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2016-439 – Medicare reimbursement for anesthesia services is currently dependent on a complex set of rules which include the rank of the anesthesia provider and the number of concurrent rooms supervised. Initial analyses show that Medicare non-compliance can result in a ~5% loss of gross revenue in the anesthesia department. Mayo Clinic investigators have developed a tool that tracks operating rooms in... Read More
2016-423 – Antimicrobial therapy can be a complex field, in which suboptimal regimens can result in ineffective treatment or development of microbial resistance. Proper antimicrobial stewardship involves not only tracking patients throughout treatment, but also documentation of treatment outcomes for future reference. This stewardship process is difficult to manage and time-consuming. Mayo Clinic... Read More
2016-389 – The treatment of cancer patients is very complex, with treatment decisions made all the more difficult in patients with multiple comorbidities and compounding drug toxicities. Front-line treatments can be straight forward, but disease relapses often require input and expertise from multidisciplinary teams. These teams utilize their collective experience in disease treatment and patient... Read More
Innovative Asthma Ascertainment by Using Natural Language Processing Algorithm Enabling Automated Chart Review
2016-271 – Mayo Clinic investigators have developed a novel natural language processing (NLP) algorithm designed to automate chart review in order to ascertain asthma status and date of onset by using free text from a patient’s medical record. An initial validation of this algorithm in a patient cohort showed a sensitivity and specificity of 89% and 97% (respectively) when compared to asthma status... Read More
2016-451 – No standard tools are currently available to measure a patient’s progress in regards to their care plan or discharge goals. Determination of patient status is dependent upon delving into multiple medical documents, a process that is cumbersome and costly. Mayo Clinic investigators have developed the Electronic Case Management Tool to simplify the ascertainment of patient status and provide... Read More
2016-135 – The advent of next-generation sequencing has opened the door to widespread identification of somatic mutations in tumor genomes. These somatic mutations can be utilized to identify “true clonal mutations”, or those that are responsible for driving tumor growth in an individual, and therefore could be useful in the identification of therapeutic targets. The primary issue in the identification... Read More
2016-163 – Every large organization has a plethora of digital solutions developed to meet the needs of their day to day business. These digital assets are time consuming and costly to develop and it can often be difficult for employees to determine which assets are already available at their organization. Mayo Clinic investigators have developed an application designed to catalog information about data... Read More
2016-142 – Surgical training using educational models generally involves explaining surgical techniques through verbalization. This training method can be ineffective for visual learners. Mayo Clinic investigators have developed an augmented reality environment that is designed to provide students with real time verbal and visual feedback. This web-based system projects a trainee’s view of a surgical... Read More
2016-216 – Rounding is an essential part of the hospital experience, but it can be difficult for patients and families to process information in real time, even when a provider organizes takes care to explain medical information in plain language. This is all the more challenging when a patient (and their family) speaks a non-native language. Mayo Clinic investigators have developed a structured format... Read More
2014-379 – The global hearing aid market is a multi-billion dollar industry. Although this industry is lucrative, market penetration is very low, primarily due to high cost and the stigma associated with hearing aids. These barriers limit the number of users that could benefit from hearing assistance technologies. Mayo Clinic investigators have developed a low-cost, non-invasive hearing solution that... Read More
2016-477 – The Establishment of primary care provider panels is a complex and difficult process. This process is made all the more difficult in the transition from fee-for service to value-based reimbursement. One of the primary focuses of value-based reimbursement is documenting the overall care of a patient, and a major component of this is assigning each patient to a primary care provider. Mayo... Read More
2016-040 – The “Clinical Registry and Machine Assisted Human Abstraction” is designed to collect and manage aggregated patient information for use in practice management and research. Clinical registries have shown to demonstrate tremendous value, however, the creation and management of registries is expensive and time consuming. This technology provides a standard means to quickly establish a... Read More
2014-026 – A peak velocity estimator algorithm for flow phantom spectra. This peak velocity estimator has been adapted for use with Doppler velocity spectra from string phantoms.
2013-186 – The PET imaging agent F-18 sodium hexafluorophosphate (Na[18F]PF6) for hNIS expression in tumors.
2013-050 – The invention is a low-cost fluorescence camera system that can be used to obtain fluorescence images.
2010-312 – The invention relates to the treatment of meningiomas using a composition including a cytotoxic agent and a compound selected from phenylbenzothiazole derivatives, stilbene derivatives, and biphenylalkyne derivatives.
2015-159 – The Anesthesia Auditing Program Software provides quality improvement for anesthesia medication administration. The program audits all anesthesia medication transactions across a number of databases. The program has demonstrated significant improvements in patient safety, financial charge capture, drug diversion prevention, and documentation accuracy. The program has the ability to work or... Read More
2015-124 – Business Enhancement Analytics Tool (BEAT) is a novel, real-time, cloud-based data analytics platform with multiple functionalities and end users. BEAT has solved hundreds of business cases by unlocking and leveraging data. It can be used on its own but also as a complementary solution for other existing business intelligence frameworks. BEAT offers a variety of functionality that on a high... Read More
Enhancing the Accuracy, Efficiency and Retention of Reading by Health Care Providers Using Electronic Medical Record Systems to Improve the Safety, Effectiveness and Value of Health Care Services
2014-031 – This technology applies and integrates significant, computationally intensive reading tools into electronic medical records (EMR) systems to enhance medical reading performance by individuals who, in any other context, would not be aware of or concerned about their reading performance compared to their peers in their working group. The technology includes: 1. A medical language database... Read More
2012-185 – This technology includes a suite of patents which advance text enhancement methods and apparatus for the presentation of text for improved human reading for the electronic medical record (EMR). The method includes extracting text specific attributes from machine readable text and varying the text presentation in accordance with the attributes. Suite of patents include: -US Patent... Read More
2012-209 – Mayo Clinic researchers have developed methods and materials for treating cancer through the use of antigen combinations. For example, Vesicular Stomatitis Virus (VSV) vectors designed to express a GNAQ antigen, a TYRP1 anti-gen, and an N-RAS antigen can be used to reduce the number of cancer cells (e.g., uveal melanoma cells) within a mammal. In some cases, VSV vectors designed to express... Read More
1998-039 – Through the use of gene targeting in mouse embryonic stem (ES) cells we have successfully generated a line of mice deficient in eosinophil granule major basic protein-1 (mMBP-1). These mice would be useful in drug discovery programs directed toward developing treatments for asthma, allergy, inflammation and a variety of eosinophil-related disorders. PMID: 11067904
Combining Single Domain Antibody Fragments and Mass Spectrometry as a Diagnostic Test for Patients with Plasma Cell Dyscrasias
2015-146 – Mass spectra of proteins isolated using single domain antibody fragments (SDAF) with affinity for immunoglobulins are used to identify, quantitate, and establish heavy and light chain pairings of M-proteins using MALDI-TOF mass spectrometry. The invention utilizes the unique molecular mass and structure of single domain antibody fragments and the unique molecular mass distributions of heavy... Read More
2015-151 – Several novel naturally processed and HLA presented influenza A/H5N1-derived peptides from a class I HLA-A0201 molecules have been identified. A mass spectrometry approach was used to identify five influenza peptides from a B-cell line (homozygous for HLA-A0201) after infection with influenza A/H5N1 virus. The immunologic relevance and specificity of these identified influenza-derived... Read More
2015-065 – Mass accuracy is used to measure free light chains in serum, urine, CSF and body fluid. The mass accuracy allows for direct quantitation of each kappa and lambda light chain. This technique is useful in the diagnosis and prognosis of multiple myeloma, MGUS, B-CLL, Waldenstroms macrogloblinemia, AL amyliodosis, non-secretory myeloma and for distinguishing an auto-immune response from a... Read More
2015-064 – High mass accuracy is used to measure Igs in CSF and serum. The mass accuracy allows for direct quantitation of each kappa and lambda light chain and can be used as a surrogate marker for active clonal B-cells. This method increases the accuracy of clone matching between serum and CSFand utilizes top-down mass spectrometry which allow for fragmentation patterns to be used for absolute... Read More
2014-430 – Mouse model for human progeroid syndrome. Genotype/Phenotype: Sprtn hypomorphic, premature aging (progeria with humans). Utility: disease model for progeria. PMID: 25501849
2014-321 – TGR5 antagonist for the treatment of cholangiopathies including polycystic liver disease.
2014-330 – An adult hypomorphic model of Propionic acidemia (PA) in Pcca− mice using a transgene bearing an A138T mutant of the human PCCA protein. Pcca−/−(A138T) mice have 2% of wild-type PCC activity, survive to adulthood, and have elevations in propionylcarnitine, methylcitrate, glycine, alanine, lysine, ammonia, and markers associated with cardiomyopathy similar to those in patients with PA. Data... Read More
2014-229 – Computer modeling followed by synthesis of novel compounds and testing for stearoyl CoA desaturase 1 (SCD1) specific growth inhibition of cancer cells has led to the identification of four novel lead SCD1 inhibitors.
2014-148 – The SR4G transgenic zebrafish stress response reporter line utilizes a tandem array of glucocorticoid response element sequences to drive expression of a short half-life green fluorescent protein when bound by active glucocorticoid receptors. High-resolution imaging and qRT-PCR have been used to characterized the spatiotemporal responses of this reporter line following exposure to exogenous... Read More
2014-102 – The device harvests a small strip of rectus fascia (1 x 5 cm) by simultaneously dilating the rectus fascial, stapling and then cutting the fascia. The device is small enough to fit through a 3-5 cm lower abdominal incision and articulates to an adjustable angle to account for possible patient obesity.
2014-055 – Exon 41 of LRRK2 is floxed, thus LRRK2 can be removed by cre-mediated deletion. Genotype/Phenotype: homozygous LRRK2loxp/ LRRK2loxp, phenotype would be dependent on which cells express Cre after crossing. Utility: Parkinson’s Disease Research PMID: 22647713
2013-206 – This invention has benefit over other methods since it directly quantitates the mAb without the need for interaction with the antigen. By monitoring tryptic peptides from the unique variable regions of the therapeutic mAb and comparing them to the constant regions of a non-human antibody added as an internal standard, the mAb can be measured. This method is superior to other methods using... Read More
2012-285 – A method to identify if an M-spike contains either a kappa or lambda light chain has been discovered through the use of liquid chromatography tandem mass spectrometry (LC-MS/MS).
2012-139 – In normal healty individuals, the plasma cells produce numerous immunoglobulins each with its own unique protein sequence and hence a unique mass. When examined together, the distribution of the masses forms a Gaussian distribution. Patients whom have plasma cells that overproduce immunoglobulins (M-proteins) are at risk for developing serious diseases such as multiple myeloma. Currently,... Read More
2012-062 – Broad patent claims have issued claiming methods for treating renal cell carcinoma by using SCD1 inhibitors and are available for licensing.
2010-196 – iPhil mouse line permitting inducible loss of eosinophils to study eosinophil-related diseases. Genotype/Phenotype: Inducible ablation of eosinophils is accomplished through expression of the human diptheria toxin receptor exclusively in cells of the eosinophil lineage. Diptheria toxin exposure completely eliminates circulating osinophils without affecting other cell types. Depletion is... Read More
2010-142 – Conditional NKAP knockout mouse. Genotype/Phenotype: NKAP is a transcriptional repressor of the Notch signaling pathway. The cre-lox system was used to remove exon 3 of NKAP and disrupt repressor function of NKAP. Loss of NKAP function early in T cell development resulted in a severe block in T cell development. Utility: Mouse model for examining NKAP function and the role of NKAP in T... Read More
2010-040 – Mouse overexpressing PAPP-A in arterial smooth muscle for the study of atherosclerotic lesion development. Genotype/Phenotype: A modified SM22alpha promoter with a deleted repressor element drives smooth muscle overexpression. Upon crossbreeding with ApoE knockout mice, PAPP-A transgenic mice develop larger atherosclerotic lesions than ApoE knockout mice. Utility: Model for examining the... Read More
2009-333 – ERB (estrogen receptor beta) mouse monoclonal antibody. Epitope: amino acids 1-140 Known Applications: Enzyme-linked immunosorbent assay (ELISA), Immunohistochemistry (IHC), Western blot (WB) Known Reactivity: Human
2009-216 – Mouse expressing human rab9 GTPase. Genotype/Phenotype: Mice demonstrate a dramatic reduction in storage of gangliosides and an approximately 22% increase in lifespan relative to controls. Utility: Useful for studies of secretion in the intestine and/or liver. Possible application to other lysosomal storage diseases. Model for in vivo studies of rab9 regulation and activity. PMID:... Read More
2008-229 – Computer input devices are claimed for use in manipulating digital images on a display apparatus in, for example, medical diagnostics. A computer input device as claimed may be particularly useful for manipulation of one or more digital images such as, for example, digital histological images, including but not limited to images of a microscopic tissue section. Manipulation of digital... Read More
2007-110 – Genotype/Phenotype: Mice expressing human MUC1 (mucin) were mated with mice expressing elastase-driven SV40 T antigen. The resulting mice spontaneously develop pancreatic tumors that express high levels of the MUC1. Utility: Useful for investigating immune responses during tumor progression. PMID link: 10975866
2007-064 – Panel is comprised of immortalized lymphopblastoid cell lines from nearly 300 healthy individuals of varying ethnicities. For each line, genome-wide SNP characterization, gene expression, genome wide copy number, and substantial genomic sequencing data are available. This panel is valuable for pharmacogenomic evaluation of drug efficacy and safety in addition to identification of... Read More
2007-016 – Mouse expressing the human alpha-synuclein gene for the study of Parkinson’s disease. Genotype/Phenotype: These mice express the human alpha-synuclein gene, under the control of its endogenous human promoter and regulatory elements. Genomic multiplication of this locus in humans results in Parkinson’s disease with subsequent dementia, with post-mortem transitional or diffuse Lewy body... Read More
2006-220 – Hi52C is a mouse monoclonal antibody (IgG) generated against recombinant human FKBP52. The antibody is highly specific for FKBP52 and recognizes antigen on Western blots and will immunoprecipitate native protein complexes containing FKBP52. Hi52C is known to crossreact with FKBP52 from human, mouse, and rabbit sources. PMID Publication:15831525
2006-219 – Hi51B is a mouse monoclonal antibody (IgG) generated against recombinant human FKBP51. The antibody is highly specific for FKBP51 and recognizes antigen on Western blots and will immunoprecipitate native protein complexes containing FKBP51. Hi51B is known to crossreact with FKBP51 from human, mouse, and rabbit sources.
2006-116 – Mice expressing multiple human HLA class II molecules for the study of immune response to bacterial superantigens. Genotype/Phenotype: Mice express multiple varieties of human HLA class II molecules. Utility: Model systems for studying bacterial superantigens. PMID: 16428778 PMID: 18501769 PMID: 18086265
2004-287 – Rabbit polyclonal antibodies were generated to a specific phosphorylated peptide in the Smad3 protein. Epitope: COOH-GSPSIRCSpSVpS Known Applications: Western blot (WB) Known Reactivity: Human PMID 15520863