Mouse overexpressing PAPP-A

Technology #2010-040

Mouse overexpressing PAPP-A in arterial smooth muscle for the study of atherosclerotic lesion development.
Genotype/Phenotype: A modified SM22alpha promoter with a deleted repressor element drives smooth muscle overexpression. Upon crossbreeding with ApoE knockout mice, PAPP-A transgenic mice develop larger atherosclerotic lesions than ApoE knockout mice.
Utility: Model for examining the role of PAPP-A in cardiovascular disease.

PMID: 20472761