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2012-123 – This mouse model contains TFPIFlox allele with LoxP sites flanking exon 4 of the TFPi gene. When bred to mice that express Cre recombinase, the resulting off spring will have the sequences encoding the Kuntz1 domain of the TFPI protein deleted in cre-expressing tissues. As the TFPI-K1 domain is necessary for TFPI inhibition of the tissue factor coagulation pathway, these mice may be useful... Read More
2012-122 – A transgenic mouse model having vascular smooth muscle cell directed overexpression of a mouse tissue factor pathway inhibitor cDNA sequence encoding the TFPI alpha isoform. These mice may be useful in studying the role of vascular TFPI expression in intravascular thrombosis, the tissue factor pathway in vascular disease, coagulation, innate immunity, angiogenesis and lipid metabolism.
2012-121 – We describe here the establishment of a new WM cell line, MWCL-1. Comprehensive genetic analyses have unequivocally confirmed a clonal relationship between this novel cell line and the founding tumor. MWCL-1 cells exhibit an immunophenotype consistent with a diverse, tumor clone composed of both small B lymphocytes and exhibit an immunophenotype consistent with a diverse, tumor clone... Read More
2012-112 – We have identified abnormalities in the B cell compartment in the circulation of patients with ALS. This abnormality could be used to develop a test to measure the prognosis of patients with ALS or to diagnose patients with different forms of the disease. Additionally, the involvement of B cells in the pathology of ALS will lead treatments that may ameliorate the disease or its symptoms.
2012-110 – Currently, cancerous pigmented lesions, i.e. malignant melanoma, are diagnosed based on morphological features such as cell size and the overall architecture of the lesion under a microscope. Risk of metastasis is primarily assessed by the depth of invasion of morphologically atypical cells into the skin (so-called Breslow depth), which can be misleading and often triggers unnecessary... Read More
2012-098 – Agelastatin A (AA) is an anti-neoplastic agent with anti-osteopontin (OPN) activity. Brain tumors often express OPN significantly. A comprehensive chemoinformatic analysis followed by in vivo pharmacokinetic evaluations in mice is performed. CNS penetration of AA is about 10%. AA should be further tested for activity against brain tumors.
2012-093 – Background LRP1 is a ubiquitously expressed receptor that mediates rapid endocytosis of various ligands. By modulating the trafficking of other signaling receptors, LRP1 plays a significant role in the central nervous system and peripheral tissue. It is thought that malfunction of the LRP1-related pathway is a causal factor of cardiovascular and Alzheimer’s disease. Thus, there is tremendous... Read More
Apoptotic Response to DNA Damage in Pluripotent Stem Cells Facilitates Pharmacologic Purging of Teratoma Forming Progenitor Cells
2012-090 – Pluripotent stem cells have been the focus of bioengineering efforts designed to generate regenerative products, yet harnessing therapeutic capacity while minimizing the risk of dysregulated growth remains a formidable challenge. The risk of residual undifferentiated stem cells within differentiated progenitors requires a targeted approach to eliminate contaminating cells prior to in vivo... Read More
2012-084 – A homozygous transgenic mouse model expressing mutant M377V human TDP-43 cDNA encoding the TAR-bindign protein 43kD - 6 fold endogenous levels (Xu et al, Molecular Neurodegeneration, 2011).
2012-083 – Coronary CT angiography (cCTA) is used to noninvasively look at the arteries that supply the heart muscle with blood, and diagnose (or rule out) blocked arteries, which are the main cause of heart attacks. cCTA is performed with either prospective or retrospective ECG gating. Irrespective of which variant is used, images are reconstructed with projection data corresponding to a partial scan... Read More
2012-073 – Erectile dysfunction (ED) is estimated to affect 20-30% of men between the ages of 40-80 years. In cases of medication-resistant ED, surgical treatment, and especially penile prosthesis implantation is the standard of care. Complications of surgery can include neurovascular and urethral injury, and other tissue damage that can contribute to sub-optimal outcomes. A Mayo Clinic investigator... Read More
2012-057 – Shear wave is used to evaluate tissue visco-elasticity, which are sensitive biomarkers of pathology. In order to obtain a 2D ultrasound elastography, an ultrafast imager with a FRAME rate of several kHz is required to capture the fast moving shear waves. This is not feasible with traditional ultrasound imagers with a frame rate of less than 100 Hz where 2D images are formed LINE BY LINE. ... Read More
2012-055 – Background Transcription factor STAT3 plays an active role in the initiation and proliferation of malignant brain tumors. Thus, small molecule STAT3 inhibitors have potential as therapeutic agents for malignant gliomas as well as other STAT3-dependent tumors. Technology Description Mayo Clinic Researchers have synthesized a series of novel compounds to block the STAT3 pathway. These... Read More
2012-051 – The Weighted Deaver Retractor was designed in response to surgeon and patient needs for a more ergonomic and efficient tool to be used during gynecological or urological surgery. The current deaver retractor on the market now requires a surgical assistant to grasp and retract to allow for increased visibility for the surgeon. Presently, the deaver retractor being used today cannot hold... Read More
2012-050 – We have shown that a combination of these vesicular stomatis viruses (VSV) that encode N-Ras, cytochrome c (ctyc), or Tyrosinase-related protein 1(TYRP1), can be used to treat melanoma. Previously, we had shown that the use of a cDNA library in packaged in VSV can treat cancer. Here we show that a combination of three particular VSVs with the cDNA of N-Ras, cyt-c and Tryp 1 given... Read More
A Novel Method to Identify Antigens Which Act Co-Operatively To Treat Established Tumors Using Viral-Expressed cDNA Libraries
2012-049 – We describe a novel technology to define new repertoires of tumor antigen(s) which work alone or in combination to generate anti tumor immune responses. Definition of arrays of antigens which co-operate in vivo to cure established tumors will inform future strategies for novel clinical vaccines through the use of vesicular stomatis virus with cDNA libraries constructed with selected, relevant... Read More
2012-045 – Normal rat cholangiocytes (NRCs) are intrahepatic bile duct epithelial cellls that have been developed as in vitro model to study the physiology and pathophysiology of these cells in culture. NRCs form a confluent polarized monolayer when grown on collagen-coated filters of tissue culture inserts with easy access to both apical and basolateral cell surfaces. NCRs display many... Read More
2012-029 – Biomarkers capable of detecting early, rapidly progressing, or subtle alterations of cardiac right ventricular (RV) load could substantially contribute to timely diagnosis and effective treatment of RV disorders, which in same cases could escalate to severe or even life threatening conditions, such as acute pulmonary embolism. This invention describes novel RV shape biomarkers sensitive to... Read More
2012-011 – Scores based on patient reported symptoms (stool frequency and rectal bleeding), endoscopic exam of bowel mucosa and physician review of patient degree of illness severity. A combined score is used to determine severity of symptoms and to assess changes with therapy over time.
Nuclear Reprogramming Through Oxygen-Independent Metabotype Purges Dysfunctional Mitochondrial Heteroplasmy
2012-007 – Mitochondrial disease is inherited through maternal transmission of mutated mitochondrial DNA (mtDNA) with disease phenotypes determined by the unpredictable mixture of mutant and wild-type mtDNA. Mitochondrial heteroplasmy is dependent upon stochastic segregation of mtDNA into discrete units during early embryogenesis as mtDNA replication is shut off during blastomere expansion. Since... Read More
2012-004 – What is envisioned is a system of electrochemical and electrical monitoring coupled with directed stimulation to bypass damaged nerve tissue. The combination of information detection, conversion algorithm and programmed stimulation will provide regeneration of the neural commands. Further it is envisioned that a pump can be added to provide neural modular/growth factors to maintain the nerve... Read More
2011-274 – The invention uses ultrasound to measure the nonlinear mechanical properties of an object including those of biological tissues. This information can be used to detect abnormalities in tissues.
2011-271 – We identified a novel translocation of TP63 gene which encodes p63 protein. The translocation leads to overexpression of a dominant negative TP63 isoform. Dominant negative TP63 isoforms lead to inactivation of p53, the most important tumor suppressor known. The translocation can be useful for diagnosis and subclassification of certain peripheral T cell lymphomas, B-cell lymphomas... Read More
2011-267 – Ink filled disk placed on patient at time of simulation (CT). Used to help mark and guide needle to give permanent tattoo.
2011-261 – A mouse monoclonal anti-human TRAIL-s antibody has been made against the novel c-terminus of the TRAIL isoform detailed in: Isolation of a TRAIL antagonist from the serum of HIV-infected patients. Schnepple DJ, Shepard B, Bren GD, Cummins NW, Natesampillai S, Trushin S, Algeciras-Schimich A, Meng XW, Sainski AM, Rizza SA, Kaufmann SH, Badley AD. J Biol Chem. 2011 Oct 14;286(41):35742-54.
2011-250 – The immune function plays an important role in many diseases including cancer. However, it is often difficult to interpret the role and responsibility of immune cells during treatment because it has been difficult to visualize all components of the immune response. We have taken global approach to understanding the immune system by measuring common multi-factorial immune profiles in patients... Read More
2011-249 – TB-ELISPOT is an optimized Interferon-gamma release assay (IGRA) that accurately detects latent tuberculosis infection (LTBI). This novel TB-ELISPOT method incorporate research-grade technology to enhance antigen-specific activation of T-cells by utilizing co-stimulatory antibodies and best antigen stimulation conditions (48 hrs) in a multiparametric platform that compare specific M.... Read More
2011-245 – Immune responses directed toward many cancers are characterized by targeted cell-killing activities mediated by cytotoxic T cells (a.k.a. Thl responses). However, certain tumors such as bladder cancer, instead appear to elicit immune responses that are traditionally linked with allergies (a.k.a. Th2 responses). These immune responses also include the tissue recruitment of rare white blood... Read More
Photo-Degradable Polycaprolactone Fumarate Block Copolymers: The First Example of Approaches to Nanoporous Biomaterials
2011-242 – Nanoporous materials have numerous applications in nonmedical industries for uses such as membranes, surface patterning, and templates for inorganic materials. These applications have typically used block copolymer (one example is A-B block copolymer) self-assembly, the block copolymers assembly by phase separation of A and B blocks to form nanostructures. Although these types of... Read More
Individualized CT Scan Protocols for Scanning with Either Lower Radiation Dose or Lower IV Contrast Dose
2011-229 – We developed a technique for creating individualized CT protocols that allow patients to be scanned with either lower radiation dose or lower intravenous contrast dose whilst maintaining iodine contrast-to-noise ratio and diagnostic image quality.
2011-226 – The segmental loss of peripheral nerve may result from open or closed extremity trauma, resection of benign or malignant primary nerve tumors, or limb-sparing tumor surgery. Currently available reconstructive options include vascularized and conventional (nonvascularised) nerve autografts, nerve conduits from a variety of materials, nerve allografts and nerve transfer. Of these, autografting... Read More
2011-224 – A method to quantify tissue mechanical properties in a model-independent way by estimating complex elastic modulus from time-dependant creep response induced by acoustic radiation force. This method uses a formula that converts time-domain creep compliance to frequency domain complex modulus. Then Shearwave Dispersion Ultrasound Vibrometry (SDUV) is used to calibrate the complex modulus so... Read More
2011-210 – Multiple short-duration ultrasound push pulses are used to deform tissue. The duration and PRF (Pulse Repetition Frequency) of these push pulses are compatible with current ultrasound scanners because these pulses are comparable to Doppler pulses. The collective effect from many push pulses generates shear waves of high amplitude for elasticity imaging. Two shear waves are produced: one at... Read More
2011-197 – Many attempts have been made to replace circumferential segments of the esophagus with tubular prostheses of various materials, but experimental and clinical trials have not been successful due to frequent complications. An artificial esophageal replacement device which aims to overcome the problems of the previous attempts. Development of viable esophageal replacement would dramatically... Read More
2011-188 – Ileostomy or colostomy are common permanent bowel procedures performed for inflammatory disease, trauma, or cancer. The development of an internal reservoir, obviating the need for an external appliance, has been hampered by the need for an interface between living tissue and the device. The invention disclosed herein is an adaptation of a floating ball valve. Within the bowel lumen lies a... Read More
2011-184 – Methods and Materials for Assessing Responsiveness PARP Inhibitors and Platinating Agents Methods and materials have been developed for assessing responsiveness to PARP inhibitors and platinating agents by using levels of non-homogous end-joining (NHEI) pathway members to determine if cancer cells that are homologous recombination (hr) - deficient are likely to be susceptible or resistant... Read More
2011-178 – Radiation dose from CT scanning is an increasing health concern, but lowering radiation dose alone generally produces a noisier image and may degrade diagnostic performance. Non-local means (NLM) denoising has become widely accepted as a very effective denoising tool in the image processing community, and has yielded very promising results in lung and abdominal CT. However, NLM requires an... Read More
2011-154 – The purpose of SAMR is to help clinicians find answers to clinical questions. The medical literature needed to correctly treat a patient grows exponentially. Data shows that both health care institutions and individual physicians are overwhelmed trying to incorporate this new knowledge. SAMR is a tool that could bridge this gap to improve patient care. SAMR uses semantic elements, the meaning... Read More
2011-130 – The calibration data for an accelerated contrast-enhanced MRA acquisition are acquired in the short time after contrast injection and before contrast arrival. This eliminates the separate acquisition for calibration data.
Mutations in the KCND3-Encoded Kv4.3 Potassium Ion Channel and Use in Diagnostic Methodologies for the Detection of Sudden Death-Predisposing Cardiac Channelopathies
2011-122 – The present invention details mutations in the KCND3-encoded Kv4.3 potassium ion channel that are associated with sudden death predisposing genetic conditions such as Brugada syndrome (BrS) and long QT syndrome (LQTS) and the mechanism by which at risk individuals can be screend for potentially life threatening mutation isn this gene. This invention is based on the that mutations within the... Read More
2011-114 – In dynamic time series imaging, noise varies from image to image, but the underlying structure (although it can vary somewhat) is generally preserved. Techniques that take advantage of this are capable of efficiently denoising such data sets. In this invention, time series images are decomposed into overlapping subblocks of size NxN, with each subblock sampled T times in the time dimension.... Read More
2011-111 – Modulating the Autonomic Nervous System to Treat Hypertension and Heart Failure Mayo Clinic physicians have demonstrated that modulation of the autonomic nervous system can reduce blood pressure and improve symptoms in congestive heart failure (CHF) patients. Afferent nerves originating from skeletal muscle or from the kidneys are blocked to achieve the reduction in blood pressure and the... Read More
2011-108 – Parallel Imaging is a widely used strategy for accelerating MRI acquisitions. Auto-calibrated coil-by-coil methods such as GRAPPA and ARC have become increasingly popular since they do not require a separate calibration scan (as do SENSE and ASSET) nor explicit estimation of coil sensitivity profiles, making them attractive for time-limited and dynamic applications like cardiac imaging.... Read More
Method for Reconstructing Dynamic Resonance Imaging Series From Limited Measurements Using Matrix Rank Constraints
2011-106 – This disclosure allows for image series to be reconstructed from only a subset of the data normally required to form the image series, and correspondingly for image acquisition time to be reduced. As demonstrated, the proposed reconstruction mechanism can provide improved temporal fidelity compared to other rank-based MRI series reconstruction methods.
2011-104 – Ileostomy patients with highly liquid effluent can experience high frequency emptying requirements that can be inconvenient to patients. This invention is a dual chamber ostomy pouch with the chambers separated by a filter. The filter allows water to pass into the second chamber while containing solid waste in the first chamber. The chambers can have separate drain valves allowing them to be... Read More
2011-092 – T cells drive adaptive immune responses that can turn out pathogenic when directed against your own body tissues and organs causing autoimmune diseases. On the other hand, T cells are the main cellular component driving acute organ rejection after transplantation. Therefore different strategies to deplete/inactivate T cells have been pursued to treat patients either suffering from autoimmime... Read More
2011-086 – A data reporting system for competency metrics has been developed that takes trainee endoscopic performance data collected by a validated assessment tool and presents the data in such a manner that allows fellowship directors to identify which trainees have achieved competence and which ones may be in need of remediation and all points between. With this system we have also identified unique... Read More
2011-076 – pEct2 antibody
2011-075 – This invention includes the development of Inducible transgenic mice expressing human TDP-cDNA encoding the TAR-binding protein 43kD utilizing the MoPrpTta promoter.
2011-065 – Three decades after the eradication of smallpox, the threat of bioterrorism and outbreaks of emerging diseases such as monkeypox have renewed interest in the development of safe and effective next-generation poxvirus vaccines and biodefense research. Current smallpox vaccines contain live virus and are contraindicated for a large percentage of the population. Safer, yet still effective... Read More