2014-321 – TGR5 antagonist for the treatment of cholangiopathies including polycystic liver disease.
2012-073 – Erectile dysfunction (ED) is estimated to affect 20-30% of men between the ages of 40-80 years. In cases of medication-resistant ED, surgical treatment, and especially penile prosthesis implantation is the standard of care. Complications of surgery can include neurovascular and urethral injury, and other tissue damage that can contribute to sub-optimal outcomes. A Mayo Clinic investigator... Read More
2011-273 – Urinary incontinence or loss of bladder control affects millions of people worldwide. An artificial urinary sphincter is one treatment option to restore continence. The basic design of the current artificial urinary sphincter was introduced in the 1980’s and has 3 separate components implanted at 3 separate surgical locations. Mechanical failure or complications often lead to revision or... Read More
2011-271 – We identified a novel translocation of TP63 gene which encodes p63 protein. The translocation leads to overexpression of a dominant negative TP63 isoform. Dominant negative TP63 isoforms lead to inactivation of p53, the most important tumor suppressor known. The translocation can be useful for diagnosis and subclassification of certain peripheral T cell lymphomas, B-cell lymphomas... Read More