Shape-Based Software Biomarkers of Altered Right Ventricular Load

Technology #2012-029

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Marek Belohlavek M.D., Ph.D.
Eileen M. McMahon Ph.D.
Managed By
Matthew K. Ennis
Patent Protection
US Patent Pending
US Patent Pending

Biomarkers capable of detecting early, rapidly progressing, or subtle alterations of cardiac right ventricular (RV) load could substantially contribute to timely diagnosis and effective treatment of RV disorders, which in same cases could escalate to severe or even life threatening conditions, such as acute pulmonary embolism. This invention describes novel RV shape biomarkers sensitive to altered RV load. The biomarkers are software algorithms that produce shape patterns and parameters, which identify altered RV load based on magnitude or dynamics of RV shape changes. Such biomarkers include, but are not limited to: 1) waving paradoxical motion of the RV inner boundary, 2) lower positive correlation between the movement of inner boundaries of the septal and free walls of the RV, 3) slower blood ejection activity by the RV, and 4) discontinuous movement observed particularly in the middle of the RV septal wall.