A Time Dependent Device for Segmental Whole Gut for Lumina & Mucosal Microbial Swab Sampling by Anatomic Location
2012-169 – Swabs from the middle portions of the gastrointestinal tract are currently very difficult to obtain due to the limitations of current techniques such as endoscopy. Understanding the biology of these regions can potentially have a large impact on the overall health of both people and animals through the effect of the GI tract on other parts of the body. Mayo Clinic investigators have... Read More
2009-379 – Technology Description Patients with extensive, longstanding inflammatory bowel diseases (ulcerative colitis or Crohn’s disease), which are diseases of chronic colonic inflammation, are at risk for colorectal cancer (CRC). Surveillance of this at-risk population remains challenging. Mayo Clinic researchers have identified biomarkers for colorectal cancer in inflammatory bowel disease... Read More
Portable Photodynamic Therapy Dosimetry Device - Hand-Held Optical Device for Rapid Determination of Local Tissue Photosensitizer Content and Oxygenation
2009-258 – This invention is a convenient, portable optical instrument for use in photodynamic therapy (PDT) dosimetry. It will provide real-time values of photosensitizer content in tissue as well as values of local tissue as well as values of local tissue oxygenation. The instrument contains a laser light source and a broad band (white) light as well as an optical detector. A fiber optic cable is... Read More
Tandem Mass Spectrometry (MS/MS) of Thiopurine Methyltransferase (TPMT) Reaction Products in order to Quantitate TPMT Enzyme Activity
2005-017 – This invention provides methods and materials related to the measurement of TPMT enzymatic activity in biological samples. The assay involves the incubation of a cell lysate with a TPMT substrate and S-adenosyl-L-methionine (SAM), which acts as a methyl donor, and an isotopically labeled internal standard corresponding to the enzymatically produced methylation product of the TPMT substrate.... Read More
2005-015 – Software that is able to recognize internal fat within the valve and eliminate it as a diagnostic possibility.