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2009-362 – Background Topoisomerase I has been used as a drug target for cancer treatment. By inhibiting the religation step of the enzyme, the formation of topo I-DNA complexes block the advancing replication complexes, which will ultimately cause cell death. Thus, measurement of the covalent topo I-DNA complexes can potentially be used to assess therapeutic efficacy of topoisomerase I poisons. ... Read More
Improved Quality for Magnetic Resonance Spectroscopy Spectra Using Eigenvalve Deconvolution and Special Lower Triangular Matrix of Time Activity Data
2009-323 – Eigenvector decomposition allows consistent eigenvalues to be produced from different data set acquisition of the same sample material.
2009-314 – This disclosure is for a continuation-in-part to US Patent Application No: US 2006/0056310 A1. The original patent application uses only a symmetrical THRU structure for de-embedding. In this disclosure both OPEN and SHORT structures are presented as additional structures that, once measured with a VNA, can yield additional equations.
2009-309 – The general method has been discussed in “System and Method for Phone Offset and Time Delay Correction in Magnetic Resonance Spectroscopy Data”. (2007-100). Here it is added that the magnitude of the real imaging parts of the data are used for the spectrum.
2009-296 – Mouse model of recessive polycystic Kidney Disease (ARPKD)
2009-278 – Specific and highly sensitive ultrasound localization of catheter placement can be accomplished by use of a catheter navigation crystal with an active (vibrating) element whose ultrasonic signal interferes with the ultrasound imaging signal as the latter propagates with each transmitted bearn though issue. The interference signal (caused by the crystal) occurs directly within the Doppler... Read More
2009-219 – Suppressive Monocytes as Markers of Response to Renal Cell Carcinoma Therapy The incidence of and deaths caused by renal cell carcinoma (RCC) are increasing in the United States. Over 80 percent of renal cell carcinomas are due to the subtype clear cell renal cell carcinoma (ccRCC). The majority of patients with renal cell carcinoma confined to the kidney can be cured by surgery; however,... Read More
2009-191 – In MR and CT imaging, any reduction in scan time offers potential benefits ranging from high temporal rate observation of physiologic processes to reduction of motion artifacts to lower radiation dose (for CT) to improve patient comfort and throughput. With compressing sensing (CS) techniques, certain classes of MR and CT images can be accurately reconstructed from highly undersampled (and... Read More
2009-179 – For certain types of time series CT studies, Prior Image Constrained Compressed Sensing (PICCS) has been shown to significantly reduce the number of required data samples that must be acquired, thereby reducing the radiation dose to patients. PICCS is based on standard compressed sensing L1-norm minimization techniques. An alternative homotopic L0-based minimization technique developed... Read More
2009-140 – This technology relates to materials and methods for inhibiting botulinum neurotoxins (BoNTs), and more particularly to materials and methods for inhibiting the zinc endopeptidase of BoNT serotypes A, D, and/or E (BoNTA, BoNTD and /or BoNTE to (1) treat botulism, (2) Protect against botulism, or (3) use as an adjunct therapy during administration of medical toxins that are based upon... Read More
2009-132 – A monoclonal antibody to MDC1, a key mediator of DNA damage response.
2009-126 – This invention includes the developement of inducible transgenic mice expressing human TDP-43 cDNA encoding the TAR-binding protein 43kD.
2009-125 – This invention includes the development of a homozygous transgenic mouse model expressing wild-type human TDP-43 cDNA encoding the TAR-binding protein 43kD endogenous levels.
WINCSWare: Two-way Wireless Communication Between Sensor and Control Unit for Data Aquisition and Selection of Sensing Parameters (Neurochemicals, Time, etc.) and Software for Processing of Incoming Data and Visual Display in Real-Time
2009-106 – Two-way Wireless Communication Between Sensor and Control Unit for Data Acquisition and Selection of Sensing Parameters (Neurochemicals, Time, etc.) and Software for Processing of Incoming Data and Visual Display in Real-Time.
WINCS Hardware & Combination of Amperometry and Voltametry in One System for Measuring Neurochemicals in Real-Time
2009-065 – Emerging evidence supports the hypothesis that modulation of specific central neuronal systems contributes to the clinical efficacy of deep brain and motor cortex stimulation. Real-time monitoring of the neurochemical output of targeted regions may therefore advance functional neurosurgery by, among other goals, providing a strategy for investigation of mechanism, identification of new... Read More
2009-064 – Previous studies had demonstrated the importance of adenosine in the mechanism of Thalamic DBS for Essential Tremor. Real-time monitoring of the neurochemical output of targeted regions may therefore advance functional neurosurgery by, among other goals, providing a strategy for investigation of mechanism, identification of new candidate neurotransmitters, and chemically guided placement of... Read More
2009-043 – To reduce radiation dose and/or improve image quality in CT, it is very important to select the optimal tube potential (kV), which is highly dependent on patient size and specific diagnostic task. In this invention, we developed a general strategy that allows for individualized automatic kV selection for each patient size and each diagnostic task. We proposed a novel concept, kV dose index... Read More
2009-017 – Very long chain polyunsaturated fatty acids (VLPUFAs) are present in the human retina and play an important role in maintaining the structure and function of the retina. A disease with a defect in the gene that synthesizes VLPUFAs in the retina leads to an early onset degeneration of the macula and severe loss of vision. Currently, these VLPUFAs and other very long chain fatty acids are not... Read More
2008-368 – We have generated a human neuronal culture to model formation of alpha-synuclein aggregates in Parkinson’s disease (PD) and dementia with Lewy bodies (DLBD). By engineering conditional expression of alpha-synuclein, we established a novel cell-based model 3D5, in which production of wild-synuclein was regulated by the tetracycline off inducible mechanism. Two to four weeks following... Read More
2008-277 – Anaplastic thyroid carcinoma (ATC) is one of the deadliest cancers with lethality of >99% and survival average of 4 months. Recent publications have demonstrated over 40% of thyroid cell lines are of questionable origin especially ATC cell lines (Schweppe et al., J Clin Endocrinol Metab 2008). We have developed four cell lines from human ATC tumor tissues. These cell lines represent the... Read More
Mathematical Model of Insulin Secretion in Response to Changing Glucose Concentrations to Allow Creation of an Artificial Pancreas
2008-201 – The relationship between insulin secretion and changes in glucose concentrations is not linear and is affected by parameters such as body weight, rate of change, time of day, concomitant activities such as exercise or eating and insulin sensitivity. This model attempts to relate the relationship of insulin to glucose in terms that would be used to program an insulin pump that could respond to... Read More
2008-195 – Retroviral or lentiviral vector-mediated stable introduction of some stem cell-associated genes can reprogram adult somatic cells into embryonic stem cell-like “induced pluripotent stem (iPS) cells.” Our inventions are i) cross-species reprogramming (e.g. use of human factors to generate iPS cells from non-human origin, such as a mouse, rat, hampster, cat, dog, pig, cow, sheep, horse or... Read More
2008-163 – These mice conditionally express the human tau cDNA (4RON isoform) containing the FTDP-17 mutation (P301L) in exon 10. These mice utilize the TET-ON/TET-OFF® system to express approximately 7X human tau in comparison to murine tau. Both the tTA transgene (Memory Pharmaceuticals) and the tau transgene (Mayo) must be present to yield expression of the human tau. Doxycycline in the diet of the... Read More
2008-184 – This invention relates to the production in large quantity and high purity of a novel peptide expression plasmid. Peptides are short polymers formed from amino acids, working as signaling molecules. In biomedicine, peptides are used as probes to resolve protein interactions, a key biological process governing multiple vital functions, as well as drugs to target disease-causing proteins.... Read More
2008-125 – Monoclonal antibodies were raised to human Abeta 1-42. The peptide used to immunize was Abeta 35-42. This antibody is also known as MM26-2.1.3 and also as clone MM26-126.96.36.199.86 and also as Ab42.2
2008-124 – Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was fibrillar Abeta 1-42. This antibody is also known as AB42-5.
2008-123 – Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was Abeta 1-16. This antibody is also known as Ab-9
2008-121 – Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was Abeta 1-16. This antibody is also known as MM27-33.1.1
2008-120 – Monoclonal antibodies were raised to human Abeta 1-40. The peptide used to immunize was Abeta 35-40. This antibody is also known as MM32-13.1.1 and also as Ab40.1
2008-115 – Technology Description Purified antibodies from rabbit serum that specifically recognize the Eps15 protein at two different and distinct regions. These antibodies have a wide variety of applications in research as well as diagnostic uses where recognition of Eps15 protein is necessary. Reference “Eps15 Mediates Vesicle Trafficking from the trans-Golgi Network via an Interaction with the... Read More
2008-084 – Validated bowel disease questionaire
2008-016 – Four mouse anti-SINA/SIAH monoclonal antibodies are available for licensing. Details are as follows. Two monoclonal antibodies against the SINA-C-terminal peptide (C-GC-FDTSIAQLFADNGNLGINVTISLV) (a 27-mer): (1) 8G7H12, (2) 4B4B6. Two monoclonal antibodies against the SINA-N-terminal peptide (SNKINPKRREPTAA-GGC) (a 17-mer): (1) 24E6H3, (2) 22B9B5. References Rebecca L. Schmidt,... Read More
2008-035 – Mice lacking 53BPI were developed at Mayo to study DNA damage responses and tumor suppression. See Ward et al. (2003) Mol Cell Biol 23(7):2556-2563
2007-330 – We created mice that contain human LRRK2 cDNA encoding either the wild-type or G2019S mutant form of the gene (hereafter termed “responder line(s).” The cDNA in these animals has been placed behind a minimal CMV promoter containing TetO and will only produce human LRRK2 protein when combined (in bigenic mice) with tTA. We have demonstrated in COS7 cells that the human LRRK2 expression from... Read More
2007-326 – JJ12 is a mouse monoclonal IgG antibody that was prepared against the human protein p23, a co-chaperone for the molecular chaperone protein Hsp90. p23 was isolated into balb/c mice, and hybridoma cells were made by fusion with the cell line P3NS-11-AG4-1(NS-1). JJ12 has a high affinity for p23 from humans and several other vertebrates. It is useful for the measurement of p23 by western... Read More
2007-325 – JJ6 is a mouse monoclonal IgG antibody that was prepared against the human protein p23, a co-chaperone for the molecular chaperone protein Hsp90. p23 was isolated and injected into balb/c mice, and hybridoma cells were made by fusion with the cell line P3NS-11-AG4-1 (NS-1). JJ6 has a high affinity for p23 from humans and several other vertebrates. It is useful for the measurement of p23 by... Read More
2007-324 – This is a monoclonal antibody, produced in mice, to the human protein tsp23 which has sequence similarity to the molecular co-chaperone p23.
2007-323 – This is a monoclonal antibody against GCUNC45 (General Cell UNC45) also called SMAP-1 which has sequence similarity with the SMUNC45 (Striated muscle UNC45). These are homologues of the C. elegans UNC45. This antibody is useful western blotting and imunohistochemistry.
2007-288 – Mice in which the endogenous leucine-rich repeat kinase 2 gene (LRRK2) has been ablated. Exon 41 has been flanked with loxP sites to alow Cre-mediated deletion. The region deleted contains the serion/threonine protein kinase catalytic domain. Splicing of exon 40 to 42 causes a frameshift mutation with the introduction of an early stop codon (TGA).
2007-279 – Description - Bilateral Denoising Optimal noise control is critical for dose reduction and image quality improvement in CT. Noise in CT images results from data noise in the projections, which have two principal sources: quantum noise and electronic noise. To overcome the effects of excessive noise, it is necessary to increase either the x-ray tube energy or the current, both which... Read More
2007-300 – Friedreich ataxia (FRDA) is an autosomal recessive degenerative disease caused by a deficiency of frataxin, a conserved mitochondrial protein of unknown function. Mitochondrial iron accumulation, loss of iron-sulfur cluster-containing enzymes and increased oxidative damage occur in yeast and mouse frataxin-depleted mutants as well as tissues and cell lines from FRDA patients, suggesting that... Read More
2007-230 – We have replace the mouse islet amyloid polypeptide (IAPP, amylin) gene with the human IAPP gene. Human IAPP is readily converted to amyloid fibrils. Amyloids have been associated with a large number of human diseases that are associated with cell death. Mouse IAPP is non-amyloidogenic. By replacing the mouse IAPP with the human IAPP gene we have created a physiologic model of hman IAPP... Read More
2007-103 – The abnormal accumulation of TDP-43 protein has been recently identified as the major protein constituent for several neurodegenerative diseases. The protein undergoes several post-translational modifications including phosphorylation, ubiquitination and proteolytic cleavage. The pathologic accumulation of these truncated species is believed to be pathologic. Using cell culture models, we... Read More
Establishment and Characterization of an Immunoglobulin Lambda Secreting Cell Line from a Patient with AL Amyloidosis
2007-050 – The ALMC-1 and ALMC-2 cell lines were established from samples before and after peripheral blood stem cell transplant. Both cell lines secrete lambda light chains and these light chains have been shown to contain a beta structure, which is necessary for the configuration of amyloid. Therefore, this cell line provides a useful tool to study the underlying biology of amloidogenic light chains... Read More
2007-027 – Mice that over-express the human wild-type and mutant leucine-rich repeat kinase 2 gene (LRRK2).
2006-231 – Rabbit polyclonal antibodies were generated to two components of the calcium-release activated calcium (CRAC) channel, Orai1 and STIM1. These antibodies can be used for immunofluorescence, immunoprecipitation and immunoblotting of Orai1 and STIM1.
2006-111 – A harvested bovine colon is layed out on a specially designed tray that allows for the colon to be arranged in a human configuration. This can then be used as a model that allows the performance of a simulated coloscopy for the purposes of training and competency assessment.
2006-059 – Peptide or GST-fusion proteins containing antigenic epitopes of WAVE2, Evl, VASP, HS1, STIM, CIN85 and TUBA were used to create polyclonal rabbit antisera. The antibodies are useful for IP, Western blotting and IF.
2005-318 – Mayo Clinic Researchers have created a positively charged hydrogel for controlled DNA delivery for cell transplantation. Oligo- (polyethylene glycol) fumarate (OPF) hydrogel was copolymerized with 2-(methacryloyloxy) ethyl-trimethylammonium chloride (MAETAC) to produce a positively charged hydrogel. This hydrogel can be crosslinked with multiple systems and fabricated into sheets, sponges,... Read More
2005-316 – These mice do not express the gene for CD229.