iPHIL Mouse

Technology #2010-196

iPhil mouse line permitting inducible loss of eosinophils to study eosinophil-related diseases.
Genotype/Phenotype: Inducible ablation of eosinophils is accomplished through expression of the human diptheria toxin receptor exclusively in cells of the eosinophil lineage. Diptheria toxin exposure completely eliminates circulating osinophils without affecting other cell types. Depletion is reversible in days.
Utility: Model for examining the role of eosinophil recruitment and activation in allergy, gastrointestinal disease, cardiovascular disease, and transplant rejection.