2013-157 – Application Enhance transduction and transgene expression of Adeno-associated virus (AAV) vectors using U2 snRNP spliceosome inhibitors Value Proposition AAV has become one of the leading gene delivery vectors in clinical development. Gene therapy using recombinant AAV has been demonstrated to be safe and well-tolerated in virtually every clinical setting in which it has been used.... Read More
2012-156 – We have developed a novel technique for in-vivo genome editing using TALENs
2008-195 – Retroviral or lentiviral vector-mediated stable introduction of some stem cell-associated genes can reprogram adult somatic cells into embryonic stem cell-like “induced pluripotent stem (iPS) cells.” Our inventions are i) cross-species reprogramming (e.g. use of human factors to generate iPS cells from non-human origin, such as a mouse, rat, hampster, cat, dog, pig, cow, sheep, horse or... Read More
2004-154 – Expression of GALV-fuse gene in tumor cells causes them to fuse with their nontransfected neighbors forming a multicellular syncytia which eventually dies.
2001-158 – The Avian Leukosis Virus (AVL) group of retroviruses offers a novel platform for the display of polypeptides and offers novel applications for polypeptide display technology. The ability to display polypeptides on the ALV envelope glycoproteins in a replicating retrovirus with an additional expression cassette presents several unique approaches to use this display platform to probe the... Read More