Susan B. Mikell
New technologies delivered to your inbox Subscribe
1998-039 – Through the use of gene targeting in mouse embryonic stem (ES) cells we have successfully generated a line of mice deficient in eosinophil granule major basic protein-1 (mMBP-1). These mice would be useful in drug discovery programs directed toward developing treatments for asthma, allergy, inflammation and a variety of eosinophil-related disorders. PMID: 11067904
2014-321 – TGR5 antagonist for the treatment of cholangiopathies including polycystic liver disease.
2014-102 – The device harvests a small strip of rectus fascia (1 x 5 cm) by simultaneously dilating the rectus fascial, stapling and then cutting the fascia. The device is small enough to fit through a 3-5 cm lower abdominal incision and articulates to an adjustable angle to account for possible patient obesity.
2014-055 – Exon 41 of LRRK2 is floxed, thus LRRK2 can be removed by cre-mediated deletion. Genotype/Phenotype: homozygous LRRK2loxp/ LRRK2loxp, phenotype would be dependent on which cells express Cre after crossing. Utility: Parkinson’s Disease Research PMID: 22647713
2010-196 – iPhil mouse line permitting inducible loss of eosinophils to study eosinophil-related diseases. Genotype/Phenotype: Inducible ablation of eosinophils is accomplished through expression of the human diptheria toxin receptor exclusively in cells of the eosinophil lineage. Diptheria toxin exposure completely eliminates circulating osinophils without affecting other cell types. Depletion is... Read More
2007-016 – Mouse expressing the human alpha-synuclein gene for the study of Parkinson’s disease. Genotype/Phenotype: These mice express the human alpha-synuclein gene, under the control of its endogenous human promoter and regulatory elements. Genomic multiplication of this locus in humans results in Parkinson’s disease with subsequent dementia, with post-mortem transitional or diffuse Lewy body... Read More
2006-116 – Mice expressing multiple human HLA class II molecules for the study of immune response to bacterial superantigens. Genotype/Phenotype: Mice express multiple varieties of human HLA class II molecules. Utility: Model systems for studying bacterial superantigens. PMID: 16428778 PMID: 18501769 PMID: 18086265
2000-124 – Rat IgG Monoclonal Antibody Reactive Against Murine MBP Major basic protein, Clone 14.7.4 Known Applications: Immunohistochemistry (IHC), Western blot (WB) Known Reactivity: Mouse NIH publication 11067904
Two Stable H4 Neuroglioma Cell Lines Expressing Alpha-synuclein Bioluminescent- and Fluorescent- Protein Complemention Pairs
2013-134 – A plasmid was constructed to contain an FRT cassette, hygromycin resistance, and a tetracycline-driven bidirectional promoter. Then the cDNA encoding alpha-synuclein protein was fused with either the N- or C-terminal half of gaussia luciferase, or with the N- or C-terminal half of Yellow Fluorescent Protein sequences. These fusion constructs were then inserted in the bidirectional plasmid... Read More
2013-107 – The generation of a mouse strain with knockout of B7-H1 gene.
2013-105 – The ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD) compared to the more common ε3 allele. Studies in animal models and humans suggest that apoE4 exhibits both loss-of-function and gain-of-toxic-function compared to apoE3. In regulating amyloid pathology, apoE4 is less efficient than apoE3 in mediating the clearance of... Read More
2012-150 – Patients who develop obstruction in the gastrointestinal track due to inflammatory strictures, or failure of sphincter muscles to relax, are benefitted by relief of that obstruction. Mayo has developed a device to stabilize the position and control length and depth. The device can be used in an lumen (gastrointestinal, vascular, urologic, gynecologic, pulmonary etc).
2012-144 – The knock-in mouse model mimics an incompletely penetrant genetic mutation found in patients with atypical autosomal dominant polycystic kidney disease (ADPKD). The model was established to investigate the pathogenic mechanism of this particular mutation (PKD1 R3277C). As in patients, mice carrying the mutation together with a PKD1 truncating change develop severe, early onset disease,... Read More
2012-093 – Background LRP1 is a ubiquitously expressed receptor that mediates rapid endocytosis of various ligands. By modulating the trafficking of other signaling receptors, LRP1 plays a significant role in the central nervous system and peripheral tissue. It is thought that malfunction of the LRP1-related pathway is a causal factor of cardiovascular and Alzheimer’s disease. Thus, there is tremendous... Read More
2012-084 – A homozygous transgenic mouse model expressing mutant M377V human TDP-43 cDNA encoding the TAR-bindign protein 43kD - 6 fold endogenous levels (Xu et al, Molecular Neurodegeneration, 2011).
2012-051 – The Weighted Deaver Retractor was designed in response to surgeon and patient needs for a more ergonomic and efficient tool to be used during gynecological or urological surgery. The current deaver retractor on the market now requires a surgical assistant to grasp and retract to allow for increased visibility for the surgeon. Presently, the deaver retractor being used today cannot hold... Read More
2012-011 – Scores based on patient reported symptoms (stool frequency and rectal bleeding), endoscopic exam of bowel mucosa and physician review of patient degree of illness severity. A combined score is used to determine severity of symptoms and to assess changes with therapy over time.
2011-076 – pEct2 antibody
2011-075 – This invention includes the development of Inducible transgenic mice expressing human TDP-cDNA encoding the TAR-binding protein 43kD utilizing the MoPrpTta promoter.
2011-074 – This invention includes the development of inducible M17 neuroblastoma cell lines expressing human TDP-43 cDNA encoding the wild type, disease associated mutants, nuclear localization mutant and RNA binding mutant TAR-binding protein 43kD.
2010-222 – This invention covers the design, genetic engineering and construction of the inducible TDP-43 wild-type and D89/219E double mutant constructs utilized to create the iTDP Tg mice.
2010-203 – Reagents to study the biology of the rare human bronchopulmonary carcinoid tumor are very limited. We have created cell lines derived from tumors resected from patients treated at Mayo Clinic. These cell lines will aid investigators to test existing and future medications for efficacy in killing these tumors on the cell lines prior to human studies. These cell lines will aid investigations... Read More
2010-178 – Technology Description We have developed human lung cancer cell lines in which the expression of the PKClota oncogene has been genetically manipulated. Specifically, the cell lines are transduced with rec ombinant lentiviruses that express either a shRNA targeting the PKCiota mRNA or a non-target control shRNA that does not target any known RNA. These cell lines allow one to investigate the... Read More
2009-362 – Background Topoisomerase I has been used as a drug target for cancer treatment. By inhibiting the religation step of the enzyme, the formation of topo I-DNA complexes block the advancing replication complexes, which will ultimately cause cell death. Thus, measurement of the covalent topo I-DNA complexes can potentially be used to assess therapeutic efficacy of topoisomerase I poisons. ... Read More
2009-300 – An endoscopic vessel harvesting device/modification will allow for independent fixation of vessel branches during the harvesting process, and thereby minimizing vessel shrinkage during vessel cauterization. This device/modification will also redirect vessel tension away from the origin of the primary vessel during the harvesting process. This redirection of stress forces along the vessel... Read More
2009-296 – Mouse model of recessive polycystic Kidney Disease (ARPKD)
2009-139 – Technology Description Mayo Clinic researchers have exploited normal blood-brain barrier (BBB) transport mechanisms utilized by apolipoproteins to deliver agents across the BBB and have designed peptides incorporating apolipoprotein LDL receptor binding sequences. These peptides contain additional amino acid sequences to facilitate the binding and delivery of various biological and chemical... Read More
2009-131 – CD2 Binding Agents for Decreasing Suppressive Monocytes in Cancer and Sepsis CD2 binding molecules, such as alefacept, have been shown to deplete immunosuppressive monocytes (e.g., CD14+/DR- or CD14+/DRlow) in patients with lymphoma. Increased levels of immunosuppressive monocytes have been found to be associated with poor prognosis. Continued depletion of immunosuppressive monocytes appeared... Read More
2009-126 – This invention includes the developement of inducible transgenic mice expressing human TDP-43 cDNA encoding the TAR-binding protein 43kD.
2009-125 – This invention includes the development of a homozygous transgenic mouse model expressing wild-type human TDP-43 cDNA encoding the TAR-binding protein 43kD endogenous levels.
2009-107 – A device which allows for rapid cleaning of the colon in preparation for colon examination by an endoscope or other imaging methods such as CT or MR colonography. The device is aimed at facilitating colonic lavage to allow either minimal prep, or no prep prior to colonoscopy.
2008-346 – Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was Fibrillar Abeta 1-42. The antibody is also known as AB42-2.
2008-277 – Anaplastic thyroid carcinoma (ATC) is one of the deadliest cancers with lethality of >99% and survival average of 4 months. Recent publications have demonstrated over 40% of thyroid cell lines are of questionable origin especially ATC cell lines (Schweppe et al., J Clin Endocrinol Metab 2008). We have developed four cell lines from human ATC tumor tissues. These cell lines represent the... Read More
2008-139 – Mouse monoclonal Ab9-A, isotype A of the original Ab9 mouse monoclonal made to human amyloid beta 1-16, was created by class-switching the original Ab9 IgG isotype. This was done with serial dilutions to find the very few clones of isotype A, identifying these clones, and growing them up. Fourteen clones were identified. All are likely to be useful. Only one, 15E7.17.10 (see table), was grown... Read More
2008-126 – Monoclonal antibodies were raised to human Abeta1-42. The peptide used to immunize was Abeta 35-42. This antibody is also known as MM40-21.3.1
2008-084 – Validated bowel disease questionaire
2008-104 – Monoclonal antibodies were raised to rodent Abeta 1-16. The peptide used to immuize was rodent Abeta 1-16. This antibody is also known as MM44-32.4.1
2008-103 – Monoclonal antibodies were raised to human Abeta 1-38. The peptide used to immunize was Abeta 35-40. This antibody is also known as MM43-14.1.1
2008-035 – Mice lacking 53BPI were developed at Mayo to study DNA damage responses and tumor suppression. See Ward et al. (2003) Mol Cell Biol 23(7):2556-2563
2007-330 – We created mice that contain human LRRK2 cDNA encoding either the wild-type or G2019S mutant form of the gene (hereafter termed “responder line(s).” The cDNA in these animals has been placed behind a minimal CMV promoter containing TetO and will only produce human LRRK2 protein when combined (in bigenic mice) with tTA. We have demonstrated in COS7 cells that the human LRRK2 expression from... Read More
2007-288 – Mice in which the endogenous leucine-rich repeat kinase 2 gene (LRRK2) has been ablated. Exon 41 has been flanked with loxP sites to alow Cre-mediated deletion. The region deleted contains the serion/threonine protein kinase catalytic domain. Splicing of exon 40 to 42 causes a frameshift mutation with the introduction of an early stop codon (TGA).
2007-027 – Mice that over-express the human wild-type and mutant leucine-rich repeat kinase 2 gene (LRRK2).
2007-012 – Technology Description The past 20 years have witnessed an unprecedented increase in eosinophil-associated diseases such as allergy, asthma, and inflammatory gastrointestinal syndromes. Despite this rise in the need for an eosinophil-specific assay few reagents are available. Mayo Clinic researchers have developed a unique monoclonal antibody reactive to the eosinophil specific protein... Read More
2006-224 – This is to provide knowledge about the use of neurotensin receptor agonists for treatment of various medical problems, including acute and chronic pain due to various causes and abuse of various types of psychostimulants (such as nicotine, cocaine, and amphetamines).
2006-154 – To increase progranulin in animals, progranulin levels and biologically active fragments of progranulin can be elevated in animals by direct administration of the protein or its fragments, either in the presence or absence of agents that stabilize the biological activity. Routes of delivery include, but are not limited to, intranasal, oral, inhalation, intracerebro-ventricular injection,... Read More
2005-293 – This antibody selectively recognizes the 38 amino acid from the amyloid beta peptide.
2005-247 – MAPT (tau) is a protein involved in regulating the structure and function of nerve cells. The clones contain DNA that encodes the tau protein and allow it to be made in cell lines.
Fluorescent In Situ Hybridization (FISH) Probe Development to Detect Immunoglobulin Light Chains Kapa (IGK) and Lambda (IGL) Translocations
2005-072 – Lymphoma, the cancer to the lymph glands and lymphocytes develop as a consequence of acquired genetic/chromosomal changes. In clinical practice identification of these genetic changes are critical in diagnosis and treatment of lymphoma patient. We have developed fluorescent in situ hybridization (FISH) for two targets frequently involved in lymphoma development. We believe that these probes... Read More
2005-031 – Technology Description HIV infected cells express an HIV protease that cleaves caspase 8 to form a polypeptide (Casp8p41) that is not expressed in uninfected cells. Mayo Clinic researchers have demonstrated that this fragment alone promotes mitochondrial depolarization, cytochrome C release, and cell death, while HIV protease resistant procaspase 8 does not. A Casp8p41-specific antibody has... Read More
Wild-type Constructs for human sulfotransferase genes: namely SULT 1A1, 1A2, 1A3, 1B1, 1C1, 1C2, 2A1, 4A1, 6B1
2005-012 – Wild-type Constructs for human sulfotransferase genes: namely SULT 1A1, 1A2, 1A3, 1B1, 1C1, 1C2, 2A1, 4A1, 6B1. Encoded by these genes are critical for enzymes, metabolism, activation and also detoxification of numerous drugs and compounds.