2013-050 – The invention is a low-cost fluorescence camera system that can be used to obtain fluorescence images.
2013-081 – Magnetic resonance imaging (MRI) is widely used to diagnostically investigate the human body. However, unlike other medical imaging modalities (e.g., X-ray CT), MRI data is not explicitly quantitative - pixel values do not directly represent physiological information. There is strong clinical interest in transforming MRI into a quantitative modality, and to measure quantities such as flow,... Read More
2013-056 – The invention is a method to prepare hydroxamate resin for use in metal ion separations.
2012-224 – Increase in bladder stiffness could be associated with various pathophysiologic conditions. We introduce Ultrasound Bladder Vibrometry (UBV), a novel method for rapid and noninvasive measurement of bladder wall viscoelasticity. UBV uses acoustic radiation force to excite mechanical waves in the bladder wall and track the motion using ultrasound pulse-echo techniques. Fourier domain analysis... Read More
2012-221 – Ultrasound radiation force is used to create propagating waves in soft tissue or other soft materials. The wave propagation is measured using pulse-echo ultrasound methods. We use a two-dimensional Fourier transform method to obtain the Fourier-space (k-space) with the coordinates of frequency (f) and wave number (k). The wave velocity © at each frequency is calculated by finding the... Read More
2012-188 – This invention is about using ultrasound for assessment of infant bone, and especially for evaluation of immature infants, who are at risk for osteopenia or other infant bone diseases. This method uses a ultrasound to generate a vibration in the bone and by analyzing the signal resulting from this vibration bone quality is evaluated.
2012-129 – A method to quantify tissue viscoelastic properties in a model-independent way by estimating the complex shear modulus from creep-recovery response and shear wave propagation speed by ultrasound acoustic radiation force. This method uses a formula that converts creep-recovery response in time to frequency domain complex modulus. The shear wave speed is used to calibrate the complex modulus... Read More
2012-083 – Coronary CT angiography (cCTA) is used to noninvasively look at the arteries that supply the heart muscle with blood, and diagnose (or rule out) blocked arteries, which are the main cause of heart attacks. cCTA is performed with either prospective or retrospective ECG gating. Irrespective of which variant is used, images are reconstructed with projection data corresponding to a partial scan... Read More
2011-274 – The invention uses ultrasound to measure the nonlinear mechanical properties of an object including those of biological tissues. This information can be used to detect abnormalities in tissues.
2011-224 – A method to quantify tissue mechanical properties in a model-independent way by estimating complex elastic modulus from time-dependant creep response induced by acoustic radiation force. This method uses a formula that converts time-domain creep compliance to frequency domain complex modulus. Then Shearwave Dispersion Ultrasound Vibrometry (SDUV) is used to calibrate the complex modulus so... Read More
2011-210 – Multiple short-duration ultrasound push pulses are used to deform tissue. The duration and PRF (Pulse Repetition Frequency) of these push pulses are compatible with current ultrasound scanners because these pulses are comparable to Doppler pulses. The collective effect from many push pulses generates shear waves of high amplitude for elasticity imaging. Two shear waves are produced: one at... Read More
2011-178 – Radiation dose from CT scanning is an increasing health concern, but lowering radiation dose alone generally produces a noisier image and may degrade diagnostic performance. Non-local means (NLM) denoising has become widely accepted as a very effective denoising tool in the image processing community, and has yielded very promising results in lung and abdominal CT. However, NLM requires an... Read More
2011-114 – In dynamic time series imaging, noise varies from image to image, but the underlying structure (although it can vary somewhat) is generally preserved. Techniques that take advantage of this are capable of efficiently denoising such data sets. In this invention, time series images are decomposed into overlapping subblocks of size NxN, with each subblock sampled T times in the time dimension.... Read More
2011-108 – Parallel Imaging is a widely used strategy for accelerating MRI acquisitions. Auto-calibrated coil-by-coil methods such as GRAPPA and ARC have become increasingly popular since they do not require a separate calibration scan (as do SENSE and ASSET) nor explicit estimation of coil sensitivity profiles, making them attractive for time-limited and dynamic applications like cardiac imaging.... Read More
Method for Reconstructing Dynamic Resonance Imaging Series From Limited Measurements Using Matrix Rank Constraints
2011-106 – This disclosure allows for image series to be reconstructed from only a subset of the data normally required to form the image series, and correspondingly for image acquisition time to be reduced. As demonstrated, the proposed reconstruction mechanism can provide improved temporal fidelity compared to other rank-based MRI series reconstruction methods.
2011-080 – The quantitative accuracy of CT numbers in myocardial perfusion computed tomography (MPCT) is degraded by artifacts arising from the use of partial scan reconstruction (PSR), which is used in cardiac CT to improve temporal resolution. Full scans do not suffer from this artifact. PSR artifacts appear because of inconsistencies in the angular range of projection data used for partial scans due... Read More
2011-026 – Propagation of shear wave (e.g., frequency dependent propagation speed and attenuation) in tissues is determined by mechanical properties of tissues. In ultrasound elasticity imaging, focused ultrasound beams are used to generate and detect shear waves in tissues. The 3D shape of the ultrasound beam can artificially increase measured shear wave speed in the transducer near field and... Read More
2010-115 – Photon counting detector technology is being actively adopted for commercial CT. One compelling reason is the advantages that it brings for spectral imaging (multi-energy CT) which allows material characterization using energy information from the detected x-rays. The ability to identify material composition regardless of material density (e.g. distinguishing iodine from bone even though they... Read More
2010-108 – SDUV is a non-invasive ultrasound technology that can qualify tissue stiffness and viscosity, which are sensitive indexes of pathology such as liver fibrosis. SDUV uses one long push toneburst of ultrasound followed by multiple detect pulses to generate and detect shear waves in tissue. Shear wave propagation information is used to estimate tissue stiffness and viscosity. The push-detect... Read More
2010-038 – The individual cross-sectional images along the arteries were analyzed individually by creating a Region-of-Interest (ROI) that encompassed the vessel wall. To ensure that the entire arterial wall was included into the ROI, the radius of the lumen ® was measured, which was used as the width of the annular ROI surrounding the arterial lumen (12). By creating a binary image of the punctate... Read More
2010-032 – A method for producing tissue motion with customized frequency content is described in which push pulses are designed using orthogonal basis functions which then produce desired tissue motion. The push pulses can be a sequence of long duration, in which case motion detection A-lines can be interleaved among the pulses. The result is a more efficient method of making tissue move with optimal... Read More
Use of Pittsburgh Compound B (PiB) Molecules and PiB-Positron Emission Tomography/Computed Tomography (PiB-PET/CT) Imaging for the Identification and Diagnosis of Meningiomas
2010-007 – Meningiomas are a common tumor often found in the thin layers of tissue that surround the brain. However, many other types of tumors can arise in the same locations. Variation in the appearance of meningiomas can make the accurate diagnosis of meningioma difficult based on current methods, such as Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). Pathologists can accurately... Read More
2009-278 – Specific and highly sensitive ultrasound localization of catheter placement can be accomplished by use of a catheter navigation crystal with an active (vibrating) element whose ultrasonic signal interferes with the ultrasound imaging signal as the latter propagates with each transmitted bearn though issue. The interference signal (caused by the crystal) occurs directly within the Doppler... Read More
2009-179 – For certain types of time series CT studies, Prior Image Constrained Compressed Sensing (PICCS) has been shown to significantly reduce the number of required data samples that must be acquired, thereby reducing the radiation dose to patients. PICCS is based on standard compressed sensing L1-norm minimization techniques. An alternative homotopic L0-based minimization technique developed... Read More
2009-043 – To reduce radiation dose and/or improve image quality in CT, it is very important to select the optimal tube potential (kV), which is highly dependent on patient size and specific diagnostic task. In this invention, we developed a general strategy that allows for individualized automatic kV selection for each patient size and each diagnostic task. We proposed a novel concept, kV dose index... Read More
1987-046 – Monoclonal Antibody to Bromo-deoxy-uridine. Useful in cell proliferation kits