deaths in the United States. Lobectomy is the gold standard extent of resection for most lung cancers, but some patients are poor candidates for lobectomy due to poor pulmonary health/function and/or other comorbities. Sublobar resection, the removal of less than a lobe of the lung, is a compromise procedure for these patients in that it allows for... Read More
A Time Dependent Device for Segmental Whole Gut for Lumina & Mucosal Microbial Swab Sampling by Anatomic Location
2012-169 – Swabs from the middle portions of the gastrointestinal tract are currently very difficult to obtain due to the limitations of current techniques such as endoscopy. Understanding the biology of these regions can potentially have a large impact on the overall health of both people and animals through the effect of the GI tract on other parts of the body. Mayo Clinic investigators have... Read More
2012-156 – We have developed a novel technique for in-vivo genome editing using TALENs
2012-153 – The practice of radiology is a non-linear process where image processing and routing decisions for best practice are often done by humans on the fly. Commercial PACS and image processing workstations assume a fixed workflow that is enshrined in their database schemas, and may only account for 4-5 stages in the lifetime of a diagnostic imaging study. DEWEY uses DICOM (with proposed expansion... Read More
2012-150 – Patients who develop obstruction in the gastrointestinal track due to inflammatory strictures, or failure of sphincter muscles to relax, are benefitted by relief of that obstruction. Mayo has developed a device to stabilize the position and control length and depth. The device can be used in an lumen (gastrointestinal, vascular, urologic, gynecologic, pulmonary etc).
2012-144 – The knock-in mouse model mimics an incompletely penetrant genetic mutation found in patients with atypical autosomal dominant polycystic kidney disease (ADPKD). The model was established to investigate the pathogenic mechanism of this particular mutation (PKD1 R3277C). As in patients, mice carrying the mutation together with a PKD1 truncating change develop severe, early onset disease,... Read More
2012-141 – Carpal tunnel syndrome (CTS) is a common problem with an estimated lifetime risk of 10%, a prevalence of about 3%, and a large economic burden of more than $1 billion annually for direct medical costs. It has been commonly recognized that carpal tunnel pressure (CTP) increases in CTS patients. However, measurement of CTP is invasive and not reliable due to technical difficulties. Although CTP... Read More
2012-136 – A patient’s heart rate, systolic blood pressure, Braden Skin Scale (a nursing assessment), arterial oxygen saturation, and respiratory rate are entered into a simple mathematical equation that calculates the patient’s risk of having cardiac arrest, emergency transfer to the ICU, or Rapid Response Team activation in the next 2-12 hours. The calculation is made every time any one of those... Read More
2012-134 – Shear wave produced by a focused ultrasound beam is used to evaluate tissue visco-elasticity, which are sensitive biomarkers of pathology. Shear waves thus produced are weak and attenuate quickly when propagating away from the push origin. We have proposed a method called CUSE where multiple unfocused push beams spaced out like a comb are used for shear wave production. Every pixel under... Read More
2012-133 – TSEC are an SV40-immortalized cell line, derived from hepatic sinusoidal endothelial cells (HSEC), that maintain an endothelial phenotype as well as some HSEC-specific features. The cells have typical microscopic features of endothelia, including formation of lamellipodia and filopodia and a cobblestone morphology of cell monolayers. TSEC maintain a limited number of fenestrae organized in... Read More
2012-129 – A method to quantify tissue viscoelastic properties in a model-independent way by estimating the complex shear modulus from creep-recovery response and shear wave propagation speed by ultrasound acoustic radiation force. This method uses a formula that converts creep-recovery response in time to frequency domain complex modulus. The shear wave speed is used to calibrate the complex modulus... Read More
2012-123 – This mouse model contains TFPIFlox allele with LoxP sites flanking exon 4 of the TFPi gene. When bred to mice that express Cre recombinase, the resulting off spring will have the sequences encoding the Kuntz1 domain of the TFPI protein deleted in cre-expressing tissues. As the TFPI-K1 domain is necessary for TFPI inhibition of the tissue factor coagulation pathway, these mice may be useful... Read More
2012-122 – A transgenic mouse model having vascular smooth muscle cell directed overexpression of a mouse tissue factor pathway inhibitor cDNA sequence encoding the TFPI alpha isoform. These mice may be useful in studying the role of vascular TFPI expression in intravascular thrombosis, the tissue factor pathway in vascular disease, coagulation, innate immunity, angiogenesis and lipid metabolism.
2012-121 – We describe here the establishment of a new WM cell line, MWCL-1. Comprehensive genetic analyses have unequivocally confirmed a clonal relationship between this novel cell line and the founding tumor. MWCL-1 cells exhibit an immunophenotype consistent with a diverse, tumor clone composed of both small B lymphocytes and exhibit an immunophenotype consistent with a diverse, tumor clone... Read More
2012-112 – We have identified abnormalities in the B cell compartment in the circulation of patients with ALS. This abnormality could be used to develop a test to measure the prognosis of patients with ALS or to diagnose patients with different forms of the disease. Additionally, the involvement of B cells in the pathology of ALS will lead treatments that may ameliorate the disease or its symptoms.
2012-110 – Currently, cancerous pigmented lesions, i.e. malignant melanoma, are diagnosed based on morphological features such as cell size and the overall architecture of the lesion under a microscope. Risk of metastasis is primarily assessed by the depth of invasion of morphologically atypical cells into the skin (so-called Breslow depth), which can be misleading and often triggers unnecessary... Read More
2012-098 – Agelastatin A (AA) is an anti-neoplastic agent with anti-osteopontin (OPN) activity. Brain tumors often express OPN significantly. A comprehensive chemoinformatic analysis followed by in vivo pharmacokinetic evaluations in mice is performed. CNS penetration of AA is about 10%. AA should be further tested for activity against brain tumors.
2012-093 – Background LRP1 is a ubiquitously expressed receptor that mediates rapid endocytosis of various ligands. By modulating the trafficking of other signaling receptors, LRP1 plays a significant role in the central nervous system and peripheral tissue. It is thought that malfunction of the LRP1-related pathway is a causal factor of cardiovascular and Alzheimer’s disease. Thus, there is tremendous... Read More
Apoptotic Response to DNA Damage in Pluripotent Stem Cells Facilitates Pharmacologic Purging of Teratoma Forming Progenitor Cells
2012-090 – Pluripotent stem cells have been the focus of bioengineering efforts designed to generate regenerative products, yet harnessing therapeutic capacity while minimizing the risk of dysregulated growth remains a formidable challenge. The risk of residual undifferentiated stem cells within differentiated progenitors requires a targeted approach to eliminate contaminating cells prior to in vivo... Read More
2012-084 – A homozygous transgenic mouse model expressing mutant M377V human TDP-43 cDNA encoding the TAR-bindign protein 43kD - 6 fold endogenous levels (Xu et al, Molecular Neurodegeneration, 2011).
2012-083 – Coronary CT angiography (cCTA) is used to noninvasively look at the arteries that supply the heart muscle with blood, and diagnose (or rule out) blocked arteries, which are the main cause of heart attacks. cCTA is performed with either prospective or retrospective ECG gating. Irrespective of which variant is used, images are reconstructed with projection data corresponding to a partial scan... Read More
2012-079 – The Genetics Supply and Inventory Management System is a full laboratory inventory management software solution built in Microsoft Access Database. gSIMS provides automation of most inventory management aspects, including supply receipt, reagent lot tracking, expiration notification, stocking instruments, reagent labeling, inventory reconciliation, reagent quality assessment, and real-time... Read More
2012-073 – Erectile dysfunction (ED) is estimated to affect 20-30% of men between the ages of 40-80 years. In cases of medication-resistant ED, surgical treatment, and especially penile prosthesis implantation is the standard of care. Complications of surgery can include neurovascular and urethral injury, and other tissue damage that can contribute to sub-optimal outcomes. A Mayo Clinic investigator... Read More
2012-057 – Shear wave is used to evaluate tissue visco-elasticity, which are sensitive biomarkers of pathology. In order to obtain a 2D ultrasound elastography, an ultrafast imager with a FRAME rate of several kHz is required to capture the fast moving shear waves. This is not feasible with traditional ultrasound imagers with a frame rate of less than 100 Hz where 2D images are formed LINE BY LINE. ... Read More
2012-055 – Background Transcription factor STAT3 plays an active role in the initiation and proliferation of malignant brain tumors. Thus, small molecule STAT3 inhibitors have potential as therapeutic agents for malignant gliomas as well as other STAT3-dependent tumors. Technology Description Mayo Clinic Researchers have synthesized a series of novel compounds to block the STAT3 pathway. These... Read More
2012-051 – The Weighted Deaver Retractor was designed in response to surgeon and patient needs for a more ergonomic and efficient tool to be used during gynecological or urological surgery. The current deaver retractor on the market now requires a surgical assistant to grasp and retract to allow for increased visibility for the surgeon. Presently, the deaver retractor being used today cannot hold... Read More
2012-050 – We have shown that a combination of these vesicular stomatis viruses (VSV) that encode N-Ras, cytochrome c (ctyc), or Tyrosinase-related protein 1(TYRP1), can be used to treat melanoma. Previously, we had shown that the use of a cDNA library in packaged in VSV can treat cancer. Here we show that a combination of three particular VSVs with the cDNA of N-Ras, cyt-c and Tryp 1 given... Read More
A Novel Method to Identify Antigens Which Act Co-Operatively To Treat Established Tumors Using Viral-Expressed cDNA Libraries
2012-049 – We describe a novel technology to define new repertoires of tumor antigen(s) which work alone or in combination to generate anti tumor immune responses. Definition of arrays of antigens which co-operate in vivo to cure established tumors will inform future strategies for novel clinical vaccines through the use of vesicular stomatis virus with cDNA libraries constructed with selected, relevant... Read More
2012-045 – Normal rat cholangiocytes (NRCs) are intrahepatic bile duct epithelial cellls that have been developed as in vitro model to study the physiology and pathophysiology of these cells in culture. NRCs form a confluent polarized monolayer when grown on collagen-coated filters of tissue culture inserts with easy access to both apical and basolateral cell surfaces. NCRs display many... Read More
2012-029 – Biomarkers capable of detecting early, rapidly progressing, or subtle alterations of cardiac right ventricular (RV) load could substantially contribute to timely diagnosis and effective treatment of RV disorders, which in same cases could escalate to severe or even life threatening conditions, such as acute pulmonary embolism. This invention describes novel RV shape biomarkers sensitive to... Read More
2012-011 – Scores based on patient reported symptoms (stool frequency and rectal bleeding), endoscopic exam of bowel mucosa and physician review of patient degree of illness severity. A combined score is used to determine severity of symptoms and to assess changes with therapy over time.
Nuclear Reprogramming Through Oxygen-Independent Metabotype Purges Dysfunctional Mitochondrial Heteroplasmy
2012-007 – Mitochondrial disease is inherited through maternal transmission of mutated mitochondrial DNA (mtDNA) with disease phenotypes determined by the unpredictable mixture of mutant and wild-type mtDNA. Mitochondrial heteroplasmy is dependent upon stochastic segregation of mtDNA into discrete units during early embryogenesis as mtDNA replication is shut off during blastomere expansion. Since... Read More
2012-004 – What is envisioned is a system of electrochemical and electrical monitoring coupled with directed stimulation to bypass damaged nerve tissue. The combination of information detection, conversion algorithm and programmed stimulation will provide regeneration of the neural commands. Further it is envisioned that a pump can be added to provide neural modular/growth factors to maintain the nerve... Read More
2011-274 – The invention uses ultrasound to measure the nonlinear mechanical properties of an object including those of biological tissues. This information can be used to detect abnormalities in tissues.
2011-271 – We identified a novel translocation of TP63 gene which encodes p63 protein. The translocation leads to overexpression of a dominant negative TP63 isoform. Dominant negative TP63 isoforms lead to inactivation of p53, the most important tumor suppressor known. The translocation can be useful for diagnosis and subclassification of certain peripheral T cell lymphomas, B-cell lymphomas... Read More
2011-267 – Ink filled disk placed on patient at time of simulation (CT). Used to help mark and guide needle to give permanent tattoo.
2011-261 – A mouse monoclonal anti-human TRAIL-s antibody has been made against the novel c-terminus of the TRAIL isoform detailed in: Isolation of a TRAIL antagonist from the serum of HIV-infected patients. Schnepple DJ, Shepard B, Bren GD, Cummins NW, Natesampillai S, Trushin S, Algeciras-Schimich A, Meng XW, Sainski AM, Rizza SA, Kaufmann SH, Badley AD. J Biol Chem. 2011 Oct 14;286(41):35742-54.
2011-250 – The immune function plays an important role in many diseases including cancer. However, it is often difficult to interpret the role and responsibility of immune cells during treatment because it has been difficult to visualize all components of the immune response. We have taken global approach to understanding the immune system by measuring common multi-factorial immune profiles in patients... Read More
2011-249 – TB-ELISPOT is an optimized Interferon-gamma release assay (IGRA) that accurately detects latent tuberculosis infection (LTBI). This novel TB-ELISPOT method incorporate research-grade technology to enhance antigen-specific activation of T-cells by utilizing co-stimulatory antibodies and best antigen stimulation conditions (48 hrs) in a multiparametric platform that compare specific M.... Read More
2011-245 – Immune responses directed toward many cancers are characterized by targeted cell-killing activities mediated by cytotoxic T cells (a.k.a. Thl responses). However, certain tumors such as bladder cancer, instead appear to elicit immune responses that are traditionally linked with allergies (a.k.a. Th2 responses). These immune responses also include the tissue recruitment of rare white blood... Read More
Photo-Degradable Polycaprolactone Fumarate Block Copolymers: The First Example of Approaches to Nanoporous Biomaterials
2011-242 – Nanoporous materials have numerous applications in nonmedical industries for uses such as membranes, surface patterning, and templates for inorganic materials. These applications have typically used block copolymer (one example is A-B block copolymer) self-assembly, the block copolymers assembly by phase separation of A and B blocks to form nanostructures. Although these types of... Read More
Individualized CT Scan Protocols for Scanning with Either Lower Radiation Dose or Lower IV Contrast Dose
2011-229 – We developed a technique for creating individualized CT protocols that allow patients to be scanned with either lower radiation dose or lower intravenous contrast dose whilst maintaining iodine contrast-to-noise ratio and diagnostic image quality.
2011-226 – The segmental loss of peripheral nerve may result from open or closed extremity trauma, resection of benign or malignant primary nerve tumors, or limb-sparing tumor surgery. Currently available reconstructive options include vascularized and conventional (nonvascularised) nerve autografts, nerve conduits from a variety of materials, nerve allografts and nerve transfer. Of these, autografting... Read More
2011-224 – A method to quantify tissue mechanical properties in a model-independent way by estimating complex elastic modulus from time-dependant creep response induced by acoustic radiation force. This method uses a formula that converts time-domain creep compliance to frequency domain complex modulus. Then Shearwave Dispersion Ultrasound Vibrometry (SDUV) is used to calibrate the complex modulus so... Read More
2011-210 – Multiple short-duration ultrasound push pulses are used to deform tissue. The duration and PRF (Pulse Repetition Frequency) of these push pulses are compatible with current ultrasound scanners because these pulses are comparable to Doppler pulses. The collective effect from many push pulses generates shear waves of high amplitude for elasticity imaging. Two shear waves are produced: one at... Read More