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2013-157 – Application Enhance transduction and transgene expression of Adeno-associated virus (AAV) vectors using U2 snRNP spliceosome inhibitors Value Proposition AAV has become one of the leading gene delivery vectors in clinical development. Gene therapy using recombinant AAV has been demonstrated to be safe and well-tolerated in virtually every clinical setting in which it has been used.... Read More
2004-222 – Mayo Clinic has patent rights claiming obesity devices.
2004-106 – Mayo Clinic as designed an Endoscopic Pneumatic Assist Device (EPAD) to help patients with weight loss and maintenance. The EPAD technology induces weight loss by creating a physical/obstructive barrier to the passage of nutrients through the pylorus. Additionally, the device induces malabsorption due to the attached optioal malbsorptive sleeve in the proximal small bowel.Finally, the use of... Read More
2014-102 – The device harvests a small strip of rectus fascia (1 x 5 cm) by simultaneously dilating the rectus fascial, stapling and then cutting the fascia. The device is small enough to fit through a 3-5 cm lower abdominal incision and articulates to an adjustable angle to account for possible patient obesity.
2008-229 – Computer input devices are claimed for use in manipulating digital images on a display apparatus in, for example, medical diagnostics. A computer input device as claimed may be particularly useful for manipulation of one or more digital images such as, for example, digital histological images, including but not limited to images of a microscopic tissue section. Manipulation of digital... Read More
2014-268 – Spinal instrumentation surgeries can often include the use of one or more pedicle screws. The pedicle screws are typically cancellous bone screws and can sustain high loads, which may render them susceptible to failure by loosening or pullout. Various devices and methods have been developed for locking or fixating pedicle screws; however, most of these devices and methods include complicated... Read More
2013-099 – Immobilization board that would be positioned under patient’s pelvis. This would allow radiation therapist to tilt pelvis when aligning patient for treatment.
2013-056 – The invention is a method to prepare hydroxamate resin for use in metal ion separations.
2013-014 – Laparoscopic Bowel Retractor for Intra-Abdominal Surgical Exposure. Development of a device that has an ease of operation and keeps the bowel away from the surgical area.
2013-005 – Mechanical, Time-based, Probiotic Delivery Device.
2012-206 – This novel digital exam camera (DEC) will allow for visualization in multiple orifices or cavities such as rectum, vagina, wounds, oropharynx, ears, nasal cavity, etc.
2012-182 – Lung cancer is the leading couse of cancer deaths in the United States. Lobectomy is the gold standard extent of resection for most lung cancers, but some patients are poor candidates for lobectomy due to poor pulmonary health/function and/or other comorbities. Sublobar resection, the removal of less than a lobe of the lung, is a compromise procedure for these patients in that it allows for... Read More
A Time Dependent Device for Segmental Whole Gut for Lumina & Mucosal Microbial Swab Sampling by Anatomic Location
2012-169 – Swabs from the middle portions of the gastrointestinal tract are currently very difficult to obtain due to the limitations of current techniques such as endoscopy. Understanding the biology of these regions can potentially have a large impact on the overall health of both people and animals through the effect of the GI tract on other parts of the body. Mayo Clinic investigators have... Read More
2012-150 – Patients who develop obstruction in the gastrointestinal track due to inflammatory strictures, or failure of sphincter muscles to relax, are benefitted by relief of that obstruction. Mayo has developed a device to stabilize the position and control length and depth. The device can be used in an lumen (gastrointestinal, vascular, urologic, gynecologic, pulmonary etc).
2012-136 – A patient’s heart rate, systolic blood pressure, Braden Skin Scale (a nursing assessment), arterial oxygen saturation, and respiratory rate are entered into a simple mathematical equation that calculates the patient’s risk of having cardiac arrest, emergency transfer to the ICU, or Rapid Response Team activation in the next 2-12 hours. The calculation is made every time any one of those... Read More
2012-134 – Shear wave produced by a focused ultrasound beam is used to evaluate tissue visco-elasticity, which are sensitive biomarkers of pathology. Shear waves thus produced are weak and attenuate quickly when propagating away from the push origin. We have proposed a method called CUSE where multiple unfocused push beams spaced out like a comb are used for shear wave production. Every pixel under... Read More
2012-073 – Erectile dysfunction (ED) is estimated to affect 20-30% of men between the ages of 40-80 years. In cases of medication-resistant ED, surgical treatment, and especially penile prosthesis implantation is the standard of care. Complications of surgery can include neurovascular and urethral injury, and other tissue damage that can contribute to sub-optimal outcomes. A Mayo Clinic investigator... Read More
2012-070 – Extraction of chronically implanted leads from pacemakers and defibrillators is difficult because the leads become scarred into position. Several tools are being developed to separate leads from scar tissue. However, a major challenge is the inability to “grip” or “grab” the lead to apply traction for removal. Proximal traction results in the lead uncoiling, as leads do not accommodate... Read More
2012-057 – Shear wave is used to evaluate tissue visco-elasticity, which are sensitive biomarkers of pathology. In order to obtain a 2D ultrasound elastography, an ultrafast imager with a FRAME rate of several kHz is required to capture the fast moving shear waves. This is not feasible with traditional ultrasound imagers with a frame rate of less than 100 Hz where 2D images are formed LINE BY LINE. ... Read More
2012-051 – The Weighted Deaver Retractor was designed in response to surgeon and patient needs for a more ergonomic and efficient tool to be used during gynecological or urological surgery. The current deaver retractor on the market now requires a surgical assistant to grasp and retract to allow for increased visibility for the surgeon. Presently, the deaver retractor being used today cannot hold... Read More
2012-004 – What is envisioned is a system of electrochemical and electrical monitoring coupled with directed stimulation to bypass damaged nerve tissue. The combination of information detection, conversion algorithm and programmed stimulation will provide regeneration of the neural commands. Further it is envisioned that a pump can be added to provide neural modular/growth factors to maintain the nerve... Read More
2011-274 – The invention uses ultrasound to measure the nonlinear mechanical properties of an object including those of biological tissues. This information can be used to detect abnormalities in tissues.
2011-267 – Ink filled disk placed on patient at time of simulation (CT). Used to help mark and guide needle to give permanent tattoo.
Photo-Degradable Polycaprolactone Fumarate Block Copolymers: The First Example of Approaches to Nanoporous Biomaterials
2011-242 – Nanoporous materials have numerous applications in nonmedical industries for uses such as membranes, surface patterning, and templates for inorganic materials. These applications have typically used block copolymer (one example is A-B block copolymer) self-assembly, the block copolymers assembly by phase separation of A and B blocks to form nanostructures. Although these types of... Read More
2011-226 – The segmental loss of peripheral nerve may result from open or closed extremity trauma, resection of benign or malignant primary nerve tumors, or limb-sparing tumor surgery. Currently available reconstructive options include vascularized and conventional (nonvascularised) nerve autografts, nerve conduits from a variety of materials, nerve allografts and nerve transfer. Of these, autografting... Read More
2011-210 – Multiple short-duration ultrasound push pulses are used to deform tissue. The duration and PRF (Pulse Repetition Frequency) of these push pulses are compatible with current ultrasound scanners because these pulses are comparable to Doppler pulses. The collective effect from many push pulses generates shear waves of high amplitude for elasticity imaging. Two shear waves are produced: one at... Read More
2011-197 – Many attempts have been made to replace circumferential segments of the esophagus with tubular prostheses of various materials, but experimental and clinical trials have not been successful due to frequent complications. An artificial esophageal replacement device which aims to overcome the problems of the previous attempts. Development of viable esophageal replacement would dramatically... Read More
2011-188 – Ileostomy or colostomy are common permanent bowel procedures performed for inflammatory disease, trauma, or cancer. The development of an internal reservoir, obviating the need for an external appliance, has been hampered by the need for an interface between living tissue and the device. The invention disclosed herein is an adaptation of a floating ball valve. Within the bowel lumen lies a... Read More
2011-111 – Modulating the Autonomic Nervous System to Treat Hypertension and Heart Failure Mayo Clinic physicians have demonstrated that modulation of the autonomic nervous system can reduce blood pressure and improve symptoms in congestive heart failure (CHF) patients. Afferent nerves originating from skeletal muscle or from the kidneys are blocked to achieve the reduction in blood pressure and the... Read More
2011-104 – Ileostomy patients with highly liquid effluent can experience high frequency emptying requirements that can be inconvenient to patients. This invention is a dual chamber ostomy pouch with the chambers separated by a filter. The filter allows water to pass into the second chamber while containing solid waste in the first chamber. The chambers can have separate drain valves allowing them to be... Read More
2011-097 – Polypropylene fumarate (PPF) is a biodegradable polyester that can be fabricated into any 3-dimensional structure via stereolithography, and implanted to stabilize bone defects while regenerating bone infiltrates, degrades, and ulitimately replaces the PPF scaffold. In order to increase the PPF scaffolds ability to promote bone regeneration the scaffolds were coated with three calcium... Read More
2011-060 – A significant hindrance to wound healing in both previously healthy individuals or those with penetrating Crohn’s disease is the presence of “dead space” as a result of pockets of inflammatory or infectious material. Keeping this dead space adequately drained and free from infection/inflammation throughout the healing process is a significant challenge resulting in significant cost and... Read More
2011-026 – Propagation of shear wave (e.g., frequency dependent propagation speed and attenuation) in tissues is determined by mechanical properties of tissues. In ultrasound elasticity imaging, focused ultrasound beams are used to generate and detect shear waves in tissues. The 3D shape of the ultrasound beam can artificially increase measured shear wave speed in the transducer near field and... Read More
2011-002 – Nonfocused ultrasound waves are produced by merely transmitting long tonebursts on each of several elements in a linear or curved or phased array. This produces an unfocused beam. Shearwave can be imaged by beams from a two-dimensional array if a shearwave is produced in a rectangular section, then the shearwaves can propagate away from the rectangular section and can be imaged. The effect... Read More
2011-001 – PCLF is currently about to enter clinical trials as a nerve conduit for guiding nerve regeneration across segmental defects. Unlike previous PCLF formulations that lead to the toxic small molecule diethylene glycol in concentrations exceeding the FDA limit, this invention utilizes 1,2 propanediol or glycerol as the initiators for the polymerization of PCL multi-alcohols as necessary for the... Read More
2010-299 – Molecular breast imaging (MBI) is a molecular imaging technique that can be used for the detection of breast cancer. MBI can detect breast tumors not visible on mammography or ultrasound. MBI images usually take 5-10 minutes to acquire 1 view. A slant-hole collimator can be used to estimate tumor depth and enable tumor biopsy using a radiolabeled guide. However, the long imaging time of 5-10... Read More
2010-294 – In laparoscopic radical prostatectomy (RP), the pedicle is transected, but care must be taken to preserve the adjacent neurovascular bundle. Electrocautery or other hemostatic energy sources are not used due to concerns over collateral thermal damage, adhesives or sutures alone have not been shown to provide reliable hemostatis, and existing clips can be difficult to place and adjust. A... Read More
Transpulmonary Induction of Therapeutic Hypothermia (In Collaboration with Minnesota High-Tech Resources LLC)
2010-284 – Therapeutic hypothermia is a widely accepted methodology for mitigating injury to vital organs following ischemic insults. Cellular metabolism decreases with lower temperatures and this reduction in metabolism protects metabolically active organs including the heart and brain during episodes of ischemia and hypoxia. Therapeutic hypothermia is currently practiced in association with a number... Read More
2010-238 – There is a need for an inexpensive, small laparoscopic scope holder that would allow for maximum flexibility and rapid position changes. We have designed a small manually adjustable holder that can be disposable or reusable (on a limited basis). This device sits at the abdominal opening and remains stable by means of adhesive tape at the lower rim. There are no robotic mounts or arms holding... Read More
2010-233 – The inner ear vestibular system reflexively controls eye position in the orbits. For example, when the head is tilted to the side (ear moved toward the shoulder) the eyes roll in the opposite direction so that they stay oriented to the horizon. This eye movement is called head tilt induced ocular counter roll and is mediated in part by the otolith organs of the vascular system. Damage to... Read More
2010-220 – Radiation therapy treatment is used in nearly two-thirds of all cancer patients. Accurate targeting of the tumor over the treatment period is critical to effective therapy. Placement of permanent tattoos is the current standard practice to aid in the alignment and targeting of radiation therapy over multiple treatments. Existing tattoo methods involve the use of freehand needle sticks,... Read More
2010-184 – Although anterior cervical fusion is one of the most commonly performed spine procedures in the world, adequate retraction and plate placement remains difficult. A Mayo inventor has created an anterior cervical retractor that minimizes its displacement, prevents tissue creep into the surgical field, does not need to be repositioned in multilevel cases, and eases the application of an... Read More
2010-177 – Background: The incidence of Barrett’s esophagus and esophageal adenocarcinoma (EAC) is rising in Western nations, and, according to the National Cancer Institute, EAC is the fastest growing form of cancer in the United States. Esophagectomy is standard treatment for Barrett’s esophagus with high grade dysplasia and malignancy. However, due to high morbidity rates associated with... Read More
2010-168 – The caloric test is commonly used as an assessment of vestibular function. The test entails delivering air or water into the external ear canal at varying temperatures, thereby stimulating vestibular labyrinthine responses. Historically, water has been the preferred stimulus for the caloric test. However, pumping air into the external canal is more convenient and is increasingly popular in... Read More
2010-157 – Transoral robotic surgery (TORS) offers potential advantages and benefits over other current treatment modalities in surgical procedures of the head and neck, but in some patients, inadequate exposure to target tissues reduces the number of cases that can be performed by this method. Transoral retractors are used to provide access to a patient’s oral cavity and larynx during these procedures,... Read More
2010-152 – A device and method for MRI in-scanner imaging of chronic exertional compartment syndrome (CECS) of the lower legs has been developed and validated.
2010-108 – SDUV is a non-invasive ultrasound technology that can qualify tissue stiffness and viscosity, which are sensitive indexes of pathology such as liver fibrosis. SDUV uses one long push toneburst of ultrasound followed by multiple detect pulses to generate and detect shear waves in tissue. Shear wave propagation information is used to estimate tissue stiffness and viscosity. The push-detect... Read More
2010-061 – Calcific aortic valve stenosis is a growing problem in developed countries, and valve replacement surgery is the second most common thoracic surgery performed worldwide (>100,000 procedures performed in the US in 2008). Bioprosthetic valves are the most commonly used devices to replace the stenotic valve, but only have a projected lifespan of 10-12 years. Cells infiltrating the... Read More
2010-054 – Transapical access is being performed increasingly for treatment for a variety of structural heart diseases. In the past, that has been done through a small mini thoracotomy. However, a percutaneous approach is being studied and will be an important means of optimizing and enhancing care of patients. Such a percutaneous transapical approach will need to have a means to percutaneously close... Read More
2010-032 – A method for producing tissue motion with customized frequency content is described in which push pulses are designed using orthogonal basis functions which then produce desired tissue motion. The push pulses can be a sequence of long duration, in which case motion detection A-lines can be interleaved among the pulses. The result is a more efficient method of making tissue move with optimal... Read More