Matthew K. Ennis
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2014-330 – An adult hypomorphic model of Propionic acidemia (PA) in Pcca− mice using a transgene bearing an A138T mutant of the human PCCA protein. Pcca−/−(A138T) mice have 2% of wild-type PCC activity, survive to adulthood, and have elevations in propionylcarnitine, methylcitrate, glycine, alanine, lysine, ammonia, and markers associated with cardiomyopathy similar to those in patients with PA. Data... Read More
2013-107 – The generation of a mouse strain with knockout of B7-H1 gene.
2012-253 – Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are devastating neurodegenerative diseases. FTLD results from the degeneration of the frontal and temporal lobes of the brain, and encompasses a group of disorders distinguished by abnormalities in behavior, language and personalityl. ALS is characterized by the degeneration of motor neurons, resulting in muscle... Read More
2012-144 – The knock-in mouse model mimics an incompletely penetrant genetic mutation found in patients with atypical autosomal dominant polycystic kidney disease (ADPKD). The model was established to investigate the pathogenic mechanism of this particular mutation (PKD1 R3277C). As in patients, mice carrying the mutation together with a PKD1 truncating change develop severe, early onset disease,... Read More
2012-093 – Background LRP1 is a ubiquitously expressed receptor that mediates rapid endocytosis of various ligands. By modulating the trafficking of other signaling receptors, LRP1 plays a significant role in the central nervous system and peripheral tissue. It is thought that malfunction of the LRP1-related pathway is a causal factor of cardiovascular and Alzheimer’s disease. Thus, there is tremendous... Read More
2011-130 – The calibration data for an accelerated contrast-enhanced MRA acquisition are acquired in the short time after contrast injection and before contrast arrival. This eliminates the separate acquisition for calibration data.
2011-076 – pEct2 antibody
2011-065 – Three decades after the eradication of smallpox, the threat of bioterrorism and outbreaks of emerging diseases such as monkeypox have renewed interest in the development of safe and effective next-generation poxvirus vaccines and biodefense research. Current smallpox vaccines contain live virus and are contraindicated for a large percentage of the population. Safer, yet still effective... Read More
2011-021 – A method is developed for eliminating the calibration scan in SENSE-accelerated time-resolved MRA.
2011-020 – Progress of an intravenously administered contrast bolus along the peripheral vasculature is tracked in real time by generating diagnostic quality images and then using the information to cause the patient table to move so as to allow generation a high quality angiogram along the entire extent of the vasculature.
2010-152 – A device and method for MRI in-scanner imaging of chronic exertional compartment syndrome (CECS) of the lower legs has been developed and validated.
2010-061 – Calcific aortic valve stenosis is a growing problem in developed countries, and valve replacement surgery is the second most common thoracic surgery performed worldwide (>100,000 procedures performed in the US in 2008). Bioprosthetic valves are the most commonly used devices to replace the stenotic valve, but only have a projected lifespan of 10-12 years. Cells infiltrating the... Read More
Matrix Metalloproteinase Inhibition to Slow Calcification and Failure of Bioprosthetic Aortic Valves
2010-060 – Calcific aortic valve stenosis is a growing problem in developed countries, and valve replacement surgery is the second most common thoracic surgery performed worldwide (>100,000 procedures performed in the US in 2008). Bioprosthetic valves are the most commonly used devices to replace the stenotic valve, but only have a projected lifespan of 10-12 years. During this time, endothelial... Read More
2010-026 – Accelerated MRI: A method is described for improving parallel acquisition along the longitudinal direction.
2009-296 – Mouse model of recessive polycystic Kidney Disease (ARPKD)
2009-235 – Using accelerated time-resolved 3-D imaging methods such as the Mayo-developed Cartesian Acquisition with Projection Reconstruction like sampling (CAPR) it is possible to generate data for both a time series of MR angiograms as well as an image of perfusion.
2009-126 – This invention includes the developement of inducible transgenic mice expressing human TDP-43 cDNA encoding the TAR-binding protein 43kD.
2008-299 – A technique is described for taking images generated from an MRI acquisition done with contrast administration and converting the image data into a single image which portrays the time of arrival (TOA) of the advancing contrast bolus. The TOA image allows distinction of arterial from venous structures based on their different arrival times. The quality of the results depends on... Read More
2008-315 – Parallel imaging can be applied to further reduce acquisition times. To do so, coil sensativities have to be determined. One option is to use self-or-auto calibrated methods which in general use unaccelerated sampling in some central region of the otherwise undersampled k-space. However, the fraction of acquisition time devoted to calibration can be substantial, particularly in high... Read More
2008-136 – A method is described which provides reduction of acquisition time for 3DFT MRI. It is based on a specific way to sample k-space which is robust to undersampling. It can be used in conjunction with other methods for reduction of acquisition time.
2008-178 – A technique is described for MR imaging of an extended field of which uses a combination of multiple-fixed-station and continuously moving table acquisitions. This preserves the ability to perform acceleration techniques and also provides high time efficiency.
2008-177 – A coil array is designed for 2D acceleration in MRI for imaging an object with markedly different fields of view in the two phase encoding directions in which the coil elements in one direction have markedly different size than elements in the other direction.
2008-059 – Clear plastic container used to transport up to 4 (1" square pathology tissue blocks) via suggested method of external transportation from Client site to a pathology lab. This container is designed to ensure that all Surgical Blocks are transported in an easily identifiable and safe manner. A Provisional patent application was filed on July 15, 2008.
2008-035 – Mice lacking 53BPI were developed at Mayo to study DNA damage responses and tumor suppression. See Ward et al. (2003) Mol Cell Biol 23(7):2556-2563
2007-103 – The abnormal accumulation of TDP-43 protein has been recently identified as the major protein constituent for several neurodegenerative diseases. The protein undergoes several post-translational modifications including phosphorylation, ubiquitination and proteolytic cleavage. The pathologic accumulation of these truncated species is believed to be pathologic. Using cell culture models, we... Read More
2007-009 – Currently, radiologists interpreting CT colonography exams find it most efficient to view colons primarily in a 2D axial mode, scrolling these slices up and down the abdomen. Typically, the entire colon is scanned twice on the computer screen, first with a “lung” window/level setting (analogous to contrast/brightness) that clearly shows protrusions into the lumen and identifies most typical... Read More
2007-008 – CT colonography (CTC) is being extensively studied for its potential value in colon examinations. Like traditional colonoscopy, CTC requires extensive preparation to cleanse the colon of fecal material. The inconvenience and discomfort associated with this preparation is an important obstacle to compliance with currently recommended colorectal screening guidelines. An alternative is to tag... Read More
2007-007 – This invention consists of a novel display technique for CT colonography data. It is based on automatic generation of a midline trace (centerline) of the colon, followed by display of a sequence of images of the colon that follow this centerline, and display a small field of view centered on it and perpendicular to it. This allows the radiologist the benefit of always seeing the colon in... Read More
2007-006 – This invention consists of a novel display technique for CT colonography data. It is based on automatic generation of a midline trace (centerline) of the colon, followed by display of a sequence of axial images that display a small field of view centered on the trace, and follow along it. This allows the radiologist the benefit of a small field of view to examine the image, but frees him from... Read More
2006-231 – Rabbit polyclonal antibodies were generated to two components of the calcium-release activated calcium (CRAC) channel, Orai1 and STIM1. These antibodies can be used for immunofluorescence, immunoprecipitation and immunoblotting of Orai1 and STIM1.
2006-059 – Peptide or GST-fusion proteins containing antigenic epitopes of WAVE2, Evl, VASP, HS1, STIM, CIN85 and TUBA were used to create polyclonal rabbit antisera. The antibodies are useful for IP, Western blotting and IF.
2005-031 – Technology Description HIV infected cells express an HIV protease that cleaves caspase 8 to form a polypeptide (Casp8p41) that is not expressed in uninfected cells. Mayo Clinic researchers have demonstrated that this fragment alone promotes mitochondrial depolarization, cytochrome C release, and cell death, while HIV protease resistant procaspase 8 does not. A Casp8p41-specific antibody has... Read More
2005-022 – CT colonography (CTC) offers advantages for colon examinations such as lower risk and less patient discomfort. However, CTC requires complete bowel preparation (cleansing). The inconvenience and discomfort of this process greatly reduces patient compliance and is a major obstacle to widespread colorectal screening. An alternative is to tag the stool with an opacifying agent so that it is... Read More
2005-015 – Software that is able to recognize internal fat within the valve and eliminate it as a diagnostic possibility.
2005-014 – Proteins of the Rho family of GTP-binding proteins regulate multiple cellular phenomenon. There are 17 separate genes that encode 18 proteins (one results from an alternatively spliced gene product). We have used a molecular genetic approach to purify all 18 proteins to homogeneity. These proteins can be used in biochemical assays to test their association and activity with upstream... Read More
Wild-type Constructs for human sulfotransferase genes: namely SULT 1A1, 1A2, 1A3, 1B1, 1C1, 1C2, 2A1, 4A1, 6B1
2005-012 – Wild-type Constructs for human sulfotransferase genes: namely SULT 1A1, 1A2, 1A3, 1B1, 1C1, 1C2, 2A1, 4A1, 6B1. Encoded by these genes are critical for enzymes, metabolism, activation and also detoxification of numerous drugs and compounds.
In vivo Visualization of Alzheimer's Amyloid Plaques by MRI in Transgenic Mice without a Contrast Agent
2004-139 – One of the cardinal pathologic features of Alzheimer’s disease (AD) is formation of senile or amyloid, plaques. Transgenic mice have been developed that express one or more of the genes responsible for familial AD in humans. Doubly transgenic mice develop “human-like” plaques, providing a mechanism to study amyloid plaque biology in a controlled manner. Imaging of labeled plaques has been... Read More
2004-061 – We have developed a series of polyclonal antibodies specific for SRC-2 and REA steroid receptor coregulators. The affinity purified antibodies have demonstrated a marked specificity of each polyclonal antibody to its specific co-regulator and this has shown to be functional with western blot analysis, co-precipitations, competition with the specific peptide used as an immunogen, and even the... Read More
2004-022 – Mice expressing human CD46 with human-like tissue specificity and efficiency. For additional information, please see the following: Mrkic et al., (1998). Measles virus spread and pathogenesis in genetically modified mice. Journal of Virology, volume 72, number 9, 7420-7427. Mrkic et al. (2000). Lymphatic dissemination and comparative pathology of recombinant measles viruses in genetically... Read More
2002-167 – An RF coil with added coils which transmit only to reduce artifactual signals due to flow or poor magnet shim.
2002-136 – Rabbit polyclonal antisera were produced against human and murine Vav-3 proteins using KLH-conjuaged peptides. These antisera recognize an approximately 98 kilodalton protein corresponding to Vav3.
2002-025 – Computer software which locates polyps and cancers of the colon on CT colonography data sets.
2001-050 – Device reproducibly positions subject’s upper extremities while allowing measurement of actively generated forearm torque against resisted rotation in variable forearm positions; used with MMV-01-049.
2001-049 – Device reproducibly positions subject’s upper extremities in field of CT imaging system; allows variable positioning of forearm rotation; allows present forearm positions to be maintained and for active force generation by patient to optimize displacement of bones to demonstrate joint instability.
2001-042 – MR based technique for accurately detecting seed locations following prostate brachytherapy seed therapy. This method optimizes phase perturbations introduced into prostate and surrounding tissue resulting from implantation of brachytherapy seeds with differing susceptibility values and can accurately determine seed location and orientation in the prosstate and surrounding tissue.
2000-038 – Controlling/predesigning the needle puncture site to allow sheath/dilator to enter vessel with minimal damage and a smaller residual hole/wound.
2000-037 – A 3D motion adjustment pulse sequence is interleaved with magnetic resonance image (MRI) acquisition. This motion adjustment pulse sequence encodes all six degrees of rigid body motion in a single 3D spherical k-space dataset and is used to measure patient motion during the scan. The MRI system’s scan parameters are prospectively adjusted during the scan to offset the effects of patient... Read More
2000-013 – The development of a delivery mechanism (pill or capsule) for barium sulfate which is used for the purpose of altering the density of stool sufficiently that it can be electronically subtracted. A new software tool (computer algorithm) for electronic subtraction of contrast-laden stool has been developed.
1998-097 – A method is described that allows both highly sensitive screening for arterial disease in conjuction with highly specific diagnoses on an MR System with high-speed gradients.
1995-155 – HFOBER cells are hFOBs stably transfected with human estrogen receptor; subclones HFOB/ER-3 and HFOB/ER-4 express levels of estrogen receptor consistent with the range of levels measured in human osteoblasts. The HFOBER cell lines have a complete concatenation of transcription factors such that the estrogen receptor is transactionally active; estrogen-regulated functions are maintained. The... Read More