2014-268 – Spinal instrumentation surgeries can often include the use of one or more pedicle screws. The pedicle screws are typically cancellous bone screws and can sustain high loads, which may render them susceptible to failure by loosening or pullout. Various devices and methods have been developed for locking or fixating pedicle screws; however, most of these devices and methods include complicated... Read More
Photo-Degradable Polycaprolactone Fumarate Block Copolymers: The First Example of Approaches to Nanoporous Biomaterials
2011-242 – Nanoporous materials have numerous applications in nonmedical industries for uses such as membranes, surface patterning, and templates for inorganic materials. These applications have typically used block copolymer (one example is A-B block copolymer) self-assembly, the block copolymers assembly by phase separation of A and B blocks to form nanostructures. Although these types of... Read More
2011-226 – The segmental loss of peripheral nerve may result from open or closed extremity trauma, resection of benign or malignant primary nerve tumors, or limb-sparing tumor surgery. Currently available reconstructive options include vascularized and conventional (nonvascularised) nerve autografts, nerve conduits from a variety of materials, nerve allografts and nerve transfer. Of these, autografting... Read More
2011-097 – Polypropylene fumarate (PPF) is a biodegradable polyester that can be fabricated into any 3-dimensional structure via stereolithography, and implanted to stabilize bone defects while regenerating bone infiltrates, degrades, and ulitimately replaces the PPF scaffold. In order to increase the PPF scaffolds ability to promote bone regeneration the scaffolds were coated with three calcium... Read More
2011-001 – PCLF is currently about to enter clinical trials as a nerve conduit for guiding nerve regeneration across segmental defects. Unlike previous PCLF formulations that lead to the toxic small molecule diethylene glycol in concentrations exceeding the FDA limit, this invention utilizes 1,2 propanediol or glycerol as the initiators for the polymerization of PCL multi-alcohols as necessary for the... Read More
2009-202 – Bacterial infection continues to negatively affect outcomes for orthopedic patients despite heightened awareness and increased technologies. Infections at the shoulder may be three times more prevalent than at the knee or hip and is recognized as a considerable clinical problem. The shoulder represents a significant challenge for infection prevention: bacteria contamination of the skin... Read More
2009-055 – Hydogels have wide applications in the biomedical field due to their ability to absorb incredible amounts of aqueous solutions and support cell viability. One particular application hydrogels are being investigated for is nerveguidance conduits to direct and stimulate nerve regeneration by supporting cell growth while simulatanously delivering biologically active molecules. Incorporation of... Read More
2008-380 – A novel electrically conductive polymer composite composed of polycaprolactone fumarate- polypyrrole (PCLF-PPy) for applications in nerve regeneration is disclosed. The synthesis and characterization of PCLF-PPy and in vitro studies showing PCLF-PPy supports both PC12 cell and dorsal root ganglia neurite extension. PCLF-PPy composite materials were synthesized by polymerizing pyrrole in... Read More
2008-317 – A novel electrically conductive polymer composite composed of polycaprolactone fumarate- polypyrrole (PCLF-PPy) for applications in nerve regeneration is disclosed. The synthesis and characterization of PCLF-PPy and in vitro studies showing PCLF-PPy supports both PC12 cell and dorsal root ganglia neurite extension. PCLF-PPy composite materials were synthesized by polymerizing pyrrole in... Read More
2008-268 – Methods and devices are disclosed for the attachment of a soft tissue structure (e.g., tendon or ligament) to bone or a prosthetic implant. In one form, the device includes a clamp comprising a porous metallic material. The clamp includes a convex tissue engaging surface. The device also includes a fastener for compressing the soft tissue between the tissue engaging surface and the bone or... Read More
2008-249 – Tendon injuries are very common, but functional restoration of the injured tendon still presents a challenge. Tissue engineering approaches provide the possibility of enhancing tendon healing or tendon tissue regeneration. Mayo Clinic researches have developed an engineered tendon substitute using acellular tendon slices seeded with cultured bone marrow stem cells as a regeneration scaffold... Read More
2008-079 – The antibiotic impregnated cement spacer replaces a shoulder arthroplasty that has been removed due to infection. There are several advantages: provides antibiotic release locally, facilitates revision surgery by maintaining joint space, allows for immediate motion, and provides faster recovery. There is only one shoulder spacer in the market, and it does not have a variety of sizes and does... Read More
2008-014 – A fracture fixation system particularly useful for bones of the hand and foot is disclosed. The system uses curved shape-memory alloy (e.g., Nitinol) wires that have a predetermined radius of curvature to accommodate different sized bones. These shape-memory alloy wire forms can be inserted into phalanx, metacarpal or metatarsal bones via a percutaneous technique. The technique uses small... Read More
2007-111 – An olecranon fracture fixation system includes an intramedullary core that is dimensioned for insertion in an intramedullary canal of the bone, and a hollow shell that is dimensioned for insertion in the intramedullary canal. The shell includes fixation elements that extend outwardly away from a proximal end of the shell. A fastener is provided for attaching the shell to the core in the... Read More
2005-136 – This device is used to treat a painful thumb base joint (1st CMC joint) from arthritis. It is composed of three parts: 1) a screw that threads across the wrist bones; 2) a screw that threads into the thumb metacarpal; and, 3) a plastic liner for the ball-and-socket joint formed by the two screws.
2005-055 – This implant is a fixation device, shaped in the form of a plate for use in the fixation and stabilization of the thoracolumbar spine. Its design and configuration allow for an anatoic fit of the plate to the spine. Its improved fixation allows it an anatomical and biomechanical advantage in stabilizing thoracolumbar spine trauma both in a primary fashion and/or in conjunction with vertebral... Read More
2004-163 – Composite of porous scaffold with cartilage growth from autologous periosteum chondrogenesis induced by tissue engineering techniques. Biological resurfacing of large osteochondral defects, or a complete joint may be feasible using a porous metal scaffold/autologous periosteal construct. The use of this construct eliminates the necessity of using normal cartilage surface as a donor site and... Read More
2003-090 – Hydrogel microparticles with entrapped liquid are used as the porogen to reproducibly form interconnected pore networks in a porous scaffold. In one embodiment, a biodegradable unsaturated polymer (for example, PPF or PCF), a crosslinking agent (like a free radical initiator), and a porogen comprising biodegradable hydrogel microparticles (such as OPEF) are mixed together and allowed to form... Read More
2003-034 – Mayo Clinic clinicians have created a clear, air - inflatable compression dressing that controls swelling and promotes wound healing.
2002-072 – Mayo Clinic researchers have developed a biodegradable polymer device for bridging a gap in a severed nerve. This implant functions both as a scaffold to support axon growth across a gap and as a conduit for the controlled local delivery of agents which may promote axon regeneration.
2001-087 – Pedicle oblique support pillar system; shares loads applied to pedicle implant in spine fracture fixation; reduces large bending moments, re-deformity, screw loosening, bending, or breakage; also may be utilized in spinal segmental unit fixation and fusion.
2000-155 – Prosthesis with varying stem stiffness from proximal to distal ends; minimizes stress shielding; decreases bone re-sorption adjacent to proximal end of stem.
1997-103 – Expanding screw with increased strength of bone-screw interface for spinal internal fixation surgeries.