Tim D. Argo
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2015-311 – Mayo Clinic has discovered that HEATR1 is a novel Akt regulator and a predictor for chemoradioresistance.
2015-312 – Mayo Clinic has discovered that the Parkin protein is a mitotic regulator. Cancer cells with deficiency or mutations in Parkin have an increase in mitotic regulator expression leading to tumorigenesis and an increase in sensitivity of Pk1 and Aurora kinase inhibitors. This newly identified mechanism has revealed that Parkin mutations may be used as a biomarker for measuring the sensitivity of... Read More
2015-164 – Mayo Clinic has discovered that WSB1 can be used as a diagnostic marker for tumor metastasis and a therapeutic target.
2003-132 – Mayo Clinic has patent rights claiming methods of detecting the autoantibody associated with NMO.
2012-062 – Broad patent claims have issued claiming methods for treating renal cell carcinoma by using SCD1 inhibitors and are available for licensing.
"FACS-TB" a Novel Laboratory Method and Biomarker for Detection and Stratification of Latent Tuberculosis Infection
2013-109 – Accurate detection of the latent form of tuberculosis (TB) infection remains a major clinical and public health problem worldwide, which in the United States, disproportionally affects minorities, foreign-born individuals and patients with weak immune defenses (e.g. patients with HIV infection andlor on immunosuppressive medications). We designed and validated a new method that detects... Read More
2012-302 – A 12 gene-panel is described capable of predicting whether an induced pluripotent stem (iPS) cell line will have high or low cardiogenic potential upon in vitro differentiation. By comparing microarray data from high-cardiogenic versus low-cardiogenic lines, a discrete panel of genes was extracted and validated in 18 undifferentiated mouse iPS lines. Using PCR for these 12 genes from... Read More
2012-112 – We have identified abnormalities in the B cell compartment in the circulation of patients with ALS. This abnormality could be used to develop a test to measure the prognosis of patients with ALS or to diagnose patients with different forms of the disease. Additionally, the involvement of B cells in the pathology of ALS will lead treatments that may ameliorate the disease or its symptoms.
2012-004 – What is envisioned is a system of electrochemical and electrical monitoring coupled with directed stimulation to bypass damaged nerve tissue. The combination of information detection, conversion algorithm and programmed stimulation will provide regeneration of the neural commands. Further it is envisioned that a pump can be added to provide neural modular/growth factors to maintain the nerve... Read More
2011-271 – We identified a novel translocation of TP63 gene which encodes p63 protein. The translocation leads to overexpression of a dominant negative TP63 isoform. Dominant negative TP63 isoforms lead to inactivation of p53, the most important tumor suppressor known. The translocation can be useful for diagnosis and subclassification of certain peripheral T cell lymphomas, B-cell lymphomas... Read More
2011-249 – TB-ELISPOT is an optimized Interferon-gamma release assay (IGRA) that accurately detects latent tuberculosis infection (LTBI). This novel TB-ELISPOT method incorporate research-grade technology to enhance antigen-specific activation of T-cells by utilizing co-stimulatory antibodies and best antigen stimulation conditions (48 hrs) in a multiparametric platform that compare specific M.... Read More
2011-245 – Immune responses directed toward many cancers are characterized by targeted cell-killing activities mediated by cytotoxic T cells (a.k.a. Thl responses). However, certain tumors such as bladder cancer, instead appear to elicit immune responses that are traditionally linked with allergies (a.k.a. Th2 responses). These immune responses also include the tissue recruitment of rare white blood... Read More
2011-184 – Methods and Materials for Assessing Responsiveness PARP Inhibitors and Platinating Agents Methods and materials have been developed for assessing responsiveness to PARP inhibitors and platinating agents by using levels of non-homogous end-joining (NHEI) pathway members to determine if cancer cells that are homologous recombination (hr) - deficient are likely to be susceptible or resistant... Read More
Mutations in the KCND3-Encoded Kv4.3 Potassium Ion Channel and Use in Diagnostic Methodologies for the Detection of Sudden Death-Predisposing Cardiac Channelopathies
2011-122 – The present invention details mutations in the KCND3-encoded Kv4.3 potassium ion channel that are associated with sudden death predisposing genetic conditions such as Brugada syndrome (BrS) and long QT syndrome (LQTS) and the mechanism by which at risk individuals can be screend for potentially life threatening mutation isn this gene. This invention is based on the that mutations within the... Read More
2011-060 – A significant hindrance to wound healing in both previously healthy individuals or those with penetrating Crohn’s disease is the presence of “dead space” as a result of pockets of inflammatory or infectious material. Keeping this dead space adequately drained and free from infection/inflammation throughout the healing process is a significant challenge resulting in significant cost and... Read More
2010-333 – A major problem in the area of electrochemistry and fast scan cyclic voltammetry is the occurrence of multiple complex analytes being measured by the fast scan cyclic voltammetry. In this invention, we developed the technique of Double Pulse Voltammetry (DPV) in which very fast scan cyclic voltammetry can be done at various voltages in this case from -0.4 volt to +1.5 volt and back down... Read More
2010-316 – Technology Description C-type natriuretic peptide (CNP) is a 22 amino acid peptide which is primarily produced by endothelial cells and possesses potent antifibrotic and antiproliferative properties. Mayo Clinic researchers have shown that elevated levels of CNP in the urine correlate with renal fibrosis and decline in renal function. In congestive heart failure patients, urinary CNP... Read More
2010-155 – Suppressive Monocytes as Markers of Immune & Therapeutic Responses Mayo Clinic researchers have identified immune phenotypes that can be used to measure the level of systemic immune suppression in patients with cancer and sepsis. Subsets of peripheral blood leukocytes can be measured using standard flow cytometry methods and used as prognostic markers in cancer and sepsis patients. ... Read More
2009-379 – Technology Description Patients with extensive, longstanding inflammatory bowel diseases (ulcerative colitis or Crohn’s disease), which are diseases of chronic colonic inflammation, are at risk for colorectal cancer (CRC). Surveillance of this at-risk population remains challenging. Mayo Clinic researchers have identified biomarkers for colorectal cancer in inflammatory bowel disease... Read More
WINCSWare: Two-way Wireless Communication Between Sensor and Control Unit for Data Aquisition and Selection of Sensing Parameters (Neurochemicals, Time, etc.) and Software for Processing of Incoming Data and Visual Display in Real-Time
2009-106 – Two-way Wireless Communication Between Sensor and Control Unit for Data Acquisition and Selection of Sensing Parameters (Neurochemicals, Time, etc.) and Software for Processing of Incoming Data and Visual Display in Real-Time.
2009-095 – Embolization to the head/brain may occur during cardiac catheterization percutaneous intervention of the coronary arteries a treatment of structural heart disease such as percutaneous aortic valve replacement a treatment of paravalvular leak. This has been the result of embolization of atherosclerosis debris. This current device has several iterations. 1) as expandable filter that can be... Read More
WINCS Hardware & Combination of Amperometry and Voltametry in One System for Measuring Neurochemicals in Real-Time
2009-065 – Emerging evidence supports the hypothesis that modulation of specific central neuronal systems contributes to the clinical efficacy of deep brain and motor cortex stimulation. Real-time monitoring of the neurochemical output of targeted regions may therefore advance functional neurosurgery by, among other goals, providing a strategy for investigation of mechanism, identification of new... Read More
2009-064 – Previous studies had demonstrated the importance of adenosine in the mechanism of Thalamic DBS for Essential Tremor. Real-time monitoring of the neurochemical output of targeted regions may therefore advance functional neurosurgery by, among other goals, providing a strategy for investigation of mechanism, identification of new candidate neurotransmitters, and chemically guided placement of... Read More
2007-295 – To address difficulties in the identification of microsporidia from stool specimens in the clinical diagnostic laboratory, we developed two rapid, real-time PCR assays designed for the LightCycler instrument (Roche Applied Sciences). The LightCycler PCR (LC PCR) assay sensitivities were compared to that of the reference method, a routine smear with trichrome blue stain. Microsporidia DNA is... Read More
2006-295 – Tandem Biomarkers Identifies a Unique Population of Cardiopoietic Stem Cells Biomarkers used to purify a cardiac-specific stem cell population have not previously been reported. This invention reports the discovery of 1) the first cell surface tag that identifies cardiac progenitors from stem cell population and 2) an efficient approach to enrich large quantities of cardiac progenitors for... Read More
2006-104 – Soluble and Extracellular Markers for Early Detection of Prostate Cancer A discriminating panel of genes has been identified that may be used for early detection of prostate cancer. Many of these genes demonstrate prostate-specific expression. Genes encoding extracellular and membrane proteins were selected to facilitate a minimally invasive (e.g. blood sample) form of detection. ... Read More
2006-019 – The invention relates to porous three dimensional structures that may be used to deliver one or more bioactive agents into a location within the body.
2006-018 – Technology Description B7-H4 is a cell surface protein whose expression on tumor cells and tumor-associated vasculature is greatly increased in renal cancers. B7-H4 expression levels on renal tumors have been shown to be a predictor of tumor aggressiveness and to increase mortality rates. B7-H4 is highly expressed on tumors and tumor-associated vasculature but not on normal tissues and... Read More
2005-273 – Methods and materials related to identifying, assessing, and predicting hypertrophic cardiomyopathy (HCM) in mammals.
Decrease of Mitral Regurgitation Severity by Cardiac Resynchronization Therapy as a Novel Method for Treatment of Central Sleep Apnea and/or Left Ventricular Dysfunction
2004-205 – Use of cardiac resynchronization therapy (CRT) as a novel method for treatment of central sleep apnea.
2001-153 – Circulating smooth muscle progenitor cells (SPC) in humans.
2000-100 – PAPSS2 is an enzyme that synthesizes PAPS; the high-energy sulfate donor molecule involved in the sulfate conjugation (metabolism) of thousands of drugs, hormones (estrogen), neurotransmitters (dopamine) and many other macromolecules. Rare inactivating mutations in orthologous PAPSS2 genes have been identified as the genetic causes for human spondyloepimetaphyseal dysplasia and murine... Read More
2000-089 – Analytical/software method to quantitate beat-to-beat non-alternating, chaotic variability in electrical repolarization of the heart. This index (TWLI) indicates the presence of a highly malignant arrhythogenic substrate and may be useful for the identification and primary prevention of sudden cardiac death.
1999-061 – This is a cell therapy delivery system which allows efficient and long term vascular delivery.
1995-102 – Detection with the use of broad range primers and the PCR assay for the detection of the WA-1 Agent.
1994-072 – The invention provides an isolated and purified human DNA molecule that encodes human estrogen sulfotransferase (EST, SULT1E1). It also provides cell lines and vectors containing human estrogen sulfotransferase DNA that can be used to express the enzyme. The enzyme is useful for screening drugs that are metabolized by human estrogen sulfotransferase.