rab9 GTPase Mouse

Technology #2009-216

Mouse expressing human rab9 GTPase.
Genotype/Phenotype: Mice demonstrate a dramatic reduction in storage of gangliosides and an approximately 22% increase in lifespan relative to controls.
Utility: Useful for studies of secretion in the intestine and/or liver. Possible application to other lysosomal storage diseases. Model for in vivo studies of rab9 regulation and activity.

PMID: 19056848