Matthew K. Ennis
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2014-330 – An adult hypomorphic model of Propionic acidemia (PA) in Pcca− mice using a transgene bearing an A138T mutant of the human PCCA protein. Pcca−/−(A138T) mice have 2% of wild-type PCC activity, survive to adulthood, and have elevations in propionylcarnitine, methylcitrate, glycine, alanine, lysine, ammonia, and markers associated with cardiomyopathy similar to those in patients with PA. Data... Read More
2013-107 – The generation of a mouse strain with knockout of B7-H1 gene.
2012-253 – Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are devastating neurodegenerative diseases. FTLD results from the degeneration of the frontal and temporal lobes of the brain, and encompasses a group of disorders distinguished by abnormalities in behavior, language and personalityl. ALS is characterized by the degeneration of motor neurons, resulting in muscle... Read More
2012-144 – The knock-in mouse model mimics an incompletely penetrant genetic mutation found in patients with atypical autosomal dominant polycystic kidney disease (ADPKD). The model was established to investigate the pathogenic mechanism of this particular mutation (PKD1 R3277C). As in patients, mice carrying the mutation together with a PKD1 truncating change develop severe, early onset disease,... Read More
2012-093 – Background LRP1 is a ubiquitously expressed receptor that mediates rapid endocytosis of various ligands. By modulating the trafficking of other signaling receptors, LRP1 plays a significant role in the central nervous system and peripheral tissue. It is thought that malfunction of the LRP1-related pathway is a causal factor of cardiovascular and Alzheimer’s disease. Thus, there is tremendous... Read More
2012-029 – Biomarkers capable of detecting early, rapidly progressing, or subtle alterations of cardiac right ventricular (RV) load could substantially contribute to timely diagnosis and effective treatment of RV disorders, which in same cases could escalate to severe or even life threatening conditions, such as acute pulmonary embolism. This invention describes novel RV shape biomarkers sensitive to... Read More
2011-076 – pEct2 antibody
2011-065 – Three decades after the eradication of smallpox, the threat of bioterrorism and outbreaks of emerging diseases such as monkeypox have renewed interest in the development of safe and effective next-generation poxvirus vaccines and biodefense research. Current smallpox vaccines contain live virus and are contraindicated for a large percentage of the population. Safer, yet still effective... Read More
2010-061 – Calcific aortic valve stenosis is a growing problem in developed countries, and valve replacement surgery is the second most common thoracic surgery performed worldwide (>100,000 procedures performed in the US in 2008). Bioprosthetic valves are the most commonly used devices to replace the stenotic valve, but only have a projected lifespan of 10-12 years. Cells infiltrating the... Read More
Matrix Metalloproteinase Inhibition to Slow Calcification and Failure of Bioprosthetic Aortic Valves
2010-060 – Calcific aortic valve stenosis is a growing problem in developed countries, and valve replacement surgery is the second most common thoracic surgery performed worldwide (>100,000 procedures performed in the US in 2008). Bioprosthetic valves are the most commonly used devices to replace the stenotic valve, but only have a projected lifespan of 10-12 years. During this time, endothelial... Read More
2009-296 – Mouse model of recessive polycystic Kidney Disease (ARPKD)
2009-281 – An ultrasound imaging system transmits a train of pulses along each scan line. The pulses are reflected at various depths and interfaces (objects). In color Doppler mode, the reflected signals from the corresponding scan line and depth correlated frame by frame. A loss of correlation is interpreted as object displacement and indicated by a color overlay. Even if an object does not move... Read More
2009-280 – Sonometry is real-time distance measurement between two piezoelectric crystals by the time of flight of an acoustic signal, transmitted by one and received by the other crystal. Three “locator” crystals define a plane. Another “navigator: crystal can be instantaneously spatially located by the distances from the "locator” crystals.
2009-278 – Specific and highly sensitive ultrasound localization of catheter placement can be accomplished by use of a catheter navigation crystal with an active (vibrating) element whose ultrasonic signal interferes with the ultrasound imaging signal as the latter propagates with each transmitted bearn though issue. The interference signal (caused by the crystal) occurs directly within the Doppler... Read More
2009-126 – This invention includes the developement of inducible transgenic mice expressing human TDP-43 cDNA encoding the TAR-binding protein 43kD.
2008-386 – The use of ionizing radiation for diagnostic and interventional procedures has been growing at an exponential rate. The technical differences which exist among the sources of ionizing radiation are large - and necessitate computationally intensive and patient specific information in order to form a reasonable summary of an individual patient’s radiation dose. The invention specifies a... Read More
2008-059 – Clear plastic container used to transport up to 4 (1" square pathology tissue blocks) via suggested method of external transportation from Client site to a pathology lab. This container is designed to ensure that all Surgical Blocks are transported in an easily identifiable and safe manner. A Provisional patent application was filed on July 15, 2008.
2008-039 – This optical edge connector is designed to meet future board-to-board optical interconnect requirements of orthogonally connected optical printed circuit boards that contain embedded optical communication channels, typically utilized for High Performance Compute Systems. The orthogonal implementation of this design is not found in any commercially available optical connectors. The design... Read More
2008-035 – Mice lacking 53BPI were developed at Mayo to study DNA damage responses and tumor suppression. See Ward et al. (2003) Mol Cell Biol 23(7):2556-2563
2007-103 – The abnormal accumulation of TDP-43 protein has been recently identified as the major protein constituent for several neurodegenerative diseases. The protein undergoes several post-translational modifications including phosphorylation, ubiquitination and proteolytic cleavage. The pathologic accumulation of these truncated species is believed to be pathologic. Using cell culture models, we... Read More
2007-009 – Currently, radiologists interpreting CT colonography exams find it most efficient to view colons primarily in a 2D axial mode, scrolling these slices up and down the abdomen. Typically, the entire colon is scanned twice on the computer screen, first with a “lung” window/level setting (analogous to contrast/brightness) that clearly shows protrusions into the lumen and identifies most typical... Read More
2007-008 – CT colonography (CTC) is being extensively studied for its potential value in colon examinations. Like traditional colonoscopy, CTC requires extensive preparation to cleanse the colon of fecal material. The inconvenience and discomfort associated with this preparation is an important obstacle to compliance with currently recommended colorectal screening guidelines. An alternative is to tag... Read More
2007-007 – This invention consists of a novel display technique for CT colonography data. It is based on automatic generation of a midline trace (centerline) of the colon, followed by display of a sequence of images of the colon that follow this centerline, and display a small field of view centered on it and perpendicular to it. This allows the radiologist the benefit of always seeing the colon in... Read More
2007-006 – This invention consists of a novel display technique for CT colonography data. It is based on automatic generation of a midline trace (centerline) of the colon, followed by display of a sequence of axial images that display a small field of view centered on the trace, and follow along it. This allows the radiologist the benefit of a small field of view to examine the image, but frees him from... Read More
2006-231 – Rabbit polyclonal antibodies were generated to two components of the calcium-release activated calcium (CRAC) channel, Orai1 and STIM1. These antibodies can be used for immunofluorescence, immunoprecipitation and immunoblotting of Orai1 and STIM1.
2006-059 – Peptide or GST-fusion proteins containing antigenic epitopes of WAVE2, Evl, VASP, HS1, STIM, CIN85 and TUBA were used to create polyclonal rabbit antisera. The antibodies are useful for IP, Western blotting and IF.
2005-022 – CT colonography (CTC) offers advantages for colon examinations such as lower risk and less patient discomfort. However, CTC requires complete bowel preparation (cleansing). The inconvenience and discomfort of this process greatly reduces patient compliance and is a major obstacle to widespread colorectal screening. An alternative is to tag the stool with an opacifying agent so that it is... Read More
2005-015 – Software that is able to recognize internal fat within the valve and eliminate it as a diagnostic possibility.
Wild-type Constructs for human sulfotransferase genes: namely SULT 1A1, 1A2, 1A3, 1B1, 1C1, 1C2, 2A1, 4A1, 6B1
2005-012 – Wild-type Constructs for human sulfotransferase genes: namely SULT 1A1, 1A2, 1A3, 1B1, 1C1, 1C2, 2A1, 4A1, 6B1. Encoded by these genes are critical for enzymes, metabolism, activation and also detoxification of numerous drugs and compounds.
In vivo Visualization of Alzheimer's Amyloid Plaques by MRI in Transgenic Mice without a Contrast Agent
2004-139 – One of the cardinal pathologic features of Alzheimer’s disease (AD) is formation of senile or amyloid, plaques. Transgenic mice have been developed that express one or more of the genes responsible for familial AD in humans. Doubly transgenic mice develop “human-like” plaques, providing a mechanism to study amyloid plaque biology in a controlled manner. Imaging of labeled plaques has been... Read More
2004-061 – We have developed a series of polyclonal antibodies specific for SRC-2 and REA steroid receptor coregulators. The affinity purified antibodies have demonstrated a marked specificity of each polyclonal antibody to its specific co-regulator and this has shown to be functional with western blot analysis, co-precipitations, competition with the specific peptide used as an immunogen, and even the... Read More
2004-012 – There are a variety of devices being developed to significantly improve the testing, characterization, and development of differential protocols, equipment, and devices. In essence, these devices provide a way of dealing with differential signals within a laboratory environment.
2003-199 – The invention is an ultra-miniature transceiver technology that allows positioning, data relaying and identification in a very tiny form factor (e.g., “pinhead” size). The transceiver is based on a system-on-a-chip (SOC) design of a radio frequency (RF) transceiver that is combined with a micro-miniature battery and an antenna (or in some cases two antennas). The invention enables... Read More
2002-136 – Rabbit polyclonal antisera were produced against human and murine Vav-3 proteins using KLH-conjuaged peptides. These antisera recognize an approximately 98 kilodalton protein corresponding to Vav3.
2002-025 – Computer software which locates polyps and cancers of the colon on CT colonography data sets.
2001-050 – Device reproducibly positions subject’s upper extremities while allowing measurement of actively generated forearm torque against resisted rotation in variable forearm positions; used with MMV-01-049.
2001-049 – Device reproducibly positions subject’s upper extremities in field of CT imaging system; allows variable positioning of forearm rotation; allows present forearm positions to be maintained and for active force generation by patient to optimize displacement of bones to demonstrate joint instability.
2000-037 – A 3D motion adjustment pulse sequence is interleaved with magnetic resonance image (MRI) acquisition. This motion adjustment pulse sequence encodes all six degrees of rigid body motion in a single 3D spherical k-space dataset and is used to measure patient motion during the scan. The MRI system’s scan parameters are prospectively adjusted during the scan to offset the effects of patient... Read More
2000-013 – The development of a delivery mechanism (pill or capsule) for barium sulfate which is used for the purpose of altering the density of stool sufficiently that it can be electronically subtracted. A new software tool (computer algorithm) for electronic subtraction of contrast-laden stool has been developed.
1998-097 – A method is described that allows both highly sensitive screening for arterial disease in conjuction with highly specific diagnoses on an MR System with high-speed gradients.
1998-060 – A stent that fractures at strategic points to relieve arterial stress after placement.
1995-155 – HFOBER cells are hFOBs stably transfected with human estrogen receptor; subclones HFOB/ER-3 and HFOB/ER-4 express levels of estrogen receptor consistent with the range of levels measured in human osteoblasts. The HFOBER cell lines have a complete concatenation of transcription factors such that the estrogen receptor is transactionally active; estrogen-regulated functions are maintained. The... Read More
1995-087 – The base sequence coding for the protein of the human kappa opioid receptor, the deduced amino acid sequence and the cell line transfected with the gene expressing the protein.
1995-055 – Imaging of Tubular Structures; Systems and methods have been developed for imaging tubular structures in the body using 2D and/or 3D.
1993-058 – Open reading frame gene sequence of the neurotensin receptors from human brain tissue.
1993-010 – Conditionally Immortalized Human Osteoblastic Cell Line: Normal human bone cells were stably transfected with a gene encoding a temperature-sensitive mutant (tsA58) of SV40 large T antigen; cells proliferate as if immortalized at 33.5C degrees but differentiate at 39.5C degrees; hFOB cells show normal bone cell characteristics with regard to responses to dihydroxyvitamin D3 and PTH, BMP’s,... Read More