2017-235 – Mayo Clinic has discovered that novel STAT3 inhibitors would potentially be a therapeutic treatment in pediatric tumor Diffuse Intrinsic Pontine Glioma (DIPG). Novel STAT3 inhibitors selectively killed tumor cells found in DIPG.
2017-036 – Mayo Clinic has discovered that inhibition of stearoyl-CoA desaturase 1, SCD1 - a key enzyme fatty acid metabolism, in combination with PD1/PD-L1 inhibition enhances T cell based cancer immunotherapy.
2017-176 – Mayo Clinic has discovered that novel SCD1 inhibitors can be used to treat liver cancer.
2016-386 – Mayo Clinic has discovered the UFM1 signaling pathway as a biomarker/therapeutic target in cancer. UFM1 is an Ub-like molecule needed for ATM activation and DNA damage response. Inhibiting the pathway could sensitize cancer cells to radiation and chemotherapy.