TFPI flox Mice

Technology #2012-123

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Mouse Model
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Researchers
Robert D. Simari M.D.
Managed By
Jon H. Behringer

This mouse model contains TFPIFlox allele with LoxP sites flanking exon 4 of the TFPi gene. When bred to mice that express Cre recombinase, the resulting off spring will have the sequences encoding the Kuntz1 domain of the TFPI protein deleted in cre-expressing tissues. As the TFPI-K1 domain is necessary for TFPI inhibition of the tissue factor coagulation pathway, these mice may be useful in generating tissue-specific TFPI deletions for such studies, as well as innate immunity, angiogenesis and lipid metabolism.