2013-081 – Magnetic resonance imaging (MRI) is widely used to diagnostically investigate the human body. However, unlike other medical imaging modalities (e.g., X-ray CT), MRI data is not explicitly quantitative - pixel values do not directly represent physiological information. There is strong clinical interest in transforming MRI into a quantitative modality, and to measure quantities such as flow,... Read More
2012-224 – Increase in bladder stiffness could be associated with various pathophysiologic conditions. We introduce Ultrasound Bladder Vibrometry (UBV), a novel method for rapid and noninvasive measurement of bladder wall viscoelasticity. UBV uses acoustic radiation force to excite mechanical waves in the bladder wall and track the motion using ultrasound pulse-echo techniques. Fourier domain analysis... Read More
2012-221 – Ultrasound radiation force is used to create propagating waves in soft tissue or other soft materials. The wave propagation is measured using pulse-echo ultrasound methods. We use a two-dimensional Fourier transform method to obtain the Fourier-space (k-space) with the coordinates of frequency (f) and wave number (k). The wave velocity © at each frequency is calculated by finding the... Read More
2012-141 – Carpal tunnel syndrome (CTS) is a common problem with an estimated lifetime risk of 10%, a prevalence of about 3%, and a large economic burden of more than $1 billion annually for direct medical costs. It has been commonly recognized that carpal tunnel pressure (CTP) increases in CTS patients. However, measurement of CTP is invasive and not reliable due to technical difficulties. Although CTP... Read More
2012-134 – Shear wave produced by a focused ultrasound beam is used to evaluate tissue visco-elasticity, which are sensitive biomarkers of pathology. Shear waves thus produced are weak and attenuate quickly when propagating away from the push origin. We have proposed a method called CUSE where multiple unfocused push beams spaced out like a comb are used for shear wave production. Every pixel under... Read More
2012-129 – A method to quantify tissue viscoelastic properties in a model-independent way by estimating the complex shear modulus from creep-recovery response and shear wave propagation speed by ultrasound acoustic radiation force. This method uses a formula that converts creep-recovery response in time to frequency domain complex modulus. The shear wave speed is used to calibrate the complex modulus... Read More
2012-083 – Coronary CT angiography (cCTA) is used to noninvasively look at the arteries that supply the heart muscle with blood, and diagnose (or rule out) blocked arteries, which are the main cause of heart attacks. cCTA is performed with either prospective or retrospective ECG gating. Irrespective of which variant is used, images are reconstructed with projection data corresponding to a partial scan... Read More
2012-057 – Shear wave is used to evaluate tissue visco-elasticity, which are sensitive biomarkers of pathology. In order to obtain a 2D ultrasound elastography, an ultrafast imager with a FRAME rate of several kHz is required to capture the fast moving shear waves. This is not feasible with traditional ultrasound imagers with a frame rate of less than 100 Hz where 2D images are formed LINE BY LINE. ... Read More
2011-274 – The invention uses ultrasound to measure the nonlinear mechanical properties of an object including those of biological tissues. This information can be used to detect abnormalities in tissues.
Individualized CT Scan Protocols for Scanning with Either Lower Radiation Dose or Lower IV Contrast Dose
2011-229 – We developed a technique for creating individualized CT protocols that allow patients to be scanned with either lower radiation dose or lower intravenous contrast dose whilst maintaining iodine contrast-to-noise ratio and diagnostic image quality.
2011-224 – A method to quantify tissue mechanical properties in a model-independent way by estimating complex elastic modulus from time-dependant creep response induced by acoustic radiation force. This method uses a formula that converts time-domain creep compliance to frequency domain complex modulus. Then Shearwave Dispersion Ultrasound Vibrometry (SDUV) is used to calibrate the complex modulus so... Read More
2011-210 – Multiple short-duration ultrasound push pulses are used to deform tissue. The duration and PRF (Pulse Repetition Frequency) of these push pulses are compatible with current ultrasound scanners because these pulses are comparable to Doppler pulses. The collective effect from many push pulses generates shear waves of high amplitude for elasticity imaging. Two shear waves are produced: one at... Read More
2011-178 – Radiation dose from CT scanning is an increasing health concern, but lowering radiation dose alone generally produces a noisier image and may degrade diagnostic performance. Non-local means (NLM) denoising has become widely accepted as a very effective denoising tool in the image processing community, and has yielded very promising results in lung and abdominal CT. However, NLM requires an... Read More
2011-114 – In dynamic time series imaging, noise varies from image to image, but the underlying structure (although it can vary somewhat) is generally preserved. Techniques that take advantage of this are capable of efficiently denoising such data sets. In this invention, time series images are decomposed into overlapping subblocks of size NxN, with each subblock sampled T times in the time dimension.... Read More
2011-108 – Parallel Imaging is a widely used strategy for accelerating MRI acquisitions. Auto-calibrated coil-by-coil methods such as GRAPPA and ARC have become increasingly popular since they do not require a separate calibration scan (as do SENSE and ASSET) nor explicit estimation of coil sensitivity profiles, making them attractive for time-limited and dynamic applications like cardiac imaging.... Read More
Method for Reconstructing Dynamic Resonance Imaging Series From Limited Measurements Using Matrix Rank Constraints
2011-106 – This disclosure allows for image series to be reconstructed from only a subset of the data normally required to form the image series, and correspondingly for image acquisition time to be reduced. As demonstrated, the proposed reconstruction mechanism can provide improved temporal fidelity compared to other rank-based MRI series reconstruction methods.
2011-080 – The quantitative accuracy of CT numbers in myocardial perfusion computed tomography (MPCT) is degraded by artifacts arising from the use of partial scan reconstruction (PSR), which is used in cardiac CT to improve temporal resolution. Full scans do not suffer from this artifact. PSR artifacts appear because of inconsistencies in the angular range of projection data used for partial scans due... Read More
2011-026 – Propagation of shear wave (e.g., frequency dependent propagation speed and attenuation) in tissues is determined by mechanical properties of tissues. In ultrasound elasticity imaging, focused ultrasound beams are used to generate and detect shear waves in tissues. The 3D shape of the ultrasound beam can artificially increase measured shear wave speed in the transducer near field and... Read More
2011-002 – Nonfocused ultrasound waves are produced by merely transmitting long tonebursts on each of several elements in a linear or curved or phased array. This produces an unfocused beam. Shearwave can be imaged by beams from a two-dimensional array if a shearwave is produced in a rectangular section, then the shearwaves can propagate away from the rectangular section and can be imaged. The effect... Read More
2010-299 – Molecular breast imaging (MBI) is a molecular imaging technique that can be used for the detection of breast cancer. MBI can detect breast tumors not visible on mammography or ultrasound. MBI images usually take 5-10 minutes to acquire 1 view. A slant-hole collimator can be used to estimate tumor depth and enable tumor biopsy using a radiolabeled guide. However, the long imaging time of 5-10... Read More
2010-152 – A device and method for MRI in-scanner imaging of chronic exertional compartment syndrome (CECS) of the lower legs has been developed and validated.
2010-115 – Photon counting detector technology is being actively adopted for commercial CT. One compelling reason is the advantages that it brings for spectral imaging (multi-energy CT) which allows material characterization using energy information from the detected x-rays. The ability to identify material composition regardless of material density (e.g. distinguishing iodine from bone even though they... Read More
2010-108 – SDUV is a non-invasive ultrasound technology that can qualify tissue stiffness and viscosity, which are sensitive indexes of pathology such as liver fibrosis. SDUV uses one long push toneburst of ultrasound followed by multiple detect pulses to generate and detect shear waves in tissue. Shear wave propagation information is used to estimate tissue stiffness and viscosity. The push-detect... Read More
2010-038 – The individual cross-sectional images along the arteries were analyzed individually by creating a Region-of-Interest (ROI) that encompassed the vessel wall. To ensure that the entire arterial wall was included into the ROI, the radius of the lumen ® was measured, which was used as the width of the annular ROI surrounding the arterial lumen (12). By creating a binary image of the punctate... Read More
2010-032 – A method for producing tissue motion with customized frequency content is described in which push pulses are designed using orthogonal basis functions which then produce desired tissue motion. The push pulses can be a sequence of long duration, in which case motion detection A-lines can be interleaved among the pulses. The result is a more efficient method of making tissue move with optimal... Read More
Use of Pittsburgh Compound B (PiB) Molecules and PiB-Positron Emission Tomography/Computed Tomography (PiB-PET/CT) Imaging for the Identification and Diagnosis of Meningiomas
2010-007 – Meningiomas are a common tumor often found in the thin layers of tissue that surround the brain. However, many other types of tumors can arise in the same locations. Variation in the appearance of meningiomas can make the accurate diagnosis of meningioma difficult based on current methods, such as Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). Pathologists can accurately... Read More
2009-278 – Specific and highly sensitive ultrasound localization of catheter placement can be accomplished by use of a catheter navigation crystal with an active (vibrating) element whose ultrasonic signal interferes with the ultrasound imaging signal as the latter propagates with each transmitted bearn though issue. The interference signal (caused by the crystal) occurs directly within the Doppler... Read More
2009-043 – To reduce radiation dose and/or improve image quality in CT, it is very important to select the optimal tube potential (kV), which is highly dependent on patient size and specific diagnostic task. In this invention, we developed a general strategy that allows for individualized automatic kV selection for each patient size and each diagnostic task. We proposed a novel concept, kV dose index... Read More
2008-299 – A technique is described for taking images generated from an MRI acquisition done with contrast administration and converting the image data into a single image which portrays the time of arrival (TOA) of the advancing contrast bolus. The TOA image allows distinction of arterial from venous structures based on their different arrival times. The quality of the results depends on... Read More
2008-315 – Parallel imaging can be applied to further reduce acquisition times. To do so, coil sensativities have to be determined. One option is to use self-or-auto calibrated methods which in general use unaccelerated sampling in some central region of the otherwise undersampled k-space. However, the fraction of acquisition time devoted to calibration can be substantial, particularly in high... Read More
2008-141 – Dual energy CT performed using dual source scanner geometry is limited to dual energy algorithms that operate using reconstructed images. This limits the ability to remove beam hardening artifacts, which are introduced during the image reconstruction process. The novel algorithm disclosed here allows for realignmnet of the high- and low-energy datasets, which are 90degrees out of phase, such... Read More
2008-136 – A method is described which provides reduction of acquisition time for 3DFT MRI. It is based on a specific way to sample k-space which is robust to undersampling. It can be used in conjunction with other methods for reduction of acquisition time.
2008-177 – A coil array is designed for 2D acceleration in MRI for imaging an object with markedly different fields of view in the two phase encoding directions in which the coil elements in one direction have markedly different size than elements in the other direction.
2008-088 – A novel surface wave method is developed for non-invasively estimating viscoelasticity of tissues. In this method, a very small force is generated on the surface of tissue either by a mechanical shaker or the radiation force of ultrasound. The surface vibration of tissue is measured non-contact by laser or ultrasound. We have developed theory and techniques for measuring the surface wave for... Read More
Quantitative Imaging of Chemical Compositions Using Dual-Energy, Dual-Source CT: Two Material Decomposition Using Reconstructed Images
2008-022 – Quantitative imaging of chemical composition in patients may be a very useful diagnostic technique for a variety of condidtions, such as iron overload in the liver - a serious and potentially life-threatening chronic disease. We have developed a method to noninvasively measure the quantity of a specific element in vivo. This method is based upon the fact that very different atomic numbers and... Read More
Quantitative Imaging of Chemical Composition Using Dual-Energy, Dual-Source CT: Three Material Decompostion Using Reconstructed Images
2008-021 – Quantitative imaging of chemical composition may be accomplished using dual energy CT. However, dual energy CT can only quantify at most two materials because dual energy CT provides two independent measures with the dual (two) energy x-ray spectra. However, it is very common to need to quantify more than two materials. We have developed a technique to quantify three materials that is an... Read More
2007-193 – The invention combines information from two different energies to create a greatly improved visualization over commonly available dual energy imaging blending techniques. Dual-energy CT may provide additional diagnostic information to the physician, but the question arises on how to best illustrate it. In conventional single energy CT, patient data is presented to the physicians using very... Read More
Adaptive Determination of Optimal Weighting Coefficient for Linear Combination of Low- and High-Energy Images
2007-117 – In dual-energy imaging, individually reconstructed images from the low- and high-energy acquisitions can be linearly combined to produce a weighted average of the respective images. This disclosure describes an optimization scheme and software tool to select the optimal weighting value. Optimization can be performed using a variety of criteria, including minimizing image noise, maximizing the... Read More
2007-100 – A mathematical method is described that is used to estimate the inherent phase offsets and timing differences between data acquisitions of raw data acquisitions from the Magnetic Resonance scanner during MR Spectroscopy. Knowledge of the phase offset and time delay of each data set allows the correction of the data so that each set reflects data collected at the same time points with the... Read More
2007-123 – Metal implants are common in patients receiving CT examinations, which can produce artifacts that can significantly degrade the diagnostic value of the image. We have developed a method to reduce the metal artifacts in multi-slice helical CT. This method is based upon the virtual radiographs (VR) created from the helical projection data for each view angle. Automatic segmentation and removal... Read More
2005-063 – Imaging systems, such as computed tomography, magnetic resonance, or echocardiography are complex devices that not only acquire imaging data but also provide various measurements and displays based on the data. Clinical diagnostic decisions, based on the imaging data, are subjective, experience-based, and affected by stress. This invention describes algorithmical implementation of a trainable... Read More
2004-237 – The present invention detects the harmonic motion of vibro-acoustography using pulse echo ultrasound and several signal processing methods. The invention estimates the amplitude and phase of the motion at a desired location within a tissue region with a high sensitivity. The tissue harmonic motion generated by the ultrasound radiation force of vibro-acoustography is presented as oscillatory... Read More
In vivo Visualization of Alzheimer's Amyloid Plaques by MRI in Transgenic Mice without a Contrast Agent
2004-139 – One of the cardinal pathologic features of Alzheimer’s disease (AD) is formation of senile or amyloid, plaques. Transgenic mice have been developed that express one or more of the genes responsible for familial AD in humans. Doubly transgenic mice develop “human-like” plaques, providing a mechanism to study amyloid plaque biology in a controlled manner. Imaging of labeled plaques has been... Read More
1999-033 – These methods reduce the audible sound produced by ultrasound scanners in patients. Reduction of fetal stress during ultrasound examination.
1996-100 – Radiation force of arbitrary frequency is generated on the object using a single ultrasound beam. This system is used for information transmission, object detection or imaging. 3D blood flow vector imaging and imaging of internal structures of living cells.
1995-094 – In this system, a low frequency radiation force is exerted point-by-point on the object by a confocal ultrasound transducer. The amplitude of the resulting acoustic field is used to produce a two-dimensional display of the object’s cross sections. This system can produce a high resolution image from an object based on its low frequency (kHz) characteristics.