2013-288 – The balance between bone loss and deposition is important for normal bone growth and remodeling, and depends on a complex interplay between the resident bone cells: osteoclasts, osteoblasts, and osteocytes. Here we show enhanced cellular production of prostacyclin and increased intra-cellular concentrations of prostacyclin synthase in osteocytes derived from sclerostin knockout mice.... Read More
2011-226 – The segmental loss of peripheral nerve may result from open or closed extremity trauma, resection of benign or malignant primary nerve tumors, or limb-sparing tumor surgery. Currently available reconstructive options include vascularized and conventional (nonvascularised) nerve autografts, nerve conduits from a variety of materials, nerve allografts and nerve transfer. Of these, autografting... Read More
Synthesis of Poly (caprolactone-fumarate) Polymer as a Novel Biocompatible, Bioresorbable, Injectable, and In-situ Hardening Scaffold for Tissue Engineering Applications
2003-044 – Mayo Clinic researchers have created a biocompatible and bioresorbable PCF material for injectable and in-situ scaffolds by polymerizing a PCF macromer with a salt of fumaric acid that self-crosslinks.
2002-226 – Our invention is the use biological, pharmacological or saccharide intervention, genetic modification or selection, for antagonist or modulation of Toll-like receptor 4 (TLR4) or other TLRs for the increase and/or maintenance of bone density, osteoporosis, Paget’s disease, or any disease or condition in which bone loss is a factor.
2002-068 – Mayo Clinic researchers have created microspheres between 1-300 micrometers comprising a blend of cross-linkable PPF for the immobilized controlled release of any bioactive agent.
1997-001 – With the aging of the population, osteoporosis is emerging as a major public health problem. Drugs used to treat osteoporosis can be classified into those that decrease bone resorption and those that increase bone formation. While a number of anti-resorptive therapies for osteoporosis are presently available, there is a clear need for novel anabolic approaches. New insights gained from a... Read More