2015-347 – Mayo Clinic has developed compositions and methods for detecting soluble PD-L1
2009-333 – ERB (estrogen receptor beta) mouse monoclonal antibody. Epitope: amino acids 1-140 Known Applications: Enzyme-linked immunosorbent assay (ELISA), Immunohistochemistry (IHC), Western blot (WB) Known Reactivity: Human
2006-220 – Hi52C is a mouse monoclonal antibody (IgG) generated against recombinant human FKBP52. The antibody is highly specific for FKBP52 and recognizes antigen on Western blots and will immunoprecipitate native protein complexes containing FKBP52. Hi52C is known to crossreact with FKBP52 from human, mouse, and rabbit sources. PMID Publication:15831525
2006-219 – Hi51B is a mouse monoclonal antibody (IgG) generated against recombinant human FKBP51. The antibody is highly specific for FKBP51 and recognizes antigen on Western blots and will immunoprecipitate native protein complexes containing FKBP51. Hi51B is known to crossreact with FKBP51 from human, mouse, and rabbit sources.
2004-287 – Rabbit polyclonal antibodies were generated to a specific phosphorylated peptide in the Smad3 protein. Epitope: COOH-GSPSIRCSpSVpS Known Applications: Western blot (WB) Known Reactivity: Human PMID 15520863
2000-124 – Rat IgG Monoclonal Antibody Reactive Against Murine MBP Major basic protein, Clone 14.7.4 Known Applications: Immunohistochemistry (IHC), Western blot (WB) Known Reactivity: Mouse NIH publication 11067904
Two Stable H4 Neuroglioma Cell Lines Expressing Alpha-synuclein Bioluminescent- and Fluorescent- Protein Complemention Pairs
2013-134 – A plasmid was constructed to contain an FRT cassette, hygromycin resistance, and a tetracycline-driven bidirectional promoter. Then the cDNA encoding alpha-synuclein protein was fused with either the N- or C-terminal half of gaussia luciferase, or with the N- or C-terminal half of Yellow Fluorescent Protein sequences. These fusion constructs were then inserted in the bidirectional plasmid... Read More
2013-082 – Antigen specific recognition is involved in adaptive immune responses. Most T lymphocytes express an antigen specific αβ T Cell Receptor (TCR) responsible for recognizing its ligand (peptide/MHC) and responding through various effector functions. In an attempt to better understand TCR function, extensive efforts have been placed in discerning the structural and biochemical makeup of the TCR.... Read More
2013-061 – We have developed an ongoing procedure at Mayo Clinic for obtaining and xenografting fresh pancreatic adenocarcinoma tumors into SCID mice. The tissues are obtained through an institutionally review board approved process, and informed consent is obtained from the patients. We have full annotation of clinical characteristics and disease course of the patients. Pretreatment blood samples... Read More
2012-302 – A 12 gene-panel is described capable of predicting whether an induced pluripotent stem (iPS) cell line will have high or low cardiogenic potential upon in vitro differentiation. By comparing microarray data from high-cardiogenic versus low-cardiogenic lines, a discrete panel of genes was extracted and validated in 18 undifferentiated mouse iPS lines. Using PCR for these 12 genes from... Read More
2012-252 – Patient derived tumor tissue samples that have been demonstrated to grow in mice.
2012-133 – TSEC are an SV40-immortalized cell line, derived from hepatic sinusoidal endothelial cells (HSEC), that maintain an endothelial phenotype as well as some HSEC-specific features. The cells have typical microscopic features of endothelia, including formation of lamellipodia and filopodia and a cobblestone morphology of cell monolayers. TSEC maintain a limited number of fenestrae organized in... Read More
2012-121 – We describe here the establishment of a new WM cell line, MWCL-1. Comprehensive genetic analyses have unequivocally confirmed a clonal relationship between this novel cell line and the founding tumor. MWCL-1 cells exhibit an immunophenotype consistent with a diverse, tumor clone composed of both small B lymphocytes and exhibit an immunophenotype consistent with a diverse, tumor clone... Read More
2012-093 – Background LRP1 is a ubiquitously expressed receptor that mediates rapid endocytosis of various ligands. By modulating the trafficking of other signaling receptors, LRP1 plays a significant role in the central nervous system and peripheral tissue. It is thought that malfunction of the LRP1-related pathway is a causal factor of cardiovascular and Alzheimer’s disease. Thus, there is tremendous... Read More
Nuclear Reprogramming Through Oxygen-Independent Metabotype Purges Dysfunctional Mitochondrial Heteroplasmy
2012-007 – Mitochondrial disease is inherited through maternal transmission of mutated mitochondrial DNA (mtDNA) with disease phenotypes determined by the unpredictable mixture of mutant and wild-type mtDNA. Mitochondrial heteroplasmy is dependent upon stochastic segregation of mtDNA into discrete units during early embryogenesis as mtDNA replication is shut off during blastomere expansion. Since... Read More
2011-261 – A mouse monoclonal anti-human TRAIL-s antibody has been made against the novel c-terminus of the TRAIL isoform detailed in: Isolation of a TRAIL antagonist from the serum of HIV-infected patients. Schnepple DJ, Shepard B, Bren GD, Cummins NW, Natesampillai S, Trushin S, Algeciras-Schimich A, Meng XW, Sainski AM, Rizza SA, Kaufmann SH, Badley AD. J Biol Chem. 2011 Oct 14;286(41):35742-54.
2011-092 – T cells drive adaptive immune responses that can turn out pathogenic when directed against your own body tissues and organs causing autoimmune diseases. On the other hand, T cells are the main cellular component driving acute organ rejection after transplantation. Therefore different strategies to deplete/inactivate T cells have been pursued to treat patients either suffering from autoimmime... Read More
2011-076 – pEct2 antibody
2011-074 – This invention includes the development of inducible M17 neuroblastoma cell lines expressing human TDP-43 cDNA encoding the wild type, disease associated mutants, nuclear localization mutant and RNA binding mutant TAR-binding protein 43kD.
2010-306 – Thyroid cancer cell lines were created from patient tumor tissues directly from the resected tumor tissue, tissue minced and cultured in cell culture media. These cells lines will be characterized at the molecular level [genetic defects, short tandem DNA repeat analysis (STR)] and phenotypically with regards to growth in cell culture and animals. These well characterized cell lines should... Read More
2010-305 – Cell lines were created from patient tumor tissues directly from the resected tumor tissue, tissue minced and cultured in cell culture media. These cells lines will be characterized at the molecular level (genetic defects, short tandem DNA repeat analysis (STR)) and phenotypically with regards to growth in cell culture and animals. These well characterized cell lines should prove to be useful... Read More
2010-278 – Nuclear reprogramming technology has provided the fundamental basis to convert ordinary cells in the adult body into pluripotent stem cells that can function as embryonic stem cells. This bioengineering platform enables a revolutionary breakthrough for stem cell biology and regenerative medicine applications despite current technology being challenged by low efficiencies and ill-defined... Read More
2010-222 – This invention covers the design, genetic engineering and construction of the inducible TDP-43 wild-type and D89/219E double mutant constructs utilized to create the iTDP Tg mice.
2010-206 – Patient derived tumor tissue samples that have been demonstrated to grow in mice.
2010-203 – Reagents to study the biology of the rare human bronchopulmonary carcinoid tumor are very limited. We have created cell lines derived from tumors resected from patients treated at Mayo Clinic. These cell lines will aid investigators to test existing and future medications for efficacy in killing these tumors on the cell lines prior to human studies. These cell lines will aid investigations... Read More
2010-178 – Technology Description We have developed human lung cancer cell lines in which the expression of the PKClota oncogene has been genetically manipulated. Specifically, the cell lines are transduced with rec ombinant lentiviruses that express either a shRNA targeting the PKCiota mRNA or a non-target control shRNA that does not target any known RNA. These cell lines allow one to investigate the... Read More
2010-061 – Calcific aortic valve stenosis is a growing problem in developed countries, and valve replacement surgery is the second most common thoracic surgery performed worldwide (>100,000 procedures performed in the US in 2008). Bioprosthetic valves are the most commonly used devices to replace the stenotic valve, but only have a projected lifespan of 10-12 years. Cells infiltrating the... Read More
2009-140 – This technology relates to materials and methods for inhibiting botulinum neurotoxins (BoNTs), and more particularly to materials and methods for inhibiting the zinc endopeptidase of BoNT serotypes A, D, and/or E (BoNTA, BoNTD and /or BoNTE to (1) treat botulism, (2) Protect against botulism, or (3) use as an adjunct therapy during administration of medical toxins that are based upon... Read More
2009-132 – A monoclonal antibody to MDC1, a key mediator of DNA damage response.
2009-017 – Very long chain polyunsaturated fatty acids (VLPUFAs) are present in the human retina and play an important role in maintaining the structure and function of the retina. A disease with a defect in the gene that synthesizes VLPUFAs in the retina leads to an early onset degeneration of the macula and severe loss of vision. Currently, these VLPUFAs and other very long chain fatty acids are not... Read More
2008-139 – Mouse monoclonal Ab9-A, isotype A of the original Ab9 mouse monoclonal made to human amyloid beta 1-16, was created by class-switching the original Ab9 IgG isotype. This was done with serial dilutions to find the very few clones of isotype A, identifying these clones, and growing them up. Fourteen clones were identified. All are likely to be useful. Only one, 15E7.17.10 (see table), was grown... Read More
2008-184 – This invention relates to the production in large quantity and high purity of a novel peptide expression plasmid. Peptides are short polymers formed from amino acids, working as signaling molecules. In biomedicine, peptides are used as probes to resolve protein interactions, a key biological process governing multiple vital functions, as well as drugs to target disease-causing proteins.... Read More
2008-126 – Monoclonal antibodies were raised to human Abeta1-42. The peptide used to immunize was Abeta 35-42. This antibody is also known as MM40-21.3.1
2008-125 – Monoclonal antibodies were raised to human Abeta 1-42. The peptide used to immunize was Abeta 35-42. This antibody is also known as MM26-2.1.3 and also as clone MM26-220.127.116.11.86 and also as Ab42.2
2008-124 – Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was fibrillar Abeta 1-42. This antibody is also known as AB42-5.
2008-123 – Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was Abeta 1-16. This antibody is also known as Ab-9
2008-121 – Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was Abeta 1-16. This antibody is also known as MM27-33.1.1
2008-120 – Monoclonal antibodies were raised to human Abeta 1-40. The peptide used to immunize was Abeta 35-40. This antibody is also known as MM32-13.1.1 and also as Ab40.1
2008-115 – Technology Description Purified antibodies from rabbit serum that specifically recognize the Eps15 protein at two different and distinct regions. These antibodies have a wide variety of applications in research as well as diagnostic uses where recognition of Eps15 protein is necessary. Reference “Eps15 Mediates Vesicle Trafficking from the trans-Golgi Network via an Interaction with the... Read More
2008-104 – Monoclonal antibodies were raised to rodent Abeta 1-16. The peptide used to immuize was rodent Abeta 1-16. This antibody is also known as MM44-32.4.1
2008-103 – Monoclonal antibodies were raised to human Abeta 1-38. The peptide used to immunize was Abeta 35-40. This antibody is also known as MM43-14.1.1
2008-016 – Four mouse anti-SINA/SIAH monoclonal antibodies are available for licensing. Details are as follows. Two monoclonal antibodies against the SINA-C-terminal peptide (C-GC-FDTSIAQLFADNGNLGINVTISLV) (a 27-mer): (1) 8G7H12, (2) 4B4B6. Two monoclonal antibodies against the SINA-N-terminal peptide (SNKINPKRREPTAA-GGC) (a 17-mer): (1) 24E6H3, (2) 22B9B5. References Rebecca L. Schmidt,... Read More
2007-326 – JJ12 is a mouse monoclonal IgG antibody that was prepared against the human protein p23, a co-chaperone for the molecular chaperone protein Hsp90. p23 was isolated into balb/c mice, and hybridoma cells were made by fusion with the cell line P3NS-11-AG4-1(NS-1). JJ12 has a high affinity for p23 from humans and several other vertebrates. It is useful for the measurement of p23 by western... Read More
2007-325 – JJ6 is a mouse monoclonal IgG antibody that was prepared against the human protein p23, a co-chaperone for the molecular chaperone protein Hsp90. p23 was isolated and injected into balb/c mice, and hybridoma cells were made by fusion with the cell line P3NS-11-AG4-1 (NS-1). JJ6 has a high affinity for p23 from humans and several other vertebrates. It is useful for the measurement of p23 by... Read More
2007-324 – This is a monoclonal antibody, produced in mice, to the human protein tsp23 which has sequence similarity to the molecular co-chaperone p23.
2007-323 – This is a monoclonal antibody against GCUNC45 (General Cell UNC45) also called SMAP-1 which has sequence similarity with the SMUNC45 (Striated muscle UNC45). These are homologues of the C. elegans UNC45. This antibody is useful western blotting and imunohistochemistry.
2007-259 – We have generated 2 B-cell lines from 2 individual CVID patients who have a specific mutation in the TACI gene. TACI gene mutations are associated with 10-15% of CVID cases. The A181E mutation has been described as being significantly associated with CVID patients compared to normal controls. EBV-transformation of B-cells has been traditionally used to immortalize patient cells and provide a... Read More
2006-231 – Rabbit polyclonal antibodies were generated to two components of the calcium-release activated calcium (CRAC) channel, Orai1 and STIM1. These antibodies can be used for immunofluorescence, immunoprecipitation and immunoblotting of Orai1 and STIM1.
2006-059 – Peptide or GST-fusion proteins containing antigenic epitopes of WAVE2, Evl, VASP, HS1, STIM, CIN85 and TUBA were used to create polyclonal rabbit antisera. The antibodies are useful for IP, Western blotting and IF.
2005-127 – Antibodies to various isoforms of HP-1 and SP-1