Bruce R. Kline
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2004-222 – Mayo Clinic has patent rights claiming obesity devices.
2004-106 – Mayo Clinic as designed an Endoscopic Pneumatic Assist Device (EPAD) to help patients with weight loss and maintenance. The EPAD technology induces weight loss by creating a physical/obstructive barrier to the passage of nutrients through the pylorus. Additionally, the device induces malabsorption due to the attached optioal malbsorptive sleeve in the proximal small bowel.Finally, the use of... Read More
2013-005 – Mechanical, Time-based, Probiotic Delivery Device.
A Time Dependent Device for Segmental Whole Gut for Lumina & Mucosal Microbial Swab Sampling by Anatomic Location
2012-169 – Swabs from the middle portions of the gastrointestinal tract are currently very difficult to obtain due to the limitations of current techniques such as endoscopy. Understanding the biology of these regions can potentially have a large impact on the overall health of both people and animals through the effect of the GI tract on other parts of the body. Mayo Clinic investigators have... Read More
2012-073 – Erectile dysfunction (ED) is estimated to affect 20-30% of men between the ages of 40-80 years. In cases of medication-resistant ED, surgical treatment, and especially penile prosthesis implantation is the standard of care. Complications of surgery can include neurovascular and urethral injury, and other tissue damage that can contribute to sub-optimal outcomes. A Mayo Clinic investigator... Read More
Photo-Degradable Polycaprolactone Fumarate Block Copolymers: The First Example of Approaches to Nanoporous Biomaterials
2011-242 – Nanoporous materials have numerous applications in nonmedical industries for uses such as membranes, surface patterning, and templates for inorganic materials. These applications have typically used block copolymer (one example is A-B block copolymer) self-assembly, the block copolymers assembly by phase separation of A and B blocks to form nanostructures. Although these types of... Read More
2011-111 – Modulating the Autonomic Nervous System to Treat Hypertension and Heart Failure Mayo Clinic physicians have demonstrated that modulation of the autonomic nervous system can reduce blood pressure and improve symptoms in congestive heart failure (CHF) patients. Afferent nerves originating from skeletal muscle or from the kidneys are blocked to achieve the reduction in blood pressure and the... Read More
2011-097 – Polypropylene fumarate (PPF) is a biodegradable polyester that can be fabricated into any 3-dimensional structure via stereolithography, and implanted to stabilize bone defects while regenerating bone infiltrates, degrades, and ulitimately replaces the PPF scaffold. In order to increase the PPF scaffolds ability to promote bone regeneration the scaffolds were coated with three calcium... Read More
2011-001 – PCLF is currently about to enter clinical trials as a nerve conduit for guiding nerve regeneration across segmental defects. Unlike previous PCLF formulations that lead to the toxic small molecule diethylene glycol in concentrations exceeding the FDA limit, this invention utilizes 1,2 propanediol or glycerol as the initiators for the polymerization of PCL multi-alcohols as necessary for the... Read More
2010-299 – Molecular breast imaging (MBI) is a molecular imaging technique that can be used for the detection of breast cancer. MBI can detect breast tumors not visible on mammography or ultrasound. MBI images usually take 5-10 minutes to acquire 1 view. A slant-hole collimator can be used to estimate tumor depth and enable tumor biopsy using a radiolabeled guide. However, the long imaging time of 5-10... Read More
2010-296 – Communications between electronic components employ one of a number of signaling schemes. Generally, digital communications use one of two classes of signaling schemes: single-ended or differential signaling. A single-ended signaling channel employs transmission of n-level (typically 2-level) signals through a single signal conductor, using a ground or power conductor as the reference for... Read More
Transpulmonary Induction of Therapeutic Hypothermia (In Collaboration with Minnesota High-Tech Resources LLC)
2010-284 – Therapeutic hypothermia is a widely accepted methodology for mitigating injury to vital organs following ischemic insults. Cellular metabolism decreases with lower temperatures and this reduction in metabolism protects metabolically active organs including the heart and brain during episodes of ischemia and hypoxia. Therapeutic hypothermia is currently practiced in association with a number... Read More
2010-177 – Background: The incidence of Barrett’s esophagus and esophageal adenocarcinoma (EAC) is rising in Western nations, and, according to the National Cancer Institute, EAC is the fastest growing form of cancer in the United States. Esophagectomy is standard treatment for Barrett’s esophagus with high grade dysplasia and malignancy. However, due to high morbidity rates associated with... Read More
2010-115 – Photon counting detector technology is being actively adopted for commercial CT. One compelling reason is the advantages that it brings for spectral imaging (multi-energy CT) which allows material characterization using energy information from the detected x-rays. The ability to identify material composition regardless of material density (e.g. distinguishing iodine from bone even though they... Read More
2009-366 – A method and system for producing 3-dimensional ultrasound images of a patient’s breast and also producing planar emission images from a radiopharmaceutical is described. The system allows perfect co-registration of both the ultrasound image and the emission image, thereby allowing comparison of anatomical and functional features of the breast tissue. The system comprises 3 primary components... Read More
2009-314 – This disclosure is for a continuation-in-part to US Patent Application No: US 2006/0056310 A1. The original patent application uses only a symmetrical THRU structure for de-embedding. In this disclosure both OPEN and SHORT structures are presented as additional structures that, once measured with a VNA, can yield additional equations.
2009-274 – System for Minimally Invasive Local Drug Delivery Local drug delivery is a useful approach to deliver much higher concentrations of a drug to a target site while minimizing systemic side effects. Drug-eluting polymers can be delivered via local injection to deliver drug over an extended period of time. Current systems for local drug delivery have two long-standing challenges: local injections... Read More
2009-264 – Conventionally, nuclear medicine gamma cameras employ an energy window centered in the primary gamma ray energy emitted by the radioisotope being detected. For example, with Tc-99m, a 20% energy window (from 126-154 keV) is centered on the 140 keV gamma rays. At lower energies, scatter within the patient and the gamma camera degrade image quality and these events are not considered useful. ... Read More
2009-246 – In a communication system consisting of multiple nodes, optical interconnects and wave-division multiplexing (WDM), this can be used to broadcast the data stream from any one node-receivers using a broadcast element such as a star coupler. “All-in-all” or “many-to-all” nodes can thus be connected for high speed data transfer. At any receiver node, the optical signal contains all of the... Read More
2009-234 – High Speed serializer/de-serializer (SerDes) paths are rapidly replacing slower local communication paths in digital systems. Engineers must accurately model the SerDes electrical interconnect paths (channels). An important structure used in many channels is loosely described as a “pin-field”. We have developed software which automatically creates these pin-field models for input into... Read More
2009-202 – Bacterial infection continues to negatively affect outcomes for orthopedic patients despite heightened awareness and increased technologies. Infections at the shoulder may be three times more prevalent than at the knee or hip and is recognized as a considerable clinical problem. The shoulder represents a significant challenge for infection prevention: bacteria contamination of the skin... Read More
Peritrode Minimally Invasive Cirmcumferential Peripheral Nerve Stimulation Electrode, Anchoring System and Placement Assist Device
2009-175 – An eight contact electrode placed “through the needle"via ultrasound visual guidance. The electrode is able to pass under a target nerve and curve over and reside circumferentially around the nerve in a "cuff” configuration thus facilitating efficient pain management.
2009-104 – Proximal migration of biliary stents can lead to difficult and time consuming endoscopic removal procedures. Separately, while the use of prophylactic pancreatic stents may be increasing due to potentially decreased risk of pancreatitis, endoscopic procedures are often required to facilitate stent removal. Design features to improve spontaneous stent removal and ease retrieval have been... Read More
2009-078 – This write-up describes a wearable electronic device, referred to as a “Biomedical Platform”, with the capability of collecting and storing within its own structure and data collected from biomedical sensors attached to a human volunteer or patient (or, in appropriate circumstances, on an experimental animal). The unit is “sensor-agnostic”, in that it can collect data from analog sensors... Read More
2009-055 – Hydogels have wide applications in the biomedical field due to their ability to absorb incredible amounts of aqueous solutions and support cell viability. One particular application hydrogels are being investigated for is nerveguidance conduits to direct and stimulate nerve regeneration by supporting cell growth while simulatanously delivering biologically active molecules. Incorporation of... Read More
2008-380 – A novel electrically conductive polymer composite composed of polycaprolactone fumarate- polypyrrole (PCLF-PPy) for applications in nerve regeneration is disclosed. The synthesis and characterization of PCLF-PPy and in vitro studies showing PCLF-PPy supports both PC12 cell and dorsal root ganglia neurite extension. PCLF-PPy composite materials were synthesized by polymerizing pyrrole in... Read More
2008-317 – A novel electrically conductive polymer composite composed of polycaprolactone fumarate- polypyrrole (PCLF-PPy) for applications in nerve regeneration is disclosed. The synthesis and characterization of PCLF-PPy and in vitro studies showing PCLF-PPy supports both PC12 cell and dorsal root ganglia neurite extension. PCLF-PPy composite materials were synthesized by polymerizing pyrrole in... Read More
2008-292 – Guiding catheters must be of sufficient stiffness to offer support during endovascular procedures, but must not be too stiff to track to their intended target. We describe a system with a relatively supple catheter that has a separate lumens or lumens within its walls, which do not communicate with the main, working lumen. The extra lumens can be used to place stiffening wires after the... Read More
2008-202 – Balloons are used to create cavities in bones for several applications, including cement injection. Current design features include initial placement of a cannula into the bone, through which the balloon is inserted. An alternative design would be to mount the balloon on the outside of the cannula itself, such that the balloon could simply be inflated once the cannula reaches its intended... Read More
2008-214 – The present invention is a circuit block used to condition and sample a variety of electrical signals in characterization and system applications. The internal passive circuitry eases characterization of high-speed differential and single-ended applications by providing impedance-matched environment and integrating unique capabilities such as true differential termination, pass-through... Read More
2008-079 – The antibiotic impregnated cement spacer replaces a shoulder arthroplasty that has been removed due to infection. There are several advantages: provides antibiotic release locally, facilitates revision surgery by maintaining joint space, allows for immediate motion, and provides faster recovery. There is only one shoulder spacer in the market, and it does not have a variety of sizes and does... Read More
2008-039 – This optical edge connector is designed to meet future board-to-board optical interconnect requirements of orthogonally connected optical printed circuit boards that contain embedded optical communication channels, typically utilized for High Performance Compute Systems. The orthogonal implementation of this design is not found in any commercially available optical connectors. The design... Read More
2007-334 – In accordance with the present invention, there is provided a device (e-pill) and technology for delivery, sensing and monitoring an exercise program that is prescribed by a health worker (or any person interested in health) to a patient (some-one with a disease or propensity for a disease that can be helped by exercise) or any person interested in completing a prescribed program for... Read More
2007-216 – An adaptive circuit that compensates for phase skew between the true and complement sides of a differential signal.
2007-154 – This invention is a technique that enables two or four port vector network analyzers (VNAs) to be probe-tip calibrated and used in applications such as automated test equipment . “Calibration” is understood to include a range of things described in more detail below. The technique complements (but is independent of) many industry¬wide standard probe-tip calibration methods such as... Read More
Rapid Electrical Link Analysis Technique for Simulating Electrical Signals Through Transmission Media Characterized by Scattering Parameters
2007-135 – This technique is a software program which permits very rapid simulation of electrical signals through passive transmission or any other interconnect characterized by scattering parameters (S-parameters). An unlimited number of 2-port and 4-port passive interconnect models are combined into a single interconnect using proper S-parameter cascading. External transient voltage waveforms... Read More
2007-132 – The test system will automate multi-port VNA S-parameters measurements of printed wiring boards (PWB). The information gathered is automatically evaluated against complex pass/fail criteria and used to grade the signal integrity quality of PWBs.
2006-245 – This differential test probe was designed to meet the requirements of an automated test system. It has features not found in commercially available test probes. The ruggedness, compliance of all test pins, and the versatility to test more than one signal/ground pattern makes it useful for the automated test system. The mounting of micro probing pins directly in the center of the signal... Read More
2005-318 – Mayo Clinic Researchers have created a positively charged hydrogel for controlled DNA delivery for cell transplantation. Oligo- (polyethylene glycol) fumarate (OPF) hydrogel was copolymerized with 2-(methacryloyloxy) ethyl-trimethylammonium chloride (MAETAC) to produce a positively charged hydrogel. This hydrogel can be crosslinked with multiple systems and fabricated into sheets, sponges,... Read More
Hydrophilic/hydrophobic Hybrid Polymer Networks Based on Poly(caprolactone fumarate) (PCLF), Poly(Ethylene Glycol Fumarate) (PEGF), and PEGF-co-PCLF
2005-077 – We have developed a new route to synthesize the biodegradeable and injectable polymer poly(ethylene glycol fumarate) (PEGF) and its copolymer with Poly (caprolactone fumarate) (PCLF), PEGF-co-PCLF. These materials can be crosslinked with other unsaturated polymers via redox- or photo-initiation to form hybrid polymer networks. Characteristics of these hybrid networks, such as... Read More
Self-Contained Semi-Active Cooling Mechanism for Very High Power Density Integrated Circuits and Electronic Modules Using a Reversible Endothermic Chemical Reaction
2005-026 – This invention is a completely self-contained and encapsulated “package” into which a high power integrated circuit (“chip”) such as an amplifier, or an entire subsystem (such as a radar “transmit-receive” module), can be installed to provide the necessary thermal and electrical environment to assure that the chip or multi-chip subsystem works correctly. The packaging approach not only... Read More
2005-021 – Injectable, biodegradable oligo(poly(ethylene glycol) fumarate) (OPF) hydrogels were made from photopolymerization of OPF macromer with UV light and photoinitiator. Hydrogels with varying mechanical property and water content can be made with the change in macromer and crosslinking agent concentration in precursor solution. The biodegradable OPF hydrogels can be injected as fluid into the... Read More
2004-286 – This invention is a completely self-contained and encapsulated “package” into which a high power integrated circuit (“chip”) such as an amplifier, or an entire subsystem (such as a radar “transmit-receive” module), can be installed to provide the necessary thermal and electrical environment to assure that the chip or multi-chip subsystem works correctly. The packaging approach not only... Read More
2004-258 – Mayo Clinic Researchers have developed a new synthetic, biodegradable, injectable polymer, poly (epsilon-caprolactone fumarate) that is also photocrosslinkable. This new material is colorless or light-colored, and is shown to be self-crosslinkable by both redox initiation and photoinitiation. The molecular weight, chain flexibility, crystallinity, degradation rate, and mechanical properties... Read More
2004-231 – The present invention details a substantial implementation improvement for a broad class of Direct Digital Synthesizers (DDSs). A DDS synthesizes a predetermined waveform via digital (i.e., sampled) methods. Typically, the output waveforms are based on sinusoidal functions. For example, a DDS may generate sine waves of various frequency (under digital control). Chirp waveforms (which are... Read More
2004-200 – Mayo Clinic Researchers have developed a new synthetic, biodegradable, injectable polymer, poly (propylene fumarate-co-caprolactone) [P(PF-co-CL)]. This new material is a block copolymer of poly (propylene fumarate) (PPF) and poly (epsilon caprolactone) (PCL). The molecular weight, mechanical strength, chain flexibility, degradation rate, and crystallinity can be controlled by varying the... Read More
2004-085 – Tissue engineering scaffolds are biomimetic “trellis-like” structures which, on implantation and integration, act as tissue/organ surrogates. This disclosure enables the construction of multi-resolution, variably-refineable, globally interconnected, monolithic and maximally porous scaffolds.
2004-084 – Tissue engineering attempts to address the widening gap between the demand and supply of organ and tissue transplants using natural and biomimetic scaffolds. This invention provides a method to enable the repeatable and rapid fabrication of structurally and functionally enhanced and maximally characterized traditional scaffolds.
2004-012 – There are a variety of devices being developed to significantly improve the testing, characterization, and development of differential protocols, equipment, and devices. In essence, these devices provide a way of dealing with differential signals within a laboratory environment.
2003-199 – The invention is an ultra-miniature transceiver technology that allows positioning, data relaying and identification in a very tiny form factor (e.g., “pinhead” size). The transceiver is based on a system-on-a-chip (SOC) design of a radio frequency (RF) transceiver that is combined with a micro-miniature battery and an antenna (or in some cases two antennas). The invention enables... Read More