Technology #2007-016

Mouse expressing the human alpha-synuclein gene for the study of Parkinson’s disease.

Genotype/Phenotype: These mice express the human alpha-synuclein gene, under the control of its endogenous human promoter and regulatory elements. Genomic multiplication of this locus in humans results in Parkinson’s disease with subsequent dementia, with post-mortem transitional or diffuse Lewy body pathology.

Utility: Model system for studying the role of alpha-synuclein in Parkinson’s disease.