Matthew K. Ennis
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2013-157 – Application Enhance transduction and transgene expression of Adeno-associated virus (AAV) vectors using U2 snRNP spliceosome inhibitors Value Proposition AAV has become one of the leading gene delivery vectors in clinical development. Gene therapy using recombinant AAV has been demonstrated to be safe and well-tolerated in virtually every clinical setting in which it has been used.... Read More
2004-222 – Mayo Clinic has patent rights claiming obesity devices.
2004-106 – Mayo Clinic as designed an Endoscopic Pneumatic Assist Device (EPAD) to help patients with weight loss and maintenance. The EPAD technology induces weight loss by creating a physical/obstructive barrier to the passage of nutrients through the pylorus. Additionally, the device induces malabsorption due to the attached optioal malbsorptive sleeve in the proximal small bowel.Finally, the use of... Read More
2014-055 – Exon 41 of LRRK2 is floxed, thus LRRK2 can be removed by cre-mediated deletion. Genotype/Phenotype: homozygous LRRK2loxp/ LRRK2loxp, phenotype would be dependent on which cells express Cre after crossing. Utility: Parkinson’s Disease Research PMID: 22647713
2008-229 – Computer input devices are claimed for use in manipulating digital images on a display apparatus in, for example, medical diagnostics. A computer input device as claimed may be particularly useful for manipulation of one or more digital images such as, for example, digital histological images, including but not limited to images of a microscopic tissue section. Manipulation of digital... Read More
2013-107 – The generation of a mouse strain with knockout of B7-H1 gene.
2012-144 – The knock-in mouse model mimics an incompletely penetrant genetic mutation found in patients with atypical autosomal dominant polycystic kidney disease (ADPKD). The model was established to investigate the pathogenic mechanism of this particular mutation (PKD1 R3277C). As in patients, mice carrying the mutation together with a PKD1 truncating change develop severe, early onset disease,... Read More
2012-093 – Background LRP1 is a ubiquitously expressed receptor that mediates rapid endocytosis of various ligands. By modulating the trafficking of other signaling receptors, LRP1 plays a significant role in the central nervous system and peripheral tissue. It is thought that malfunction of the LRP1-related pathway is a causal factor of cardiovascular and Alzheimer’s disease. Thus, there is tremendous... Read More
2012-084 – A homozygous transgenic mouse model expressing mutant M377V human TDP-43 cDNA encoding the TAR-bindign protein 43kD - 6 fold endogenous levels (Xu et al, Molecular Neurodegeneration, 2011).
2011-130 – The calibration data for an accelerated contrast-enhanced MRA acquisition are acquired in the short time after contrast injection and before contrast arrival. This eliminates the separate acquisition for calibration data.
2011-076 – pEct2 antibody
2011-075 – This invention includes the development of Inducible transgenic mice expressing human TDP-cDNA encoding the TAR-binding protein 43kD utilizing the MoPrpTta promoter.
2011-074 – This invention includes the development of inducible M17 neuroblastoma cell lines expressing human TDP-43 cDNA encoding the wild type, disease associated mutants, nuclear localization mutant and RNA binding mutant TAR-binding protein 43kD.
2011-021 – A method is developed for eliminating the calibration scan in SENSE-accelerated time-resolved MRA.
2011-020 – Progress of an intravenously administered contrast bolus along the peripheral vasculature is tracked in real time by generating diagnostic quality images and then using the information to cause the patient table to move so as to allow generation a high quality angiogram along the entire extent of the vasculature.
2010-222 – This invention covers the design, genetic engineering and construction of the inducible TDP-43 wild-type and D89/219E double mutant constructs utilized to create the iTDP Tg mice.
2010-178 – Technology Description We have developed human lung cancer cell lines in which the expression of the PKClota oncogene has been genetically manipulated. Specifically, the cell lines are transduced with rec ombinant lentiviruses that express either a shRNA targeting the PKCiota mRNA or a non-target control shRNA that does not target any known RNA. These cell lines allow one to investigate the... Read More
2010-152 – A device and method for MRI in-scanner imaging of chronic exertional compartment syndrome (CECS) of the lower legs has been developed and validated.
2010-026 – Accelerated MRI: A method is described for improving parallel acquisition along the longitudinal direction.
2009-362 – Background Topoisomerase I has been used as a drug target for cancer treatment. By inhibiting the religation step of the enzyme, the formation of topo I-DNA complexes block the advancing replication complexes, which will ultimately cause cell death. Thus, measurement of the covalent topo I-DNA complexes can potentially be used to assess therapeutic efficacy of topoisomerase I poisons. ... Read More
2009-235 – Using accelerated time-resolved 3-D imaging methods such as the Mayo-developed Cartesian Acquisition with Projection Reconstruction like sampling (CAPR) it is possible to generate data for both a time series of MR angiograms as well as an image of perfusion.
2009-126 – This invention includes the developement of inducible transgenic mice expressing human TDP-43 cDNA encoding the TAR-binding protein 43kD.
2009-125 – This invention includes the development of a homozygous transgenic mouse model expressing wild-type human TDP-43 cDNA encoding the TAR-binding protein 43kD endogenous levels.
2008-299 – A technique is described for taking images generated from an MRI acquisition done with contrast administration and converting the image data into a single image which portrays the time of arrival (TOA) of the advancing contrast bolus. The TOA image allows distinction of arterial from venous structures based on their different arrival times. The quality of the results depends on... Read More
2008-315 – Parallel imaging can be applied to further reduce acquisition times. To do so, coil sensativities have to be determined. One option is to use self-or-auto calibrated methods which in general use unaccelerated sampling in some central region of the otherwise undersampled k-space. However, the fraction of acquisition time devoted to calibration can be substantial, particularly in high... Read More
2008-136 – A method is described which provides reduction of acquisition time for 3DFT MRI. It is based on a specific way to sample k-space which is robust to undersampling. It can be used in conjunction with other methods for reduction of acquisition time.
2008-178 – A technique is described for MR imaging of an extended field of which uses a combination of multiple-fixed-station and continuously moving table acquisitions. This preserves the ability to perform acceleration techniques and also provides high time efficiency.
2008-177 – A coil array is designed for 2D acceleration in MRI for imaging an object with markedly different fields of view in the two phase encoding directions in which the coil elements in one direction have markedly different size than elements in the other direction.
2008-035 – Mice lacking 53BPI were developed at Mayo to study DNA damage responses and tumor suppression. See Ward et al. (2003) Mol Cell Biol 23(7):2556-2563
2007-009 – Currently, radiologists interpreting CT colonography exams find it most efficient to view colons primarily in a 2D axial mode, scrolling these slices up and down the abdomen. Typically, the entire colon is scanned twice on the computer screen, first with a “lung” window/level setting (analogous to contrast/brightness) that clearly shows protrusions into the lumen and identifies most typical... Read More
2007-008 – CT colonography (CTC) is being extensively studied for its potential value in colon examinations. Like traditional colonoscopy, CTC requires extensive preparation to cleanse the colon of fecal material. The inconvenience and discomfort associated with this preparation is an important obstacle to compliance with currently recommended colorectal screening guidelines. An alternative is to tag... Read More
2007-007 – This invention consists of a novel display technique for CT colonography data. It is based on automatic generation of a midline trace (centerline) of the colon, followed by display of a sequence of images of the colon that follow this centerline, and display a small field of view centered on it and perpendicular to it. This allows the radiologist the benefit of always seeing the colon in... Read More
2007-006 – This invention consists of a novel display technique for CT colonography data. It is based on automatic generation of a midline trace (centerline) of the colon, followed by display of a sequence of axial images that display a small field of view centered on the trace, and follow along it. This allows the radiologist the benefit of a small field of view to examine the image, but frees him from... Read More
2006-231 – Rabbit polyclonal antibodies were generated to two components of the calcium-release activated calcium (CRAC) channel, Orai1 and STIM1. These antibodies can be used for immunofluorescence, immunoprecipitation and immunoblotting of Orai1 and STIM1.
2006-059 – Peptide or GST-fusion proteins containing antigenic epitopes of WAVE2, Evl, VASP, HS1, STIM, CIN85 and TUBA were used to create polyclonal rabbit antisera. The antibodies are useful for IP, Western blotting and IF.
2005-031 – Technology Description HIV infected cells express an HIV protease that cleaves caspase 8 to form a polypeptide (Casp8p41) that is not expressed in uninfected cells. Mayo Clinic researchers have demonstrated that this fragment alone promotes mitochondrial depolarization, cytochrome C release, and cell death, while HIV protease resistant procaspase 8 does not. A Casp8p41-specific antibody has... Read More
2005-022 – CT colonography (CTC) offers advantages for colon examinations such as lower risk and less patient discomfort. However, CTC requires complete bowel preparation (cleansing). The inconvenience and discomfort of this process greatly reduces patient compliance and is a major obstacle to widespread colorectal screening. An alternative is to tag the stool with an opacifying agent so that it is... Read More
2005-015 – Software that is able to recognize internal fat within the valve and eliminate it as a diagnostic possibility.
2005-014 – Proteins of the Rho family of GTP-binding proteins regulate multiple cellular phenomenon. There are 17 separate genes that encode 18 proteins (one results from an alternatively spliced gene product). We have used a molecular genetic approach to purify all 18 proteins to homogeneity. These proteins can be used in biochemical assays to test their association and activity with upstream... Read More
Wild-type Constructs for human sulfotransferase genes: namely SULT 1A1, 1A2, 1A3, 1B1, 1C1, 1C2, 2A1, 4A1, 6B1
2005-012 – Wild-type Constructs for human sulfotransferase genes: namely SULT 1A1, 1A2, 1A3, 1B1, 1C1, 1C2, 2A1, 4A1, 6B1. Encoded by these genes are critical for enzymes, metabolism, activation and also detoxification of numerous drugs and compounds.
2004-061 – We have developed a series of polyclonal antibodies specific for SRC-2 and REA steroid receptor coregulators. The affinity purified antibodies have demonstrated a marked specificity of each polyclonal antibody to its specific co-regulator and this has shown to be functional with western blot analysis, co-precipitations, competition with the specific peptide used as an immunogen, and even the... Read More
2004-022 – Mice expressing human CD46 with human-like tissue specificity and efficiency. For additional information, please see the following: Mrkic et al., (1998). Measles virus spread and pathogenesis in genetically modified mice. Journal of Virology, volume 72, number 9, 7420-7427. Mrkic et al. (2000). Lymphatic dissemination and comparative pathology of recombinant measles viruses in genetically... Read More
2002-244 – Mayo has discovered a gene, PKHDL1, that shows significant homology to PKHD1 (the gene mutated in autosomal recessive polycystic kidney disease that was discovered at Mayo and for which a patent application is pending). The protein predicted to be encoded by PKHDL1, fibrocystin-L, is a large receptor-like protein that is highly expressed on T lymphocytes. The protein is postulated to be an... Read More
2002-167 – An RF coil with added coils which transmit only to reduce artifactual signals due to flow or poor magnet shim.
2002-136 – Rabbit polyclonal antisera were produced against human and murine Vav-3 proteins using KLH-conjuaged peptides. These antisera recognize an approximately 98 kilodalton protein corresponding to Vav3.
2002-025 – Computer software which locates polyps and cancers of the colon on CT colonography data sets.
2001-042 – MR based technique for accurately detecting seed locations following prostate brachytherapy seed therapy. This method optimizes phase perturbations introduced into prostate and surrounding tissue resulting from implantation of brachytherapy seeds with differing susceptibility values and can accurately determine seed location and orientation in the prosstate and surrounding tissue.
2000-037 – A 3D motion adjustment pulse sequence is interleaved with magnetic resonance image (MRI) acquisition. This motion adjustment pulse sequence encodes all six degrees of rigid body motion in a single 3D spherical k-space dataset and is used to measure patient motion during the scan. The MRI system’s scan parameters are prospectively adjusted during the scan to offset the effects of patient... Read More
2000-013 – The development of a delivery mechanism (pill or capsule) for barium sulfate which is used for the purpose of altering the density of stool sufficiently that it can be electronically subtracted. A new software tool (computer algorithm) for electronic subtraction of contrast-laden stool has been developed.
1998-076 – Short term paralysis of underlying musculature to improve cutaneous wound healing in tramatic and non-tramatic wounds.