- Animal Model
- Cardiovascular - Cardiology
- Endocrine - Metabolic
- Gastroenterology - Hepatology
- Gene Therapy
- Immunology - Allergy
- Infection - Infectious Diseases
- Obstetrics & Gynecology
- Oncology - Cancer
- Orthopedics - Musculoskeletal
- Orthopedics - Muskuloskeletal
- Psychiatry - Psychology
- Small Molecule
- Urology - Nephrology
- Vascular - Pulmonary
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1997-072 – We generated mice transgenic for HLA-DQ6, an allele associated with a nonsusceptible haplotype. These mice were found to be resistant to collagen induced arthritis. These mice are a model for rheumatoid arthritis.
1997-071 – We generated an HLA-DR4ß(NT) transgene construct in which positions 110 and 139 were altered to resemble endogenous mouse H2 Aß molecules. This construct was introduced into (B10 x SWR) embryos, and DR4ß(NT) transgenic mice were produced. The transgene was transferred into B10.RFB3 (Eß0 Ealphap) mice. The transgene-encoded DR4ß molecules paired with endogenous Ealpha chains to form stable... Read More
1997-069 – We developed an HLA-DR2 mouse model by introducing a human DRB1*1502(DR2DW12) transgene into CIA susceptible BIO.RQB3 (H2A8) mice. These mice showed a significant reduction in the incidence and severity of arthritis. For further information please see Human Immunology, 1996, 50:54-60.
1997-035 – This technology is a T-cell line that lacks the protein tyrosine kinase, ZAP-70. ZAP-70 plays a critical role in the initiation of lymphocyte activation responses to antigenic stimuli. The cell line can be used to define the mechanisms of ZAP-70 activation and function in T-cell signaling. This line can be used also to confirm the mechanism of action of ZAP-70 targeted drugs. This is the... Read More
1996-076 – Transgenic mouse (Tg2576) carrying the Swedish mutation for Alzheimer’s Disease. This mouse was developed by Dr. Karen Hsiao Ashe at the University of Minnesota and is exclusively licensed to Mayo. This mouse develops age-related neuropathology, including development of amyloid plaques and behavioral changes, and can be used in research related to Alzheimer’s Disease and other... Read More
1995-155 – HFOBER cells are hFOBs stably transfected with human estrogen receptor; subclones HFOB/ER-3 and HFOB/ER-4 express levels of estrogen receptor consistent with the range of levels measured in human osteoblasts. The HFOBER cell lines have a complete concatenation of transcription factors such that the estrogen receptor is transactionally active; estrogen-regulated functions are maintained. The... Read More
1995-140 – Transgenic mouse models for asthma were developed that express interleukin-5 under the control of a lung epithelial specific promoter. All mice express abnormally high levels of eosinophils in those regions and display symptoms consistent with the underlying physiologic conditions. The CCIL-5 mouse line is a superb animal model for the study of asthma. The animals show hyperactivity to... Read More
1995-139 – Transgenic mouse models for eosinophil-mediated tissue inflammation were developed that express interleukin-5 under the control of a T-cell specific promoter. All mice express abnormally high levels of eosinophils in those regions and display symptoms consistent with the underlying physiologic conditions. The NJ1638 mice are models for hypereosinophilic syndromes and have high levels of... Read More
1995-110 – These radiolabeled agents are designed to allow for simple preparation of radioactive markers for measuring colonic transit without the need for an Investigational New Drug application (IND). These radiolabeled agents can be used to evaluate patients with suspected colonic motility disorders.
1995-087 – The base sequence coding for the protein of the human kappa opioid receptor, the deduced amino acid sequence and the cell line transfected with the gene expressing the protein.
1995-051 – Sequence analysis has been used to select synthetic peptides for use in the development of rabbit polyclonal antibodies against each of the known human cytosolic sulfotransferase enzymes. These antibodies, in turn, can be used to characterize these enzymes for both research purposes and in the development of drugs that are metabolized by sulfatino in humans.
1993-058 – Open reading frame gene sequence of the neurotensin receptors from human brain tissue.
1993-030 – Human Thiopurine Methyltransferase (TPMT) Gene Discovery - Stably-transformed cells expressing human thiopurine methyltransferase Human Thiopurine Methyltransferase (TPMT) Gene Discovery. Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine and azathioprine. Patent claims to the DNA coding sequence, amino acid sequence and cell lines and mammals in which... Read More
1993-010 – Conditionally Immortalized Human Osteoblastic Cell Line: Normal human bone cells were stably transfected with a gene encoding a temperature-sensitive mutant (tsA58) of SV40 large T antigen; cells proliferate as if immortalized at 33.5C degrees but differentiate at 39.5C degrees; hFOB cells show normal bone cell characteristics with regard to responses to dihydroxyvitamin D3 and PTH, BMP’s,... Read More
1988-049 – HMC-1 is a one-of-a kind human cell line which can serve as a resource for mast cell proteins including granule proteins and mast cell genetic material (DNA and RNA). The HMC-1 line was derived from a patient with mast cell leukemia and we believe it is comprised of immature mast cells. These cells may not respond in all ways as would mature mast cells. HMC-1 cells lack a functional IgE... Read More
1987-046 – Monoclonal Antibody to Bromo-deoxy-uridine. Useful in cell proliferation kits