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2006-018 – Technology Description B7-H4 is a cell surface protein whose expression on tumor cells and tumor-associated vasculature is greatly increased in renal cancers. B7-H4 expression levels on renal tumors have been shown to be a predictor of tumor aggressiveness and to increase mortality rates. B7-H4 is highly expressed on tumors and tumor-associated vasculature but not on normal tissues and... Read More
Quantitative Imaging of Iron as a Marker of Vulnerable Atherosclerotic Lesions Using Computed Tomography
2006-017 – Intraplaque hemorrhage represents an event in the induction and/or as a consequence of instability of advanced atherosclerotic lesions. Iron should accumulate in a lesion after hemorrhage, as part of each erythrocyte, whether isolated or within macrophage-derived cells that have phagocytosed the red blood cells. Moreover, ectopic neovascularization is also a major feature of... Read More
2005-273 – Methods and materials related to identifying, assessing, and predicting hypertrophic cardiomyopathy (HCM) in mammals.
2005-180 – The subsynovial connective tissue (SSCT) is a thin (~1 mm), loose tissue layer around the tendons and median nerve in the carpal tunnel, which has been implicated in the etiology of carpal tunnel syndrome (CTS). A test which could detect abnormalities in the SSCT before the nerve becomes involved could allow interventions before surgery becomes necessary. We have combined a diverse set of... Read More
Genetic Polymorphisms in the Human Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) gene in Caucasian, African American, Han Chinese and Mexican American Populations
2005-156 – Some of the known substrates of CYP19A1 (aromatase) include testosterone and androstenedione. It is expressed in the ovaries, testes, placenta, fetal liver, adipose tissue, chondrocytes, osteoblasts, vasculature smooth muscle, and brain. Increased or decreased enzyme activity is associated with several diseases including breast and endometrial cancer. Several novel polymorphisms have been... Read More
2005-124 – Common, functionally relevant mutations in the SULT1A1 have been recently discovered. These mutations have a significant effect on SULT1A1 enzyme activity.
Fluorescent In Situ Hybridization (FISH) Probe Development to Detect Immunoglobulin Light Chains Kapa (IGK) and Lambda (IGL) Translocations
2005-072 – Lymphoma, the cancer to the lymph glands and lymphocytes develop as a consequence of acquired genetic/chromosomal changes. In clinical practice identification of these genetic changes are critical in diagnosis and treatment of lymphoma patient. We have developed fluorescent in situ hybridization (FISH) for two targets frequently involved in lymphoma development. We believe that these probes... Read More
2005-063 – Imaging systems, such as computed tomography, magnetic resonance, or echocardiography are complex devices that not only acquire imaging data but also provide various measurements and displays based on the data. Clinical diagnostic decisions, based on the imaging data, are subjective, experience-based, and affected by stress. This invention describes algorithmical implementation of a trainable... Read More
Self-Contained Semi-Active Cooling Mechanism for Very High Power Density Integrated Circuits and Electronic Modules Using a Reversible Endothermic Chemical Reaction
2005-026 – This invention is a completely self-contained and encapsulated “package” into which a high power integrated circuit (“chip”) such as an amplifier, or an entire subsystem (such as a radar “transmit-receive” module), can be installed to provide the necessary thermal and electrical environment to assure that the chip or multi-chip subsystem works correctly. The packaging approach not only... Read More
Tandem Mass Spectrometry (MS/MS) of Thiopurine Methyltransferase (TPMT) Reaction Products in order to Quantitate TPMT Enzyme Activity
2005-017 – This invention provides methods and materials related to the measurement of TPMT enzymatic activity in biological samples. The assay involves the incubation of a cell lysate with a TPMT substrate and S-adenosyl-L-methionine (SAM), which acts as a methyl donor, and an isotopically labeled internal standard corresponding to the enzymatically produced methylation product of the TPMT substrate.... Read More
2005-015 – Software that is able to recognize internal fat within the valve and eliminate it as a diagnostic possibility.
2004-291 – Technology Description Pathogenic mutations of the Leucine-Rich Repeat Kinase 2 (LRRK2) enzyme are recognized as the most frequent genetic cause of both familial and sporadic parkinsonism. Mayo Clinic researchers were the first to identify this association and have gone on to develop an in-depth understanding of LRRK2 function as well as numerous tools to help identify therapeutic agents to... Read More
Genetic Polymorphisms in the Human Hydroxy-delta-5-steroid Dehydrogenase, 3 Beta-and steroid delta-isomerase 1 (HSD3B1) gene in Caucasian, African American, Han Chinese and Mexican American populations
2004-274 – Substrates include pregnenolone, 17-hydroxypregnenolone (17-OH-Preg), dehydroepiandrosterone (DHEA) and androst-5-ene-3-B,17B-diol. Tissue specificity includes the placenta and skin but it is predominantly expressed in mammary gland tissue. Subcellularly, it is located in the endoplasmic reticulum and the mitochondrial membrane. Congenital deficiency of 3 beta HSD activity causes severe... Read More
Genetic Polymorphisms in the Human Glutathione S-transferase Omega 2 (GSTO2) Gene in Caucasian, African American, Han Chinese and Mexican American Populations
2004-273 – GST02 is a phase II enzyme that utilize glutathione in reactions contributing to the transformation of a wide range of exogenous and endogenous compounds, including carcinogens, therapeutic drugs, and products of oxidative stress. Known substrates are glutathione (GSH) and dehydroascorbate (DHA. It is expressed in liver, kidney and skeletal muscle and at high levels in the testes and low... Read More
2004-244 – Technology Description Measurement of patient vitamin D levels in clinical laboratories is one of the most rapidly growing clinical tests in the United States. This is due in part to recent studies demonstrating the beneficial effects of vitamin D and the surprising percentage of the population that is vitamin D deficient. Assays measuring vitamin D are used to diagnose vitamin D deficiency... Read More
2004-237 – The present invention detects the harmonic motion of vibro-acoustography using pulse echo ultrasound and several signal processing methods. The invention estimates the amplitude and phase of the motion at a desired location within a tissue region with a high sensitivity. The tissue harmonic motion generated by the ultrasound radiation force of vibro-acoustography is presented as oscillatory... Read More
2004-185 – Discovery of the genetic cause of clinical, late-onset (typical) Parkinson’s disease in multiple families with an autosomal pattern of disease inheritance. Six coding mutations have now been identified within eight families, in a novel gene that is comprised of 61 exons (alternately spliced) that encodes a protein of ~280kD. The gene is located on chromosome 12p11.2-q13.1 and is responsible... Read More
In vivo Visualization of Alzheimer's Amyloid Plaques by MRI in Transgenic Mice without a Contrast Agent
2004-139 – One of the cardinal pathologic features of Alzheimer’s disease (AD) is formation of senile or amyloid, plaques. Transgenic mice have been developed that express one or more of the genes responsible for familial AD in humans. Doubly transgenic mice develop “human-like” plaques, providing a mechanism to study amyloid plaque biology in a controlled manner. Imaging of labeled plaques has been... Read More
2003-149 – Technology Description Compositions and methods have been developed for detecting plaques and treating CNS disorders. Polyamine modification of amyloid beta peptides or antibodies binding to amyloid beta increases blood-brain barrier (BBB) permeability and incorporation of a contrast agent permits MRI detection of plaque deposits. A novel peptide-based imaging agent has also been developed... Read More
2002-227 – The enzyme utilizes S-adenosylmethionine to methylate aresenite to monomethylarsonate, and can further methylate this product to form dimethylarsinic acid. Known substrates are Aresenite, Methylarsonous acid, Methylarsonous acid. It is known to be expressed in liver, kidney and brain. Arsenic exposure outcomes (death, cancer, neurotoxicity, liver damage, and cardiovascular disease et. al.)... Read More
2002-179 – Mayo researchers have developed a method to allow clinical x-ray imaging to reach its full potential. This is achieved by reducing the x-ray dose absorbed by the patient by orders of magnitude and by enhancing the contrast discrimination of the x-ray interaction with different soft-tissue components so that little, if any, contrast agent need be administered. The Time-Of-Flight X-ray... Read More
2002-152 – PNMT is the terminal enzyme in catecholamine biosynthesis and catalyses the synthesis of epinephrine from norepinephrine. Norepinephrine and Phenylethanolamine are substrates. The activation is methylation. It is expressed in Chromaffin cells of the Adrenal Medulla, medulla oblongata, hypothalamus, and sensory nuclei of the vagus nerve. Diseases and conditions that may be associated with... Read More
2002-151 – SULT1A3 is involved in the sulfation of Dopamine,other catechol monoamines, serotonin, and Troglitazone. It is expressed in liver, brain, jejunum, kidney and platelets. It may be associated with schizophrenia, affective disorders, renal disease and chemical carcinogenesis. One particular polymorphism, resulting in an amino acid change, was found to be present in 4% of the African American... Read More
2002-126 – The activity of the gene product is Sulfate conjugation. Several non-synonymous CSNPs have been discovered that affect the enzyme activity.
2001-139 – There are two separate 3'-phosphoadenosine 5'-phosphosulfate synthetase (PAPSS) isoforms in humans (PAPSS1 and PAPSS2). Both isoforms catalyze the formation of PAPS, the universal high-energy sulfate donor for all sulfotransferases. Functionally relevant PAPSS1 polymorphisms have been discovered that decrease PAPSS1 activity and result in undersulfation of drugs, procarcinogens, glycoproteins... Read More
2001-138 – SULT1E1 catalyzes reactions with steroid hormones e.g. ß-Estradiol, by transferring a sulfonate group from PAPS to the hydroxy group at position 3 of the estrogen to form Estradiol 3-O-sulfate. Known substrates are estrone and estradiol, catecholestrogens and 2-Methoxyestradiol. SULT1E1 is expressed in the liver, small intestine, adrenal cortex, adrenal medulla, lung, kidney, mammary gland,... Read More
2001-050 – Device reproducibly positions subject’s upper extremities while allowing measurement of actively generated forearm torque against resisted rotation in variable forearm positions; used with MMV-01-049.
2001-049 – Device reproducibly positions subject’s upper extremities in field of CT imaging system; allows variable positioning of forearm rotation; allows present forearm positions to be maintained and for active force generation by patient to optimize displacement of bones to demonstrate joint instability.
2001-009 – SULT2A1 catalyzes the transfer of inorganic sulfate to hydroxysteroids and uses PAPS as the sulfate donor. Genetically based variations in SULT2A1 may affect the metabolism of steroid compounds (DHEA, ethinyl estradiol, minoxidil, androsterone, androstenediol, epiandrosterone, androgens, estrogens, testosterone, and pregnenolone) that are used for drugs, as well as structurally related... Read More
2000-100 – PAPSS2 is an enzyme that synthesizes PAPS; the high-energy sulfate donor molecule involved in the sulfate conjugation (metabolism) of thousands of drugs, hormones (estrogen), neurotransmitters (dopamine) and many other macromolecules. Rare inactivating mutations in orthologous PAPSS2 genes have been identified as the genetic causes for human spondyloepimetaphyseal dysplasia and murine... Read More
2000-089 – Analytical/software method to quantitate beat-to-beat non-alternating, chaotic variability in electrical repolarization of the heart. This index (TWLI) indicates the presence of a highly malignant arrhythogenic substrate and may be useful for the identification and primary prevention of sudden cardiac death.
2000-031 – Human SULT1C1 has been shown to metabolically activate planar phenols and the chemical procarcinogen N-OH-2-acetylaminoflurorene. Therefore, genetically based variations in the activity of this enzyme may affect the activation of procarcinogens. In addition, SULT1C1 polymorphisms may play a role in thyroid hormone inactivation since this enzyme metabolizes thyroid hormones. Therefore,... Read More
2000-025 – Technology Description Compositions and methods have been developed for detecting plaques and treating CNS disorders. Polyamine modification of amyloid beta peptides or antibodies binding to amyloid beta increases blood-brain barrier (BBB) permeability and incorporation of a contrast agent permits MRI detection of plaque deposits. A novel peptide-based imaging agent has also been developed... Read More
1999-033 – These methods reduce the audible sound produced by ultrasound scanners in patients. Reduction of fetal stress during ultrasound examination.
1998-071 – Substrates for SULT1A1 are; 4-nitrophenol, 17beta-estradiol (E2), diethylstilboestrol (DES), 1-naphol, 4-hydroxytamoxifen, minoxidil, estrone (E1), epinephrine, dopamine, acetaminophen, genistein, other monocyclic phenols. The gene is ubiquitously expressed but especially prominent in liver but also lung, brain, platelet, prostate, placenta, and adrenal gland. Diseases associated with... Read More
1998-036 – Histamine N-methyltransferase (HNMT, EC184.108.40.206) catalyzes a major pathway in the metabolism of histamine. The only pathway for the termination of the neurotransmitter actions of histamine in the human CNS is N-methylation catalyzed by HNMT, and approximately 70% of histamine in bronchial epithelium is metabolized by HNMT. Mayo investigators have cloned the cDNA and gene for HNMT in humans and... Read More
1995-102 – Detection with the use of broad range primers and the PCR assay for the detection of the WA-1 Agent.
1995-094 – In this system, a low frequency radiation force is exerted point-by-point on the object by a confocal ultrasound transducer. The amplitude of the resulting acoustic field is used to produce a two-dimensional display of the object’s cross sections. This system can produce a high resolution image from an object based on its low frequency (kHz) characteristics.
1994-072 – The invention provides an isolated and purified human DNA molecule that encodes human estrogen sulfotransferase (EST, SULT1E1). It also provides cell lines and vectors containing human estrogen sulfotransferase DNA that can be used to express the enzyme. The enzyme is useful for screening drugs that are metabolized by human estrogen sulfotransferase.
1993-030 – Human Thiopurine Methyltransferase (TPMT) Gene Discovery - Stably-transformed cells expressing human thiopurine methyltransferase Human Thiopurine Methyltransferase (TPMT) Gene Discovery. Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine and azathioprine. Patent claims to the DNA coding sequence, amino acid sequence and cell lines and mammals in which... Read More