Human Cell Line Panel for Preclinical Pharmacogenomics Testing

Technology #2007-064

Panel is comprised of immortalized lymphopblastoid cell lines from nearly 300 healthy individuals of varying ethnicities. For each line, genome-wide SNP characterization, gene expression, genome wide copy number, and substantial genomic sequencing data are available. This panel is valuable for pharmacogenomic evaluation of drug efficacy and safety in addition to identification of drug-specific biomarkers for optimizing therapy and drug discovery. Panel has been used to identify markers predicting response to radiation therapy and anti-neoplastic cytidine analogs.