A Novel Translocation Involving TP63 and TBL1XR1 Resulting in a Dominant Negative TP63 Isoform

Technology #2011-271

We identified a novel translocation of TP63 gene which encodes p63 protein. The translocation leads to overexpression of a dominant negative TP63 isoform. Dominant negative TP63 isoforms lead to inactivation of p53, the most important tumor suppressor known. The translocation can be useful for diagnosis and subclassification of certain peripheral T cell lymphomas, B-cell lymphomas including diffuse large B-cell lymphoma, as well as other cancers. It results in overexpression of a dominant negative form of p63 which could also be used for diagnostic testing and for determining prognosis. In addition, this finding also could stratify patients to receive therapies and or enroll in clinical trials targeting p63 and/or p53 family of proteins. This discovery could lead to novel therapies to directly target the p63-p53 interaction.