Use of Pittsburgh Compound B (PiB) Molecules and PiB-Positron Emission Tomography/Computed Tomography (PiB-PET/CT) Imaging for the Identification and Diagnosis of Meningiomas

Technology #2010-007

Meningiomas are a common tumor often found in the thin layers of tissue that surround the brain. However, many other types of tumors can arise in the same locations. Variation in the appearance of meningiomas can make the accurate diagnosis of meningioma difficult based on current methods, such as Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). Pathologists can accurately diagnose meningiomas based on biopsy tissue, but the surgical biopsy procedure can cause harm. In patients who have symptoms, a meningioma may be surgically removed. However, residual meningioma left after surgery, and recurrent meningioma growing in the same surgical location are common and very difficult to diagnose with MRI and CT. We have discovered that when Pittsburgh compound B (PiB) molecules are injected into a patient, they accumulate within meningiomas. PiB molecules are radioactive, and therefore their location within the body can be detected from outside the body using Positron Emission Tomography/CT (PiB-PET/CT) imaging. We show that meningiomas can therefore be diagnosed by PiB-PiB-PET/CT imaging. Based on this discovery, we propose new uses of the PiB molecule, and new medical indications for PiB.