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- Orthopedics - Muskuloskeletal
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2007-279 – Description - Bilateral Denoising Optimal noise control is critical for dose reduction and image quality improvement in CT. Noise in CT images results from data noise in the projections, which have two principal sources: quantum noise and electronic noise. To overcome the effects of excessive noise, it is necessary to increase either the x-ray tube energy or the current, both which... Read More
2007-300 – Friedreich ataxia (FRDA) is an autosomal recessive degenerative disease caused by a deficiency of frataxin, a conserved mitochondrial protein of unknown function. Mitochondrial iron accumulation, loss of iron-sulfur cluster-containing enzymes and increased oxidative damage occur in yeast and mouse frataxin-depleted mutants as well as tissues and cell lines from FRDA patients, suggesting that... Read More
2007-230 – We have replace the mouse islet amyloid polypeptide (IAPP, amylin) gene with the human IAPP gene. Human IAPP is readily converted to amyloid fibrils. Amyloids have been associated with a large number of human diseases that are associated with cell death. Mouse IAPP is non-amyloidogenic. By replacing the mouse IAPP with the human IAPP gene we have created a physiologic model of hman IAPP... Read More
2007-103 – The abnormal accumulation of TDP-43 protein has been recently identified as the major protein constituent for several neurodegenerative diseases. The protein undergoes several post-translational modifications including phosphorylation, ubiquitination and proteolytic cleavage. The pathologic accumulation of these truncated species is believed to be pathologic. Using cell culture models, we... Read More
Establishment and Characterization of an Immunoglobulin Lambda Secreting Cell Line from a Patient with AL Amyloidosis
2007-050 – The ALMC-1 and ALMC-2 cell lines were established from samples before and after peripheral blood stem cell transplant. Both cell lines secrete lambda light chains and these light chains have been shown to contain a beta structure, which is necessary for the configuration of amyloid. Therefore, this cell line provides a useful tool to study the underlying biology of amloidogenic light chains... Read More
2007-027 – Mice that over-express the human wild-type and mutant leucine-rich repeat kinase 2 gene (LRRK2).
2006-231 – Rabbit polyclonal antibodies were generated to two components of the calcium-release activated calcium (CRAC) channel, Orai1 and STIM1. These antibodies can be used for immunofluorescence, immunoprecipitation and immunoblotting of Orai1 and STIM1.
2006-111 – A harvested bovine colon is layed out on a specially designed tray that allows for the colon to be arranged in a human configuration. This can then be used as a model that allows the performance of a simulated coloscopy for the purposes of training and competency assessment.
2006-059 – Peptide or GST-fusion proteins containing antigenic epitopes of WAVE2, Evl, VASP, HS1, STIM, CIN85 and TUBA were used to create polyclonal rabbit antisera. The antibodies are useful for IP, Western blotting and IF.
2005-318 – Mayo Clinic Researchers have created a positively charged hydrogel for controlled DNA delivery for cell transplantation. Oligo- (polyethylene glycol) fumarate (OPF) hydrogel was copolymerized with 2-(methacryloyloxy) ethyl-trimethylammonium chloride (MAETAC) to produce a positively charged hydrogel. This hydrogel can be crosslinked with multiple systems and fabricated into sheets, sponges,... Read More
2005-316 – These mice do not express the gene for CD229.
2005-247 – MAPT (tau) is a protein involved in regulating the structure and function of nerve cells. The clones contain DNA that encodes the tau protein and allow it to be made in cell lines.
2005-231 – Under the Minnesota Partnership, researchers at the University of Minnesota and at Mayo have developed a database for use in the evaluation of potential prostate cancer biomarkers. Researchers have profiled gene expression of benign and malignant cells that were laser capture microdissected (LCM) from prostate tissues and metastatic adenocarcinomas. In addition, researchers have conducted... Read More
2005-127 – Antibodies to various isoforms of HP-1 and SP-1
Hydrophilic/hydrophobic Hybrid Polymer Networks Based on Poly(caprolactone fumarate) (PCLF), Poly(Ethylene Glycol Fumarate) (PEGF), and PEGF-co-PCLF
2005-077 – We have developed a new route to synthesize the biodegradeable and injectable polymer poly(ethylene glycol fumarate) (PEGF) and its copolymer with Poly (caprolactone fumarate) (PCLF), PEGF-co-PCLF. These materials can be crosslinked with other unsaturated polymers via redox- or photo-initiation to form hybrid polymer networks. Characteristics of these hybrid networks, such as... Read More
2005-021 – Injectable, biodegradable oligo(poly(ethylene glycol) fumarate) (OPF) hydrogels were made from photopolymerization of OPF macromer with UV light and photoinitiator. Hydrogels with varying mechanical property and water content can be made with the change in macromer and crosslinking agent concentration in precursor solution. The biodegradable OPF hydrogels can be injected as fluid into the... Read More
2005-016 – These transgenic mice have regulatable tau expression and profound neurofibrillary pathology, neurodegeneration and memory impairment. The key features are (1) Protein expressed is human tau P301L; (2) Expression of transgenic tau is restricted to the forebrain; (3) Mice develop memory impairment by 2.5 months; (4) Mice develop argyrophilic neurofibrillary tangles by 4 months; (5) Mice... Read More
Wild-type Constructs for human sulfotransferase genes: namely SULT 1A1, 1A2, 1A3, 1B1, 1C1, 1C2, 2A1, 4A1, 6B1
2005-012 – Wild-type Constructs for human sulfotransferase genes: namely SULT 1A1, 1A2, 1A3, 1B1, 1C1, 1C2, 2A1, 4A1, 6B1. Encoded by these genes are critical for enzymes, metabolism, activation and also detoxification of numerous drugs and compounds.
2004-258 – Mayo Clinic Researchers have developed a new synthetic, biodegradable, injectable polymer, poly (epsilon-caprolactone fumarate) that is also photocrosslinkable. This new material is colorless or light-colored, and is shown to be self-crosslinkable by both redox initiation and photoinitiation. The molecular weight, chain flexibility, crystallinity, degradation rate, and mechanical properties... Read More
2004-200 – Mayo Clinic Researchers have developed a new synthetic, biodegradable, injectable polymer, poly (propylene fumarate-co-caprolactone) [P(PF-co-CL)]. This new material is a block copolymer of poly (propylene fumarate) (PPF) and poly (epsilon caprolactone) (PCL). The molecular weight, mechanical strength, chain flexibility, degradation rate, and crystallinity can be controlled by varying the... Read More
2004-154 – Expression of GALV-fuse gene in tumor cells causes them to fuse with their nontransfected neighbors forming a multicellular syncytia which eventually dies.
2004-109 – This invention is a mouse line in which we disrupted the gene for FKBP52, a protein component of steroid receptor complexes. The animals are reproductively compromised. These animals can be helpful in screening for environmental compounds and drugs that might bind FKBP52 and alter FKBP52-dependent processes. Of particular interest will be compounds that may promote defects in sexual... Read More
2004-108 – The invention is a mouse line in which we disrupted the gene for FKBP51, a protein component of steroid receptor complexes. These animals can be helpful in screening for compounds and drugs that bind FKBP51 and alter FKBP51-dependent processes.
2004-061 – We have developed a series of polyclonal antibodies specific for SRC-2 and REA steroid receptor coregulators. The affinity purified antibodies have demonstrated a marked specificity of each polyclonal antibody to its specific co-regulator and this has shown to be functional with western blot analysis, co-precipitations, competition with the specific peptide used as an immunogen, and even the... Read More
2003-196 – Transgenic mice were created through DNA microinjection of a construct utilizing mouse EPO derived regulatory sequences in conjunction with the Diptheria Toxin A chain (DT-A) open reading frame and a series of exons/introns derived from the human growth hormone gene to provide the necessary splicing events required for high-level expression. Assessments of circulating leukocytes and other... Read More
2003-150 – A mouse lacking both copies of the IEX-1 gene was generated. These mice have a mean arterial blood pressure that is approximately 30mm of Hg higher than that seen in wild type mice. These mice are useful for assessing compounds for the ability to reduce high blood pressure.
2002-136 – Rabbit polyclonal antisera were produced against human and murine Vav-3 proteins using KLH-conjuaged peptides. These antisera recognize an approximately 98 kilodalton protein corresponding to Vav3.
2002-121 – A monoclonal antibody that interacts with the liver and bone isoenzymes of human alkaline phosphatase.
2002-116 – H4 cell line stably transfected with an APP695wt clone in the pCDNA3 vector.
2002-039 – Technology Description T cell-mediated immune responses are often harmful in transplant patients and patients with autoimmune disease. Currents treatments to suppress T cell-mediated immune responses include a number of immunosuppressive and anti-inflammatory therapies. A novel means of suppressing this immune response has been developed that utilizes mutant forms of a protein normally... Read More
2001-158 – The Avian Leukosis Virus (AVL) group of retroviruses offers a novel platform for the display of polypeptides and offers novel applications for polypeptide display technology. The ability to display polypeptides on the ALV envelope glycoproteins in a replicating retrovirus with an additional expression cassette presents several unique approaches to use this display platform to probe the... Read More
2001-040 – Using monoclonal antibodies (mAb) to 4-1BB (CD137) T cell molecule, we will be able to show that this treatment can regress established tumors in mouse models in combination with antigenic peptides and cytokine-modified tumor vaccines. Furthermore, treatment by anti-4-1BB mAb also ameliorates experimental autoimmune encephalomyelitis (EAE) in mice, a model of multiple sclerosis in human. ... Read More
2001-023 – A novel expression system has been developed that selectively expresses ABeta40 or ABeta42 in the secretory pathway. This system enables expression of high levels of specific ABeta peptides. Such a system may be invaluable in developing animal models that critically determine the pathogenicity of individual ABeta peptides. In addition, the system may have general utility as a means of... Read More
2001-021 – Monoclonal antibodies developed against specific portion of the huma sodium iodide symporter (hNIS). Antibody 2-2 and 14f were developed against synthetic peptides representing the 2nd and 14th extramembranous loops of hNIS and antibody FP5a was developed against an MBP-hNIS fusion protein including a carboxyl terminal sequence of hNIS. The antibodies have been characterized and were found... Read More
2000-176 – Polyclonal antibodies, NR1, NR2 and NR3 against human and rat PMCa isoforms 1, 2 and 3.
2000-066 – We have created two lines of transgenic mice expressing human tau with the P301L mutation. Mice expressing the 2-3-10+ human isoform with the P301L mutation develop tau neurofibrillary tangles, motor deficits, and behavioral abnormalities. Mice expressing the longest human tau isofrom (2+3+10+) with the P301L mutation develop balloned neurons as well as neurofibrillary tangles. Motor and... Read More
2000-065 – Mouse class II-deficient HLA-DQB10302, DQA10301 (DQ8) transgenic mice are susceptible to severe collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. To examine whether polymorphism at the DRB1 locus can modulate DQ-restricted arthritis, we generated double- transgenic (DR/DQ) mice. DRB1*0301 (DR3) was introduced into CIA susceptible DQ8.Abeta transgenic mice to generate... Read More
2000-064 – We developed an HLA-DR3.Abo mouse by introducing the DR3 transgene into a H2Abo mouse, class II negative strain, by mating with BIO.M-DRB1*0301 mice. Experimental autoimmune thyroiditis (EAT) is induced in these mice when immunized with either MTg or HTg.
1999-065 – Investigators are combining mEPO and together with mEPO deficient gene knock-out animals to create a battery of monoclonal antibodies against this eosinophil granular ribonuclease. Highly specific, sensitive antibodies will be produced that will be useful in assays and drug discovery programs for eosinophil-related diseases such as asthma, allergy and inflammation.
1999-064 – Investigators have developed a rabbit polyclonal antisera reactive against murine major basic protein-1 (native protein purified from isolated mouse eosinophils). MBP is a known factor in the asthma, inflammation and allergy pathways. This antibody is highly specific and would be useful in a variety of assays where high specificity and sensitivity are desired.
1999-003 – Polyclonal antibody and purification thereof that recognizes the Amyloid B. peptide (AB).
1998-026 – Mutations in the tau gene have been discovered that are linked to Tau pathologies. Identification of these mutations can lead to animal models of neurodegenerative diseases to be developed and provides methods for determining a diagnosis of neurodegenerative disease in a patient.
1997-112 – An inbred strain of transgenic mice that show tissue-specific expression of the human MUC1 gene. These animals express a form of the human MUC1 gene which codes for the core protein of a mucin expressed by glandular epithelia and carcinomas which develop from these tissues. The core protein is underglycosylated in these cancers and therefore represents a possible target for immunotherapy.... Read More
1997-106 – Mayo researchers have established several human multiple myeloma cell lines, including the ANBL-6, KP-6, KAS-6/1 and DP-6 lines.
1997-071 – We generated an HLA-DR4ß(NT) transgene construct in which positions 110 and 139 were altered to resemble endogenous mouse H2 Aß molecules. This construct was introduced into (B10 x SWR) embryos, and DR4ß(NT) transgenic mice were produced. The transgene was transferred into B10.RFB3 (Eß0 Ealphap) mice. The transgene-encoded DR4ß molecules paired with endogenous Ealpha chains to form stable... Read More
1997-069 – We developed an HLA-DR2 mouse model by introducing a human DRB1*1502(DR2DW12) transgene into CIA susceptible BIO.RQB3 (H2A8) mice. These mice showed a significant reduction in the incidence and severity of arthritis. For further information please see Human Immunology, 1996, 50:54-60.
1997-035 – This technology is a T-cell line that lacks the protein tyrosine kinase, ZAP-70. ZAP-70 plays a critical role in the initiation of lymphocyte activation responses to antigenic stimuli. The cell line can be used to define the mechanisms of ZAP-70 activation and function in T-cell signaling. This line can be used also to confirm the mechanism of action of ZAP-70 targeted drugs. This is the... Read More
1996-076 – Transgenic mouse (Tg2576) carrying the Swedish mutation for Alzheimer’s Disease. This mouse was developed by Dr. Karen Hsiao Ashe at the University of Minnesota and is exclusively licensed to Mayo. This mouse develops age-related neuropathology, including development of amyloid plaques and behavioral changes, and can be used in research related to Alzheimer’s Disease and other... Read More
1995-155 – HFOBER cells are hFOBs stably transfected with human estrogen receptor; subclones HFOB/ER-3 and HFOB/ER-4 express levels of estrogen receptor consistent with the range of levels measured in human osteoblasts. The HFOBER cell lines have a complete concatenation of transcription factors such that the estrogen receptor is transactionally active; estrogen-regulated functions are maintained. The... Read More
1995-140 – Transgenic mouse models for asthma were developed that express interleukin-5 under the control of a lung epithelial specific promoter. All mice express abnormally high levels of eosinophils in those regions and display symptoms consistent with the underlying physiologic conditions. The CCIL-5 mouse line is a superb animal model for the study of asthma. The animals show hyperactivity to... Read More