NKAP Knockout Mouse

Technology #2010-142

Conditional NKAP knockout mouse.
Genotype/Phenotype: NKAP is a transcriptional repressor of the Notch signaling pathway. The cre-lox system was used to remove exon 3 of NKAP and disrupt repressor function of NKAP. Loss of NKAP function early in T cell development resulted in a severe block in T cell development.
Utility: Mouse model for examining NKAP function and the role of NKAP in T cell development.

PMID: 19409814