2013-288 – The balance between bone loss and deposition is important for normal bone growth and remodeling, and depends on a complex interplay between the resident bone cells: osteoclasts, osteoblasts, and osteocytes. Here we show enhanced cellular production of prostacyclin and increased intra-cellular concentrations of prostacyclin synthase in osteocytes derived from sclerostin knockout mice.... Read More
2011-226 – The segmental loss of peripheral nerve may result from open or closed extremity trauma, resection of benign or malignant primary nerve tumors, or limb-sparing tumor surgery. Currently available reconstructive options include vascularized and conventional (nonvascularised) nerve autografts, nerve conduits from a variety of materials, nerve allografts and nerve transfer. Of these, autografting... Read More
A Novel Simple Scoring System to Predict the Risk of Prosthetic Joint Infection, the Mayo PJI Risk Score
2011-141 – A list of risk factors have been identified for patients undergoing prosthetic joint infections that has been statistically weighted to develop a novel scoring system that has a strong prognostic ability for determining the risk of patients developing postsurgical prosthetic joint infection. The scores could be used potentially as guides for prophylactic infection control and patient... Read More
Synthesis of Poly (caprolactone-fumarate) Polymer as a Novel Biocompatible, Bioresorbable, Injectable, and In-situ Hardening Scaffold for Tissue Engineering Applications
2003-044 – Mayo Clinic researchers have created a biocompatible and bioresorbable PCF material for injectable and in-situ scaffolds by polymerizing a PCF macromer with a salt of fumaric acid that self-crosslinks.
2002-226 – Our invention is the use biological, pharmacological or saccharide intervention, genetic modification or selection, for antagonist or modulation of Toll-like receptor 4 (TLR4) or other TLRs for the increase and/or maintenance of bone density, osteoporosis, Paget’s disease, or any disease or condition in which bone loss is a factor.
2002-068 – Mayo Clinic researchers have created microspheres between 1-300 micrometers comprising a blend of cross-linkable PPF for the immobilized controlled release of any bioactive agent.
1997-001 – With the aging of the population, osteoporosis is emerging as a major public health problem. Drugs used to treat osteoporosis can be classified into those that decrease bone resorption and those that increase bone formation. While a number of anti-resorptive therapies for osteoporosis are presently available, there is a clear need for novel anabolic approaches. New insights gained from a... Read More