Target for Sensitizing Tumor Cells to Radiation and Chemotherapy

Technology #2016-386

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Researchers
Zhenkun Lou Ph.D.
Bo Qin Ph.D.
Managed By
Panya Taysavang
Patent Protection
US Patent Pending

Mayo Clinic has discovered the UFM1 signaling pathway as a biomarker/therapeutic target in cancer. UFM1 is an Ub-like molecule needed for ATM activation and DNA damage response. Inhibiting the pathway could sensitize cancer cells to radiation and chemotherapy.