2013-081 – Magnetic resonance imaging (MRI) is widely used to diagnostically investigate the human body. However, unlike other medical imaging modalities (e.g., X-ray CT), MRI data is not explicitly quantitative - pixel values do not directly represent physiological information. There is strong clinical interest in transforming MRI into a quantitative modality, and to measure quantities such as flow,... Read More
2012-224 – Increase in bladder stiffness could be associated with various pathophysiologic conditions. We introduce Ultrasound Bladder Vibrometry (UBV), a novel method for rapid and noninvasive measurement of bladder wall viscoelasticity. UBV uses acoustic radiation force to excite mechanical waves in the bladder wall and track the motion using ultrasound pulse-echo techniques. Fourier domain analysis... Read More
2012-221 – Ultrasound radiation force is used to create propagating waves in soft tissue or other soft materials. The wave propagation is measured using pulse-echo ultrasound methods. We use a two-dimensional Fourier transform method to obtain the Fourier-space (k-space) with the coordinates of frequency (f) and wave number (k). The wave velocity © at each frequency is calculated by finding the... Read More
2012-141 – Carpal tunnel syndrome (CTS) is a common problem with an estimated lifetime risk of 10%, a prevalence of about 3%, and a large economic burden of more than $1 billion annually for direct medical costs. It has been commonly recognized that carpal tunnel pressure (CTP) increases in CTS patients. However, measurement of CTP is invasive and not reliable due to technical difficulties. Although CTP... Read More
2012-134 – Shear wave produced by a focused ultrasound beam is used to evaluate tissue visco-elasticity, which are sensitive biomarkers of pathology. Shear waves thus produced are weak and attenuate quickly when propagating away from the push origin. We have proposed a method called CUSE where multiple unfocused push beams spaced out like a comb are used for shear wave production. Every pixel under... Read More
2012-129 – A method to quantify tissue viscoelastic properties in a model-independent way by estimating the complex shear modulus from creep-recovery response and shear wave propagation speed by ultrasound acoustic radiation force. This method uses a formula that converts creep-recovery response in time to frequency domain complex modulus. The shear wave speed is used to calibrate the complex modulus... Read More
2012-083 – Coronary CT angiography (cCTA) is used to noninvasively look at the arteries that supply the heart muscle with blood, and diagnose (or rule out) blocked arteries, which are the main cause of heart attacks. cCTA is performed with either prospective or retrospective ECG gating. Irrespective of which variant is used, images are reconstructed with projection data corresponding to a partial scan... Read More
2012-057 – Shear wave is used to evaluate tissue visco-elasticity, which are sensitive biomarkers of pathology. In order to obtain a 2D ultrasound elastography, an ultrafast imager with a FRAME rate of several kHz is required to capture the fast moving shear waves. This is not feasible with traditional ultrasound imagers with a frame rate of less than 100 Hz where 2D images are formed LINE BY LINE. ... Read More
2011-274 – The invention uses ultrasound to measure the nonlinear mechanical properties of an object including those of biological tissues. This information can be used to detect abnormalities in tissues.
Individualized CT Scan Protocols for Scanning with Either Lower Radiation Dose or Lower IV Contrast Dose
2011-229 – We developed a technique for creating individualized CT protocols that allow patients to be scanned with either lower radiation dose or lower intravenous contrast dose whilst maintaining iodine contrast-to-noise ratio and diagnostic image quality.
2011-224 – A method to quantify tissue mechanical properties in a model-independent way by estimating complex elastic modulus from time-dependant creep response induced by acoustic radiation force. This method uses a formula that converts time-domain creep compliance to frequency domain complex modulus. Then Shearwave Dispersion Ultrasound Vibrometry (SDUV) is used to calibrate the complex modulus so... Read More
2011-210 – Multiple short-duration ultrasound push pulses are used to deform tissue. The duration and PRF (Pulse Repetition Frequency) of these push pulses are compatible with current ultrasound scanners because these pulses are comparable to Doppler pulses. The collective effect from many push pulses generates shear waves of high amplitude for elasticity imaging. Two shear waves are produced: one at... Read More
2011-178 – Radiation dose from CT scanning is an increasing health concern, but lowering radiation dose alone generally produces a noisier image and may degrade diagnostic performance. Non-local means (NLM) denoising has become widely accepted as a very effective denoising tool in the image processing community, and has yielded very promising results in lung and abdominal CT. However, NLM requires an... Read More
2011-114 – In dynamic time series imaging, noise varies from image to image, but the underlying structure (although it can vary somewhat) is generally preserved. Techniques that take advantage of this are capable of efficiently denoising such data sets. In this invention, time series images are decomposed into overlapping subblocks of size NxN, with each subblock sampled T times in the time dimension.... Read More
2011-108 – Parallel Imaging is a widely used strategy for accelerating MRI acquisitions. Auto-calibrated coil-by-coil methods such as GRAPPA and ARC have become increasingly popular since they do not require a separate calibration scan (as do SENSE and ASSET) nor explicit estimation of coil sensitivity profiles, making them attractive for time-limited and dynamic applications like cardiac imaging.... Read More
Method for Reconstructing Dynamic Resonance Imaging Series From Limited Measurements Using Matrix Rank Constraints
2011-106 – This disclosure allows for image series to be reconstructed from only a subset of the data normally required to form the image series, and correspondingly for image acquisition time to be reduced. As demonstrated, the proposed reconstruction mechanism can provide improved temporal fidelity compared to other rank-based MRI series reconstruction methods.
2011-080 – The quantitative accuracy of CT numbers in myocardial perfusion computed tomography (MPCT) is degraded by artifacts arising from the use of partial scan reconstruction (PSR), which is used in cardiac CT to improve temporal resolution. Full scans do not suffer from this artifact. PSR artifacts appear because of inconsistencies in the angular range of projection data used for partial scans due... Read More
2011-026 – Propagation of shear wave (e.g., frequency dependent propagation speed and attenuation) in tissues is determined by mechanical properties of tissues. In ultrasound elasticity imaging, focused ultrasound beams are used to generate and detect shear waves in tissues. The 3D shape of the ultrasound beam can artificially increase measured shear wave speed in the transducer near field and... Read More
2011-002 – Nonfocused ultrasound waves are produced by merely transmitting long tonebursts on each of several elements in a linear or curved or phased array. This produces an unfocused beam. Shearwave can be imaged by beams from a two-dimensional array if a shearwave is produced in a rectangular section, then the shearwaves can propagate away from the rectangular section and can be imaged. The effect... Read More
2010-115 – Photon counting detector technology is being actively adopted for commercial CT. One compelling reason is the advantages that it brings for spectral imaging (multi-energy CT) which allows material characterization using energy information from the detected x-rays. The ability to identify material composition regardless of material density (e.g. distinguishing iodine from bone even though they... Read More
2010-108 – SDUV is a non-invasive ultrasound technology that can qualify tissue stiffness and viscosity, which are sensitive indexes of pathology such as liver fibrosis. SDUV uses one long push toneburst of ultrasound followed by multiple detect pulses to generate and detect shear waves in tissue. Shear wave propagation information is used to estimate tissue stiffness and viscosity. The push-detect... Read More
2010-038 – The individual cross-sectional images along the arteries were analyzed individually by creating a Region-of-Interest (ROI) that encompassed the vessel wall. To ensure that the entire arterial wall was included into the ROI, the radius of the lumen ® was measured, which was used as the width of the annular ROI surrounding the arterial lumen (12). By creating a binary image of the punctate... Read More
2010-032 – A method for producing tissue motion with customized frequency content is described in which push pulses are designed using orthogonal basis functions which then produce desired tissue motion. The push pulses can be a sequence of long duration, in which case motion detection A-lines can be interleaved among the pulses. The result is a more efficient method of making tissue move with optimal... Read More
2009-179 – For certain types of time series CT studies, Prior Image Constrained Compressed Sensing (PICCS) has been shown to significantly reduce the number of required data samples that must be acquired, thereby reducing the radiation dose to patients. PICCS is based on standard compressed sensing L1-norm minimization techniques. An alternative homotopic L0-based minimization technique developed... Read More
2009-083 – MR Spectroscopy data is analyzed to yield high quality spectral images. Multiple acquisitions of MRS data are combines. The images are combined by time a phase shifting the data in the time domain (equivalent to interpolation) so that the data points all coincide on the same set of frequency points after fourier transforming. This avoids cancelation of the desired signal that would occur... Read More
2009-049 – Technology Description Due to the rapid increase in use of CT imaging and the recently-heightened awareness of radiation-induced cancer, improving the diagnostic quality of low dose CT has become increasingly important. The signal-to-noise level of low dose CT scans is significantly lower than for normal dose scans, and thus may cause a decrease in diagnostic accuracy. Mayo Clinic... Read More
2009-048 – Technology Description Intracranial aneurysms represent a difficult to detect cause of morbidity and mortality. Digital subtraction angiography is considered the gold standard for intracranial aneurysm detection, but this technique is associated with risk of neurologic complications. 3D time-of-flight magnetic resonance angiograpy (MRA) has recently emerged as a non- invasive screening... Read More
2009-043 – To reduce radiation dose and/or improve image quality in CT, it is very important to select the optimal tube potential (kV), which is highly dependent on patient size and specific diagnostic task. In this invention, we developed a general strategy that allows for individualized automatic kV selection for each patient size and each diagnostic task. We proposed a novel concept, kV dose index... Read More
2007-184 – In MR and CT imaging, any reduction in scan time offers potential benefits ranging from high temporal rate observation of physiologic processes to reduction of motion artifacts to lower radiation dose (for CT) to improved patient comfort and throughout. Following recent developments in compressive sensing theory, it has been shown that certain classes of MR imaging can be accurately... Read More
2007-129 – Material-specific removal of image signal using dual-energy CT subtraction paradigms has the undesirable effect of altering signal throughout the image while increasing image noise. This novel algorithm preselects the material of interest and performs the dual-energy subtraction process only on those voxels meeting certain criteria. In this manner, material-specific subtraction is... Read More
2007-009 – Currently, radiologists interpreting CT colonography exams find it most efficient to view colons primarily in a 2D axial mode, scrolling these slices up and down the abdomen. Typically, the entire colon is scanned twice on the computer screen, first with a “lung” window/level setting (analogous to contrast/brightness) that clearly shows protrusions into the lumen and identifies most typical... Read More
2007-008 – CT colonography (CTC) is being extensively studied for its potential value in colon examinations. Like traditional colonoscopy, CTC requires extensive preparation to cleanse the colon of fecal material. The inconvenience and discomfort associated with this preparation is an important obstacle to compliance with currently recommended colorectal screening guidelines. An alternative is to tag... Read More
2007-007 – This invention consists of a novel display technique for CT colonography data. It is based on automatic generation of a midline trace (centerline) of the colon, followed by display of a sequence of images of the colon that follow this centerline, and display a small field of view centered on it and perpendicular to it. This allows the radiologist the benefit of always seeing the colon in... Read More
2007-006 – This invention consists of a novel display technique for CT colonography data. It is based on automatic generation of a midline trace (centerline) of the colon, followed by display of a sequence of axial images that display a small field of view centered on the trace, and follow along it. This allows the radiologist the benefit of a small field of view to examine the image, but frees him from... Read More
2006-196 – The MR shell k-space trajectory is a way to acquire MRI data. It has several intrinsic advantages over standard methods, including improved acquisition efficiency per unit time, compatibility with motion correction methods, and a high degree of venous suppression when used to acquire contrast-enhanced MR angiograms of arteries with intravenous injection of gadolinium-chelate contrast agents.... Read More
2004-085 – Tissue engineering scaffolds are biomimetic “trellis-like” structures which, on implantation and integration, act as tissue/organ surrogates. This disclosure enables the construction of multi-resolution, variably-refineable, globally interconnected, monolithic and maximally porous scaffolds.
2004-084 – Tissue engineering attempts to address the widening gap between the demand and supply of organ and tissue transplants using natural and biomimetic scaffolds. This invention provides a method to enable the repeatable and rapid fabrication of structurally and functionally enhanced and maximally characterized traditional scaffolds.
2004-056 – This disclosure provides a way to improve the Talairach Labeling scheme that allows labelings to be reported at 0.2 mm resolution - providing 2500% increase over the current standard.
2004-055 – This invention performs a robust, fast and fully automatic parameterization of T2 images into an intensity space that all existing approaches optimized to handle T1 images can benefit from.
2004-027 – To accomplish a given computational task, a number of algorithmic and heuristic approaches can be implemented to act upon the given instance of the input data. Depending upon the intrinsic and extrinsic assumptions made regarding the data, algorithm and the task, the end result from each of these approaches could be different. Currently, there does not exist an automatic fast, robust, precise... Read More
Prior Knowledge-Based Rapid Predicted Preview of Multiple Contrast Magnetic Resonance Images Derived from a Single Time Budgeted Acquisition
2004-023 – This invention presents a method for producing multiple MR images with different contrast from a single image acquisition. (MR T2) The methodology is used to enhance the T2 related contrast in an MRI image acquired at, but no restricted to, just-enough-to-highlight-T2, repetition time so as to produce a computed mosaic of the same image at different repetition (TR) and echo (TE) times. This... Read More
2004-020 – The CCAP program accurately and efficiently counts and analyzes cells in microscope images. A user interactively completes the followings steps: 1) Inhomogeneity correction: A digital filter is applied to correct for uneven illumination. 2) Calibration: A line is placed over an object of known size, usually a ruler, to determine the size of the image pixels. 3) Segmentation: The cells... Read More
Projection Angle Order and Correction Algorithm to Compensate In-Plane Rotation and Translation in Radial MRI Scans
2004-008 – The motion correction strategy compensates for rigid-body in-plane rotation and translation of the imaged object by collecting radial MRI data with a novel projection view angle acquisition order followed by a data correction algorithm. A custom MR pulse sequence was created to collect radial projections with a consistent spacing of approximately 45 degrees, which is crucial for the novel... Read More
2002-025 – Computer software which locates polyps and cancers of the colon on CT colonography data sets.
2001-160 – A common problem in clinical magnetic resonance imaging is misalignment of the individual imaging slices on sequential patient examinations. This inter-image misregistration frequently confounds accurate assignment of change or lack thereof in pathologic lesions across serial studies. We describe a rapid and accurate method to register the individual slices of MR images obtained at... Read More
2001-069 – Rigid body translations of an object in MRI will create image artifacts along the phase enclode (PE) direction in standard 2DFT imaging. If two images are acquired with swapped PE direction, it is theoretically possible to determine and correct for arbitrary translational motions in both images directly from the phase differences in the k-space acquisitions by solving a large system of... Read More
2001-042 – MR based technique for accurately detecting seed locations following prostate brachytherapy seed therapy. This method optimizes phase perturbations introduced into prostate and surrounding tissue resulting from implantation of brachytherapy seeds with differing susceptibility values and can accurately determine seed location and orientation in the prosstate and surrounding tissue.
2001-001 – Nearly all elderly persons develop pathologic areas of cell loss and demyelination (called leukoaraiosis), in the central areas of the brain. We have developed an accurate and highly reproducible method for quantitatively measuring the volume of leukoaraiosis from a magnetic resonance image of the brain.
2000-131 – An interactive software interface to a detailed brain atlas developed by Kent Ridge Digital Laboratories in Singapore which permits access, display and manipulation of the atlas within the analyze software system. The interface permits rapid and accurate registration of the brain atlas to MRI scans of the brain for the purpose of labeling, segmentation or other functions where defined and... Read More
2000-037 – A 3D motion adjustment pulse sequence is interleaved with magnetic resonance image (MRI) acquisition. This motion adjustment pulse sequence encodes all six degrees of rigid body motion in a single 3D spherical k-space dataset and is used to measure patient motion during the scan. The MRI system’s scan parameters are prospectively adjusted during the scan to offset the effects of patient... Read More