An Animal Model to Study the Effects of Bone Cells on Systemic Energy Metabolism and Fatty Liver

Technology #2013-102

The Hdac3 conditional knockout mouse model made with Osx-Cre is a useful tool to study the molecular and physiological mechanisms by which factors (e.g., OPG and others) produced in the skeleton, particularly by immature osteoblasts and osteoblast progenitor cells, influence energy metabolism and prevent diseases like type 2 diabetes.