Methods and Materials for Assessing Responsiveness PARP Inhibitors and Platinating Agents

Technology #2011-184

Methods and Materials for Assessing Responsiveness PARP Inhibitors and Platinating Agents

Methods and materials have been developed for assessing responsiveness to PARP inhibitors and platinating agents by using levels of non-homogous end-joining (NHEI) pathway members to determine if cancer cells that are homologous recombination (hr) - deficient are likely to be susceptible or resistant to PARP inhibitors and platinating agents.